{"id":"https://openalex.org/W2906925441","doi":"https://doi.org/10.1002/nau.23900","title":"GAG replenishment therapy for bladder pain syndrome/interstitial cystitis","display_name":"GAG replenishment therapy for bladder pain syndrome/interstitial cystitis","publication_year":2018,"publication_date":"2018-12-28","ids":{"openalex":"https://openalex.org/W2906925441","doi":"https://doi.org/10.1002/nau.23900","mag":"2906925441","pmid":"https://pubmed.ncbi.nlm.nih.gov/30592544"},"language":"en","primary_location":{"id":"doi:10.1002/nau.23900","doi":"https://doi.org/10.1002/nau.23900","is_oa":false,"landing_page_url":"https://doi.org/10.1002/nau.23900","pdf_url":null,"source":{"id":"https://openalex.org/S22797964","display_name":"Neurourology and Urodynamics","issn_l":"0733-2467","issn":["0733-2467","1520-6777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurourology and Urodynamics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043271778","display_name":"Jean\u2010Jacques Wyndaele","orcid":"https://orcid.org/0000-0002-0879-6854","observed_orcids":["https://orcid.org/0000-0002-0879-6854"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean Jacques J Wyndaele","raw_affiliation_strings":["Universiteit Antwerpen, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiteit Antwerpen, Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112220068","display_name":"CLAUS R. RIEDL","orcid":"https://orcid.org/0000-0001-5544-9540","observed_orcids":["https://orcid.org/0000-0001-5544-9540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claus Riedl","raw_affiliation_strings":["Urology Department, Landesklinikum Thermenregion, Baden, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Department, Landesklinikum Thermenregion, Baden, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012021163","display_name":"Rajesh Taneja","orcid":"https://orcid.org/0000-0002-1726-9263","observed_orcids":["https://orcid.org/0000-0002-1726-9263"]},"institutions":[{"id":"https://openalex.org/I1302839792","display_name":"Indraprastha Apollo Hospitals","ror":"https://ror.org/013vzz882","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1302839792"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajesh Taneja","raw_affiliation_strings":["Urology and Robotic Surgery, Indraprastha Apollo Hospitals, New Delhi, India"],"raw_orcid":"https://orcid.org/0000-0002-1726-9263","affiliations":[{"raw_affiliation_string":"Urology and Robotic Surgery, Indraprastha Apollo Hospitals, New Delhi, India","institution_ids":["https://openalex.org/I1302839792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018001274","display_name":"S\u00e1ndor Lov\u00e1sz","orcid":"https://orcid.org/0000-0003-3609-5681","observed_orcids":["https://orcid.org/0000-0003-3609-5681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u00e1ndor Lov\u00e1sz","raw_affiliation_strings":["R\u00f3zsakert Medical Center Budapest Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R\u00f3zsakert Medical Center Budapest Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024098161","display_name":"Tomohiro Ueda","orcid":"https://orcid.org/0000-0002-9611-5691","observed_orcids":["https://orcid.org/0000-0002-9611-5691"]},"institutions":[{"id":"https://openalex.org/I4210135804","display_name":"Japanese Urological Association","ror":"https://ror.org/03jrxdc53","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210135804"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Ueda","raw_affiliation_strings":["Department of Urology, Ueda Clinic, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Ueda Clinic, Kyoto, Japan","institution_ids":["https://openalex.org/I4210135804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074486703","display_name":"Mauro Cervigni","orcid":"https://orcid.org/0000-0003-4071-4393","observed_orcids":["https://orcid.org/0000-0003-4071-4393","https://orcid.org/0000-0002-0441-8194"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mauro Cervigni","raw_affiliation_strings":["Female Pelvic Medicine &amp; Reconstructive Surgery Center Catholic University Catholic University Rome Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Female Pelvic Medicine &amp; Reconstructive Surgery Center Catholic University Catholic University Rome Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074486703"],"corresponding_institution_ids":[],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":1.3303,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.79193206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"38","issue":"2","first_page":"535","last_page":"544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interstitial-cystitis","display_name":"interstitial cystitis","score":1.0},{"id":"https://openalex.org/keywords/intravesical-therapy","display_name":"intravesical therapy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/permeability-barrier","display_name":"permeability barrier","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5960000157356262},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2778508898","wikidata":"https://www.wikidata.org/wiki/Q1671412","display_name":"Interstitial cystitis","level":3,"score":0.9774014949798584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8885247707366943},{"id":"https://openalex.org/C2909931192","wikidata":"https://www.wikidata.org/wiki/Q1671412","display_name":"Bladder Pain Syndrome","level":4,"score":0.8881239891052246},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48512133955955505},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.41958385705947876},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.38914749026298523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3509977459907532}],"mesh":[{"descriptor_ui":"D000283","descriptor_name":"Administration, Intravesical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018856","descriptor_name":"Cystitis, Interstitial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018856","descriptor_name":"Cystitis, Interstitial","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/nau.23900","doi":"https://doi.org/10.1002/nau.23900","is_oa":false,"landing_page_url":"https://doi.org/10.1002/nau.23900","pdf_url":null,"source":{"id":"https://openalex.org/S22797964","display_name":"Neurourology and Urodynamics","issn_l":"0733-2467","issn":["0733-2467","1520-6777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurourology and Urodynamics","raw_type":"journal-article"},{"id":"pmid:30592544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30592544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurourology and urodynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W118551320","https://openalex.org/W126670769","https://openalex.org/W134497476","https://openalex.org/W170268810","https://openalex.org/W1485681879","https://openalex.org/W1571172760","https://openalex.org/W1965812264","https://openalex.org/W1974795690","https://openalex.org/W1975032807","https://openalex.org/W1984641133","https://openalex.org/W1986703328","https://openalex.org/W1988525139","https://openalex.org/W2005573004","https://openalex.org/W2007844025","https://openalex.org/W2009455582","https://openalex.org/W2010329574","https://openalex.org/W2013941038","https://openalex.org/W2016473780","https://openalex.org/W2020657423","https://openalex.org/W2026624072","https://openalex.org/W2030829370","https://openalex.org/W2035679857","https://openalex.org/W2037928415","https://openalex.org/W2055335442","https://openalex.org/W2066631607","https://openalex.org/W2072489066","https://openalex.org/W2074449899","https://openalex.org/W2085145142","https://openalex.org/W2102178595","https://openalex.org/W2102267945","https://openalex.org/W2105790195","https://openalex.org/W2107677807","https://openalex.org/W2114400373","https://openalex.org/W2115334311","https://openalex.org/W2120187828","https://openalex.org/W2122480745","https://openalex.org/W2128478523","https://openalex.org/W2131807130","https://openalex.org/W2133017542","https://openalex.org/W2135841958","https://openalex.org/W2138093169","https://openalex.org/W2144204901","https://openalex.org/W2148097744","https://openalex.org/W2151805229","https://openalex.org/W2154245618","https://openalex.org/W2161807262","https://openalex.org/W2168556036","https://openalex.org/W2230271694","https://openalex.org/W2258110775","https://openalex.org/W2341891678","https://openalex.org/W2403389225","https://openalex.org/W2416475551","https://openalex.org/W2471498593","https://openalex.org/W2518961845","https://openalex.org/W2522892065","https://openalex.org/W2544794469","https://openalex.org/W2613635652"],"related_works":["https://openalex.org/W2177217585","https://openalex.org/W2555699915","https://openalex.org/W1499185678","https://openalex.org/W2139095593","https://openalex.org/W2751340980","https://openalex.org/W4280569601","https://openalex.org/W2015014465","https://openalex.org/W7160153238","https://openalex.org/W2065699932","https://openalex.org/W3120881628"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"present":[2],"a":[3,54,87,92],"rationale":[4],"for":[5,68,167,171],"the":[6,13,22,35,41,48,61,65,69,104,109,114,127,152,159],"inclusion":[7],"of":[8,15,29,37,44,64,71,98,108,116,123,154,162],"urothelial":[9,83],"coating":[10],"dysfunction":[11],"in":[12,27,34,47,76,79,90,130],"etipathogenesis":[14],"bladder":[16,105],"pain":[17],"syndrome/interstitial":[18],"cystitis":[19],"(BPS/IC)":[20],"and":[21,24,50,101,135,151,156],"preclinical":[23],"clinical":[25,42,149],"evidence":[26,119],"support":[28,158],"glycosaminoglycan":[30],"(GAG)":[31],"replenishment":[32,58,122,165],"therapy":[33,166],"treatment":[36],"BPS/IC,":[38,131],"supplemented":[39],"by":[40],"experience":[43,153],"medical":[45],"experts":[46],"field":[49],"patient":[51],"advocates":[52],"attending":[53],"symposium":[55],"on":[56],"GAG":[57,84,110,128,164],"at":[59],"ESSIC'17,":[60],"annual":[62],"Meeting":[63],"International":[66],"Society":[67],"Study":[70],"Bladder":[72],"Pain":[73],"Syndrome,":[74],"held":[75],"Budapest,":[77],"Hungary":[78],"2017.":[80],"RESULTS:":[81],"The":[82,118],"layer":[85,111,129],"has":[86],"primary":[88],"role":[89],"providing":[91,168],"permeability":[93],"barrier":[94],"to":[95,113],"prevent":[96],"penetration":[97],"urinary":[99],"toxins":[100],"pathogens":[102],"into":[103],"wall.":[106],"Disruption":[107],"contributes":[112],"development":[115],"BPS/IC.":[117,174],"shows":[120],"that":[121],"GAGs":[124],"can":[125],"restore":[126],"reducing":[132],"inflammation,":[133],"pain,":[134],"other":[136],"symptoms.":[137],"CONCLUSIONS:":[138],"Although":[139],"data":[140],"from":[141],"large":[142],"randomized":[143],"controlled":[144],"studies":[145],"are":[146],"limited,":[147],"long":[148],"observation":[150],"clinicians":[155],"patients":[157,172],"beneficial":[160],"effects":[161],"intravesical":[163],"symptomatic":[169],"relief":[170],"with":[173]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-01-11T00:00:00"}
