{"id":"https://openalex.org/W2906978652","doi":"https://doi.org/10.1182/blood-2018-99-112745","title":"Association of MHC Class I Chain-Related Gene a (MICA) Polymorphisms with Allogeneic Hematopoietic Cell Transplantation Outcomes in Acute Myeloid Leukemia","display_name":"Association of MHC Class I Chain-Related Gene a (MICA) Polymorphisms with Allogeneic Hematopoietic Cell Transplantation Outcomes in Acute Myeloid Leukemia","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2906978652","doi":"https://doi.org/10.1182/blood-2018-99-112745","mag":"2906978652"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-112745","doi":"https://doi.org/10.1182/blood-2018-99-112745","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-112745","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043016347","display_name":"Sagar S. Patel","orcid":"https://orcid.org/0000-0001-9949-3615","observed_orcids":["https://orcid.org/0000-0001-9949-3615"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sagar S. Patel","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050880000","display_name":"Betty K. Hamilton","orcid":"https://orcid.org/0000-0003-1252-6539","observed_orcids":["https://orcid.org/0000-0003-1252-6539"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty K. Hamilton","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046052708","display_name":"Lisa A Rybicki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lisa Rybicki","raw_affiliation_strings":["Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023705866","display_name":"Dawn Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dawn Thomas","raw_affiliation_strings":["Allogen Laboratories, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allogen Laboratories, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086971204","display_name":"Arden Emrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arden Emrick","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086233229","display_name":"Aziz Nazha","orcid":"https://orcid.org/0000-0002-6695-7994","observed_orcids":["https://orcid.org/0000-0002-6695-7994"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aziz Nazha","raw_affiliation_strings":["Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102826236","display_name":"Sudipto Mukherjee","orcid":"https://orcid.org/0000-0002-8325-2603","observed_orcids":["https://orcid.org/0000-0002-8325-2603","https://orcid.org/0009-0002-0717-6319"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudipto Mukherjee","raw_affiliation_strings":["Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082944296","display_name":"Anjali S. Advani","orcid":"https://orcid.org/0000-0003-0015-5902","observed_orcids":["https://orcid.org/0000-0003-0015-5902"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjali S. Advani","raw_affiliation_strings":["Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016810759","display_name":"Hetty E. Carraway","orcid":"https://orcid.org/0000-0001-5241-3614","observed_orcids":["https://orcid.org/0000-0001-5241-3614"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hetty E. Carraway","raw_affiliation_strings":["Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013767912","display_name":"Brad L. Pohlman","orcid":"https://orcid.org/0000-0001-6006-3714","observed_orcids":["https://orcid.org/0000-0001-6006-3714"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Pohlman","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109109837","display_name":"Brian James Bolwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Bolwell","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011431831","display_name":"Robert M. Dean","orcid":"https://orcid.org/0000-0003-2559-563X","observed_orcids":["https://orcid.org/0000-0003-2559-563X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Dean","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023728016","display_name":"Aaron Thomas Gerds","orcid":"https://orcid.org/0000-0002-3422-1309","observed_orcids":["https://orcid.org/0000-0002-3422-1309"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron T. Gerds","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049744314","display_name":"Rabi Hanna","orcid":"https://orcid.org/0000-0001-7518-309X","observed_orcids":["https://orcid.org/0000-0001-7518-309X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rabi Hanna","raw_affiliation_strings":["Pediatric Blood and Marrow Transplant Program, Pediatrics Institute and Children's Hospital, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Blood and Marrow Transplant Program, Pediatrics Institute and Children's Hospital, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112129467","display_name":"Matt E Kalaycio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt Kalaycio","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102809348","display_name":"Aiwen Zhang","orcid":"https://orcid.org/0000-0001-5573-4026","observed_orcids":["https://orcid.org/0000-0001-5573-4026"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aiwen Zhang","raw_affiliation_strings":["Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055740968","display_name":"Mikkael Aaron Sekeres","orcid":"https://orcid.org/0000-0003-2009-6524","observed_orcids":["https://orcid.org/0000-0003-2009-6524"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikkael A. Sekeres","raw_affiliation_strings":["Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085974329","display_name":"Jaroslaw Pawel Maciejewski","orcid":"https://orcid.org/0000-0002-6837-4346","observed_orcids":["https://orcid.org/0000-0002-6837-4346"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaroslaw P. Maciejewski","raw_affiliation_strings":["Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019494133","display_name":"Navneet S. Majhail","orcid":"https://orcid.org/0000-0001-7082-891X","observed_orcids":["https://orcid.org/0000-0001-7082-891X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navneet S. Majhail","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029422642","display_name":"Medhat Z. Askar","orcid":"https://orcid.org/0000-0003-2633-9363","observed_orcids":["https://orcid.org/0000-0003-2633-9363"]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Medhat Askar","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Baylor University Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Baylor University Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I2802366037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011655907","display_name":"Ronald M. Sobecks","orcid":"https://orcid.org/0000-0003-1608-3261","observed_orcids":["https://orcid.org/0000-0003-1608-3261"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Sobecks","raw_affiliation_strings":["Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023705866","https://openalex.org/A5029422642","https://openalex.org/A5046052708","https://openalex.org/A5086971204","https://openalex.org/A5102809348"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I2802366037"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"2075","last_page":"2075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.4975999891757965,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.4975999891757965,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.44510000944137573,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mica","display_name":"mica","score":0.8519999980926514},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.8970000147819519},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.828000009059906},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.671999990940094},{"id":"https://openalex.org/keywords/cytogenetic-risk-stratification","display_name":"cytogenetic risk stratification","score":0.7250000238418579},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9359999895095825},{"id":"https://openalex.org/keywords/flt3","display_name":"FLT3","score":0.671999990940094},{"id":"https://openalex.org/keywords/npm1","display_name":"NPM1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":0.949999988079071},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.8769999742507935},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.538143515586853},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5361195802688599},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5315392017364502},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5119984745979309},{"id":"https://openalex.org/C2778867473","wikidata":"https://www.wikidata.org/wiki/Q17544382","display_name":"NKG2D","level":4,"score":0.49988818168640137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48373866081237793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41830191016197205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33776605129241943},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32816243171691895},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17835664749145508},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.09588798880577087},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-112745","doi":"https://doi.org/10.1182/blood-2018-99-112745","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-112745","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3047219393","https://openalex.org/W2551519093","https://openalex.org/W904299164","https://openalex.org/W2913969031","https://openalex.org/W2100730047","https://openalex.org/W2997571270","https://openalex.org/W3206502108","https://openalex.org/W2053327312","https://openalex.org/W2914349153","https://openalex.org/W2562089275"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"MHC":[2],"class":[3],"I":[4],"chain-related":[5],"gene":[6,47],"A":[7,300],"(MICA)":[8],"is":[9,77],"a":[10,100,158,163,297,312,360,397,427,459],"polymorphic":[11],"ligand":[12],"of":[13,44,51,105,160,210,264,294,307,327,337,363,400,426,462,471,480,507,546,615,635,662,673,718,736,751,776,787,798,809,830,850],"the":[14,45,177,208,424,440,443,483,486,525,558,562],"natural":[15],"killer":[16],"(NKG2D)":[17],"receptor":[18,26,195,560],"on":[19,607,631,658,669,714,732,747,772,783,794,805,826,846],"immune":[20,28,567],"effector":[21],"cells.":[22,38],"The":[23,275,317,335,476,553],"activating":[24],"NKG2D":[25,55,559],"controls":[27],"responses":[29,568],"by":[30,148,172,561],"regulating":[31],"NK":[32,550],"cells,":[33],"NKT":[34],"cells":[35],"and":[36,73,84,139,199,212,220,256,271,290,309,346,370,423,442,451,455,485,494,510,524,590],"\u03b3\u03b4-T":[37],"Dimorphisms":[39,175],"at":[40,176,240,251,416],"sequence":[41],"position":[42,179],"129":[43],"MICA":[46,57,80,134,211,330,353,605],"confers":[48],"varying":[49],"levels":[50],"binding":[52,196,555],"affinity":[53,556],"to":[54,89,130,143,170,206,356,530,541,557,574,588],"receptor.":[56],"previously":[58,181],"has":[59],"been":[60,182],"associated":[61,358,383,395],"with":[62,82,214,246,332,359,384,396,412,512,549,596,604,691],"post-allogeneic":[63],"hematopoietic":[64],"cell":[65,551],"transplantation":[66],"(alloHCT)":[67],"outcomes":[68,91,213,514,609],"including":[69],"graft-versus-host-disease":[70],"(GvHD),":[71],"infection,":[72],"relapse.":[74],"However,":[75],"it":[76],"unclear":[78],"how":[79],"interacts":[81],"cytogenetic":[83,144],"somatic":[85,165,279,447,508,602],"mutations":[86,280,509,521,548,603],"in":[87,92,109,305,522,643,688],"regards":[88],"these":[90],"acute":[93,373],"myeloid":[94],"leukemia":[95],"(AML).":[96],"Methods":[97],"We":[98],"conducted":[99],"single":[101],"center,":[102],"retrospective":[103],"analysis":[104],"adult":[106],"AML":[107,231,601],"patients":[108,161,232,265,295,308,328,472,616],"first":[110],"or":[111,123,191,201,637,664,675,720,738,753,778,789,800,811,832,852],"second":[112],"complete":[113],"remission":[114],"(CR1,":[115],"CR2),":[116],"who":[117,132],"underwent":[118],"T-cell":[119],"replete":[120],"matched":[121],"related":[122,298],"unrelated":[124],"donor":[125,338,391,527,592],"alloHCT.":[126],"Analysis":[127],"was":[128,204,242,303,323,381,394,489],"limited":[129],"those":[131],"had":[133,162,296,311],"data":[135],"available":[136],"for":[137,465,517,534,543,582],"donors":[138],"recipients.":[140],"In":[141,349,388],"addition":[142],"risk":[145,260,362,399,585],"group":[146],"stratification":[147,261,586],"European":[149],"LeukemiaNet":[150],"criteria":[151],"(D\u00f6hner":[152],"H,":[153],"et":[154],"al,":[155],"Blood":[156],"2016),":[157],"subset":[159],"36-gene":[164],"mutation":[166,429],"panel":[167],"assessed":[168],"prior":[169,587],"alloHCT":[171,516],"next-generation":[173],"sequencing.":[174],"MICA-129":[178,339,392,528],"have":[180,504,580],"categorized":[183],"as":[184,216,266,269,273],"weaker":[185,554],"(valine/valine:":[186],"V/V),":[187],"heterozygous":[188],"(methionine/valine:":[189],"M/V),":[190],"stronger":[192],"(methionine/methionine:":[193],"M/M)":[194],"affinity.":[197],"Fine":[198],"Gray":[200],"Cox":[202],"regression":[203],"used":[205,322],"identify":[207],"association":[209],"results":[215],"hazard":[217],"ratios":[218],"(HR)":[219],"95%":[221],"confidence":[222],"intervals":[223],"(CI).":[224],"Results":[225],"From":[226],"2000":[227],"-":[228],"2017,":[229],"131":[230],"were":[233,281,329,341,436],"identified":[234],"meeting":[235],"inclusion":[236],"criteria.":[237],"Median":[238],"age":[239,415],"transplant":[241,252,302,417,589],"54":[243],"years":[244],"(18-74),":[245],"98%":[247],"Caucasian.":[248],"Disease":[249],"status":[250],"included":[253],"78%":[254],"CR1":[255],"22%":[257],"CR2.":[258],"Cytogenetic":[259],"showed":[262],"13%":[263],"favorable,":[267],"56%":[268],"intermediate,":[270],"31%":[272],"adverse-risk.":[274],"five":[276],"most":[277,318,477,619],"common":[278,319,478],"FLT3":[282],"(15%),":[283],"NPM1":[284],"(14%),":[285],"DNMT3A":[286],"(11%),":[287],"TET2":[288,428,523,547],"(7%),":[289],"NRAS":[291],"(6%).":[292],"60%":[293],"donor.":[299,334],"myeloablative":[301],"performed":[304],"84%":[306],"53%":[310,344],"bone":[313],"marrow":[314],"graft":[315],"source.":[316],"conditioning":[320],"regimen":[321],"busulfan/cyclophosphamide":[324],"(52%).":[325],"12%":[326],"mismatched":[331],"their":[333],"distribution":[336],"polymorphisms":[340,606],"41%":[342],"V/V,":[343],"M/V,":[345],"6%":[347],"M/M.":[348],"univariable":[350],"analysis,":[351,390],"donor-recipient":[352],"mismatch":[354],"tended":[355],"be":[357,531,539],"lower":[361],"infection":[364,495],"(HR":[365,375,404,418,430],"0.49,":[366],"CI":[367,377,406,420,432],"0.23-1.02,":[368],"P=0.06)":[369,379],"grade":[371],"2-4":[372],"GvHD":[374],"0.25,":[376],"0.06-1.04,":[378],"but":[380],"not":[382],"other":[385,452],"post-transplant":[386,456,608],"outcomes.":[387,457],"multivariable":[389],"V/V":[393,441,484,526,563],"higher":[398,575],"non-relapse":[401],"mortality":[402],"(NRM)":[403],"2.02,":[405],"1.01-4.05,":[407],"P=0.047)":[408],"(Figure":[409],"1)":[410],"along":[411],"increasing":[413],"patient":[414,584],"1.46,":[419],"1.10-1.93,":[421],"p=0.008)":[422],"presence":[425],"6.00,":[431],"1.77-20.3,":[433],"P=0.004).":[434],"There":[435],"no":[437],"differences":[438],"between":[439,482],"M/V+M/M":[444,487],"cohorts":[445,488,598],"regarding":[446],"mutational":[448],"status,":[449],"cytogenetics":[450,511],"pre-transplant":[453,600],"characteristics":[454],"With":[458],"median":[460],"follow-up":[461],"65":[463],"months":[464],"both":[466],"cohorts,":[467],"45%":[468],"vs.":[469,492,497],"49%":[470],"remain":[473],"alive,":[474],"respectively.":[475,499],"causes":[479],"death":[481],"relapse":[490],"(38%":[491],"62%)":[493],"(31%":[496],"8%),":[498],"Conclusion":[500],"While":[501],"previous":[502],"studies":[503,537],"demonstrated":[505],"associations":[506],"survival":[513],"after":[515],"AML,":[518],"we":[519],"observed":[520],"polymorphism":[529],"independently":[532],"prognostic":[533],"NRM.":[535,576],"Mechanistic":[536],"may":[538,565,579,610,617],"considered":[540],"assess":[542],"possible":[544],"interactions":[545],"alloreactivity.":[552],"phenotype":[564],"diminish":[566],"against":[569],"pathogens":[570],"that":[571],"subsequently":[572],"contribute":[573],"These":[577],"observations":[578],"implications":[581],"enhancing":[583],"optimizing":[591],"selection.":[593],"Future":[594],"investigation":[595],"larger":[597],"interrogating":[599],"further":[611],"elucidate":[612],"which":[613],"subsets":[614],"benefit":[618],"from":[620],"transplant.":[621],"Disclosures":[622],"Nazha:":[623],"MEI:":[624],"Consultancy.":[625,708,769,859],"Mukherjee:Pfizer:":[626],"Honoraria;":[627,645,681,861],"Novartis:":[628,707],"Consultancy,":[629,680,757,824,844],"Membership":[630,657,668,713,731,746,771,782,793,804,825,845],"an":[632,659,670,715,733,748,773,784,795,806,827,847],"entity's":[633,660,671,716,734,749,774,785,796,807,828,848],"Board":[634,661,672,717,735,750,775,786,797,808,829,849],"Directors":[636,663,674,719,737,752,777,788,799,810,831,851],"advisory":[638,665,676,721,739,754,779,790,801,812,833,853],"committees,":[639,722,740,834,854],"Research":[640,699,703,741],"Funding;":[641,700,704],"Projects":[642],"Knowledge:":[644],"BioPharm":[646],"Communications:":[647],"Consultancy;":[648,706,729,762,764,766,816,820,840,864],"Bristol":[649],"Myers":[650],"Squib:":[651],"Honoraria,":[652,702],"Speakers":[653,710,723,726,743,758,835,855],"Bureau;":[654,711,724,727,744,836,856],"Takeda":[655],"Pharmaceuticals:":[656,815,858],"committees;":[666,677,755,780,791,802],"Takeda:":[667],"LEK":[678],"Consulting:":[679],"Aplastic":[682],"Anemia":[683],"&":[684],"MDS":[685],"International":[686],"Foundation":[687],"Joint":[689],"Partnership":[690],"Cleveland":[692],"Clinic":[693],"Taussig":[694],"Cancer":[695],"Institute:":[696],"Honoraria.":[697,866],"Advani:Amgen:":[698],"Pfizer:":[701],"Glycomimetics:":[705],"Carraway:Novartis:":[709],"Balaxa:":[712],"Jazz:":[725],"FibroGen:":[728],"Celgene:":[730,763,792],"Funding,":[742],"Amgen:":[745],"Agios:":[756],"Bureau.":[759],"Gerds:Apexx":[760],"Oncology:":[761],"Incyte:":[765],"CTI":[767],"Biopharma:":[768],"Sekeres:Celgene:":[770],"Opsona:":[781,803],"committees.":[813],"Maciejewski:Apellis":[814],"Ra":[817,837],"Pharmaceuticals,":[818,822,838,842],"Inc:":[819,839],"Alexion":[821,841],"Inc.:":[823,843,863],"Apellis":[857],"Majhail:Incyte:":[860],"Anthem,":[862],"Atara:":[865]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2019-01-11T00:00:00"}