{"id":"https://openalex.org/W2906828866","doi":"https://doi.org/10.3389/fphar.2018.01145","title":"Drug Interactions With New Synthetic Opioids","display_name":"Drug Interactions With New Synthetic Opioids","publication_year":2018,"publication_date":"2018-10-11","ids":{"openalex":"https://openalex.org/W2906828866","doi":"https://doi.org/10.3389/fphar.2018.01145","mag":"2906828866","pmid":"https://pubmed.ncbi.nlm.nih.gov/30364252"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2018.01145","doi":"https://doi.org/10.3389/fphar.2018.01145","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.01145","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.01145/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.01145/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083373223","display_name":"Clara P\u00e9rez\u2010Ma\u00f1\u00e1","orcid":"https://orcid.org/0000-0001-6343-6918","observed_orcids":["https://orcid.org/0000-0001-6343-6918"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210137002","display_name":"Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol","ror":"https://ror.org/03bzdww12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210137002","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Clara P\u00e9rez-Ma\u00f1\u00e1","raw_affiliation_strings":["Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol (HUGTP-IGTP), Badalona, Spain","Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol (HUGTP-IGTP), Badalona, Spain","institution_ids":["https://openalex.org/I4210137002","https://openalex.org/I4210153460"]},{"raw_affiliation_string":"Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058384218","display_name":"Esther Papaseit","orcid":"https://orcid.org/0000-0003-2620-4274","observed_orcids":["https://orcid.org/0000-0003-2620-4274"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210137002","display_name":"Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol","ror":"https://ror.org/03bzdww12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210137002","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Esther Papaseit","raw_affiliation_strings":["Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol (HUGTP-IGTP), Badalona, Spain","Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol (HUGTP-IGTP), Badalona, Spain","institution_ids":["https://openalex.org/I4210137002","https://openalex.org/I4210153460"]},{"raw_affiliation_string":"Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036630051","display_name":"Francina Fonseca","orcid":"https://orcid.org/0000-0002-0779-6545","observed_orcids":["https://orcid.org/0000-0002-0779-6545"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francina Fonseca","raw_affiliation_strings":["Department of Psychiatry and Legal Medicine, Autonomous University of Barcelona, Barcelona, Spain","Drug Addiction Unit, Institute of Neuropsychiatry and Addictions, Hospital del Mar Medical Research Institute, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Legal Medicine, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Drug Addiction Unit, Institute of Neuropsychiatry and Addictions, Hospital del Mar Medical Research Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113480968","display_name":"Adriana Farr\u00e9","orcid":"https://orcid.org/0000-0001-6396-1771","observed_orcids":["https://orcid.org/0000-0001-6396-1771"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adriana Farr\u00e9","raw_affiliation_strings":["Department of Psychiatry and Legal Medicine, Autonomous University of Barcelona, Barcelona, Spain","Drug Addiction Unit, Institute of Neuropsychiatry and Addictions, Hospital del Mar Medical Research Institute, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Legal Medicine, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Drug Addiction Unit, Institute of Neuropsychiatry and Addictions, Hospital del Mar Medical Research Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036831245","display_name":"Marta Torrens","orcid":"https://orcid.org/0000-0001-6222-4761","observed_orcids":["https://orcid.org/0000-0001-6222-4761"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Torrens","raw_affiliation_strings":["Department of Psychiatry and Legal Medicine, Autonomous University of Barcelona, Barcelona, Spain","Drug Addiction Unit, Institute of Neuropsychiatry and Addictions, Hospital del Mar Medical Research Institute, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Legal Medicine, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Drug Addiction Unit, Institute of Neuropsychiatry and Addictions, Hospital del Mar Medical Research Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033539160","display_name":"Mag\u0131\u0301 Farr\u00e9","orcid":"https://orcid.org/0000-0001-8338-7543","observed_orcids":["https://orcid.org/0000-0001-8338-7543"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210137002","display_name":"Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol","ror":"https://ror.org/03bzdww12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210137002","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Magi Farr\u00e9","raw_affiliation_strings":["Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol (HUGTP-IGTP), Badalona, Spain","Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol (HUGTP-IGTP), Badalona, Spain","institution_ids":["https://openalex.org/I4210137002","https://openalex.org/I4210153460"]},{"raw_affiliation_string":"Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5058384218"],"corresponding_institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210137002","https://openalex.org/I4210153460"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":15.3421,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.99008303,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"1145","last_page":"1145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.14480000734329224,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7799999713897705},{"id":"https://openalex.org/keywords/synthetic-opioids","display_name":"synthetic opioids","score":0.7910000085830688},{"id":"https://openalex.org/keywords/fentanyl-analogs","display_name":"fentanyl analogs","score":0.9829999804496765},{"id":"https://openalex.org/keywords/new-psychoactive-substances","display_name":"new psychoactive substances","score":0.9760000109672546},{"id":"https://openalex.org/keywords/opioid-poisoning","display_name":"opioid toxicity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/mu-opioid-receptor-agonism","display_name":"mu-opioid receptor agonism","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pharmacodynamic-interactions","display_name":"pharmacodynamic interactions","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.8109999895095825},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9660000205039978},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.796999990940094},{"id":"https://openalex.org/keywords/opioid-misuse","display_name":"opioid misuse","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C38829236","wikidata":"https://www.wikidata.org/wiki/Q203994","display_name":"Euphoriant","level":2,"score":0.7576886415481567},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.6999579071998596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.661410927772522},{"id":"https://openalex.org/C2778903686","wikidata":"https://www.wikidata.org/wiki/Q60168","display_name":"Heroin","level":3,"score":0.6294018626213074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6089653968811035},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5986486077308655},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5875629782676697},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.528253436088562},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19269713759422302},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09143361449241638},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06815668940544128}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fphar.2018.01145","doi":"https://doi.org/10.3389/fphar.2018.01145","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.01145","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.01145/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:30364252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30364252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:ddd.uab.cat:253694","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/253694","pdf_url":"https://ddd.uab.cat/pub/artpub/2018/pmc_30364252/pmc_30364252.pdf","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:5146391","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6193107","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6193107","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6193107","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:29dab7df38d341a5a2c24d5dce63c554","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29dab7df38d341a5a2c24d5dce63c554","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 9 (2018)","raw_type":"article"},{"id":"pmh:oai:repositori.upf.edu:10230/37155","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/37155","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2018.01145","doi":"https://doi.org/10.3389/fphar.2018.01145","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.01145","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.01145/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1096289937","display_name":null,"funder_award_id":"JR16/00020","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G1779409644","display_name":null,"funder_award_id":"JUST-2017-AG-DRUG","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2046123590","display_name":null,"funder_award_id":"RD16/0017/0010","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2049800632","display_name":null,"funder_award_id":"2017 SGR530","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G2615643966","display_name":null,"funder_award_id":"RD16/0017","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2848797422","display_name":null,"funder_award_id":"RD12/0028","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3307904870","display_name":null,"funder_award_id":"2017\u2010SGR\u2010316","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G3559709381","display_name":null,"funder_award_id":"PI14/","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4714563556","display_name":null,"funder_award_id":"RD12/0028/0009","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5059540759","display_name":null,"funder_award_id":"RD16/0017/0003","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5554424168","display_name":null,"funder_award_id":"2017SGR","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G5657096599","display_name":null,"funder_award_id":"RD12/0028/0009","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G6224149704","display_name":"Potencial de abuso y farmacolog\u00eda humana de nuevas catinonas sint\u00e9ticas","funder_award_id":"PI17/01962","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6438713526","display_name":null,"funder_award_id":"RTA RD12/0028/0009","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G7337082804","display_name":null,"funder_award_id":"RD12/0028/0009","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8220120278","display_name":"Nuevas sustancias psicoactivas: evaluaci\u00f3n del potencial de abuso y farmacolog\u00eda humana de un cannabinoide sint\u00e9tico","funder_award_id":"PI14/00715","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8489041226","display_name":null,"funder_award_id":"PI17/01962","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320314152","display_name":"Directorate-General for Migration and Home Affairs","ror":"https://ror.org/02qc43v06"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321600","display_name":"Departament d'Innovaci\u00f3, Universitats i Empresa, Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906828866.pdf","grobid_xml":"https://content.openalex.org/works/W2906828866.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W170544965","https://openalex.org/W1147826944","https://openalex.org/W1527556500","https://openalex.org/W1564827175","https://openalex.org/W1867412696","https://openalex.org/W1894676325","https://openalex.org/W1959147491","https://openalex.org/W1965999023","https://openalex.org/W1972589489","https://openalex.org/W1975104237","https://openalex.org/W1976309976","https://openalex.org/W1976368284","https://openalex.org/W1982399270","https://openalex.org/W1982940569","https://openalex.org/W1987869897","https://openalex.org/W2004431923","https://openalex.org/W2023345139","https://openalex.org/W2025085061","https://openalex.org/W2031323283","https://openalex.org/W2046027935","https://openalex.org/W2056519723","https://openalex.org/W2058924856","https://openalex.org/W2060476415","https://openalex.org/W2067078906","https://openalex.org/W2072543293","https://openalex.org/W2074539984","https://openalex.org/W2076045136","https://openalex.org/W2083424276","https://openalex.org/W2083600976","https://openalex.org/W2086371280","https://openalex.org/W2090562839","https://openalex.org/W2094598782","https://openalex.org/W2095195769","https://openalex.org/W2101238223","https://openalex.org/W2112634018","https://openalex.org/W2125885488","https://openalex.org/W2132164596","https://openalex.org/W2138334482","https://openalex.org/W2142849985","https://openalex.org/W2144791106","https://openalex.org/W2150533935","https://openalex.org/W2153985019","https://openalex.org/W2155398389","https://openalex.org/W2296986887","https://openalex.org/W2306084999","https://openalex.org/W2313135452","https://openalex.org/W2394801614","https://openalex.org/W2410143774","https://openalex.org/W2425287903","https://openalex.org/W2462952435","https://openalex.org/W2479252594","https://openalex.org/W2497557477","https://openalex.org/W2517237778","https://openalex.org/W2517807482","https://openalex.org/W2528892361","https://openalex.org/W2535076807","https://openalex.org/W2539890992","https://openalex.org/W2564411459","https://openalex.org/W2566961868","https://openalex.org/W2582418833","https://openalex.org/W2589956685","https://openalex.org/W2596617588","https://openalex.org/W2604198339","https://openalex.org/W2617242401","https://openalex.org/W2617279801","https://openalex.org/W2618160665","https://openalex.org/W2622699130","https://openalex.org/W2727271381","https://openalex.org/W2730603686","https://openalex.org/W2742295098","https://openalex.org/W2745670698","https://openalex.org/W2749895937","https://openalex.org/W2751358495","https://openalex.org/W2751965395","https://openalex.org/W2752053505","https://openalex.org/W2762128566","https://openalex.org/W2765815655","https://openalex.org/W2766585125","https://openalex.org/W2767283662","https://openalex.org/W2767447902","https://openalex.org/W2768721860","https://openalex.org/W2771307521","https://openalex.org/W2772873931","https://openalex.org/W2773962638","https://openalex.org/W2784310546","https://openalex.org/W2790470440","https://openalex.org/W2793837493","https://openalex.org/W2794764561","https://openalex.org/W2794847387","https://openalex.org/W2796165444","https://openalex.org/W2802566712","https://openalex.org/W2806616881","https://openalex.org/W2889306508","https://openalex.org/W2915910198","https://openalex.org/W2920592781","https://openalex.org/W4211214267"],"related_works":["https://openalex.org/W4323652728","https://openalex.org/W2549328549","https://openalex.org/W1580218291","https://openalex.org/W2990296528","https://openalex.org/W2782079232","https://openalex.org/W2376489418","https://openalex.org/W2468816421","https://openalex.org/W2921971750","https://openalex.org/W2530122656","https://openalex.org/W4225293048"],"abstract_inverted_index":{"Fentanyl,":[0],"fentanyl":[1,91,104],"analogs,":[2],"and":[3,30,78,111,117,154,170,183,219],"other":[4,47,115,149,167],"new":[5,17,235],"synthetic":[6],"opioids":[7],"(NSO)":[8],"have":[9,106],"burst":[10],"onto":[11],"the":[12,62,65,128,139,143],"illegal":[13,150,171],"drug":[14],"market":[15],"as":[16,25,61,190],"psychoactive":[18],"substances":[19,116],"(NPS).":[20],"They":[21],"are":[22,87,158,214],"often":[23,44,215],"sold":[24],"heroin":[26],"to":[27,51,181,233],"unsuspecting":[28],"users":[29],"produce":[31],"euphoria":[32],"through":[33],"their":[34],"agonist":[35],"action":[36,110],"on":[37,127],"\u03bc-":[38],"opioid":[39,134,202],"receptors.":[40],"Their":[41],"high":[42],"consumption,":[43],"combined":[45],"with":[46,114],"substances,":[48],"has":[49,75],"led":[50],"multiple":[52],"intoxications":[53],"during":[54],"recent":[55],"years.":[56],"In":[57],"some":[58,103],"countries,":[59],"such":[60],"United":[63],"States,":[64],"consumption":[66],"of":[67,109,133,146,152,173,224,237],"opioids,":[68,168,212],"whether":[69],"for":[70,200],"medical":[71],"or":[72],"recreational":[73],"purposes,":[74],"become":[76],"epidemic":[77],"is":[79,95,125,205],"considered":[80],"a":[81],"public":[82],"health":[83],"problem.":[84],"Fentanyl":[85],"analogs":[86,105],"more":[88,98,121],"potent":[89,99],"than":[90,100,199],"which":[92,213],"in":[93,142,231],"turn":[94],"50":[96],"times":[97],"morphine.":[101],"Furthermore,":[102],"longer":[107],"duration":[108],"therefore":[112],"interactions":[113,132,176,230],"medicines":[118],"can":[119,177,187],"be":[120,178,188,197,222],"serious.":[122],"This":[123],"review":[124],"focused":[126],"potentially":[129,227],"most":[130],"frequent":[131],"NPS":[135,220],"taking":[136],"into":[137],"account":[138],"drugs":[140,151,172],"present":[141],"reported":[144],"cases":[145,236],"poly-intoxication,":[147],"including":[148],"abuse":[153],"medication.":[155],"Substances":[156],"involved":[157],"mainly":[159],"antidepressants,":[160],"antihistamines,":[161],"antipsychotics,":[162],"benzodiazepines,":[163],"analgesics,":[164],"anesthetics,":[165],"psychostimulants,":[166],"alcohol,":[169],"abuse.":[174],"The":[175],"produced":[179],"due":[180],"pharmacokinetic":[182],"pharmacodynamic":[184],"mechanisms.":[185],"Naloxone":[186],"used":[189],"an":[191],"antidote,":[192],"although":[193],"required":[194],"doses":[195],"might":[196],"higher":[198],"traditional":[201],"intoxications.":[203],"It":[204],"crucial":[206],"that":[207],"doctors":[208],"who":[209],"habitually":[210],"prescribe":[211],"misused":[216],"by":[217],"patients":[218],"users,":[221],"aware":[223],"designer":[225],"opioids'":[226],"life-threatening":[228],"drug-drug":[229],"order":[232],"prevent":[234],"intoxication.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}