{"id":"https://openalex.org/W2907036216","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.e14027","title":"Molecular surgery using a novel biological agent, OBP-301, for lymph node micrometastasis in human colorectal cancer.","display_name":"Molecular surgery using a novel biological agent, OBP-301, for lymph node micrometastasis in human colorectal cancer.","publication_year":2014,"publication_date":"2014-05-20","ids":{"openalex":"https://openalex.org/W2907036216","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.e14027","mag":"2907036216"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.15_suppl.e14027","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.e14027","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.e14027","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034496276","display_name":"Satoru Kikuchi","orcid":"https://orcid.org/0000-0002-7671-0696","observed_orcids":["https://orcid.org/0000-0002-7671-0696"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Kikuchi","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035456514","display_name":"Hiroyuki Kishimoto","orcid":"https://orcid.org/0000-0001-8174-3508","observed_orcids":["https://orcid.org/0000-0001-8174-3508"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kishimoto","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015421086","display_name":"Hiroshi Tazawa","orcid":"https://orcid.org/0000-0003-4658-1050","observed_orcids":["https://orcid.org/0000-0003-4658-1050"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Tazawa","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049100460","display_name":"Shunsuke Kagawa","orcid":"https://orcid.org/0000-0002-3610-8211","observed_orcids":["https://orcid.org/0000-0002-3610-8211"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Kagawa","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045812","display_name":"Yasuo Urata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164470","display_name":"Oncolys BioPharma (Japan)","ror":"https://ror.org/05qvatg15","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210164470"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuo Urata","raw_affiliation_strings":["Oncolys BioPharma Inc., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncolys BioPharma Inc., Tokyo, Japan","institution_ids":["https://openalex.org/I4210164470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["AntiCancer, Inc. and University of California, San Diego, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc. and University of California, San Diego, San Diego, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068717107","display_name":"Toshiyoshi Fujiwara","orcid":"https://orcid.org/0000-0002-5377-6051","observed_orcids":["https://orcid.org/0000-0002-5377-6051"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyoshi Fujiwara","raw_affiliation_strings":["Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"15_suppl","first_page":"e14027","last_page":"e14027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obp-301","display_name":"OBP-301","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.8169999718666077},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.6809999942779541},{"id":"https://openalex.org/keywords/endoscopic-submucosal-dissection","display_name":"endoscopic submucosal dissection","score":0.9760000109672546},{"id":"https://openalex.org/keywords/peritumoral-injection","display_name":"peritumoral injection","score":0.7829999923706055},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.6060000061988831},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5090000033378601},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/colo-205-cells","display_name":"COLO 205 cells","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8339726328849792},{"id":"https://openalex.org/C2778123414","wikidata":"https://www.wikidata.org/wiki/Q2779635","display_name":"Micrometastasis","level":4,"score":0.7510910630226135},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6774165034294128},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.6593438982963562},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6444639563560486},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5740883946418762},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46517157554626465},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4541265070438385},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.4316819906234741},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3779982328414917},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32566189765930176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2858960032463074}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.15_suppl.e14027","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.e14027","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.e14027","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2014230740","https://openalex.org/W1510603086","https://openalex.org/W1996996990","https://openalex.org/W7027737367","https://openalex.org/W3204007858","https://openalex.org/W2099110428","https://openalex.org/W2264130485","https://openalex.org/W2050349145","https://openalex.org/W2168261379","https://openalex.org/W4248950209"],"abstract_inverted_index":{"e14027":[0],"Background:":[1],"Endoscopic":[2],"submucosal":[3,79,87,144,204],"dissection":[4],"(ESD)":[5],"for":[6,15,128],"early-stage":[7],"colo-rectal":[8],"cancer":[9,63,90,121,197],"(CRC)":[10],"is":[11],"not":[12,176],"yet":[13],"effective":[14],"lymph":[16],"node":[17],"(LN)":[18],"metastasis.":[19,93],"We":[20],"previously":[21],"constructed":[22],"a":[23,33,55],"telomerase-dependent":[24],"oncolytic":[25],"adenoviral":[26],"agent":[27],"(OBP-301),":[28],"which":[29],"was":[30,115,133,139,150,158,175],"evaluated":[31],"in":[32,38,42,54,111,178,202,224],"Phase":[34],"1":[35],"clinical":[36,235],"trial":[37],"the":[39,78,97,112,124,142,147,168,179,203,207],"United":[40],"States":[41],"2008.":[43],"The":[44],"current":[45],"study":[46],"determined":[47],"whether":[48],"OBP-301":[49,105,138,157,215],"could":[50,107],"inhibit":[51],"LN":[52,92,109,125,164,172,217],"metastasis":[53,110,165,218],"rectal":[56,89,100],"tumor":[57,101,149,155,186],"mouse":[58,83,113,208],"model.":[59],"Methods:":[60],"Human":[61],"colon":[62,196],"HCT-116":[64],"and":[65,91,146,219],"Colo-205":[66],"cells,":[67],"both":[68],"expressing":[69],"green":[70],"fluorescent":[71],"protein":[72],"(GFP),":[73],"were":[74,190],"orthotopically":[75],"implanted":[76,130,201],"into":[77],"layer":[80,145,205],"of":[81,96,206,222],"nude":[82],"rectum":[84],"with":[85,102,131,193,226],"resultant":[86],"invasive":[88,99],"Whether":[94],"resection":[95],"SM":[98],"prior":[103],"peritumoral":[104,143],"injection":[106],"sterilize":[108],"model":[114],"assessed.":[116],"Results:":[117],"Seven":[118,152],"days":[119,153],"after":[120,154,185],"cell":[122,198],"implantation,":[123],"metastatic":[126,173],"rate":[127],"mice":[129],"HCT-116-GFP":[132],"78.5%.":[134],"At":[135],"that":[136,214],"time,":[137],"injected":[140],"to":[141,160,167],"primary":[148],"resected.":[151],"resection,":[156],"observed":[159,192],"have":[161],"significantly":[162],"inhibited":[163],"compared":[166],"untreated":[169],"group.":[170],"Moreover,":[171],"recurrence":[174],"detected":[177],"OBP-301-treated":[180],"group":[181],"even":[182],"4":[183],"weeks":[184],"excision.":[187],"Similar":[188],"results":[189,212],"also":[191],"another":[194],"human":[195],"line,":[199],"Colo-205,":[200],"rectum.":[209],"Conclusions:":[210],"These":[211],"demonstrate":[213],"inhibits":[216],"should":[220],"be":[221],"use":[223],"conjunction":[225],"ESD.":[227],"Based":[228],"on":[229],"these":[230],"promising":[231],"preclinical":[232],"results,":[233],"multicenter":[234],"traials":[236],"are":[237],"warranted.":[238]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-11T00:00:00"}
