{"id":"https://openalex.org/W2906856043","doi":null,"title":"On the entry and entrapment of picornaviruses","display_name":"On the entry and entrapment of picornaviruses","publication_year":2018,"publication_date":"2018-11-06","ids":{"openalex":"https://openalex.org/W2906856043","mag":"2906856043"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/372513","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/372513","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/372513","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053870145","display_name":"Jacqueline Staring","orcid":"https://orcid.org/0000-0001-7376-8107","observed_orcids":["https://orcid.org/0000-0001-7376-8107"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jacqueline Staring","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7376-8107","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053870145"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/picornavirus","display_name":"picornavirus","score":0.9430000185966492},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.8289999961853027},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.7599999904632568},{"id":"https://openalex.org/keywords/poliovirus","display_name":"poliovirus","score":0.7639999985694885},{"id":"https://openalex.org/keywords/enterovirus-d68","display_name":"enterovirus D68","score":0.8190000057220459},{"id":"https://openalex.org/keywords/sialic-acid-receptors","display_name":"sialic acid receptors","score":0.7699999809265137},{"id":"https://openalex.org/keywords/kremen1","display_name":"KREMEN1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/coxsackievirus-a","display_name":"coxsackievirus A","score":0.9079999923706055},{"id":"https://openalex.org/keywords/restriction-factors","display_name":"host restriction factors","score":0.4830000102519989},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"mutagenesis","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2778009244","wikidata":"https://www.wikidata.org/wiki/Q936600","display_name":"Picornavirus","level":4,"score":0.8979283571243286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7927213907241821},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5368006825447083},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5093446969985962},{"id":"https://openalex.org/C2779631682","wikidata":"https://www.wikidata.org/wiki/Q12438936","display_name":"Poliovirus","level":3,"score":0.4812164604663849},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4300052523612976},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.42654576897621155},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.41763049364089966},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3339741826057434},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.306068480014801},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19975736737251282},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/372513","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/372513","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/372513","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/372513","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2906856043","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/1874/372513/1/Staring.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/372513","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/372513","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.5099999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1919905560","https://openalex.org/W1979661536","https://openalex.org/W1994527574","https://openalex.org/W2002995480","https://openalex.org/W2028776321","https://openalex.org/W2031869299","https://openalex.org/W2057723954","https://openalex.org/W2071004446","https://openalex.org/W2112199224","https://openalex.org/W2117156715","https://openalex.org/W2140915719","https://openalex.org/W2143353745","https://openalex.org/W2144123285","https://openalex.org/W2152832434","https://openalex.org/W2167066405","https://openalex.org/W2170585188","https://openalex.org/W2208524302","https://openalex.org/W2255998354","https://openalex.org/W2266837556","https://openalex.org/W2540522966","https://openalex.org/W2575376556","https://openalex.org/W2762873154","https://openalex.org/W2802681989"],"related_works":["https://openalex.org/W303853695","https://openalex.org/W2328734956","https://openalex.org/W1993560419","https://openalex.org/W2169149538","https://openalex.org/W1503537061","https://openalex.org/W2948582769","https://openalex.org/W1171463846","https://openalex.org/W2077602926","https://openalex.org/W2772648860","https://openalex.org/W3015638647","https://openalex.org/W784826639","https://openalex.org/W2119477250","https://openalex.org/W2886981530","https://openalex.org/W1985737501","https://openalex.org/W2012441269","https://openalex.org/W2049649968","https://openalex.org/W2411153978","https://openalex.org/W147543956","https://openalex.org/W1975723973","https://openalex.org/W1545989146"],"abstract_inverted_index":{"The":[0,95,227,353],"family":[1,51],"of":[2,6,36,49,85,97,115,140,184,229,254,259,273,309,360,367,379,402,414],"Picornaviruses":[3],"is":[4,88,100,108,170,203,232,298,318,336,340],"one":[5],"the":[7,37,112,116,138,141,199,206,212,215,255,257,271,307,358,365,380,388,399,424,437],"most":[8],"diverse":[9],"pathogenic":[10],"families":[11],"known":[12,299],"to":[13,58,78,110,137,172,198,208,270,300,363,376,393,421],"infect":[14],"humans":[15],"and":[16,44,81,133,238,275,387],"animals.":[17],"As":[18],"described":[19,193],"in":[20,91,102,160,235,264,306,346,351,406,440],"chapter":[21,103,123,236,239,283,431],"1,":[22],"these":[23,86,372,385],"viruses":[24,295,386],"have":[25,374],"been":[26],"studied":[27,118],"for":[28,46,194,205,248,280,291,342],"more":[29],"than":[30],"a":[31,125,145,156,161,244,302,330,407],"century.":[32],"Surprisingly,":[33],"many":[34],"aspects":[35],"viral":[38,62],"life":[39],"cycle":[40],"still":[41],"remain":[42],"unclear,":[43],"although":[45],"some":[47],"members":[48,183],"this":[50,98,106,220,252,315,403,441],"vaccination":[52],"campaigns":[53],"are":[54,64],"highly":[55],"effective,":[56],"medications":[57],"treat":[59],"or":[60],"prevent":[61],"infection":[63,344],"not":[65],"available.":[66],"Chapter":[67,151,241,396],"2":[68],"describes":[69,124],"how":[70,126],"different":[71,418],"genetic":[72,129,157,361],"techniques":[73],"that":[74,201,320,322,338,391],"can":[75,324],"be":[76,301],"used":[77,109,383,416],"identify":[79],"host":[80,149,213,261,368],"restriction":[82,389],"factors.":[83],"One":[84],"approaches":[87],"mutagenesis-based":[89],"genetics":[90,231],"haploid":[92,230],"human":[93],"cells.":[94],"strength":[96],"technique":[99],"illustrated":[101],"3,":[104],"where":[105],"method":[107],"unravel":[111],"unknown":[113,222],"biology":[114],"heavily":[117],"prototype":[119],"picornavirus;":[120],"poliovirus.":[121],"This":[122,179],"multiple":[127,292],"phenotypic":[128],"screens":[130,362],"with":[131,327],"poliovirus":[132],"other":[134],"enteroviruses":[135],"lead":[136],"identification":[139,258,272],"phospholipase":[142],"PLA2G16":[143,169,202],"as":[144,278,287,329,348,350],"broadly":[146],"required":[147,204,341],"picornavirus":[148],"factor.":[150],"3":[152],"continues":[153],"by":[154,176,219,384,417],"applying":[155],"suppressor":[158,180],"screen":[159,181],"PLA2G16-null":[162],"background,":[163],"which":[164,190],"provides":[165],"insight":[166],"into":[167,211],"why":[168],"recruited":[171],"endosomal":[173],"damage":[174],"induced":[175],"entering":[177],"picornaviruses.":[178],"highlights":[182],"an":[185,288,412],"anti-viral":[186,224],"autophagic":[187],"response":[188],"pathway,":[189],"was":[191],"previously":[192,221],"bacterial":[195],"infections,":[196],"leading":[197],"hypothesis":[200],"virus":[207,216,343,419],"gain":[209],"entry":[210,289,332,381],"before":[214],"gets":[217],"sequestered":[218],"innate":[223],"immune":[225],"response.":[226],"potential":[228,245],"further":[233],"explored":[234],"4":[237,242],"5.":[240],"presents":[243,285],"new":[246],"receptor":[247,290],"enterovirus-D68":[249],"(EV-D68).":[250],"In":[251,314],"part":[253],"thesis,":[256],"several":[260],"factors":[262,390],"involved":[263,305],"sialic":[265],"acid":[266],"(Sia)":[267],"biosynthesis":[268],"leads":[269],"-2,6-":[274],"-2,3-linked":[276],"Sia":[277],"receptors":[279],"EV-D68.":[281],"Likewise,":[282],"5":[284],"KREMEN1":[286,297,323,339],"coxsackie":[293],"A":[294],"(CV-A).":[296],"transmembrane":[303],"protein":[304],"trafficking":[308],"Dickkopf":[310],"through":[311],"clathrin-mediated":[312],"endocytosis.":[313],"chapter,":[316],"data":[317],"presented":[319,439],"demonstrates":[321],"directly":[325],"interact":[326],"CV-A10":[328],"functional":[331],"receptor.":[333],"Furthermore,":[334,371],"it":[335],"shown":[337],"both":[345],"vitro":[347],"well":[349],"vivo.":[352],"above-mentioned":[354],"experimental":[355],"chapters":[356,373],"highlight":[357],"capability":[359],"elucidate":[364],"importance":[366],"factor":[369],"biology.":[370],"added":[375],"our":[377],"understanding":[378],"pathways":[382],"try":[392],"counteract":[394],"it.":[395],"6":[397],"explores":[398],"current":[400],"knowledge":[401],"host-pathogen":[404],"interplay":[405],"broader":[408],"context,":[409],"thereby":[410],"providing":[411],"overview":[413],"strategies":[415],"species":[420],"escape":[422],"from":[423],"endolysosomal":[425],"compartment":[426],"without":[427],"getting":[428],"detected.":[429],"Finally,":[430],"7":[432],"discusses":[433],"future":[434],"perspectives":[435],"considering":[436],"work":[438],"thesis.":[442]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2025-10-10T00:00:00"}