{"id":"https://openalex.org/W2906819261","doi":"https://doi.org/10.4103/asl.asl_173_17","title":"Attenuation of cisplatin-induced nephrotoxicity by ethanol extract of seeds of Lens culinaris medik","display_name":"Attenuation of cisplatin-induced nephrotoxicity by ethanol extract of seeds of Lens culinaris medik","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2906819261","doi":"https://doi.org/10.4103/asl.asl_173_17","mag":"2906819261"},"language":"en","primary_location":{"id":"doi:10.4103/asl.asl_173_17","doi":"https://doi.org/10.4103/asl.asl_173_17","is_oa":true,"landing_page_url":"https://doi.org/10.4103/asl.asl_173_17","pdf_url":null,"source":{"id":"https://openalex.org/S2736520405","display_name":"Ancient Science of Life","issn_l":"0257-7941","issn":["0257-7941","2249-9547"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ancient Science of Life","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2906819261"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/asl.asl_173_17","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102811012","display_name":"Sreedevi Adikay","orcid":"https://orcid.org/0000-0002-4380-2973","observed_orcids":["https://orcid.org/0000-0002-4380-2973","https://orcid.org/0000-0001-7330-5612"]},"institutions":[{"id":"https://openalex.org/I94415630","display_name":"Sri Padmavati Mahila Visvavidyalayam","ror":"https://ror.org/02zptxe07","country_code":"IN","type":"education","lineage":["https://openalex.org/I94415630"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Adikay Sreedevi","raw_affiliation_strings":["Division of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India","institution_ids":["https://openalex.org/I94415630"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076036846","display_name":"Kaveripakam Sai Sruthi","orcid":"https://orcid.org/0009-0005-3000-7187","observed_orcids":["https://orcid.org/0009-0005-3000-7187"]},"institutions":[{"id":"https://openalex.org/I94415630","display_name":"Sri Padmavati Mahila Visvavidyalayam","ror":"https://ror.org/02zptxe07","country_code":"IN","type":"education","lineage":["https://openalex.org/I94415630"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kaveripakam Saisruthi","raw_affiliation_strings":["Division of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India","institution_ids":["https://openalex.org/I94415630"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I94415630"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"2","first_page":"74","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin-induced-nephrotoxicity","display_name":"cisplatin nephrotoxicity","score":0.921999990940094},{"id":"https://openalex.org/keywords/lentil","display_name":"lentil","score":0.9079999923706055},{"id":"https://openalex.org/keywords/fenugreek-seeds","display_name":"fenugreek seeds","score":0.7350000143051147},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.7940000295639038},{"id":"https://openalex.org/keywords/renal-oxidative-stress","display_name":"renal oxidative stress","score":0.7059999704360962},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ethnomedicinal-plants","display_name":"ethnomedicinal plants","score":0.6489999890327454},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.8990514874458313},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.7726514339447021},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6260716915130615},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6255176067352295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5633600950241089},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.555530846118927},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5347028970718384},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5223420858383179},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.47420480847358704},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.46256765723228455},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.43164360523223877},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.42313534021377563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39919281005859375},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3655792474746704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30928465723991394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1654244065284729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1623404622077942},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12292373180389404},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0780080258846283},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4103/asl.asl_173_17","doi":"https://doi.org/10.4103/asl.asl_173_17","is_oa":true,"landing_page_url":"https://doi.org/10.4103/asl.asl_173_17","pdf_url":null,"source":{"id":"https://openalex.org/S2736520405","display_name":"Ancient Science of Life","issn_l":"0257-7941","issn":["0257-7941","2249-9547"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ancient Science of Life","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:08922a4b330140a7bc145cef2578f101","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/08922a4b330140a7bc145cef2578f101","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ancient Science of Life, Vol 37, Iss 2, Pp 74-80 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/asl.asl_173_17","doi":"https://doi.org/10.4103/asl.asl_173_17","is_oa":true,"landing_page_url":"https://doi.org/10.4103/asl.asl_173_17","pdf_url":null,"source":{"id":"https://openalex.org/S2736520405","display_name":"Ancient Science of Life","issn_l":"0257-7941","issn":["0257-7941","2249-9547"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ancient Science of Life","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1939012534","https://openalex.org/W1949878994","https://openalex.org/W1965788245","https://openalex.org/W1972366609","https://openalex.org/W1973781204","https://openalex.org/W1975555032","https://openalex.org/W1983310681","https://openalex.org/W1983965827","https://openalex.org/W1987604182","https://openalex.org/W2006370393","https://openalex.org/W2018596550","https://openalex.org/W2020455907","https://openalex.org/W2023773512","https://openalex.org/W2030932310","https://openalex.org/W2059068055","https://openalex.org/W2062655222","https://openalex.org/W2083386249","https://openalex.org/W2094639894","https://openalex.org/W2121930621","https://openalex.org/W2127618819","https://openalex.org/W2144108073","https://openalex.org/W2150256712","https://openalex.org/W2159226953","https://openalex.org/W2184498869","https://openalex.org/W2278393921","https://openalex.org/W2498618429","https://openalex.org/W2521329524","https://openalex.org/W4205407119","https://openalex.org/W4229942339","https://openalex.org/W4250210754"],"related_works":["https://openalex.org/W2184461659","https://openalex.org/W2994058995","https://openalex.org/W1963929392","https://openalex.org/W4232029071","https://openalex.org/W2092316416","https://openalex.org/W4311290809","https://openalex.org/W2396373263","https://openalex.org/W2023997709","https://openalex.org/W43018332","https://openalex.org/W2013660096"],"abstract_inverted_index":{"Aim:":[0],"The":[1,47,161,200],"present":[2,204],"study":[3,205],"was":[4,41,52,71,90,108],"undertaken":[5],"to":[6,54],"evaluate":[7],"the":[8,167,173,196,203,211,223],"potential":[9,68],"role":[10],"of":[11,14,16,21,32,69,97,102,163,202,213,218,226],"ethanol":[12,39,48],"extract":[13,40,49,70,164],"seeds":[15,217,228],"Lens":[17,33,219],"culinaris":[18,34,220],"in":[19,24,79,85,121,138,149,179,185],"attenuation":[20,212],"Cisplatin-induced":[22,168,214],"nephrotoxicity":[23,169,215],"male":[25,86],"Albino":[26,87],"rats.":[27,88],"Materials":[28],"and":[29,38,58,75,82,118,147,157,175,182,191,221],"Methods:":[30],"Seeds":[31],"were":[35],"powdered,":[36],"defatted":[37],"prepared":[42,51],"by":[43,92,110,134,171,216],"hot":[44],"extraction":[45],"method.":[46],"so":[50],"subjected":[53],"preliminary":[55],"phytochemical":[56],"evaluation":[57],"fingerprint":[59],"analysis":[60],"using":[61],"high":[62],"performance":[63],"thin":[64],"layer":[65],"chromatography.":[66],"Nephroprotective":[67,106],"evaluated":[72],"at":[73,99],"200":[74],"400":[76],"mg/kg":[77,104],"b.w.":[78,105],"both":[80,180],"curative":[81,181],"prophylactic":[83,183],"regimens":[84,184],"Nephrotoxicity":[89],"induced":[91,127],"single":[93],"intra":[94],"peritoneal":[95],"injection":[96],"Cisplatin":[98,125],"a":[100,135,186],"dose":[101,187],"5":[103],"activity":[107],"assessed":[109],"determining":[111],"serum":[112,139],"markers,":[113],"urinary":[114,142,150],"parameters,":[115],"lipid":[116,145],"peroxidation":[117,146],"antioxidant":[119],"levels":[120],"renal":[122,130],"tissue.":[123],"Results:":[124],"had":[126],"marked":[128],"acute":[129],"toxicity":[131],"as":[132,229],"manifested":[133],"significant":[136],"increase":[137],"marker":[140],"levels,":[141],"total":[143],"protein,":[144],"decrease":[148],"creatinine,":[151],"catalase":[152],"(CAT),":[153],"superoxide":[154],"dismutase":[155],"(SOD),":[156],"reduced":[158],"glutathione":[159],"(GSH).":[160],"administration":[162],"significantly":[165],"attenuated":[166],"remarkably":[170],"restoring":[172],"biochemical":[174,197],"oxidative":[176],"stress":[177],"markers":[178],"dependent":[188],"manner.":[189],"Histological":[190],"immunohistochemical":[192],"studies":[193],"also":[194],"substantiated":[195],"studies.":[198],"Conclusion:":[199],"findings":[201],"provides":[206],"corroborative":[207],"scientific":[208],"evidence":[209],"for":[210],"validates":[222],"ethno-medicinal":[224],"use":[225],"this":[227],"renoprotective":[230],"agent.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-11T00:00:00"}