{"id":"https://openalex.org/W2906867697","doi":"https://doi.org/10.1021/acsami.8b18497","title":"An Enzyme-Free \u201cON-OFF\u201d Electrochemiluminescence Biosensor for Ultrasensitive Detection of PML/RAR\u03b1 based on Target-Switched DNA Nanotweezer","display_name":"An Enzyme-Free \u201cON-OFF\u201d Electrochemiluminescence Biosensor for Ultrasensitive Detection of PML/RAR\u03b1 based on Target-Switched DNA Nanotweezer","publication_year":2019,"publication_date":"2019-01-04","ids":{"openalex":"https://openalex.org/W2906867697","doi":"https://doi.org/10.1021/acsami.8b18497","mag":"2906867697","pmid":"https://pubmed.ncbi.nlm.nih.gov/30608120"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.8b18497","doi":"https://doi.org/10.1021/acsami.8b18497","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.8b18497","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023255855","display_name":"Xintong Bian","orcid":"https://orcid.org/0000-0001-8071-0974","observed_orcids":["https://orcid.org/0000-0001-8071-0974"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xintong Bian","raw_affiliation_strings":["Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028078249","display_name":"Bin Guo","orcid":"https://orcid.org/0000-0002-8194-9669","observed_orcids":["https://orcid.org/0000-0002-8194-9669"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Guo","raw_affiliation_strings":["Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012280998","display_name":"Min Zhao","orcid":"https://orcid.org/0000-0001-8884-0888","observed_orcids":["https://orcid.org/0000-0001-8884-0888"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zhao","raw_affiliation_strings":["Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027099911","display_name":"Daobin Han","orcid":"https://orcid.org/0009-0009-7298-9261","observed_orcids":["https://orcid.org/0009-0009-7298-9261"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daobin Han","raw_affiliation_strings":["Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027996570","display_name":"Wei Cheng","orcid":"https://orcid.org/0000-0002-1921-9761","observed_orcids":["https://orcid.org/0000-0002-1921-9761"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Cheng","raw_affiliation_strings":["The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China"],"raw_orcid":"https://orcid.org/0000-0002-1921-9761","affiliations":[{"raw_affiliation_string":"The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102734472","display_name":"Fangzhou Song","orcid":"https://orcid.org/0000-0002-9786-7414","observed_orcids":["https://orcid.org/0000-0002-9786-7414"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangzhou Song","raw_affiliation_strings":["Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053417739","display_name":"Shijia Ding","orcid":"https://orcid.org/0000-0002-9183-1656","observed_orcids":["https://orcid.org/0000-0002-9183-1656"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shijia Ding","raw_affiliation_strings":["Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China"],"raw_orcid":"https://orcid.org/0000-0002-9183-1656","affiliations":[{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China","institution_ids":["https://openalex.org/I87780372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053417739"],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.3823,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.79833271,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"4","first_page":"3715","last_page":"3721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrochemiluminescence-biosensor","display_name":"electrochemiluminescence biosensor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pml-rara-fusion","display_name":"PML-RARA fusion","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hemin","display_name":"hemin","score":0.6060000061988831},{"id":"https://openalex.org/keywords/ru-bpy-3-2","display_name":"Ru(bpy)3 2+","score":0.8510000109672546},{"id":"https://openalex.org/keywords/enzyme-free-detection","display_name":"enzyme-free detection","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nucleic-acid-detection","display_name":"nucleic acid detection","score":0.8550000190734863},{"id":"https://openalex.org/keywords/signal-quenching","display_name":"signal quenching","score":0.6909999847412109},{"id":"https://openalex.org/keywords/leukemia-biomarkers","display_name":"leukemia biomarkers","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2777723881","wikidata":"https://www.wikidata.org/wiki/Q107315604","display_name":"Hemin","level":4,"score":0.9506437182426453},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.852790355682373},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.8247536420822144},{"id":"https://openalex.org/C38965407","wikidata":"https://www.wikidata.org/wiki/Q755961","display_name":"Electrochemiluminescence","level":3,"score":0.6887906789779663},{"id":"https://openalex.org/C10349863","wikidata":"https://www.wikidata.org/wiki/Q6553497","display_name":"Linear range","level":3,"score":0.5759162306785583},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5537930130958557},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.549201250076294},{"id":"https://openalex.org/C84211826","wikidata":"https://www.wikidata.org/wiki/Q5260078","display_name":"Deoxyribozyme","level":3,"score":0.5180268883705139},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.5092281103134155},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.47252872586250305},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.45164817571640015},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.398957222700119},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32257142663002014},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.31067192554473877},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.21193864941596985},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19937723875045776},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.19438883662223816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1709280014038086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09753137826919556},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.084238201379776},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006427","descriptor_name":"Hemin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055664","descriptor_name":"Electrochemical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.8b18497","doi":"https://doi.org/10.1021/acsami.8b18497","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.8b18497","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},{"id":"pmid:30608120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30608120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G296847275","display_name":null,"funder_award_id":"(81873980","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G573785057","display_name":null,"funder_award_id":"cstc2018jcyjAX0206","funder_id":"https://openalex.org/F4320321550","funder_display_name":"Chongqing Science and Technology Commission"},{"id":"https://openalex.org/G8897664230","display_name":null,"funder_award_id":"cstc2016shmszx130043","funder_id":"https://openalex.org/F4320321550","funder_display_name":"Chongqing Science and Technology Commission"},{"id":"https://openalex.org/G992105034","display_name":null,"funder_award_id":"21804015","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321550","display_name":"Chongqing Science and Technology Commission","ror":"https://ror.org/05w9erc61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1969104051","https://openalex.org/W1978045399","https://openalex.org/W1982914755","https://openalex.org/W1990260285","https://openalex.org/W2046502411","https://openalex.org/W2055007731","https://openalex.org/W2060865001","https://openalex.org/W2064615230","https://openalex.org/W2071534620","https://openalex.org/W2090385470","https://openalex.org/W2154832644","https://openalex.org/W2282392286","https://openalex.org/W2323647387","https://openalex.org/W2327602725","https://openalex.org/W2332692293","https://openalex.org/W2444018196","https://openalex.org/W2467832899","https://openalex.org/W2591729765","https://openalex.org/W2597813395","https://openalex.org/W2603936977","https://openalex.org/W2606310745","https://openalex.org/W2744737635","https://openalex.org/W2744929498","https://openalex.org/W2766870170","https://openalex.org/W2767521523","https://openalex.org/W2779610831","https://openalex.org/W2782472446","https://openalex.org/W2788165493","https://openalex.org/W2793577402","https://openalex.org/W2794772690","https://openalex.org/W2798055106","https://openalex.org/W4211087902"],"related_works":["https://openalex.org/W2126131500","https://openalex.org/W3089954627","https://openalex.org/W4387032819","https://openalex.org/W2012442387","https://openalex.org/W2016839980","https://openalex.org/W4309771559","https://openalex.org/W2379590007","https://openalex.org/W2007387006","https://openalex.org/W2353247272","https://openalex.org/W4223613571"],"abstract_inverted_index":{"Herein,":[0],"an":[1,64,80],"enzyme-free":[2],"\u201cON-OFF\u201d":[3],"electrochemiluminescence":[4],"(ECL)":[5],"biosensor":[6,151],"for":[7,188],"ultrasensitive":[8,123,189],"detection":[9,124,141,190],"of":[10,39,57,73,90,100,111,125,140,159,174,191],"fusion":[11],"gene":[12],"PML/RAR\u03b1":[13,126,160],"is":[14,33,47],"constructed":[15],"based":[16],"on":[17],"a":[18,70,108,128,181],"simple":[19],"target-switched":[20],"DNA":[21,41,175],"nanotweezer":[22],"as":[23,50,142,144],"hemin":[24,31,46,74,112],"concentration":[25,32,45,72,110],"controller.":[26],"In":[27,54,87,147],"this":[28,177],"biosensor,":[29],"the":[30,37,55,58,60,76,88,91,93,98,104,116,149,156,170,195],"primarily":[34],"controlled":[35],"by":[36],"conversion":[38],"\u201copened-closed\u201d":[40],"nanotweezers":[42,61,95],"and":[43,113,138,165],"low":[44,71,143],"first":[48],"used":[49],"electrochemically":[51],"regenerable":[52],"enhancer.":[53],"absence":[56],"target,":[59,92],"are":[62],"in":[63,75,79,194],"opened":[65],"state":[66],"which":[67,106],"lead":[68],"to":[69,135,155,169],"solution,":[77],"resulting":[78],"enhanced":[81],"Ru(bpy)":[82,183],"3":[83,184],"2+":[84,185],"ECL":[85,117,150,186],"signal.":[86,118],"presence":[89],"closed":[94],"absorbed":[96],"onto":[97],"surface":[99],"electrode":[101],"can":[102],"capture":[103],"hemin,":[105],"achieves":[107,122],"high":[109,171],"then":[114],"quenches":[115],"The":[119],"developed":[120],"method":[121,178],"with":[127],"wide":[129],"linear":[130],"range":[131],"from":[132],"1":[133,136],"fM":[134],"nM":[137],"limit":[139],"0.125":[145],"fM.":[146],"addition,":[148],"shows":[152],"excellent":[153],"specificity":[154],"other":[157],"subtypes":[158],"(subtype":[161],"\u201cS\u201d,":[162],"\u201cV\u201d),":[163],"\u201cPML\u201d,":[164],"\u201cRAR\u03b1\u201d.":[166],"Moreover,":[167],"due":[168],"designable":[172],"character":[173],"nanotweezer,":[176],"might":[179],"provide":[180],"pragmatic":[182],"platform":[187],"nucleic":[192],"acid":[193],"future.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-01-11T00:00:00"}