{"id":"https://openalex.org/W2906864455","doi":"https://doi.org/10.1007/s12018-018-9256-x","title":"Bone Fracture Acute Phase Response\u2014A Unifying Theory of Fracture Repair: Clinical and Scientific Implications","display_name":"Bone Fracture Acute Phase Response\u2014A Unifying Theory of Fracture Repair: Clinical and Scientific Implications","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2906864455","doi":"https://doi.org/10.1007/s12018-018-9256-x","mag":"2906864455","pmid":"https://pubmed.ncbi.nlm.nih.gov/30930699"},"language":"en","primary_location":{"id":"doi:10.1007/s12018-018-9256-x","doi":"https://doi.org/10.1007/s12018-018-9256-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12018-018-9256-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12018-018-9256-x.pdf","source":{"id":"https://openalex.org/S12145631","display_name":"Clinical Reviews in Bone and Mineral Metabolism","issn_l":"1534-8644","issn":["1534-8644","1559-0119"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Reviews in Bone and Mineral Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12018-018-9256-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113795718","display_name":"Courtney E. Baker","orcid":"https://orcid.org/0000-0002-4088-2947","observed_orcids":["https://orcid.org/0000-0002-4088-2947"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney E. Baker","raw_affiliation_strings":["1Department of Orthopaedics, Mayo Clinic, 200 1st Ave SW, Rochester, MN 55903 USA","Department of Orthopaedics, Mayo Clinic, 200 1st Ave SW, Rochester, MN, 55903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Orthopaedics, Mayo Clinic, 200 1st Ave SW, Rochester, MN 55903 USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Orthopaedics, Mayo Clinic, 200 1st Ave SW, Rochester, MN, 55903, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068037858","display_name":"Stephanie N. Moore\u2010Lotridge","orcid":"https://orcid.org/0000-0002-3045-4199","observed_orcids":["https://orcid.org/0000-0002-3045-4199"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie N. Moore-Lotridge","raw_affiliation_strings":["2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN 37232 USA","Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062343437","display_name":"Alexander A. Hysong","orcid":"https://orcid.org/0000-0002-1731-1775","observed_orcids":["https://orcid.org/0000-0002-1731-1775"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Hysong","raw_affiliation_strings":["4Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN 37232 USA","Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011976427","display_name":"Samuel L. Posey","orcid":"https://orcid.org/0000-0002-7794-0944","observed_orcids":["https://orcid.org/0000-0002-7794-0944"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel L. Posey","raw_affiliation_strings":["4Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN 37232 USA","Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034621238","display_name":"J. Patton Robinette","orcid":"https://orcid.org/0000-0002-3765-6754","observed_orcids":["https://orcid.org/0000-0002-3765-6754"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Patton Robinette","raw_affiliation_strings":["4Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN 37232 USA","Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071537116","display_name":"Deke M. Blum","orcid":"https://orcid.org/0000-0002-0300-2365","observed_orcids":["https://orcid.org/0000-0002-0300-2365"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deke M. Blum","raw_affiliation_strings":["4Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN 37232 USA","Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University School of Medicine, 1161 21st Ave S, #D3300, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040862534","display_name":"Michael A. Benvenuti","orcid":"https://orcid.org/0000-0002-3251-3893","observed_orcids":["https://orcid.org/0000-0002-3251-3893"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Benvenuti","raw_affiliation_strings":["2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003143622","display_name":"Heather Cole","orcid":"https://orcid.org/0000-0002-8890-1748","observed_orcids":["https://orcid.org/0000-0002-8890-1748","https://orcid.org/0000-0003-1830-2544"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather A. Cole","raw_affiliation_strings":["2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081284316","display_name":"Satoru Egawa","orcid":"https://orcid.org/0000-0001-9367-3906","observed_orcids":["https://orcid.org/0000-0001-9367-3906"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Satoru Egawa","raw_affiliation_strings":["2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","5Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519 Japan","Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"5Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030396786","display_name":"Atsushi Okawa","orcid":"https://orcid.org/0000-0003-0227-8658","observed_orcids":["https://orcid.org/0000-0003-0227-8658"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Okawa","raw_affiliation_strings":["5Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519 Japan","Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038056427","display_name":"Masanori Saito","orcid":"https://orcid.org/0000-0002-4139-4013","observed_orcids":["https://orcid.org/0000-0002-4139-4013"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masanori Saito","raw_affiliation_strings":["2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","5Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519 Japan","Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"5Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005270186","display_name":"Jason R. McCarthy","orcid":"https://orcid.org/0000-0002-5302-2030","observed_orcids":["https://orcid.org/0000-0002-5302-2030"]},"institutions":[{"id":"https://openalex.org/I4210088652","display_name":"Masonic Medical Research Laboratory","ror":"https://ror.org/004rs4477","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210088652"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R. McCarthy","raw_affiliation_strings":["Masonic Research Institute, 2150 Bleecker St, Utica, NY 13501 USA","Masonic Research Institute, 2150 Bleecker St, Utica, NY, 13501, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Research Institute, 2150 Bleecker St, Utica, NY 13501 USA","institution_ids":[]},{"raw_affiliation_string":"Masonic Research Institute, 2150 Bleecker St, Utica, NY, 13501, USA","institution_ids":["https://openalex.org/I4210088652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017780140","display_name":"Jeffry Stephen Nyman","orcid":"https://orcid.org/0000-0001-7403-7605","observed_orcids":["https://orcid.org/0000-0001-7403-7605"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I4210103776","display_name":"Nashville VA Medical Center","ror":"https://ror.org/024xyyq03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210103776","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffry S. Nyman","raw_affiliation_strings":["2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","7Department of Biomedical Engineering, Vanderbilt University, PMB 351631, 2301 Vanderbilt Place, Nashville, TN 37235 USA","Department of Veterans Affairs, Tennessee Valley Health Care System, F-519 VA Acre Building, 1210 24th Ave. South, Nashville, TN 37232 USA","Department of Biomedical Engineering, Vanderbilt University, PMB 351631, 2301 Vanderbilt Place, Nashville, TN, 37235, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"7Department of Biomedical Engineering, Vanderbilt University, PMB 351631, 2301 Vanderbilt Place, Nashville, TN 37235 USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Veterans Affairs, Tennessee Valley Health Care System, F-519 VA Acre Building, 1210 24th Ave. South, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I4210101790","https://openalex.org/I4210103776"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University, PMB 351631, 2301 Vanderbilt Place, Nashville, TN, 37235, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015328275","display_name":"Masato Yuasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masato Yuasa","raw_affiliation_strings":["2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","5Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519 Japan","Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"5Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima Bunkyo Ward, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022984651","display_name":"Jonathan G. Schoenecker","orcid":"https://orcid.org/0000-0002-3097-5496","observed_orcids":["https://orcid.org/0000-0002-3097-5496"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan G. Schoenecker","raw_affiliation_strings":["10Department of Pediatrics, Vanderbilt University Medical Center, 4202 Doctor's Office Tower, 2200 Children's Way, Nashville, TN 37232 USA","2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN 37232 USA","9Department of Pharmacology, Vanderbilt University, 2200 Pierce Ave, Robinson Research Building, Nashville, TN 37232 USA","Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN, 37232, USA"],"raw_orcid":"https://orcid.org/0000-0002-3097-5496","affiliations":[{"raw_affiliation_string":"10Department of Pediatrics, Vanderbilt University Medical Center, 4202 Doctor's Office Tower, 2200 Children's Way, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"9Department of Pharmacology, Vanderbilt University, 2200 Pierce Ave, Robinson Research Building, Nashville, TN 37232 USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5022984651"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":{"value":4490,"currency":"USD","value_usd":4490},"fwci":4.944,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.96140266,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"16","issue":"4","first_page":"142","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.9319999814033508},{"id":"https://openalex.org/keywords/acute-phase-response","display_name":"acute phase response","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nonunion","display_name":"nonunion","score":0.7540000081062317},{"id":"https://openalex.org/keywords/intramembranous-ossification","display_name":"intramembranous ossification","score":0.9309999942779541},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":1.0},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/fracture-related-infection","display_name":"fracture-related infection","score":0.4099999964237213},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-syndrome","display_name":"systemic inflammatory response syndrome","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fracture-strain","display_name":"fracture strain","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.7438589334487915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7369421124458313},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.7052696943283081},{"id":"https://openalex.org/C2779330695","wikidata":"https://www.wikidata.org/wiki/Q7049641","display_name":"Nonunion","level":2,"score":0.47883346676826477},{"id":"https://openalex.org/C2776692886","wikidata":"https://www.wikidata.org/wiki/Q2103168","display_name":"Polytrauma","level":2,"score":0.44697439670562744},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.44648292660713196},{"id":"https://openalex.org/C188945261","wikidata":"https://www.wikidata.org/wiki/Q10746904","display_name":"Intramembranous ossification","level":2,"score":0.4394156336784363},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.431893527507782},{"id":"https://openalex.org/C2777560053","wikidata":"https://www.wikidata.org/wiki/Q503629","display_name":"Avascular necrosis","level":3,"score":0.41048258543014526},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32856687903404236},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.224849671125412},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.18875253200531006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0994357168674469},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09693676233291626},{"id":"https://openalex.org/C2779100257","wikidata":"https://www.wikidata.org/wiki/Q582849","display_name":"Femoral head","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s12018-018-9256-x","doi":"https://doi.org/10.1007/s12018-018-9256-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12018-018-9256-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12018-018-9256-x.pdf","source":{"id":"https://openalex.org/S12145631","display_name":"Clinical Reviews in Bone and Mineral Metabolism","issn_l":"1534-8644","issn":["1534-8644","1559-0119"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Reviews in Bone and Mineral Metabolism","raw_type":"journal-article"},{"id":"pmid:30930699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30930699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical reviews in bone and mineral metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5415469","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6404386","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6404386","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6404386","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Rev Bone Miner Metab","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12018-018-9256-x","doi":"https://doi.org/10.1007/s12018-018-9256-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12018-018-9256-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12018-018-9256-x.pdf","source":{"id":"https://openalex.org/S12145631","display_name":"Clinical Reviews in Bone and Mineral Metabolism","issn_l":"1534-8644","issn":["1534-8644","1559-0119"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Reviews in Bone and Mineral Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1979509808","display_name":null,"funder_award_id":"R01 HL122238","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6419016549","display_name":null,"funder_award_id":"R01HL133153","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906864455.pdf","grobid_xml":"https://content.openalex.org/works/W2906864455.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W119888207","https://openalex.org/W125852247","https://openalex.org/W135216744","https://openalex.org/W140585242","https://openalex.org/W648632191","https://openalex.org/W1042093625","https://openalex.org/W1504707262","https://openalex.org/W1512967649","https://openalex.org/W1583699618","https://openalex.org/W1901404250","https://openalex.org/W1916156238","https://openalex.org/W1939820136","https://openalex.org/W1962869168","https://openalex.org/W1968923669","https://openalex.org/W1969251725","https://openalex.org/W1970549759","https://openalex.org/W1971791504","https://openalex.org/W1973514169","https://openalex.org/W1978172024","https://openalex.org/W1978226596","https://openalex.org/W1979137563","https://openalex.org/W1980051005","https://openalex.org/W1982694911","https://openalex.org/W1982859926","https://openalex.org/W1984758838","https://openalex.org/W1986590688","https://openalex.org/W1988796528","https://openalex.org/W1998890750","https://openalex.org/W1999252621","https://openalex.org/W2002310197","https://openalex.org/W2006908960","https://openalex.org/W2007949614","https://openalex.org/W2011114620","https://openalex.org/W2011576192","https://openalex.org/W2014528765","https://openalex.org/W2014679360","https://openalex.org/W2015050458","https://openalex.org/W2017820958","https://openalex.org/W2019744993","https://openalex.org/W2022019211","https://openalex.org/W2026775213","https://openalex.org/W2037219613","https://openalex.org/W2038607522","https://openalex.org/W2048961290","https://openalex.org/W2054157485","https://openalex.org/W2057225029","https://openalex.org/W2060816393","https://openalex.org/W2061211607","https://openalex.org/W2065548060","https://openalex.org/W2065616581","https://openalex.org/W2072100512","https://openalex.org/W2073742371","https://openalex.org/W2074987261","https://openalex.org/W2078086616","https://openalex.org/W2083407704","https://openalex.org/W2085481239","https://openalex.org/W2095589986","https://openalex.org/W2100648520","https://openalex.org/W2101896131","https://openalex.org/W2102618636","https://openalex.org/W2104904633","https://openalex.org/W2108906450","https://openalex.org/W2109503431","https://openalex.org/W2112174625","https://openalex.org/W2112451920","https://openalex.org/W2116581287","https://openalex.org/W2116992742","https://openalex.org/W2120989136","https://openalex.org/W2130607897","https://openalex.org/W2133819222","https://openalex.org/W2138011807","https://openalex.org/W2139116328","https://openalex.org/W2145667992","https://openalex.org/W2147438333","https://openalex.org/W2152441430","https://openalex.org/W2157269551","https://openalex.org/W2173073937","https://openalex.org/W2208382163","https://openalex.org/W2210805883","https://openalex.org/W2272870230","https://openalex.org/W2277498060","https://openalex.org/W2287068574","https://openalex.org/W2291522985","https://openalex.org/W2325056738","https://openalex.org/W2332282810","https://openalex.org/W2339217045","https://openalex.org/W2376333474","https://openalex.org/W2396134644","https://openalex.org/W2408615209","https://openalex.org/W2466208620","https://openalex.org/W2567640618","https://openalex.org/W2579276054","https://openalex.org/W2587038181","https://openalex.org/W2588534180","https://openalex.org/W2599346166","https://openalex.org/W2613148192","https://openalex.org/W2709109746","https://openalex.org/W2809728248","https://openalex.org/W2903302497","https://openalex.org/W4300989689"],"related_works":["https://openalex.org/W2353378266","https://openalex.org/W2039419642","https://openalex.org/W3111436710","https://openalex.org/W2025253407","https://openalex.org/W2979256684","https://openalex.org/W2160769459","https://openalex.org/W18760785","https://openalex.org/W2149581206","https://openalex.org/W2284078820","https://openalex.org/W2305606475"],"abstract_inverted_index":{"Bone":[0],"fractures":[1],"create":[2],"five":[3],"problems":[4,36,73],"that":[5,33,57,113,257],"must":[6],"be":[7],"resolved:":[8],"bleeding,":[9],"risk":[10],"of":[11,29,44,54,66,74,124,141,161,184,201,213,242,250,255,265,279,298],"infection,":[12,192],"hypoxia,":[13],"disproportionate":[14,177],"strain,":[15],"and":[16,39,64,86,92,126,134,144,151,163,215,233,291],"inability":[17],"to":[18,69,115,167,182,293],"bear":[19],"weight.":[20],"There":[21],"have":[22],"been":[23,174],"enormous":[24],"advancements":[25],"in":[26,40,129,148,217,235,248],"our":[27],"understanding":[28,91,241],"the":[30,59,62,71,102,110,142,210,218,243,277,288],"molecular":[31,111],"mechanisms":[32,112],"resolve":[34],"these":[35],"after":[37],"fractures,":[38],"best":[41],"clinical":[42],"practices":[43],"repairing":[45],"fractures.":[46,75],"We":[47],"put":[48],"forth":[49],"a":[50,80,158,236,296],"modern,":[51],"comprehensive":[52],"model":[53,78,98,264],"fracture":[55,67,84,103,205,219,231,251,260,266,299],"repair":[56,68,168,195,206,267],"synthesizes":[58],"literature":[60],"on":[61,209],"biology":[63],"biomechanics":[65],"address":[70],"primary":[72],"This":[76,97,262],"updated":[77],"is":[79,99,119,155,207],"framework":[81,278],"for":[82,204],"both":[83],"management":[85],"future":[87],"studies":[88],"aimed":[89],"at":[90],"treating":[93],"this":[94,225],"complex":[95],"process.":[96],"based":[100],"upon":[101],"acute":[104],"phase":[105],"response":[106,190],"(APR),":[107],"which":[108],"encompasses":[109],"respond":[114],"injury.":[116],"The":[117,199],"APR":[118],"divided":[120],"into":[121],"sequential":[122],"stages":[123],"\"survival\"":[125],"\"repair.\"":[127],"Early":[128],"convalescence,":[130],"during":[131,295],"\"survival,\"":[132],"bleeding":[133],"infection":[135],"are":[136],"resolved":[137],"by":[138,157],"collaborative":[139],"efforts":[140],"hemostatic":[143],"inflammatory":[145,189],"pathways.":[146],"Later,":[147],"\"repair,\"":[149],"avascular":[150],"biomechanically":[152],"insufficient":[153,179],"bone":[154],"replaced":[156],"variable":[159],"combination":[160],"intramembranous":[162],"endochondral":[164],"ossification.":[165],"Progression":[166],"cannot":[169],"occur":[170],"until":[171],"survival":[172,185],"has":[173],"ensured.":[175],"A":[176],"APR-either":[178],"or":[180,197,229,253],"exuberant-leads":[181],"complications":[183],"(hemorrhage,":[186],"thrombosis,":[187],"systemic":[188],"syndrome,":[191],"death)":[193],"and/or":[194],"(delayed-":[196],"non-union).":[198],"type":[200],"ossification":[202],"utilized":[203],"dependent":[208],"relative":[211],"amounts":[212],"strain":[214],"vascularity":[216],"microenvironment,":[220],"but":[221,283],"any":[222],"failure":[223],"along":[224],"process":[226],"can":[227,246],"disrupt":[228],"delay":[230],"healing":[232,282],"result":[234,247],"similar":[237],"non-union.":[238],"Therefore,":[239],"incomplete":[240],"principles":[244],"herein":[245],"mismanagement":[249],"care":[252],"application":[254],"hardware":[256],"interferes":[258],"with":[259],"repair.":[261,300],"unifying":[263],"not":[268],"only":[269],"informs":[270],"clinicians":[271],"how":[272],"their":[273],"interventions":[274],"fit":[275],"within":[276],"normal":[280],"biological":[281],"also":[284],"instructs":[285],"investigators":[286],"about":[287],"critical":[289],"variables":[290],"outputs":[292],"assess":[294],"study":[297]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}