{"id":"https://openalex.org/W2906716059","doi":null,"title":"MicroRNAs in T cell acute lymphoblastic leukemia","display_name":"MicroRNAs in T cell acute lymphoblastic leukemia","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2906716059","mag":"2906716059"},"language":"en","primary_location":{"id":"mag:2906716059","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/67/9_Supplement/4519","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069730927","display_name":"Elizabeth Nakae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Nakae","raw_affiliation_strings":["UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024810268","display_name":"John E. Cornell","orcid":"https://orcid.org/0000-0003-1648-7549","observed_orcids":["https://orcid.org/0000-0003-1648-7549"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Cornell","raw_affiliation_strings":["UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH"],"raw_orcid":"https://orcid.org/0000-0003-1648-7549","affiliations":[{"raw_affiliation_string":"UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105873618","display_name":"George Adrian Calin","orcid":"https://orcid.org/0000-0002-7427-0578","observed_orcids":["https://orcid.org/0000-0002-7427-0578"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George A. Calin","raw_affiliation_strings":["UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH"],"raw_orcid":"https://orcid.org/0000-0001-6704-5615","affiliations":[{"raw_affiliation_string":"UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091880488","display_name":"Brad H. Pollock","orcid":"https://orcid.org/0000-0003-4415-8638","observed_orcids":["https://orcid.org/0000-0003-4415-8638","https://orcid.org/0000-0003-4534-0941"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad H. Pollock","raw_affiliation_strings":["UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH"],"raw_orcid":"https://orcid.org/0000-0003-4415-8638","affiliations":[{"raw_affiliation_string":"UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079700663","display_name":"Carlo Maria Croce","orcid":"https://orcid.org/0000-0003-3788-1457","observed_orcids":["https://orcid.org/0000-0003-3788-1457"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo M. Croce","raw_affiliation_strings":["UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH"],"raw_orcid":"https://orcid.org/0000-0003-3788-1457","affiliations":[{"raw_affiliation_string":"UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055148154","display_name":"Alice Lin-Tsing Yu","orcid":"https://orcid.org/0000-0003-2444-0505","observed_orcids":["https://orcid.org/0000-0003-2444-0505"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice L. Yu","raw_affiliation_strings":["UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH"],"raw_orcid":"https://orcid.org/0000-0003-2444-0505","affiliations":[{"raw_affiliation_string":"UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079060579","display_name":"Mitchell B. Diccianni","orcid":"https://orcid.org/0000-0002-5017-9585","observed_orcids":["https://orcid.org/0000-0002-5017-9585"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell B. Diccianni","raw_affiliation_strings":["UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH"],"raw_orcid":"https://orcid.org/0000-0002-5017-9585","affiliations":[{"raw_affiliation_string":"UCSD Medical Center, San Diego, CA, Unversity of Texas Health Science Center, San Antonio, TX, Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3223,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70994355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":null,"first_page":"4519","last_page":"4519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.2117999941110611,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8769999742507935},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.949999988079071},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6909999847412109},{"id":"https://openalex.org/keywords/19p13","display_name":"19p13","score":0.996999979019165},{"id":"https://openalex.org/keywords/microrna-downregulation","display_name":"microRNA downregulation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/leukemia-cell-lines","display_name":"leukemia cell lines","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8253037929534912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6796383857727051},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6469576358795166},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5745824575424194},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5561738014221191},{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.5347937941551208},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5299863815307617},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5281025171279907},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4247533082962036},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41612130403518677},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3600204586982727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35558605194091797},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0745212733745575}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2906716059","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/67/9_Supplement/4519","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3044776284","https://openalex.org/W2979901518","https://openalex.org/W2219607431","https://openalex.org/W2308641807","https://openalex.org/W2598712600","https://openalex.org/W2779191023","https://openalex.org/W2566047879","https://openalex.org/W3161805843","https://openalex.org/W2150350697","https://openalex.org/W2918788283"],"abstract_inverted_index":{"4519":[0],"Treatment":[2],"success":[3],"for":[4,29,35,137,160],"Acute":[5],"Lymphoblastic":[6],"Leukemia":[7],"(ALL),":[8],"both":[9],"B-":[10],"and":[11,57,96,169,201],"T-cell,":[12],"is":[13,232],"one":[14,259],"of":[15,24,75,153,199,219,227,263],"cancer":[16],"research\u2019s":[17],"greatest":[18],"achievements.":[19],"However,":[20,236],"while":[21],"molecular":[22],"determinants":[23],"outcome":[25],"have":[26,37,58,63,193,202],"been":[27,38,60],"identified":[28,172,203],"B-ALL,":[30],"no":[31],"useful":[32],"prognostic":[33,64],"factors":[34],"T-ALL":[36,89,123,142,168,200,254,271],"identified.":[39],"MicroRNAs":[40],"(miRNAs)":[41],"are":[42,210,244],"small":[43],"21-23":[44],"nucleotide":[45],"non-coding":[46],"RNA":[47,85],"molecules":[48],"that":[49,148,152,175,209,239,258],"can":[50],"positively":[51],"or":[52,111,155,206,260],"negatively":[53],"regulate":[54],"gene":[55,69],"expression":[56,83,135,166,181,197],"recently":[59],"shown":[61],"to":[62,71,163],"potential.":[65],"Using":[66,157],"a":[67,146,204,268],"miRNA":[68,76,82,115,196],"chip":[70],"investigate":[72],"the":[73,81,125,184,195,228,237,247,256],"involvement":[74],"in":[77,84,122,180,234,253,270],"T-ALL,":[78],"we":[79,171,192],"analyzed":[80],"from":[86,151],"41":[87],"individual":[88],"cell":[90,101],"samples,":[91],"4":[92],"normal":[93,98,126,214],"thymocyte":[94],"samples":[95,103,143],"9":[97],"blood":[99],"mono-nuclear":[100],"(MNC)":[102],"hybridized":[104],"against":[105],"arrays":[106],"containing":[107],"368":[108],"(161":[109],"human":[110],"460":[112],"(235":[113],"human)":[114],"genes.":[116],"Differentially":[117],"expressed":[118],"miRNAs":[119],"were":[120],"observed":[121],"vs.":[124,213],"samples.":[127],"Unsupervised":[128],"hierarchical":[129],"clustering":[130],"revealed":[131],"homogenous":[132],"but":[133],"distinctive":[134],"profiles":[136],"each":[138],"sample":[139],"type,":[140],"with":[141],"falling":[144],"into":[145],"cluster":[147,265],"was":[149],"distinct":[150],"MNCs":[154],"thymocytes.":[156,215],"LInear":[158],"Models":[159],"MicroArrays":[161],"(LIMMA)":[162],"evaluate":[164],"differential":[165],"between":[167,183],"thymocytes,":[170],"43":[173],"genes":[174,208,222,241,252,262],"had":[176],"statistically":[177],"significant":[178],"differences":[179],"levels":[182],"two":[185],"groups":[186],"(P":[187],"In":[190],"conclusion,":[191],"characterized":[194],"profile":[198],"number":[205],"miR":[207,221,251],"highly":[211],"downregulated":[212],"The":[216],"combined":[217],"downregulation":[218,226],"related":[220,240],"on":[223,242],"9q22":[224],"suggests":[225],"entire":[229],"primary":[230],"transcript":[231],"occurring":[233],"T-ALL.":[235],"observation":[238],"19p13":[243],"also":[245],"among":[246],"most":[248],"significantly":[249],"down-regulated":[250],"increases":[255],"likelihood":[257],"more":[261],"this":[264],"may":[266],"play":[267],"role":[269],"biology.":[272]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-01-11T00:00:00"}
