{"id":"https://openalex.org/W2907038720","doi":"https://doi.org/10.1101/510362","title":"Embryonic signals perpetuate polar-like trophoblast stem cells and pattern the blastocyst axis","display_name":"Embryonic signals perpetuate polar-like trophoblast stem cells and pattern the blastocyst axis","publication_year":2019,"publication_date":"2019-01-03","ids":{"openalex":"https://openalex.org/W2907038720","doi":"https://doi.org/10.1101/510362","mag":"2907038720"},"language":"en","primary_location":{"id":"doi:10.1101/510362","doi":"https://doi.org/10.1101/510362","is_oa":true,"landing_page_url":"https://doi.org/10.1101/510362","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/13/510362.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/13/510362.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031342983","display_name":"Javier Frias-Aldeguer","orcid":"https://orcid.org/0000-0003-2465-2081","observed_orcids":["https://orcid.org/0000-0003-2465-2081"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Javier Frias-Aldeguer","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","MERLN Institute for Technology-inspired Regenerative Medicine, Maastricht University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]},{"raw_affiliation_string":"MERLN Institute for Technology-inspired Regenerative Medicine, Maastricht University, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054876905","display_name":"Maarten Kip","orcid":"https://orcid.org/0000-0002-7357-4465","observed_orcids":["https://orcid.org/0000-0002-7357-4465"]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maarten Kip","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009656050","display_name":"Judith Vivi\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Judith Vivi\u00e9","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343202","display_name":"Linfeng Li","orcid":"https://orcid.org/0000-0002-1970-568X","observed_orcids":["https://orcid.org/0000-0002-1970-568X"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Linfeng Li","raw_affiliation_strings":["MERLN Institute for Technology-inspired Regenerative Medicine, Maastricht University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MERLN Institute for Technology-inspired Regenerative Medicine, Maastricht University, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026729663","display_name":"Anna Alemany","orcid":"https://orcid.org/0000-0002-0795-0290","observed_orcids":["https://orcid.org/0000-0002-0795-0290"]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anna Alemany","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031529442","display_name":"Jeroen Korving","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen Korving","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050147814","display_name":"Frank Darmis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank Darmis","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035202405","display_name":"Alexander van Oudenaarden","orcid":"https://orcid.org/0000-0002-9442-3551","observed_orcids":["https://orcid.org/0000-0002-9442-3551"]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alexander van Oudenaarden","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072347898","display_name":"Niels Geijsen","orcid":"https://orcid.org/0000-0003-3592-4353","observed_orcids":["https://orcid.org/0000-0003-3592-4353"]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niels Geijsen","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085037923","display_name":"Nicolas C. Rivron","orcid":"https://orcid.org/0000-0003-1590-5964","observed_orcids":["https://orcid.org/0000-0003-1590-5964","https://orcid.org/0000-0002-2774-673X"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Nicolas C. Rivron","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","MERLN Institute for Technology-inspired Regenerative Medicine, Maastricht University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]},{"raw_affiliation_string":"MERLN Institute for Technology-inspired Regenerative Medicine, Maastricht University, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085037923"],"corresponding_institution_ids":["https://openalex.org/I34352273","https://openalex.org/I4210115206"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trophoblast-stem-cells","display_name":"trophoblast stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/blastoids","display_name":"blastoids","score":0.6710000038146973},{"id":"https://openalex.org/keywords/trophoblast-differentiation","display_name":"trophoblast differentiation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7730000019073486},{"id":"https://openalex.org/keywords/epithelial-phenotype","display_name":"epithelial phenotype","score":0.6850000023841858},{"id":"https://openalex.org/keywords/early-mammalian-development","display_name":"early mammalian development","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.8871594667434692},{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.8618954420089722},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.8126648664474487},{"id":"https://openalex.org/C32253518","wikidata":"https://www.wikidata.org/wiki/Q5158447","display_name":"Conceptus","level":4,"score":0.7481609582901001},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6922611594200134},{"id":"https://openalex.org/C159399396","wikidata":"https://www.wikidata.org/wiki/Q1335221","display_name":"Inner cell mass","level":5,"score":0.5893964767456055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5420769453048706},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4802429974079132},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.34934741258621216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32541942596435547},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2669658362865448},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.172761470079422},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14741861820220947},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.12665849924087524},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.11800193786621094},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.05680274963378906}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/510362","doi":"https://doi.org/10.1101/510362","is_oa":true,"landing_page_url":"https://doi.org/10.1101/510362","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/13/510362.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/510362","doi":"https://doi.org/10.1101/510362","is_oa":true,"landing_page_url":"https://doi.org/10.1101/510362","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/13/510362.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2907038720.pdf","grobid_xml":"https://content.openalex.org/works/W2907038720.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1599762863","https://openalex.org/W1822354612","https://openalex.org/W1967071065","https://openalex.org/W1970062529","https://openalex.org/W1971377045","https://openalex.org/W1971582979","https://openalex.org/W1975751233","https://openalex.org/W1977203045","https://openalex.org/W1979298412","https://openalex.org/W1981641790","https://openalex.org/W1984883254","https://openalex.org/W1994144105","https://openalex.org/W1995674786","https://openalex.org/W2001090533","https://openalex.org/W2004102023","https://openalex.org/W2012305943","https://openalex.org/W2020413440","https://openalex.org/W2030613990","https://openalex.org/W2031911979","https://openalex.org/W2032337062","https://openalex.org/W2042754794","https://openalex.org/W2043980237","https://openalex.org/W2053482584","https://openalex.org/W2058521801","https://openalex.org/W2060928558","https://openalex.org/W2061933884","https://openalex.org/W2062403136","https://openalex.org/W2071353985","https://openalex.org/W2073107003","https://openalex.org/W2075769159","https://openalex.org/W2077765163","https://openalex.org/W2079421773","https://openalex.org/W2088237277","https://openalex.org/W2098094337","https://openalex.org/W2102298903","https://openalex.org/W2102687261","https://openalex.org/W2105469909","https://openalex.org/W2105749330","https://openalex.org/W2106115330","https://openalex.org/W2113732577","https://openalex.org/W2114436231","https://openalex.org/W2123829995","https://openalex.org/W2131586796","https://openalex.org/W2132069716","https://openalex.org/W2134873562","https://openalex.org/W2137874965","https://openalex.org/W2138417516","https://openalex.org/W2143098527","https://openalex.org/W2147680328","https://openalex.org/W2151718079","https://openalex.org/W2154558456","https://openalex.org/W2155676222","https://openalex.org/W2160236349","https://openalex.org/W2171898197","https://openalex.org/W2176310740","https://openalex.org/W2263039557","https://openalex.org/W2283074790","https://openalex.org/W2288998277","https://openalex.org/W2343245016","https://openalex.org/W2422099550","https://openalex.org/W2475625365","https://openalex.org/W2556998459","https://openalex.org/W2583486049","https://openalex.org/W2583745008","https://openalex.org/W2591350842","https://openalex.org/W2735493218","https://openalex.org/W2740747584","https://openalex.org/W2746140935","https://openalex.org/W2800655655","https://openalex.org/W2804980798","https://openalex.org/W2883177040","https://openalex.org/W2887741093","https://openalex.org/W2900051320","https://openalex.org/W2903810909","https://openalex.org/W2908122605","https://openalex.org/W2989560955"],"related_works":["https://openalex.org/W2800655655","https://openalex.org/W2204248006","https://openalex.org/W3002348470","https://openalex.org/W4284886829","https://openalex.org/W4413138246","https://openalex.org/W7096970757","https://openalex.org/W7099681023","https://openalex.org/W4361208553","https://openalex.org/W2073107003","https://openalex.org/W2166438339"],"abstract_inverted_index":{"Summary":[0],"The":[1],"early":[2,37,145],"mammalian":[3],"conceptus":[4],"(blastocyst)":[5],"comprises":[6],"an":[7,13,84],"outer":[8],"trophoblast":[9],"globe":[10],"that":[11,42,100],"forms":[12,103],"axis":[14,131],"originating":[15],"from":[16,51],"the":[17,22,79,111,117,122,139],"inner":[18,80,106],"embryonic":[19,64,81,107],"cells.":[20],"From":[21],"mouse":[23],"conceptus,":[24],"Trophoblast":[25],"stem":[26],"cells":[27,108],"(TSCs)":[28],"are":[29,32],"derived,":[30],"which":[31],"in":[33,133],"vitro":[34,134],"analogues":[35],"of":[36,63,71,91,113,126,144],"trophoblasts.":[38,55],"Here,":[39],"we":[40],"show":[41],"TSCs":[43,67,93],"contain":[44],"plastic":[45],"subpopulations":[46],"reflecting":[47],"developmental":[48],"states":[49],"ranging":[50],"pre-":[52],"to":[53,59],"post-implantation":[54],"However,":[56],"upon":[57],"exposure":[58],"a":[60,96,136],"specific":[61],"combination":[62],"inductive":[65],"signals,":[66],"globally":[68],"acquire":[69],"properties":[70,125],"pre-implantation":[72],"polar":[73,127],"trophoblasts":[74,128],"(gene":[75],"expression,":[76],"self-renewal)":[77],"juxtaposing":[78],"cells,":[82],"and":[83,124,129,142],"enhanced,":[85],"homogeneous":[86],"epithelial":[87],"phenotype.":[88],"These":[89],"lines":[90],"polar-like":[92],"(pTSCs)":[94],"represent":[95],"transcriptionally":[97],"earlier":[98],"state":[99],"more":[101],"efficiently":[102],"blastoids,":[104],"whose":[105],"then":[109],"induce":[110],"patterning":[112],"gene":[114],"expression":[115],"along":[116],"embryonic-abembryonic":[118],"axis.":[119],"Altogether,":[120],"delineating":[121],"requirements":[123],"blastocyst":[130],"formation":[132],"provides":[135],"foundation":[137],"for":[138],"precise":[140],"description":[141],"dissection":[143],"development.":[146]},"counts_by_year":[{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-01-11T00:00:00"}
