{"id":"https://openalex.org/W2906561470","doi":"https://doi.org/10.1080/02652048.2018.1559247","title":"Two-level delivery systems based on CaCO3cores for oral administration of therapeutic peptides","display_name":"Two-level delivery systems based on CaCO3cores for oral administration of therapeutic peptides","publication_year":2018,"publication_date":"2018-11-17","ids":{"openalex":"https://openalex.org/W2906561470","doi":"https://doi.org/10.1080/02652048.2018.1559247","mag":"2906561470","pmid":"https://pubmed.ncbi.nlm.nih.gov/30582428"},"language":"en","primary_location":{"id":"doi:10.1080/02652048.2018.1559247","doi":"https://doi.org/10.1080/02652048.2018.1559247","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02652048.2018.1559247","pdf_url":null,"source":{"id":"https://openalex.org/S160681128","display_name":"Journal of Microencapsulation","issn_l":"0265-2048","issn":["0265-2048","1464-5246"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microencapsulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088961114","display_name":"Natalia Sudareva","orcid":"https://orcid.org/0000-0002-2122-4498","observed_orcids":["https://orcid.org/0000-0002-2122-4498"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210091702","display_name":"Institute of Macromolecular Compounds","ror":"https://ror.org/00hgmwb30","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091702","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Natalia Sudareva","raw_affiliation_strings":["Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063636515","display_name":"Olga M. Suvorova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210091702","display_name":"Institute of Macromolecular Compounds","ror":"https://ror.org/00hgmwb30","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091702","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga Suvorova","raw_affiliation_strings":["Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063085180","display_name":"Natalia Saprykina","orcid":"https://orcid.org/0000-0002-9240-1690","observed_orcids":["https://orcid.org/0000-0002-9240-1690"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210091702","display_name":"Institute of Macromolecular Compounds","ror":"https://ror.org/00hgmwb30","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091702","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia Saprykina","raw_affiliation_strings":["Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011854616","display_name":"Natalia V. Smirnova","orcid":"https://orcid.org/0000-0001-5524-2785","observed_orcids":["https://orcid.org/0000-0001-5524-2785"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210091702","display_name":"Institute of Macromolecular Compounds","ror":"https://ror.org/00hgmwb30","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091702","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia Smirnova","raw_affiliation_strings":["Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055886146","display_name":"Petr P. Beltyukov","orcid":"https://orcid.org/0000-0003-4050-6172","observed_orcids":["https://orcid.org/0000-0003-4050-6172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petr Bel'tyukov","raw_affiliation_strings":["Occupational Pathology and Human Ecology, Research Institute of Hygiene, Kuzmolovsky, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Occupational Pathology and Human Ecology, Research Institute of Hygiene, Kuzmolovsky, Russian Federation;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083649737","display_name":"Sergey Gervasievich Petunov","orcid":"https://orcid.org/0000-0001-6781-8315","observed_orcids":["https://orcid.org/0000-0001-6781-8315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergey Petunov","raw_affiliation_strings":["Occupational Pathology and Human Ecology, Research Institute of Hygiene, Kuzmolovsky, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Occupational Pathology and Human Ecology, Research Institute of Hygiene, Kuzmolovsky, Russian Federation;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085155621","display_name":"Andrey S. Radilov","orcid":"https://orcid.org/0000-0003-0776-7434","observed_orcids":["https://orcid.org/0000-0003-0776-7434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrey Radilov","raw_affiliation_strings":["Occupational Pathology and Human Ecology, Research Institute of Hygiene, Kuzmolovsky, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Occupational Pathology and Human Ecology, Research Institute of Hygiene, Kuzmolovsky, Russian Federation;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039165206","display_name":"Alexander D. Vilesov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I2799540354","display_name":"First Pavlov State Medical University of St. Petersburg","ror":"https://ror.org/04g525b43","country_code":"RU","type":"education","lineage":["https://openalex.org/I2799540354"]},{"id":"https://openalex.org/I4210091702","display_name":"Institute of Macromolecular Compounds","ror":"https://ror.org/00hgmwb30","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091702","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Vilesov","raw_affiliation_strings":["I.P.Pavlov St. Petersburg Medical University, Saint Petersburg, Russian Federation","Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.P.Pavlov St. Petersburg Medical University, Saint Petersburg, Russian Federation","institution_ids":["https://openalex.org/I2799540354"]},{"raw_affiliation_string":"Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russian Federation;","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088961114"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"],"apc_list":null,"apc_paid":null,"fwci":1.1138,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.68567455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"7-8","first_page":"619","last_page":"634"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.10130000114440918,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-peptide-delivery","display_name":"oral peptide delivery","score":0.796999990940094},{"id":"https://openalex.org/keywords/peptide-encapsulation","display_name":"peptide encapsulation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/peptide-hydrophobicity","display_name":"peptide hydrophobicity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/intragastric-administration","display_name":"intragastric administration","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.6593722105026245},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.6199439167976379},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6058302521705627},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5769309997558594},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5293115973472595},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.522828221321106},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.5211453437805176},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.4390026926994324},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.42603611946105957},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35909610986709595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30568966269493103},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.30025845766067505},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29802870750427246},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.1963786780834198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15639621019363403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1316693127155304},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002119","descriptor_name":"Calcium Carbonate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/02652048.2018.1559247","doi":"https://doi.org/10.1080/02652048.2018.1559247","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02652048.2018.1559247","pdf_url":null,"source":{"id":"https://openalex.org/S160681128","display_name":"Journal of Microencapsulation","issn_l":"0265-2048","issn":["0265-2048","1464-5246"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microencapsulation","raw_type":"journal-article"},{"id":"pmid:30582428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30582428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microencapsulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W824904887","https://openalex.org/W1481172200","https://openalex.org/W1538433979","https://openalex.org/W1775749144","https://openalex.org/W1873584307","https://openalex.org/W1940083644","https://openalex.org/W1949428744","https://openalex.org/W1989001741","https://openalex.org/W1989952061","https://openalex.org/W1991410755","https://openalex.org/W1992279584","https://openalex.org/W1992450378","https://openalex.org/W1997154876","https://openalex.org/W2003859016","https://openalex.org/W2009473148","https://openalex.org/W2012310790","https://openalex.org/W2016205135","https://openalex.org/W2019853549","https://openalex.org/W2023585844","https://openalex.org/W2032541154","https://openalex.org/W2040243871","https://openalex.org/W2044868813","https://openalex.org/W2046518118","https://openalex.org/W2048736491","https://openalex.org/W2064718053","https://openalex.org/W2067178597","https://openalex.org/W2067306688","https://openalex.org/W2069726267","https://openalex.org/W2077118209","https://openalex.org/W2079898284","https://openalex.org/W2081704662","https://openalex.org/W2092791248","https://openalex.org/W2093138186","https://openalex.org/W2098097053","https://openalex.org/W2100605840","https://openalex.org/W2103161580","https://openalex.org/W2105804200","https://openalex.org/W2110739884","https://openalex.org/W2111483372","https://openalex.org/W2115885357","https://openalex.org/W2124158735","https://openalex.org/W2135404867","https://openalex.org/W2160350335","https://openalex.org/W2170369551","https://openalex.org/W2227758419","https://openalex.org/W2256400420","https://openalex.org/W2294095488","https://openalex.org/W2315844657","https://openalex.org/W2337891976","https://openalex.org/W2395200752","https://openalex.org/W2462738901","https://openalex.org/W2483996247","https://openalex.org/W2546734776","https://openalex.org/W2593566190","https://openalex.org/W2701122073","https://openalex.org/W2746297535","https://openalex.org/W2748255792","https://openalex.org/W2795432914","https://openalex.org/W2800877622","https://openalex.org/W4211124701","https://openalex.org/W4255399671"],"related_works":["https://openalex.org/W3006688353","https://openalex.org/W2746297535","https://openalex.org/W1994265790","https://openalex.org/W4311763535","https://openalex.org/W7223646014","https://openalex.org/W7100665571","https://openalex.org/W1982724093","https://openalex.org/W2495038758","https://openalex.org/W2002187709","https://openalex.org/W7092204785"],"abstract_inverted_index":{"Two-level":[0],"systems":[1,21],"for":[2,25,53,64],"oral":[3],"delivery":[4,27,88,101,126],"of":[5,13,28,38,40,49,89,93,100,106,115,123,138,140,148],"therapeutic":[6],"peptides":[7,41,66],"were":[8,22],"developed;":[9],"the":[10,26,50,61,68,82,90,104,113,124,136],"carriers":[11,143],"consist":[12],"CaCO3":[14,55,72,84],"cores":[15,73],"included":[16],"into":[17,67],"alginate":[18],"granules.":[19],"Such":[20],"first":[23],"used":[24,52],"low":[29],"molecular":[30],"weight":[31],"drugs.":[32],"It":[33],"was":[34],"shown":[35],"that":[36],"efficiency":[37],"encapsulation":[39],"depends":[42],"on":[43],"their":[44,57,78],"pI":[45],"value,":[46],"hydrophobicity,":[47],"characteristics":[48],"compounds":[51],"doping":[54],"cores,":[56,85],"surface":[58],"potential":[59],"and":[60,131,146],"techniques":[62],"employed":[63],"loading":[65],"first-level":[69,142],"carriers.":[70],"Doping":[71],"with":[74],"dextran":[75],"sulphate":[76],"save":[77],"viability":[79],"compared":[80],"to":[81,109],"pristine":[83],"but":[86],"ensures":[87],"desired":[91],"quantity":[92],"peptide":[94,116],"when":[95],"using":[96],"a":[97],"smaller":[98],"amount":[99],"systems.":[102,127],"Introducing":[103],"inhibitor":[105],"peptidases":[107],"leads":[108],"an":[110],"increase":[111],"in":[112,117,144],"concentration":[114],"rat":[118],"blood":[119,145],"after":[120],"intragastric":[121],"administration":[122],"developed":[125],"Scanning":[128],"electron":[129],"microscopy":[130],"energy-dispersive":[132],"X-ray":[133],"spectroscopy":[134],"demonstrated":[135],"presence":[137],"fragments":[139],"destructed":[141],"plasma":[147],"experimental":[149],"animals.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-01-01T00:00:00"}