{"id":"https://openalex.org/W2907014288","doi":"https://doi.org/10.1111/ijlh.12963","title":"Development of new methodologies for the chromogenic estimation of betrixaban concentrations in plasma","display_name":"Development of new methodologies for the chromogenic estimation of betrixaban concentrations in plasma","publication_year":2019,"publication_date":"2019-01-03","ids":{"openalex":"https://openalex.org/W2907014288","doi":"https://doi.org/10.1111/ijlh.12963","mag":"2907014288","pmid":"https://pubmed.ncbi.nlm.nih.gov/30604921"},"language":"en","primary_location":{"id":"doi:10.1111/ijlh.12963","doi":"https://doi.org/10.1111/ijlh.12963","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ijlh.12963","pdf_url":null,"source":{"id":"https://openalex.org/S66208518","display_name":"International Journal of Laboratory Hematology","issn_l":"1751-5521","issn":["1751-5521","1751-553X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Laboratory Hematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2078.1/210181","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023872367","display_name":"Romain Siriez","orcid":"https://orcid.org/0000-0002-5003-6939","observed_orcids":["https://orcid.org/0000-0002-5003-6939"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Romain Siriez","raw_affiliation_strings":["Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-5003-6939","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088589131","display_name":"Jonathan Evrard","orcid":"https://orcid.org/0000-0003-4255-1591","observed_orcids":["https://orcid.org/0000-0003-4255-1591"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jonathan Evrard","raw_affiliation_strings":["Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-4255-1591","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041424887","display_name":"Jean\u2010Michel Dogn\u00e9","orcid":"https://orcid.org/0000-0003-2107-1804","observed_orcids":["https://orcid.org/0000-0003-2107-1804"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean\u2010Michel Dogn\u00e9","raw_affiliation_strings":["Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023392033","display_name":"Lionel Pochet","orcid":"https://orcid.org/0000-0002-2560-9555","observed_orcids":["https://orcid.org/0000-0002-2560-9555"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lionel Pochet","raw_affiliation_strings":["Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2560-9555","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062344404","display_name":"C\u00e9line Bouvy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9line Bouvy","raw_affiliation_strings":["Qualiblood s.a, Namur, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qualiblood s.a, Namur, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082941105","display_name":"Sarah Lessire","orcid":"https://orcid.org/0000-0001-6689-6100","observed_orcids":["https://orcid.org/0000-0001-6689-6100"]},"institutions":[{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sarah Lessire","raw_affiliation_strings":["Department of Anesthesiology, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS) Universit\u00e9 Catholique de Louvain, CHU UCL Namur Yvoir Belgium"],"raw_orcid":"https://orcid.org/0000-0001-6689-6100","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS) Universit\u00e9 Catholique de Louvain, CHU UCL Namur Yvoir Belgium","institution_ids":["https://openalex.org/I4391767857","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000944048","display_name":"Fran\u00e7ois Mullier","orcid":"https://orcid.org/0000-0001-6947-6099","observed_orcids":["https://orcid.org/0000-0001-6947-6099"]},"institutions":[{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Mullier","raw_affiliation_strings":["Hematology Laboratory, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS) Universit\u00e9 Catholique de Louvain, CHU UCL Namur Yvoir Belgium"],"raw_orcid":"https://orcid.org/0000-0001-6947-6099","affiliations":[{"raw_affiliation_string":"Hematology Laboratory, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS) Universit\u00e9 Catholique de Louvain, CHU UCL Namur Yvoir Belgium","institution_ids":["https://openalex.org/I4391767857","https://openalex.org/I95674353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078686392","display_name":"Jonathan Douxfils","orcid":"https://orcid.org/0000-0002-7644-5298","observed_orcids":["https://orcid.org/0000-0002-7644-5298"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jonathan Douxfils","raw_affiliation_strings":["Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium","Qualiblood s.a, Namur, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-7644-5298","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"raw_affiliation_string":"Qualiblood s.a, Namur, Belgium","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023872367"],"corresponding_institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":null,"fwci":1.4798,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81707946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"41","issue":"2","first_page":"250","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.10010000318288803,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betrixaban","display_name":"betrixaban","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.5709999799728394},{"id":"https://openalex.org/keywords/assay-sensitivity","display_name":"assay sensitivity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/sample-dilution","display_name":"sample dilution","score":0.800000011920929},{"id":"https://openalex.org/keywords/unfractionated-heparin","display_name":"unfractionated heparin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fondaparinux","display_name":"fondaparinux","score":0.996999979019165},{"id":"https://openalex.org/keywords/cross-interference","display_name":"cross-interference","score":0.7480000257492065},{"id":"https://openalex.org/keywords/anticoagulation-monitoring","display_name":"anticoagulation monitoring","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C128463046","wikidata":"https://www.wikidata.org/wiki/Q22315590","display_name":"Chromogenic","level":2,"score":0.8620122671127319},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7161551713943481},{"id":"https://openalex.org/C2776877702","wikidata":"https://www.wikidata.org/wiki/Q27077698","display_name":"Fondaparinux","level":4,"score":0.7148553133010864},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6376951336860657},{"id":"https://openalex.org/C184112429","wikidata":"https://www.wikidata.org/wiki/Q476174","display_name":"Serial dilution","level":3,"score":0.5862612724304199},{"id":"https://openalex.org/C2776884760","wikidata":"https://www.wikidata.org/wiki/Q2750727","display_name":"Low molecular weight heparin","level":3,"score":0.4829553961753845},{"id":"https://openalex.org/C96618451","wikidata":"https://www.wikidata.org/wiki/Q3028008","display_name":"Dilution","level":2,"score":0.46932098269462585},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.4422647953033447},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.41723716259002686},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.20322531461715698},{"id":"https://openalex.org/C2991741193","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thromboembolism","level":3,"score":0.14770853519439697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14238274097442627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1112866997718811},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08832100033760071},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08274993300437927},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D065427","descriptor_name":"Factor Xa Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/ijlh.12963","doi":"https://doi.org/10.1111/ijlh.12963","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ijlh.12963","pdf_url":null,"source":{"id":"https://openalex.org/S66208518","display_name":"International Journal of Laboratory Hematology","issn_l":"1751-5521","issn":["1751-5521","1751-553X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Laboratory Hematology","raw_type":"journal-article"},{"id":"pmid:30604921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30604921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of laboratory hematology","raw_type":"Clinical Trial"},{"id":"pmh:oai:dial.uclouvain.be:boreal:210181","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/210181","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International journal of laboratory hematology, (2019)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.unamur.be:openaire_cris_publications/95bac97f-13ae-40ba-ba3f-c843aefd8b70","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.unamur.be/en/publications/95bac97f-13ae-40ba-ba3f-c843aefd8b70","pdf_url":null,"source":{"id":"https://openalex.org/S4406922457","display_name":"Repository of the University of Namur","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Siriez, R, Evrard, J, Dogn\u00e9, J-M, Pochet, L, Bouvy, C, Lessire, S, Mullier, F & Douxfils, J 2019, 'Development of new methodologies for the chromogenic estimation of betrixaban concentrations in plasma', International Journal of Laboratory Hematology, vol. 41, no. 2, pp. 250-261. https://doi.org/10.1111/ijlh.12963","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:dial.uclouvain.be:boreal:210181","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/210181","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International journal of laboratory hematology, (2019)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1707073606","https://openalex.org/W1963968439","https://openalex.org/W1965446865","https://openalex.org/W1974024236","https://openalex.org/W2015940002","https://openalex.org/W2023363122","https://openalex.org/W2030594826","https://openalex.org/W2038830184","https://openalex.org/W2053361486","https://openalex.org/W2063207586","https://openalex.org/W2067666141","https://openalex.org/W2072162822","https://openalex.org/W2073510057","https://openalex.org/W2082571460","https://openalex.org/W2087630384","https://openalex.org/W2103196751","https://openalex.org/W2107151329","https://openalex.org/W2115279806","https://openalex.org/W2128811936","https://openalex.org/W2128844712","https://openalex.org/W2156970332","https://openalex.org/W2160030871","https://openalex.org/W2163853479","https://openalex.org/W2170260432","https://openalex.org/W2548076162","https://openalex.org/W2769760280","https://openalex.org/W2800785414","https://openalex.org/W2801340189","https://openalex.org/W4213173863"],"related_works":["https://openalex.org/W4213185099","https://openalex.org/W2964132548","https://openalex.org/W3006253728","https://openalex.org/W2912325088","https://openalex.org/W2087630384","https://openalex.org/W2466857300","https://openalex.org/W1484066528","https://openalex.org/W1963968439","https://openalex.org/W2184361698","https://openalex.org/W3096350082"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Chromogenic":[2],"anti\u2010Xa":[3,184],"assays":[4,191],"are":[5,28],"the":[6,12,19,32,95,117,122,179,187,221,224,238,241,246,250],"most":[7],"appropriate":[8],"tests":[9,23,54,126],"to":[10,30,44,98,102,116,127,143,160,171,192,196,207],"estimate":[11],"amount":[13],"of":[14,21,65,83,124,131,181,189,203,209,223,240,254],"betrixaban":[15,128,193,210],"in":[16,47,112,212,237],"plasma":[17,48,79],"but":[18,194],"sensitivity":[20,101,123,159,188],"available":[22],"is":[24,141,257],"limited":[25],"and":[26,60,63,173,252],"improvements":[27],"needed":[29],"encompass":[31],"on\u2010therapy":[33,96],"range.":[34],"Methods":[35],"Betrixaban":[36],"was":[37,70],"spiked":[38,80],"at":[39],"concentrations":[40,211],"ranging":[41],"from":[42,49],"0":[43],"500":[45],"ng/mL":[46,133,145],"healthy":[50],"donors.":[51],"Three":[52],"commercial":[53],"were":[55,75],"used":[56],"(Biophen\u00aeDiXaI\u00ae,":[57],"STA\u00aeLiquid":[58],"Anti\u2010Xa,":[59],"HemosIL\u00aeLiquid":[61],"Anti\u2010Xa),":[62],"adaptation":[64],"their":[66,100],"sample":[67],"dilution":[68],"scheme":[69],"performed.":[71],"These":[72],"new":[73],"methodologies":[74,185],"also":[76,155,195],"tested":[77],"on":[78],"with":[81,215],"amounts":[82],"unfractionated":[84],"heparin":[85],"(UFH),":[86],"low":[87],"molecular":[88],"weight":[89],"heparins":[90],"(LMWH),":[91],"or":[92],"fondaparinux":[93,232],"covering":[94],"ranges":[97],"evaluate":[99],"indirect":[103,161,197],"factor":[104,162,198],"Xa":[105,163,199],"inhibitors.":[106,200],"Results":[107,108,176],"showed":[109,156,177],"concentration\u2010dependent":[110],"decreases":[111],"OD/min":[113],"inversely":[114],"proportional":[115],"dilutions.":[118],"While":[119],"modifications":[120],"improve":[121],"these":[125,190],"(eg,":[129],"\u00bd*OD/min":[130],"502":[132],"[95%":[134,146],"CI:":[135,147],"495\u2010508":[136],"ng/mL]":[137,149],"for":[138,150,166,231],"Biophen\u00aeDiXaI\u00ae":[139,152,167,225],"[1:50]":[140],"reduced":[142],"51":[144],"50\u201052":[148],"improved":[151],"[1:5]),":[153],"results":[154],"an":[157],"increased":[158],"inhibitors,":[164],"except":[165,230],"which":[168,233],"remains":[169,234],"insensitive":[170],"UFH":[172],"LMWH.":[174],"Conclusions":[175],"that":[178],"improvement":[180],"current":[182],"chromogenic":[183,248],"enhances":[186],"This":[201],"lack":[202],"specificity":[204],"may":[205,226],"lead":[206],"overestimation":[208],"patients":[213],"bridged":[214],"heparins.":[216],"To":[217],"avoid":[218],"this":[219],"cross\u2010interference,":[220],"use":[222],"be":[227],"a":[228],"solution":[229],"active":[235],"even":[236],"presence":[239],"Biophen\u00aeDiXaI\u00ae\u2019s":[242],"specific":[243,255],"buffer.":[244],"For":[245],"other":[247],"assays,":[249],"conception":[251],"validation":[253],"buffer":[256],"required.":[258]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-11T00:00:00"}