{"id":"https://openalex.org/W2906649237","doi":"https://doi.org/10.1021/jacs.8b13354","title":"Navigating the Structural Landscape of De Novo \u03b1-Helical Bundles","display_name":"Navigating the Structural Landscape of De Novo \u03b1-Helical Bundles","publication_year":2019,"publication_date":"2019-05-08","ids":{"openalex":"https://openalex.org/W2906649237","doi":"https://doi.org/10.1021/jacs.8b13354","mag":"2906649237","pmid":"https://pubmed.ncbi.nlm.nih.gov/31066556"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.8b13354","doi":"https://doi.org/10.1021/jacs.8b13354","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.8b13354","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2018/12/21/503698.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025593092","display_name":"Guto G. Rhys","orcid":"https://orcid.org/0000-0002-0247-9495","observed_orcids":["https://orcid.org/0000-0002-0247-9495"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guto G. Rhys","raw_affiliation_strings":["School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0247-9495","affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085979292","display_name":"Christopher W. Wood","orcid":"https://orcid.org/0000-0003-1243-3105","observed_orcids":["https://orcid.org/0000-0003-1243-3105"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher W. Wood","raw_affiliation_strings":["School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-1243-3105","affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007700556","display_name":"Joseph L. Beesley","orcid":"https://orcid.org/0000-0003-2203-0027","observed_orcids":["https://orcid.org/0000-0003-2203-0027"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph L. Beesley","raw_affiliation_strings":["School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-2203-0027","affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062266782","display_name":"Nathan R. Zaccai","orcid":"https://orcid.org/0000-0002-1476-2044","observed_orcids":["https://orcid.org/0000-0002-1476-2044"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nathan R. Zaccai","raw_affiliation_strings":["School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-1476-2044","affiliations":[{"raw_affiliation_string":"School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076968101","display_name":"Antony J. Burton","orcid":"https://orcid.org/0000-0002-2340-3262","observed_orcids":["https://orcid.org/0000-0002-2340-3262"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Antony J. Burton","raw_affiliation_strings":["Frick Chemistry Laboratory, Princeton University, Princeton, New Jersey 08544, United States","School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frick Chemistry Laboratory, Princeton University, Princeton, New Jersey 08544, United States","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019465087","display_name":"R.L. Brady","orcid":"https://orcid.org/0000-0002-3575-5513","observed_orcids":["https://orcid.org/0000-0002-3575-5513"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Leo Brady","raw_affiliation_strings":["School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081992710","display_name":"Andrew R. Thomson","orcid":"https://orcid.org/0000-0002-1066-1369","observed_orcids":["https://orcid.org/0000-0002-1066-1369"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew R. Thomson","raw_affiliation_strings":["School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom","School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-1066-1369","affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023900250","display_name":"Derek N. Woolfson","orcid":"https://orcid.org/0000-0002-0394-3202","observed_orcids":["https://orcid.org/0000-0002-0394-3202"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4405271600","display_name":"BrisSynBio","ror":"https://ror.org/02q281255","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4405271600"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Derek N. Woolfson","raw_affiliation_strings":["BrisSynBio, University of Bristol, Life Sciences Building, Tyndall Avenue, Bristol BS8 1TQ, United Kingdom","School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom","School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0394-3202","affiliations":[{"raw_affiliation_string":"BrisSynBio, University of Bristol, Life Sciences Building, Tyndall Avenue, Bristol BS8 1TQ, United Kingdom","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4405271600"]},{"raw_affiliation_string":"School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"School of Chemistry, University of Bristol, Cantock\u2019s Close, Bristol BS8 1TS, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023900250"],"corresponding_institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4405271600"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.9045,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.86313739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"141","issue":"22","first_page":"8787","last_page":"8797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-helical-coiled-coil","display_name":"alpha-helical coiled coil","score":0.8849999904632568},{"id":"https://openalex.org/keywords/de-novo-protein-design","display_name":"de novo protein design","score":0.8709999918937683},{"id":"https://openalex.org/keywords/amphipathic-helix","display_name":"amphipathic helix","score":0.7599999904632568},{"id":"https://openalex.org/keywords/hydrophobic-effect","display_name":"hydrophobic effect","score":0.9350000023841858},{"id":"https://openalex.org/keywords/synthetic-peptides","display_name":"synthetic peptides","score":0.6690000295639038},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.4560000002384186},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.3109999895095825},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.9347589015960693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7723023295402527},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.7385244965553284},{"id":"https://openalex.org/C55988834","wikidata":"https://www.wikidata.org/wiki/Q903650","display_name":"Coiled coil","level":2,"score":0.7273591756820679},{"id":"https://openalex.org/C203087120","wikidata":"https://www.wikidata.org/wiki/Q372229","display_name":"Helix bundle","level":3,"score":0.5925356149673462},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.558795154094696},{"id":"https://openalex.org/C2778134712","wikidata":"https://www.wikidata.org/wiki/Q1047307","display_name":"Bundle","level":2,"score":0.5545795559883118},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4982438087463379},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.49216383695602417},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.48704054951667786},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.48502224683761597},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.46997612714767456},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.45309972763061523},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.4443008005619049},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3387065529823303},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17622381448745728},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11337032914161682},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1021/jacs.8b13354","doi":"https://doi.org/10.1021/jacs.8b13354","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.8b13354","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"doi:10.1101/503698","doi":"https://doi.org/10.1101/503698","is_oa":true,"landing_page_url":"https://doi.org/10.1101/503698","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/12/21/503698.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:31066556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31066556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/11ef0084-c524-4d83-8525-164f0fe7bbfd","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/11ef0084-c524-4d83-8525-164f0fe7bbfd","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhys, G G, Wood, C W, Beesley, J L, Zaccai, N R, Burton, A J, Brady, R L, Thomson, A R & Woolfson, D N 2019, 'Navigating the Structural Landscape of De Novo \u03b1-Helical Bundles', Journal of the American Chemical Society, vol. 141, no. 22, pp. 8787-8797. https://doi.org/10.1021/jacs.8b13354","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.gla.ac.uk:200899","doi":null,"is_oa":true,"landing_page_url":"http://eprints.gla.ac.uk/200899/1/200899.pdf","pdf_url":"http://eprints.gla.ac.uk/200899/1/200899.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:153748","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/153748/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/b6a2450e-a08b-46b6-b0b4-afc85ac1107a","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11820/b6a2450e-a08b-46b6-b0b4-afc85ac1107a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rhys, G G, Wood, C W, Beesley, J L, Zaccai, N R, Burton, A J, Brady, R L, Thomson, A R & Woolfson, D N 2019, 'Navigating the structural landscape of de Novo \u03b1-helical bundles', Journal of the American Chemical Society, vol. 141, no. 22, pp. 8787-8797. https://doi.org/10.1021/jacs.8b13354","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1101/503698","doi":"https://doi.org/10.1101/503698","is_oa":true,"landing_page_url":"https://doi.org/10.1101/503698","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/12/21/503698.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1954672288","display_name":"BrisSynBio: Bristol Centre for Synthetic Biology","funder_award_id":"BB/L01386X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2222137848","display_name":"Rational computational protein design in ISAMBARD: new approaches, folds and functions","funder_award_id":"BB/R00661X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3855338415","display_name":"A Holistic Doctoral Training Centre for Chemical Synthesis","funder_award_id":"EP/G036764/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4015668119","display_name":null,"funder_award_id":"WM140008","funder_id":"https://openalex.org/F4320320670","funder_display_name":"Wolfson Foundation"},{"id":"https://openalex.org/G4274015539","display_name":null,"funder_award_id":"EP/G036764","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5071732228","display_name":null,"funder_award_id":"BB/J014400/1","funder_id":"https://openalex.org/F4320320240","funder_display_name":"Research Councils UK"},{"id":"https://openalex.org/G5421220093","display_name":null,"funder_award_id":"1364038","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7017159301","display_name":null,"funder_award_id":"1115150","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7154832502","display_name":null,"funder_award_id":"1501425","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7446500017","display_name":null,"funder_award_id":"EP/G036764/1","funder_id":"https://openalex.org/F4320320240","funder_display_name":"Research Councils UK"},{"id":"https://openalex.org/G7450767908","display_name":null,"funder_award_id":"340764","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7479446710","display_name":"BB/J014400/1","funder_award_id":"BB/J014400/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G751335451","display_name":null,"funder_award_id":"WM140008","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G7577612469","display_name":null,"funder_award_id":"BB/R00661X/1","funder_id":"https://openalex.org/F4320320240","funder_display_name":"Research Councils UK"},{"id":"https://openalex.org/G7930062281","display_name":"Core Capability for Chemistry Research - Strategic Investment in Mass Spectrometry","funder_award_id":"EP/K03927X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8166486876","display_name":null,"funder_award_id":"BB/J014400/1","funder_id":"https://openalex.org/F4320320360","funder_display_name":"University of Bristol"},{"id":"https://openalex.org/G8608418393","display_name":null,"funder_award_id":"340764","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"}],"funders":[{"id":"https://openalex.org/F4320313096","display_name":"Diamond Light Source","ror":"https://ror.org/05etxs293"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320360","display_name":"University of Bristol","ror":"https://ror.org/0524sp257"},{"id":"https://openalex.org/F4320320670","display_name":"Wolfson Foundation","ror":"https://ror.org/0333xzh65"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906649237.pdf","grobid_xml":"https://content.openalex.org/works/W2906649237.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W160836250","https://openalex.org/W834977926","https://openalex.org/W1560197628","https://openalex.org/W1791073674","https://openalex.org/W1822252127","https://openalex.org/W1834588461","https://openalex.org/W1916034164","https://openalex.org/W1969660397","https://openalex.org/W1973228350","https://openalex.org/W1973751911","https://openalex.org/W1974312616","https://openalex.org/W1974521227","https://openalex.org/W1976603396","https://openalex.org/W1978959984","https://openalex.org/W1980254610","https://openalex.org/W1980581336","https://openalex.org/W1987063642","https://openalex.org/W1987630197","https://openalex.org/W1995487009","https://openalex.org/W1997484779","https://openalex.org/W1998377570","https://openalex.org/W2001856516","https://openalex.org/W2005763580","https://openalex.org/W2008866677","https://openalex.org/W2009365528","https://openalex.org/W2009528324","https://openalex.org/W2013041880","https://openalex.org/W2014059004","https://openalex.org/W2017774235","https://openalex.org/W2020610175","https://openalex.org/W2020751169","https://openalex.org/W2023671553","https://openalex.org/W2024562806","https://openalex.org/W2025864476","https://openalex.org/W2026506773","https://openalex.org/W2026863841","https://openalex.org/W2032155561","https://openalex.org/W2033993127","https://openalex.org/W2034947598","https://openalex.org/W2038573488","https://openalex.org/W2040720845","https://openalex.org/W2043829693","https://openalex.org/W2046994420","https://openalex.org/W2060547523","https://openalex.org/W2060967383","https://openalex.org/W2064233574","https://openalex.org/W2067598960","https://openalex.org/W2068254342","https://openalex.org/W2073184464","https://openalex.org/W2074362388","https://openalex.org/W2075919550","https://openalex.org/W2077934271","https://openalex.org/W2080195992","https://openalex.org/W2080757193","https://openalex.org/W2082625715","https://openalex.org/W2083645532","https://openalex.org/W2086856168","https://openalex.org/W2088409695","https://openalex.org/W2088616323","https://openalex.org/W2089958448","https://openalex.org/W2090265120","https://openalex.org/W2092139560","https://openalex.org/W2102028493","https://openalex.org/W2102455520","https://openalex.org/W2108816504","https://openalex.org/W2112157595","https://openalex.org/W2113127595","https://openalex.org/W2113912523","https://openalex.org/W2114598719","https://openalex.org/W2116441099","https://openalex.org/W2134900594","https://openalex.org/W2138323709","https://openalex.org/W2146886181","https://openalex.org/W2148306017","https://openalex.org/W2149707830","https://openalex.org/W2152986015","https://openalex.org/W2155912203","https://openalex.org/W2156697496","https://openalex.org/W2157455847","https://openalex.org/W2165499430","https://openalex.org/W2171379989","https://openalex.org/W2197964340","https://openalex.org/W2218549401","https://openalex.org/W2219910005","https://openalex.org/W2232609933","https://openalex.org/W2312425924","https://openalex.org/W2345914382","https://openalex.org/W2347038344","https://openalex.org/W2404789208","https://openalex.org/W2465773022","https://openalex.org/W2483319449","https://openalex.org/W2510208169","https://openalex.org/W2518493009","https://openalex.org/W2553669656","https://openalex.org/W2562450246","https://openalex.org/W2564205565","https://openalex.org/W2575569425","https://openalex.org/W2579233876","https://openalex.org/W2603653075","https://openalex.org/W2747118545","https://openalex.org/W2747381152","https://openalex.org/W2748293325","https://openalex.org/W2751085720","https://openalex.org/W2765373652","https://openalex.org/W2783249537","https://openalex.org/W2810304717","https://openalex.org/W2889086095","https://openalex.org/W2892868407","https://openalex.org/W2895171702","https://openalex.org/W4233851223","https://openalex.org/W4247233735"],"related_works":["https://openalex.org/W1980581336","https://openalex.org/W2806959317","https://openalex.org/W4323276421","https://openalex.org/W2050888116","https://openalex.org/W1983869242","https://openalex.org/W4296502374","https://openalex.org/W1983955924","https://openalex.org/W3132071138","https://openalex.org/W2020387506","https://openalex.org/W2073184464"],"abstract_inverted_index":{"The":[0,123],"association":[1],"of":[2,32,61,89,127,150,161,165],"amphipathic":[3],"\u03b1":[4],"helices":[5,33],"in":[6,34,115,134,137,176,206],"water":[7],"leads":[8],"to":[9,117,140,181],"\u03b1-helical-bundle":[10],"protein":[11,196,207],"structures.":[12,146],"However,":[13,92],"the":[14,27,30,35,90,155,162,170],"driving":[15],"force":[16],"for":[17,53,200],"this-the":[18],"hydrophobic":[19],"effect-is":[20],"not":[21,25],"specific":[22],"and":[23,75,86,111,120,148,172,186,203,209],"does":[24],"define":[26],"number":[28],"or":[29],"orientation":[31],"associated":[36],"state.":[37],"Rather,":[38],"this":[39,80],"is":[40],"achieved":[41],"through":[42],"deeper":[43],"sequence-to-structure":[44],"relationships,":[45],"which":[46],"are":[47,81,84,96,131],"increasingly":[48],"being":[49],"discerned.":[50],"For":[51],"example,":[52],"one":[54],"structurally":[55],"extreme":[56],"but":[57],"nevertheless":[58],"ubiquitous":[59],"class":[60],"bundle-the":[62],"\u03b1-helical":[63,166],"coiled":[64,167],"coils-relationships":[65],"have":[66],"been":[67],"established":[68],"that":[69,106,174],"discriminate":[70],"between":[71,108],"all-parallel":[72],"dimers,":[73],"trimers,":[74],"tetramers.":[76],"Association":[77],"states":[78,95,126,157],"above":[79,169],"known,":[82],"as":[83],"antiparallel":[85,188],"mixed":[87],"arrangements":[88],"helices.":[91],"these":[93,151],"alternative":[94],"less":[97],"well":[98],"understood.":[99],"Here,":[100],"we":[101],"describe":[102],"a":[103,184],"synthetic-peptide":[104],"system":[105],"switches":[107],"parallel":[109],"hexamers":[110],"various":[112],"up-down-up-down":[113],"tetramers":[114],"response":[116],"single-amino-acid":[118],"changes":[119],"solution":[121,135],"conditions.":[122],"main":[124],"accessible":[125],"each":[128],"peptide":[129],"variant":[130],"characterized":[132],"fully":[133],"and,":[136],"most":[138],"cases,":[139],"high":[141],"resolution":[142],"with":[143],"X-ray":[144],"crystal":[145],"Analysis":[147],"inspection":[149],"structures":[152],"helps":[153],"rationalize":[154],"different":[156],"formed.":[158],"This":[159,192],"navigation":[160],"structural":[163,202],"landscape":[164],"coils":[168],"dimers":[171],"trimers":[173],"dominate":[175],"nature":[177],"has":[178],"allowed":[179],"us":[180],"design":[182],"rationally":[183],"well-defined":[185],"hyperstable":[187],"coiled-coil":[189],"tetramer":[190],"(apCC-Tet).":[191],"robust":[193],"de":[194],"novo":[195],"provides":[197],"another":[198],"scaffold":[199],"further":[201],"functional":[204],"designs":[205],"engineering":[208],"synthetic":[210],"biology.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-01-01T00:00:00"}