{"id":"https://openalex.org/W2906816588","doi":"https://doi.org/10.1002/2211-5463.12586","title":"RDM 1 promotes neuroblastoma growth through the RAS \u2013Raf\u2013 MEK \u2013 ERK pathway","display_name":"RDM 1 promotes neuroblastoma growth through the RAS \u2013Raf\u2013 MEK \u2013 ERK pathway","publication_year":2019,"publication_date":"2019-01-04","ids":{"openalex":"https://openalex.org/W2906816588","doi":"https://doi.org/10.1002/2211-5463.12586","mag":"2906816588","pmid":"https://pubmed.ncbi.nlm.nih.gov/30868057","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6396142"},"language":"en","primary_location":{"id":"doi:10.1002/2211-5463.12586","doi":"https://doi.org/10.1002/2211-5463.12586","is_oa":true,"landing_page_url":"https://doi.org/10.1002/2211-5463.12586","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12586","source":{"id":"https://openalex.org/S2898225119","display_name":"FEBS Open Bio","issn_l":"2211-5463","issn":["2211-5463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Open Bio","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12586","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058350785","display_name":"Guojin Xie","orcid":"https://orcid.org/0000-0002-6923-6703","observed_orcids":["https://orcid.org/0000-0002-6923-6703"]},"institutions":[{"id":"https://openalex.org/I4210138078","display_name":"Second Affiliated Hospital of Nanjing Medical University","ror":"https://ror.org/04pge2a40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138078"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guojin Xie","raw_affiliation_strings":["Children<sup>\u2019</sup>s Hospital of Nanjing Medical University Jiangsu China","Children\u2019s Hospital of Nanjing Medical University Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children<sup>\u2019</sup>s Hospital of Nanjing Medical University Jiangsu China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Children\u2019s Hospital of Nanjing Medical University Jiangsu China","institution_ids":["https://openalex.org/I4210138078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079046653","display_name":"Haiyan Wu","orcid":"https://orcid.org/0000-0002-4708-3697","observed_orcids":["https://orcid.org/0000-0002-4708-3697"]},"institutions":[{"id":"https://openalex.org/I4210138078","display_name":"Second Affiliated Hospital of Nanjing Medical University","ror":"https://ror.org/04pge2a40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138078"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Wu","raw_affiliation_strings":["Children<sup>\u2019</sup>s Hospital of Nanjing Medical University Jiangsu China","Children\u2019s Hospital of Nanjing Medical University Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children<sup>\u2019</sup>s Hospital of Nanjing Medical University Jiangsu China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Children\u2019s Hospital of Nanjing Medical University Jiangsu China","institution_ids":["https://openalex.org/I4210138078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082034635","display_name":"Weiluo Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiluo Cai","raw_affiliation_strings":["Department of Musculoskeletal Tumor, Shanghai Cancer Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Musculoskeletal Tumor, Shanghai Cancer Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387246","display_name":"Mo Chen","orcid":"https://orcid.org/0000-0002-1822-2731","observed_orcids":["https://orcid.org/0000-0002-1822-2731","https://orcid.org/0009-0003-9777-3439"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mo Chen","raw_affiliation_strings":["Department of Musculoskeletal Tumor, Shanghai Cancer Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Musculoskeletal Tumor, Shanghai Cancer Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112536237","display_name":"Wending Huang","orcid":"https://orcid.org/0000-0002-8473-3003","observed_orcids":["https://orcid.org/0000-0002-8473-3003"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wending Huang","raw_affiliation_strings":["Department of Musculoskeletal Tumor, Shanghai Cancer Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Musculoskeletal Tumor, Shanghai Cancer Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061531767","display_name":"Wangjun Yan","orcid":"https://orcid.org/0000-0001-9178-0687","observed_orcids":["https://orcid.org/0000-0001-9178-0687","https://orcid.org/0000-0003-1509-6546","https://orcid.org/0000-0001-5023-8146"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wangjun Yan","raw_affiliation_strings":["Department of Musculoskeletal Tumor, Shanghai Cancer Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Musculoskeletal Tumor, Shanghai Cancer Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050252155","display_name":"Yong Seok Chang","orcid":"https://orcid.org/0000-0003-4735-1302","observed_orcids":["https://orcid.org/0000-0003-4735-1302"]},"institutions":[{"id":"https://openalex.org/I4210138078","display_name":"Second Affiliated Hospital of Nanjing Medical University","ror":"https://ror.org/04pge2a40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138078"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Chang","raw_affiliation_strings":["Children<sup>\u2019</sup>s Hospital of Nanjing Medical University Jiangsu China","Children\u2019s Hospital of Nanjing Medical University Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children<sup>\u2019</sup>s Hospital of Nanjing Medical University Jiangsu China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Children\u2019s Hospital of Nanjing Medical University Jiangsu China","institution_ids":["https://openalex.org/I4210138078"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050252155","https://openalex.org/A5061531767","https://openalex.org/A5112536237"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194","https://openalex.org/I4210138078","https://openalex.org/I83519826"],"apc_list":{"value":1750,"currency":"USD","value_usd":1750},"apc_paid":{"value":1750,"currency":"USD","value_usd":1750},"fwci":1.0121,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73325408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"3","first_page":"490","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.9200000166893005},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6470000147819519},{"id":"https://openalex.org/keywords/cisplatin-sensitivity","display_name":"cisplatin sensitivity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.871999979019165},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.4880000054836273},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7532399892807007},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6139571666717529},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5472880601882935},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5434624552726746},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5323035717010498},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4461131691932678},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4202842712402344},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.40025269985198975},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3867376744747162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3764026165008545},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11757248640060425}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048490","descriptor_name":"raf Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/2211-5463.12586","doi":"https://doi.org/10.1002/2211-5463.12586","is_oa":true,"landing_page_url":"https://doi.org/10.1002/2211-5463.12586","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12586","source":{"id":"https://openalex.org/S2898225119","display_name":"FEBS Open Bio","issn_l":"2211-5463","issn":["2211-5463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Open Bio","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5398497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6396142","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6396142","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6396142","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Open Bio","raw_type":"Text"},{"id":"pmid:30868057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30868057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS open bio","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/2211-5463.12586","doi":"https://doi.org/10.1002/2211-5463.12586","is_oa":true,"landing_page_url":"https://doi.org/10.1002/2211-5463.12586","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12586","source":{"id":"https://openalex.org/S2898225119","display_name":"FEBS Open Bio","issn_l":"2211-5463","issn":["2211-5463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Open Bio","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G97035185","display_name":null,"funder_award_id":"81261120555","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906816588.pdf","grobid_xml":"https://content.openalex.org/works/W2906816588.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1865110278","https://openalex.org/W1968069886","https://openalex.org/W1971050469","https://openalex.org/W1971496531","https://openalex.org/W2006268714","https://openalex.org/W2010978319","https://openalex.org/W2011795445","https://openalex.org/W2043600941","https://openalex.org/W2052909547","https://openalex.org/W2065504949","https://openalex.org/W2067606868","https://openalex.org/W2086153601","https://openalex.org/W2106985615","https://openalex.org/W2110024172","https://openalex.org/W2119151801","https://openalex.org/W2136597072","https://openalex.org/W2140428506","https://openalex.org/W2144999788","https://openalex.org/W2145200068","https://openalex.org/W2169911836","https://openalex.org/W2278267409","https://openalex.org/W2513279524","https://openalex.org/W2760283254","https://openalex.org/W2793089631","https://openalex.org/W2794520602","https://openalex.org/W2804537883"],"related_works":["https://openalex.org/W4295592345","https://openalex.org/W7130704270","https://openalex.org/W7171871911","https://openalex.org/W1977665202","https://openalex.org/W2896276029","https://openalex.org/W7100861595","https://openalex.org/W2907468897","https://openalex.org/W2521007856","https://openalex.org/W3180019872","https://openalex.org/W2011432874"],"abstract_inverted_index":{"Neuroblastoma":[0],"(NB)":[1],"is":[2,36],"an":[3],"aggressive":[4],"cancer":[5],"that":[6,20,74,87,105],"originates":[7],"in":[8,97,140],"the":[9,111,124,136],"sympathetic":[10],"nervous":[11],"system":[12],"and":[13,63,81,86,135],"primarily":[14],"affects":[15],"children.":[16],"Here,":[17],"we":[18,103],"show":[19],"high":[21],"levels":[22],"of":[23,65,76,90],"RAD52":[24],"motif":[25],"containing":[26],"1":[27],"(RDM1;":[28],"a":[29,59,98,128],"protein":[30,113],"with":[31,44],"similarities":[32],"to":[33,57],"RAD52,":[34],"which":[35],"important":[37],"for":[38,48],"double\u2010strand":[39],"DNA":[40,131],"repair)":[41],"are":[42],"associated":[43],"poor":[45],"clinical":[46],"outcomes":[47],"NB.":[49,141],"In":[50,122],"addition,":[51],"RDM1\u2212/\u2212":[52],"cells":[53],"exhibited":[54],"increased":[55],"sensitivity":[56],"cisplatin,":[58],"common":[60],"chemotherapy":[61],"drug,":[62],"disruption":[64],"RDM1":[66,77,91,106,134],"suppressed":[67],"NB":[68,94],"cell":[69,79,83,108],"proliferation.":[70],"We":[71],"also":[72],"report":[73],"loss":[75],"augmented":[78],"apoptosis":[80],"induced":[82],"cycle":[84],"arrest,":[85],"stable":[88],"knockdown":[89],"significantly":[92],"inhibited":[93],"tumor":[95],"growth":[96],"xenograft":[99],"mouse":[100],"model.":[101],"Importantly,":[102],"identified":[104],"promoted":[107],"proliferation":[109],"via":[110],"RAS\u2013Raf\u2013mitogen\u2010activated":[112],"kinase":[114,115,118],"(MEK)\u2013extracellular":[116],"signal\u2010regulated":[117],"(ERK)":[119],"signaling":[120],"pathway.":[121],"conclusion,":[123],"current":[125],"study":[126],"demonstrates":[127],"correlation":[129],"between":[130],"damage":[132],"regulator":[133],"oncogenic":[137],"RAS\u2013Raf\u2013MEK\u2013ERK":[138],"pathway":[139]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-01-11T00:00:00"}