{"id":"https://openalex.org/W2906878605","doi":"https://doi.org/10.1080/13543776.2019.1562547","title":"Scientific and technological prospection on transdermal formulations and complementary therapies for the treatment of primary dysmenorrhea","display_name":"Scientific and technological prospection on transdermal formulations and complementary therapies for the treatment of primary dysmenorrhea","publication_year":2018,"publication_date":"2018-12-27","ids":{"openalex":"https://openalex.org/W2906878605","doi":"https://doi.org/10.1080/13543776.2019.1562547","mag":"2906878605","pmid":"https://pubmed.ncbi.nlm.nih.gov/30587041"},"language":"en","primary_location":{"id":"doi:10.1080/13543776.2019.1562547","doi":"https://doi.org/10.1080/13543776.2019.1562547","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13543776.2019.1562547","pdf_url":null,"source":{"id":"https://openalex.org/S3784663","display_name":"Expert Opinion on Therapeutic Patents","issn_l":"1354-3776","issn":["1354-3776","1744-7674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Patents","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080988346","display_name":"S\u00e1via Francisca Lopes Dias","orcid":"https://orcid.org/0000-0002-4490-8331","observed_orcids":["https://orcid.org/0000-0002-4490-8331"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"S\u00e1via Francisca Lopes Dias","raw_affiliation_strings":["Postgraduate Program in Biotechnology \u2013 RENORBIO, Focal Point - Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Program in Biotechnology \u2013 RENORBIO, Focal Point - Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102847496","display_name":"Layane Carneiro Alves Pereira","orcid":"https://orcid.org/0000-0001-6304-2038","observed_orcids":["https://orcid.org/0000-0001-6304-2038"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Layane Carneiro Alves Pereira","raw_affiliation_strings":["Department of Pharmacy, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062790000","display_name":"Alde\u00eddia Pereira de Oliveira","orcid":"https://orcid.org/0000-0003-3286-4295","observed_orcids":["https://orcid.org/0000-0003-3286-4295"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aldeidia Pereira de Oliveira","raw_affiliation_strings":["Medicinal Plants Research Center, Federal University of Piaui, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Plants Research Center, Federal University of Piaui, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019329518","display_name":"Rosimeire Ferreira dos Santos","orcid":"https://orcid.org/0000-0003-1552-6649","observed_orcids":["https://orcid.org/0000-0003-1552-6649"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rosimeire Ferreira dos Santos","raw_affiliation_strings":["Medicinal Plants Research Center, Federal University of Piaui, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Plants Research Center, Federal University of Piaui, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003176340","display_name":"L\u00edvio C\u00e9sar Cunha Nunes","orcid":"https://orcid.org/0000-0002-1178-7940","observed_orcids":["https://orcid.org/0000-0002-1178-7940"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"L\u00edvio C\u00e9sar Cunha Nunes","raw_affiliation_strings":["Postgraduate Program in Biotechnology \u2013 RENORBIO, Focal Point - Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Program in Biotechnology \u2013 RENORBIO, Focal Point - Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003176340"],"corresponding_institution_ids":["https://openalex.org/I3121799822"],"apc_list":null,"apc_paid":null,"fwci":0.3026,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.32959532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"29","issue":"2","first_page":"115","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-dysmenorrhea","display_name":"primary dysmenorrhea","score":1.0},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9369999766349792},{"id":"https://openalex.org/keywords/complementary-therapy","display_name":"complementary therapy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dysmenorrhea","display_name":"dysmenorrhea","score":0.7319999933242798},{"id":"https://openalex.org/keywords/technology-prospecting","display_name":"technological prospecting","score":0.5109999775886536},{"id":"https://openalex.org/keywords/patents","display_name":"patents","score":0.4749999940395355},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.8872432708740234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7671718597412109},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4851251542568207},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.46004346013069153},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.45389506220817566},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45384520292282104},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.42527467012405396},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4090527296066284},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000529","descriptor_name":"Complementary Therapies","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000529","descriptor_name":"Complementary Therapies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004412","descriptor_name":"Dysmenorrhea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004412","descriptor_name":"Dysmenorrhea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010330","descriptor_name":"Patents as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/13543776.2019.1562547","doi":"https://doi.org/10.1080/13543776.2019.1562547","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13543776.2019.1562547","pdf_url":null,"source":{"id":"https://openalex.org/S3784663","display_name":"Expert Opinion on Therapeutic Patents","issn_l":"1354-3776","issn":["1354-3776","1744-7674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Patents","raw_type":"journal-article"},{"id":"pmid:30587041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30587041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic patents","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W383640208","https://openalex.org/W1619037340","https://openalex.org/W1660840368","https://openalex.org/W1834542484","https://openalex.org/W1862591333","https://openalex.org/W1888201325","https://openalex.org/W1968660996","https://openalex.org/W1969654631","https://openalex.org/W1974759537","https://openalex.org/W2009950850","https://openalex.org/W2019111873","https://openalex.org/W2028224386","https://openalex.org/W2031983526","https://openalex.org/W2052141752","https://openalex.org/W2058238941","https://openalex.org/W2062652554","https://openalex.org/W2074845402","https://openalex.org/W2075368687","https://openalex.org/W2076990918","https://openalex.org/W2081202974","https://openalex.org/W2096781277","https://openalex.org/W2121007875","https://openalex.org/W2127418869","https://openalex.org/W2133559654","https://openalex.org/W2134765039","https://openalex.org/W2142844116","https://openalex.org/W2145481458","https://openalex.org/W2151156646","https://openalex.org/W2157584807","https://openalex.org/W2159054627","https://openalex.org/W2164902242","https://openalex.org/W2192360912","https://openalex.org/W2315237286","https://openalex.org/W2347203410","https://openalex.org/W2615713587","https://openalex.org/W2753057473","https://openalex.org/W2788495083","https://openalex.org/W2788990438","https://openalex.org/W2800616231"],"related_works":["https://openalex.org/W2909562300","https://openalex.org/W7123335436","https://openalex.org/W2621461254","https://openalex.org/W7125644317","https://openalex.org/W7055936452","https://openalex.org/W1967187113","https://openalex.org/W7154838151","https://openalex.org/W4221036781","https://openalex.org/W4379232392","https://openalex.org/W2900504843"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Primary":[1,79],"dysmenorrhea":[2],"(PD)":[3],"is":[4],"another":[5],"term":[6],"for":[7,50,103,106,154],"idiopathic":[8],"menstrual":[9],"cramps.":[10],"Treatments":[11],"include":[12],"the":[13,39,45,51,68,101,107,124,134,147,155,158,168,179],"use":[14,46,136],"of":[15,29,42,47,53,62,109,128,137,143,157,170,181,185,191],"oral":[16],"non-steroidal":[17],"anti-inflammatory":[18],"drugs":[19,22,43],"(NSAIDs).":[20],"These":[21],"have":[23],"several":[24],"side":[25,116,198],"effects.":[26,199],"The":[27,57,98,141,164],"objective":[28],"this":[30,162,189],"study":[31,142],"was":[32],"to":[33,122,196],"perform":[34],"a":[35],"systematic":[36],"review":[37],"on":[38,78],"transdermal":[40],"administration":[41,192],"and":[44,65,67,74,81,88,93,114,126,173,187],"alternative":[48,104],"therapies":[49,105],"treatment":[52,108],"PD.":[54],"AREAS":[55],"COVERED:":[56],"article":[58],"bases":[59,70],"were":[60,71,96],"Web":[61],"Science,":[63],"PubMed":[64],"Sciencedirect":[66],"patent":[69],"INPI,":[72],"EPO":[73],"WIPO":[75],"with":[76,83,111],"publications":[77],"Dysmenorrhea":[80],"associations":[82],"Transdermal":[84],"Administration;":[85],"Complementary":[86],"Therapies":[87],"Medicinal":[89],"Plants.":[90],"21":[91],"articles":[92],"12":[94],"patents":[95],"analyzed.":[97],"results":[99],"demonstrate":[100],"need":[102],"PD,":[110],"greater":[112],"effectiveness":[113],"lower":[115],"effects,":[117],"mainly":[118,177],"in":[119,150,167,178,193],"an":[120,194],"attempt":[121,195],"reduce":[123,197],"intensity":[125],"duration":[127],"pain":[129],"as":[130,132],"well":[131],"reducing":[133],"continuous":[135],"medications.":[138],"EXPERT":[139],"OPINION:":[140],"technological":[144],"prospection":[145],"highlighted":[146],"relevant":[148],"importance":[149],"seeking":[151],"new":[152,171,182],"methods":[153],"relief":[156],"symptoms":[159],"provoked":[160],"by":[161],"condition.":[163],"perspectives":[165],"coexist":[166],"discovery":[169],"natural":[172],"biotechnological":[174],"pharmacological":[175],"applications,":[176],"development":[180],"devices":[183],"capable":[184],"facilitating":[186],"optimizing":[188],"form":[190]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-01-11T00:00:00"}