{"id":"https://openalex.org/W2906520338","doi":"https://doi.org/10.1183/13993003.congress-2018.oa3797","title":"PRM metrics predict COPD progression","display_name":"PRM metrics predict COPD progression","publication_year":2018,"publication_date":"2018-09-15","ids":{"openalex":"https://openalex.org/W2906520338","doi":"https://doi.org/10.1183/13993003.congress-2018.oa3797","mag":"2906520338"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2018.oa3797","doi":"https://doi.org/10.1183/13993003.congress-2018.oa3797","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2018.oa3797","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Imaging","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076786308","display_name":"Paula Belloni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Belloni","raw_affiliation_strings":["Genentech, S. San Francisco, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, S. San Francisco, United States of America","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114046171","display_name":"Dorothy S Cheung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy Cheung","raw_affiliation_strings":["Genentech, S. San Francisco, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, S. San Francisco, United States of America","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101531671","display_name":"Xiaoying Yang","orcid":"https://orcid.org/0000-0003-1776-2469","observed_orcids":["https://orcid.org/0000-0003-1776-2469"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoying Yang","raw_affiliation_strings":["Genentech, S. San Francisco, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, S. San Francisco, United States of America","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070321113","display_name":"Alex J. de Crespigny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex De Crespigny","raw_affiliation_strings":["Genentech, S. San Francisco, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, S. San Francisco, United States of America","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015807980","display_name":"Alexandre Fernandez Coimbra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre Coimbra","raw_affiliation_strings":["Genentech, S. San Francisco, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, S. San Francisco, United States of America","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OA3797","last_page":"OA3797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fev1-decline","display_name":"FEV1 decline","score":0.8040000200271606},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7229999899864197},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7639999985694885},{"id":"https://openalex.org/keywords/gold-classification","display_name":"GOLD classification","score":0.5320000052452087},{"id":"https://openalex.org/keywords/lung-ct","display_name":"lung CT","score":0.5},{"id":"https://openalex.org/keywords/copd-phenotypes","display_name":"COPD phenotypes","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8614907264709473},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6514849662780762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6408165097236633},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.4684491455554962},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3222609758377075},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2018.oa3797","doi":"https://doi.org/10.1183/13993003.congress-2018.oa3797","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2018.oa3797","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047568182","https://openalex.org/W2551461441","https://openalex.org/W4379375489","https://openalex.org/W4415501758","https://openalex.org/W2562526948","https://openalex.org/W4392240124","https://openalex.org/W2884234612","https://openalex.org/W3095069840","https://openalex.org/W4254252318","https://openalex.org/W4410271250"],"abstract_inverted_index":{"Rationale:":[0],"Parametric":[1],"response":[2],"map":[3],"(PRM)":[4],"is":[5],"a":[6],"promising":[7],"method":[8],"to":[9,21,77,106,178],"differentiate":[10],"COPD":[11,204],"phenotypes":[12],"and":[13,31,58,68,84,91,94,99,130,150,185,191,205],"progression.":[14,36],"In":[15],"this":[16],"longitudinal":[17],"study,":[18],"we":[19],"aimed":[20],"confirm":[22],"the":[23,32,53,79],"association":[24,80],"of":[25,148,165],"PRM":[26,38,83,90,98,174],"metrics":[27,175],"with":[28,125,131,142,155,188],"GOLD":[29,197],"status,":[30],"prognostic":[33,194],"value":[34,195],"for":[35,199],"Methods:":[37],"analysis":[39],"was":[40,104,138],"performed":[41,63],"using":[42],"images":[43],"collected":[44],"over":[45],"2":[46],"years":[47],"from":[48,52],"100":[49],"placebo":[50],"patients":[51],"TESRA":[54],"study[1].":[55],"Paired":[56],"inspiratory":[57],"expiratory":[59],"CT":[60],"scans":[61],"were":[62,75],"at":[64,86],"baseline,":[65],"6,":[66],"12":[67],"24":[69],"months.":[70],"Three":[71],"linear":[72],"regression":[73],"models":[74],"used":[76,105],"assess":[78],"between:":[81],"1)":[82],"FEV1,":[85],"baseline":[87,89,108,126,143,166,189],"2)":[88],"FEV1":[92,117,127,132,144,156],"progression,":[93,157],"3)":[95],"progression":[96,133,181,202],"in":[97,168,203],"FEV1.":[100],"Random":[101],"forest":[102,170],"modeling":[103],"identify":[107],"parameters":[109,167],"that":[110,173],"most":[111],"accurately":[112],"predict":[113,179],"normal":[114],"vs":[115,196],"rapid":[116],"annual":[118],"decline.":[119],"Results:":[120],"Baseline":[121,136],"PRMNormal":[122,149,184],"significantly":[123,140],"correlated":[124,141],"(0.62,":[128],"p=0.0003)":[129],"(0.22,":[134],"p=0.022).":[135],"PRMfSAD":[137,151,186],"also":[139],"(0.61,":[145],"p=0.001)":[146],"Progression":[147],"showed":[152],"similar":[153],"correlations":[154],"respectively":[158],"(":[159],"0.31,":[160],"p=0.001&":[161],"0.24,":[162],"p=0.041).":[163],"Assessment":[164],"random":[169],"model":[171],"suggests":[172],"ranked":[176],"highest":[177],"FVC":[180],"(Fig.1).":[182],"Conclusion:":[183],"correlate":[187],"FEV-1":[190,201],"show":[192],"greater":[193],"status":[198],"future":[200],"warrant":[206],"further":[207],"study.":[208],"Reference":[209],"[1]":[210],"Am":[211],"J":[212],"Respir":[213],"Crit":[214],"Care":[215],"Med":[216],"2011;183:A6418":[217]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-01-01T00:00:00"}