{"id":"https://openalex.org/W2906837589","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.7028","title":"A phase I study of the mitochondrial metabolism inhibitor CPI-613 in combination with high-dose ara-C (HDAC) and mitoxantrone for relapsed or refractory acute myeloid leukemia (AML).","display_name":"A phase I study of the mitochondrial metabolism inhibitor CPI-613 in combination with high-dose ara-C (HDAC) and mitoxantrone for relapsed or refractory acute myeloid leukemia (AML).","publication_year":2014,"publication_date":"2014-05-20","ids":{"openalex":"https://openalex.org/W2906837589","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.7028","mag":"2906837589"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.15_suppl.7028","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.7028","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.7028","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049848146","display_name":"Timothy S. Pardee","orcid":"https://orcid.org/0000-0002-1186-6948","observed_orcids":["https://orcid.org/0000-0002-1186-6948"]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy S. Pardee","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033627041","display_name":"Kristin M. Stadelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Stadelman","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079840473","display_name":"Scott P. Isom","orcid":"https://orcid.org/0000-0002-6658-3865","observed_orcids":["https://orcid.org/0000-0002-6658-3865"]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Isom","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015883421","display_name":"Leslie Renee Ellis","orcid":"https://orcid.org/0000-0003-0459-7951","observed_orcids":["https://orcid.org/0000-0003-0459-7951"]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie R. Ellis","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112627345","display_name":"Dmitriy P. Berenzon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitriy P. Berenzon","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022580164","display_name":"Robin Harrelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Harrelson","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Wisnton-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Wisnton-Salem, NC","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086623759","display_name":"Megan Manuel","orcid":"https://orcid.org/0009-0000-6828-9136","observed_orcids":["https://orcid.org/0009-0000-6828-9136"]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Manuel","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012371637","display_name":"Sarah Dralle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Dralle","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015253432","display_name":"Susan Lyerly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Lyerly","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109344899","display_name":"Bayard L. Powell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bayard L. Powell","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"15_suppl","first_page":"7028","last_page":"7028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpi-613","display_name":"CPI-613","score":0.9980000257492065},{"id":"https://openalex.org/keywords/high-dose-cytarabine","display_name":"high-dose cytarabine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/relapsed-refractory-acute-myeloid-leukemia","display_name":"relapsed/refractory acute myeloid leukemia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7210000157356262},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9290000200271606},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7710000276565552},{"id":"https://openalex.org/keywords/poor-risk-cytogenetics","display_name":"poor-risk cytogenetics","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ampk-phosphorylation","display_name":"AMPK phosphorylation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.3959999978542328},{"id":"https://openalex.org/keywords/reinduction-therapy","display_name":"reinduction therapy","score":0.5289999842643738},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2780923524","wikidata":"https://www.wikidata.org/wiki/Q239426","display_name":"Mitoxantrone","level":3,"score":0.8846507668495178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8527652025222778},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5971899628639221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5567747354507446},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49909114837646484},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.45306169986724854},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.43063926696777344},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38562655448913574},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.34811389446258545},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33315080404281616},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.15_suppl.7028","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.7028","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.7028","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2501199222","https://openalex.org/W2469744851","https://openalex.org/W2583698456","https://openalex.org/W2784675694","https://openalex.org/W2793125515","https://openalex.org/W2751000504","https://openalex.org/W2912324218","https://openalex.org/W2564257916","https://openalex.org/W2603905094","https://openalex.org/W2964624807"],"abstract_inverted_index":{"7028":[0],"Background:":[1],"Altered":[2],"metabolism":[3],"is":[4,16,326],"an":[5],"emerging":[6],"hallmark":[7],"of":[8,38,68,155,180,190,242,253,296,305,342,350],"cancer":[9],"and":[10,36,45,93,172,205,248,281,324,335],"a":[11,17,66,125,136,239,260,287,313,327,348],"possible":[12],"therapeutic":[13],"target.":[14],"CPI-613":[15,39,55,105,283,319],"first":[18],"in":[19,41,47,199,203,207,312,320,332],"class":[20],"agent":[21],"that":[22],"targets":[23],"mitochondrial":[24],"metabolism.This":[25],"trial":[26,353],"was":[27,56,85,98,107,115,163,192,212,223,235,309],"designed":[28],"to":[29,109],"determine":[30],"the":[31,122,187,220,232],"maximum":[32],"tolerated":[33],"dose,":[34],"safety,":[35],"efficacy":[37],"given":[40,57,86,99],"combination":[42,321],"with":[43,49,121,142,184,228,245,255,273,303,315,322,337],"HDAC":[44,75,323],"mitoxantrone":[46,94,247,325],"patients":[48,157,168,183,216,227,243,254,263,272,334],"relapsed":[50,185],"or":[51,124,140,176,267],"refractory":[52,170],"AML.":[53],"Methods:":[54],"daily":[58,100],"on":[59,72,117,266],"days":[60],"1":[61],"through":[62],"5":[63,91],"starting":[64],"at":[65,76,95],"dose":[67,106],"500":[69],"mg/m2.":[70,111],"Beginning":[71],"day":[73,118,127,269],"3,":[74],"3,000":[77],"mg/m2":[78,81,97],"(or":[79],"1,500":[80],"for":[82,90,101],"age":[83,162],"\u226560)":[84],"every":[87],"12":[88],"hours":[89],"doses":[92],"6":[96],"3":[102],"doses.":[103],"The":[104,160,209],"escalated":[108],"2250":[110],"If":[112],"residual":[113],"disease":[114,171,186],"present":[116],"14":[119],"re-induction":[120],"same":[123],"three":[126],"abbreviated":[128],"course":[129],"could":[130,147],"be":[131],"given.":[132],"Patients":[133],"who":[134,289],"achieved":[135,259],"complete":[137],"remission":[138],"(CR)":[139],"CR":[141],"incomplete":[143],"count":[144],"recovery":[145],"(CRi)":[146],"receive":[148],"additional":[149],"consolidation":[150],"cycles.":[151],"Results:":[152],"A":[153],"total":[154],"24":[156],"were":[158,196],"enrolled.":[159],"median":[161,188],"58":[164],"(range":[165],"21-76).":[166],"Four":[167],"had":[169,276],"six":[173],"received":[174],"two":[175],"more":[177],"previous":[178],"lines":[179],"therapy.":[181],"In":[182,215,226,238],"duration":[189],"CR1":[191],"7.5":[193],"months.":[194],"Cytogenetics":[195],"poor":[197,229,256],"risk":[198,230,257,339],"13":[200],"patients,":[201],"intermediate":[202],"8":[204],"good":[206],"3.":[208],"response":[210],"rate":[211,222,234],"54%":[213],"(11CR+2CRi).":[214],"\u226560":[217],"years":[218],"old":[219],"CR/CRi":[221,233],"55%":[224],"(6/11).":[225],"cytogenetics":[231,258],"53%":[236],"(7/13).":[237],"historical":[240],"cohort":[241],"treated":[244],"HDAC,":[246],"asparaginase,":[249],"only":[250],"25%":[251],"(4/16)":[252],"CR/CRi.":[261],"Five":[262],"(21%)":[264],"died":[265],"before":[268,280],"30.":[270],"Two":[271],"circulating":[274],"blasts":[275],"blood":[277],"samples":[278],"taken":[279],"after":[282],"infusion.":[284],"Samples":[285],"from":[286],"patient":[288,314],"cleared":[290],"her":[291],"marrow":[292],"demonstrated":[293],"robust":[294],"phosphorylation":[295,308,344],"adenosine":[297],"monophosphate-activated":[298],"protein":[299],"kinase":[300],"(AMPK)":[301],"consistent":[302],"depletion":[304],"ATP.":[306],"This":[307],"not":[310],"seen":[311],"persistent":[316],"disease.":[317,340],"Conclusions:":[318],"promising":[328],"salvage":[329],"regimen,":[330],"especially":[331],"older":[333],"those":[336],"high":[338],"Induction":[341],"AMPK":[343],"may":[345],"serve":[346],"as":[347],"predictor":[349],"response.":[351],"Clinical":[352],"information:":[354],"NCT01768897.":[355]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-01-11T00:00:00"}