{"id":"https://openalex.org/W2906838351","doi":null,"title":"The Role of the Dopamine D1-D2 Receptor Heteromer in Brain Reward Function: Relevance to Drug Addiction and Depression","display_name":"The Role of the Dopamine D1-D2 Receptor Heteromer in Brain Reward Function: Relevance to Drug Addiction and Depression","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2906838351","mag":"2906838351"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/82526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/82526","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ef97113b-1c00-4d1b-ba29-f6fc87a74b0e/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/ef97113b-1c00-4d1b-ba29-f6fc87a74b0e/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shen, Yen Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shen, Yen Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine-dependence","display_name":"cocaine dependence","score":0.9710000157356262},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gq-protein-signaling","display_name":"Gq protein signaling","score":0.6779999732971191},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9229999780654907},{"id":"https://openalex.org/keywords/intracellular-calcium-release","display_name":"intracellular calcium release","score":0.8270000219345093},{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.8190000057220459},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cocaine-self-administration","display_name":"cocaine self-administration","score":0.9359999895095825},{"id":"https://openalex.org/keywords/locomotor-sensitization","display_name":"locomotor sensitization","score":0.8709999918937683},{"id":"https://openalex.org/keywords/conditioned-place-aversion","display_name":"conditioned place aversion","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lateral-habenula","display_name":"lateral habenula","score":0.7879999876022339},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.9169999957084656},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.8217161297798157},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6769436597824097},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.6643948554992676},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.6401992440223694},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5906373858451843},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5695258378982544},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5507137775421143},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.498776912689209},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4781306982040405},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.4497983157634735},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.445807546377182},{"id":"https://openalex.org/C64948172","wikidata":"https://www.wikidata.org/wiki/Q1653277","display_name":"Brain stimulation reward","level":4,"score":0.4289079010486603},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3670300841331482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32478833198547363},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.14616471529006958},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.11919528245925903},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/82526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/82526","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ef97113b-1c00-4d1b-ba29-f6fc87a74b0e/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:localhost:1807/82527","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/82527","pdf_url":null,"source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/82526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/82526","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ef97113b-1c00-4d1b-ba29-f6fc87a74b0e/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906838351.pdf","grobid_xml":"https://content.openalex.org/works/W2906838351.grobid-xml"},"referenced_works_count":352,"referenced_works":["https://openalex.org/W88161901","https://openalex.org/W149290994","https://openalex.org/W175006040","https://openalex.org/W184284683","https://openalex.org/W196383744","https://openalex.org/W278478146","https://openalex.org/W965515483","https://openalex.org/W1238819995","https://openalex.org/W1481125086","https://openalex.org/W1486362699","https://openalex.org/W1487049819","https://openalex.org/W1519847602","https://openalex.org/W1529918245","https://openalex.org/W1536787393","https://openalex.org/W1546116904","https://openalex.org/W1551779512","https://openalex.org/W1556555813","https://openalex.org/W1578789617","https://openalex.org/W1579518684","https://openalex.org/W1592376644","https://openalex.org/W1607644643","https://openalex.org/W1677042430","https://openalex.org/W1681161665","https://openalex.org/W1771503649","https://openalex.org/W1783438623","https://openalex.org/W1820118415","https://openalex.org/W1823711977","https://openalex.org/W1831515958","https://openalex.org/W1832650412","https://openalex.org/W1873552451","https://openalex.org/W1902071963","https://openalex.org/W1917554980","https://openalex.org/W1917605014","https://openalex.org/W1922497758","https://openalex.org/W1925492557","https://openalex.org/W1933997583","https://openalex.org/W1935461641","https://openalex.org/W1935648224","https://openalex.org/W1943803076","https://openalex.org/W1950426535","https://openalex.org/W1954660866","https://openalex.org/W1964240411","https://openalex.org/W1964284359","https://openalex.org/W1964812893","https://openalex.org/W1965242156","https://openalex.org/W1965835906","https://openalex.org/W1966795950","https://openalex.org/W1966998035","https://openalex.org/W1967017538","https://openalex.org/W1968139716","https://openalex.org/W1969457887","https://openalex.org/W1969969246","https://openalex.org/W1970238016","https://openalex.org/W1970249278","https://openalex.org/W1970290214","https://openalex.org/W1970726732","https://openalex.org/W1970777708","https://openalex.org/W1971112968","https://openalex.org/W1971417227","https://openalex.org/W1971434236","https://openalex.org/W1971690948","https://openalex.org/W1971808954","https://openalex.org/W1973512436","https://openalex.org/W1973663764","https://openalex.org/W1976550939","https://openalex.org/W1976642662","https://openalex.org/W1976982330","https://openalex.org/W1977078739","https://openalex.org/W1977533543","https://openalex.org/W1978550954","https://openalex.org/W1978731562","https://openalex.org/W1980321165","https://openalex.org/W1980571433","https://openalex.org/W1980717157","https://openalex.org/W1980737345","https://openalex.org/W1981195348","https://openalex.org/W1981654563","https://openalex.org/W1982383406","https://openalex.org/W1982474254","https://openalex.org/W1982912361","https://openalex.org/W1983272530","https://openalex.org/W1983348906","https://openalex.org/W1983759112","https://openalex.org/W1984777669","https://openalex.org/W1984785177","https://openalex.org/W1984941790","https://openalex.org/W1986408025","https://openalex.org/W1986446339","https://openalex.org/W1987604172","https://openalex.org/W1987769158","https://openalex.org/W1989416066","https://openalex.org/W1989570097","https://openalex.org/W1990046088","https://openalex.org/W1990677732","https://openalex.org/W1991105330","https://openalex.org/W1991603311","https://openalex.org/W1993485378","https://openalex.org/W1994675437","https://openalex.org/W1994949622","https://openalex.org/W1994953274","https://openalex.org/W1996061528","https://openalex.org/W1996108093","https://openalex.org/W1996261857","https://openalex.org/W1997245512","https://openalex.org/W1998033984","https://openalex.org/W1998414644","https://openalex.org/W2001056665","https://openalex.org/W2001891260","https://openalex.org/W2002493948","https://openalex.org/W2002630545","https://openalex.org/W2003289804","https://openalex.org/W2003367821","https://openalex.org/W2005614924","https://openalex.org/W2005999079","https://openalex.org/W2006193711","https://openalex.org/W2007149985","https://openalex.org/W2007706798","https://openalex.org/W2008762508","https://openalex.org/W2008826113","https://openalex.org/W2009243814","https://openalex.org/W2009252637","https://openalex.org/W2009578696","https://openalex.org/W2009680578","https://openalex.org/W2009740212","https://openalex.org/W2010129023","https://openalex.org/W2011918984","https://openalex.org/W2012129255","https://openalex.org/W2013366889","https://openalex.org/W2013622904","https://openalex.org/W2014944895","https://openalex.org/W2015933168","https://openalex.org/W2016738453","https://openalex.org/W2016773078","https://openalex.org/W2017279410","https://openalex.org/W2017549779","https://openalex.org/W2018231450","https://openalex.org/W2019074781","https://openalex.org/W2021534324","https://openalex.org/W2022104671","https://openalex.org/W2023042672","https://openalex.org/W2023230757","https://openalex.org/W2023637370","https://openalex.org/W2025417981","https://openalex.org/W2025857038","https://openalex.org/W2026873245","https://openalex.org/W2027159196","https://openalex.org/W2028980996","https://openalex.org/W2029725565","https://openalex.org/W2029897042","https://openalex.org/W2030401640","https://openalex.org/W2030644595","https://openalex.org/W2030687244","https://openalex.org/W2030780744","https://openalex.org/W2030817912","https://openalex.org/W2031647610","https://openalex.org/W2031999765","https://openalex.org/W2032436575","https://openalex.org/W2032538117","https://openalex.org/W2033110852","https://openalex.org/W2033323125","https://openalex.org/W2033836192","https://openalex.org/W2033844584","https://openalex.org/W2034493924","https://openalex.org/W2035068403","https://openalex.org/W2035179537","https://openalex.org/W2035590629","https://openalex.org/W2036366633","https://openalex.org/W2036768211","https://openalex.org/W2037457092","https://openalex.org/W2037639590","https://openalex.org/W2037874188","https://openalex.org/W2038284470","https://openalex.org/W2038787827","https://openalex.org/W2039482493","https://openalex.org/W2040883320","https://openalex.org/W2040903782","https://openalex.org/W2041211150","https://openalex.org/W2042688689","https://openalex.org/W2043610928","https://openalex.org/W2044182043","https://openalex.org/W2045129849","https://openalex.org/W2045821490","https://openalex.org/W2046270739","https://openalex.org/W2046717433","https://openalex.org/W2047110318","https://openalex.org/W2047284927","https://openalex.org/W2048575458","https://openalex.org/W2048770548","https://openalex.org/W2049182645","https://openalex.org/W2049367666","https://openalex.org/W2049547155","https://openalex.org/W2049587475","https://openalex.org/W2049683554","https://openalex.org/W2050264591","https://openalex.org/W2050836998","https://openalex.org/W2051106500","https://openalex.org/W2051274411","https://openalex.org/W2051487428","https://openalex.org/W2051778074","https://openalex.org/W2052078815","https://openalex.org/W2052102717","https://openalex.org/W2053070706","https://openalex.org/W2053613528","https://openalex.org/W2054046728","https://openalex.org/W2054378529","https://openalex.org/W2057135100","https://openalex.org/W2057905064","https://openalex.org/W2057931519","https://openalex.org/W2058578514","https://openalex.org/W2058640434","https://openalex.org/W2058867280","https://openalex.org/W2059057223","https://openalex.org/W2059945497","https://openalex.org/W2060476762","https://openalex.org/W2060810779","https://openalex.org/W2061350749","https://openalex.org/W2061359205","https://openalex.org/W2061575992","https://openalex.org/W2061823894","https://openalex.org/W2062570667","https://openalex.org/W2063340172","https://openalex.org/W2063576205","https://openalex.org/W2065241932","https://openalex.org/W2065693683","https://openalex.org/W2065969460","https://openalex.org/W2066144671","https://openalex.org/W2066248256","https://openalex.org/W2066848874","https://openalex.org/W2067592930","https://openalex.org/W2068420002","https://openalex.org/W2068501956","https://openalex.org/W2069992321","https://openalex.org/W2070288681","https://openalex.org/W2071793091","https://openalex.org/W2071815275","https://openalex.org/W2072457730","https://openalex.org/W2072531628","https://openalex.org/W2073003311","https://openalex.org/W2073595900","https://openalex.org/W2075625204","https://openalex.org/W2076866333","https://openalex.org/W2077008768","https://openalex.org/W2077727405","https://openalex.org/W2079590230","https://openalex.org/W2080774795","https://openalex.org/W2080875376","https://openalex.org/W2080876332","https://openalex.org/W2081950565","https://openalex.org/W2082778544","https://openalex.org/W2083415560","https://openalex.org/W2084376094","https://openalex.org/W2085376923","https://openalex.org/W2085520758","https://openalex.org/W2086015992","https://openalex.org/W2086114962","https://openalex.org/W2086459628","https://openalex.org/W2087657646","https://openalex.org/W2088715247","https://openalex.org/W2089198034","https://openalex.org/W2089468762","https://openalex.org/W2089816026","https://openalex.org/W2090763917","https://openalex.org/W2091082924","https://openalex.org/W2091680313","https://openalex.org/W2092103977","https://openalex.org/W2092780033","https://openalex.org/W2092821774","https://openalex.org/W2093154691","https://openalex.org/W2093398004","https://openalex.org/W2093745333","https://openalex.org/W2095056388","https://openalex.org/W2095088925","https://openalex.org/W2095219741","https://openalex.org/W2098303384","https://openalex.org/W2098304576","https://openalex.org/W2099319294","https://openalex.org/W2100336567","https://openalex.org/W2102821668","https://openalex.org/W2104961861","https://openalex.org/W2105668301","https://openalex.org/W2106862702","https://openalex.org/W2108879519","https://openalex.org/W2108917606","https://openalex.org/W2111038577","https://openalex.org/W2111112265","https://openalex.org/W2111324372","https://openalex.org/W2112953965","https://openalex.org/W2116342741","https://openalex.org/W2116385925","https://openalex.org/W2117003397","https://openalex.org/W2117093530","https://openalex.org/W2117913614","https://openalex.org/W2118698909","https://openalex.org/W2119168667","https://openalex.org/W2119222668","https://openalex.org/W2121379737","https://openalex.org/W2124203952","https://openalex.org/W2124427838","https://openalex.org/W2124673755","https://openalex.org/W2126172702","https://openalex.org/W2126342361","https://openalex.org/W2126931771","https://openalex.org/W2132334517","https://openalex.org/W2132629785","https://openalex.org/W2134330719","https://openalex.org/W2134893922","https://openalex.org/W2137480418","https://openalex.org/W2139129258","https://openalex.org/W2139299435","https://openalex.org/W2140159910","https://openalex.org/W2140175678","https://openalex.org/W2140338624","https://openalex.org/W2140986639","https://openalex.org/W2141783556","https://openalex.org/W2143015200","https://openalex.org/W2144387894","https://openalex.org/W2145594774","https://openalex.org/W2146439993","https://openalex.org/W2147773916","https://openalex.org/W2149119305","https://openalex.org/W2149885167","https://openalex.org/W2149904207","https://openalex.org/W2153763527","https://openalex.org/W2153999002","https://openalex.org/W2154579172","https://openalex.org/W2155353589","https://openalex.org/W2155685628","https://openalex.org/W2156165361","https://openalex.org/W2156894810","https://openalex.org/W2158995449","https://openalex.org/W2159891593","https://openalex.org/W2160835699","https://openalex.org/W2163334673","https://openalex.org/W2163346307","https://openalex.org/W2163805252","https://openalex.org/W2165345221","https://openalex.org/W2165590312","https://openalex.org/W2167021628","https://openalex.org/W2167200470","https://openalex.org/W2167857702","https://openalex.org/W2170595339","https://openalex.org/W2171553829","https://openalex.org/W2172011217","https://openalex.org/W2175261180","https://openalex.org/W2238091929","https://openalex.org/W2312741033","https://openalex.org/W2339399100","https://openalex.org/W2411246271","https://openalex.org/W2414344550","https://openalex.org/W2415402860","https://openalex.org/W2470955427","https://openalex.org/W4323238559"],"related_works":["https://openalex.org/W2782427095","https://openalex.org/W7132926757","https://openalex.org/W2476634580","https://openalex.org/W2031999765","https://openalex.org/W3122892489","https://openalex.org/W1822523013","https://openalex.org/W3207835780","https://openalex.org/W1991154371","https://openalex.org/W7162800260","https://openalex.org/W4409026381"],"abstract_inverted_index":{"We":[0],"have":[1],"identified":[2],"a":[3,58,87,145,155,193,282,304],"novel":[4,314],"dopamine-mediated":[5],"signaling":[6],"complex,":[7],"the":[8,26,34,42,79,90,124,133,182,199,206,224,241,248,258,263,268,277,308],"D1-D2":[9,27,91,108,141,164,186,225,278,309],"receptor":[10,305],"heteromer,":[11],"which":[12,60,260],"couples":[13],"to":[14,17,32,85,138,170],"Gq":[15],"protein":[16],"elicit":[18],"phospholipase":[19],"C-mediated":[20],"intracellular":[21],"Ca2+":[22],"release.":[23],"Activation":[24],"of":[25,36,63,81,99,128,135,236,267,297,303],"heteromer":[28,92,109,142,165,187,226,279,310],"was":[29,84,168,221],"further":[30],"shown":[31,169,222],"modulate":[33,289],"expression":[35,134],"proteins":[37],"implicated":[38],"in":[39,41,65,93,198,233,240,247],"reward":[40,71,291],"nucleus":[43],"accumbens,":[44],"such":[45,73,161],"as":[46,74],"calcium":[47],"calmodulin":[48],"kinase":[49],"II":[50],"(CaMKII)":[51],"and":[52,76,102,126,132,195,205,243,250,257,313,320],"brain":[53,290],"derived":[54],"neurotrophic":[55],"factor":[56],"(BDNF),":[57],"finding":[59],"may":[61,280],"be":[62,281],"relevance":[64],"neuropsychiatric":[66,325],"disorders":[67,326],"that":[68,107,211,223,276,286,327],"exhibit":[69],"altered":[70],"perception":[72],"addiction":[75,101,319],"depression.":[77,103],"Therefore,":[78],"purpose":[80],"current":[82],"study":[83],"investigate":[86],"role":[88],"for":[89,184,317],"reward-related":[94,324],"behaviours":[95,117],"using":[96],"animal":[97],"models":[98],"cocaine":[100,119,129,318],"The":[104],"results":[105],"show":[106],"stimulation":[110,166,188],"by":[111,144,189,214],"agonist":[112],"SKF":[113,190],"83959":[114,191],"attenuated":[115],"addiction-related":[116],"including":[118],"conditioned":[120,172],"place":[121,173],"preference":[122],"(CPP),":[123],"maintenance":[125],"reinstatement":[127],"self-administration":[130],"(SA),":[131],"locomotor":[136],"sensitization":[137],"cocaine,":[139],"whereas":[140,154,175],"inactivation":[143,178],"selective":[146,177],"disrupting":[147],"peptide":[148,158],"TAT-D1":[149,217],"consistently":[150],"augmented":[151],"cocaine-induced":[152],"behaviours,":[153],"control":[156],"scrambled":[157],"had":[159],"no":[160],"effects.":[162],"Moreover,":[163],"alone":[167],"induce":[171],"aversion,":[174],"its":[176,295],"induced":[179,192],"CPP.":[180],"In":[181],"tests":[183],"depression,":[185,322],"pro-depressive":[194],"anxiogenic":[196],"state":[197,296],"forced":[200],"swim":[201],"test,":[202],"novelty-induced":[203],"hypophagia,":[204],"elevated":[207],"plus":[208],"maze,":[209],"effects":[210],"were":[212],"abolished":[213],"pretreatment":[215],"with":[216],"peptide.":[218],"Lastly,":[219],"it":[220],"exerts":[227],"dual":[228,264],"modulation":[229],"on":[230,294],"neuronal":[231],"activity":[232,239],"certain":[234],"regions":[235],"brain,":[237],"increasing":[238],"NAc,":[242],"exerting":[244],"tonic":[245],"inhibition":[246],"prelimbic":[249],"infralimbic":[251],"cortex,":[252,254],"orbitofrontal":[253],"lateral":[255],"habenula,":[256],"thalamus,":[259],"likely":[261],"reflects":[262],"excitatory/inhibitory":[265],"capabilities":[266],"GABA/Glu-co-expressing":[269],"D1R/D2R":[270],"MSNs.":[271],"Collectively,":[272],"these":[273],"findings":[274],"indicate":[275],"single":[283],"molecular":[284],"entity":[285],"could":[287],"bidirectionally":[288],"function":[292,302],"depending":[293],"activation.":[298],"Such":[299],"an":[300,311],"unprecedented":[301],"complex":[306],"makes":[307],"attractive":[312],"therapeutic":[315],"target":[316],"major":[321],"two":[323],"are":[328],"currently":[329],"without":[330],"effective":[331],"treatments.":[332]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
