{"id":"https://openalex.org/W2906469882","doi":null,"title":"UNCONVENTIONAL PROTEIN SECRETION OF KERATIN 75 BY AMELOBLASTS IN VIVO","display_name":"UNCONVENTIONAL PROTEIN SECRETION OF KERATIN 75 BY AMELOBLASTS IN VIVO","publication_year":2018,"publication_date":"2018-04-24","ids":{"openalex":"https://openalex.org/W2906469882","mag":"2906469882"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:34348","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/34348/1/Xu%20Yang.pdf","pdf_url":"https://d-scholarship.pitt.edu/34348/1/Xu%20Yang.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105422154","display_name":"Xu Yang","orcid":"https://orcid.org/0000-0002-3513-6501","observed_orcids":["https://orcid.org/0000-0002-3513-6501"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xu Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5105422154"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.4083999991416931,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ameloblasts","display_name":"ameloblasts","score":0.9449999928474426},{"id":"https://openalex.org/keywords/enamel-matrix-proteins","display_name":"enamel matrix proteins","score":0.8640000224113464},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ameloblastin","display_name":"ameloblastin","score":0.7400000095367432},{"id":"https://openalex.org/keywords/amelogenin","display_name":"amelogenin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.5370000004768372},{"id":"https://openalex.org/keywords/er-golgi-intermediate-compartment","display_name":"ER-Golgi intermediate compartment","score":0.7929999828338623},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.546999990940094},{"id":"https://openalex.org/keywords/tomes-process","display_name":"Tomes' process","score":0.7250000238418579},{"id":"https://openalex.org/keywords/caries-risk","display_name":"caries risk","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cytokeratin","display_name":"cytokeratin","score":0.6890000104904175},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.5860000252723694},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C104392178","wikidata":"https://www.wikidata.org/wiki/Q351499","display_name":"Ameloblast","level":3,"score":0.9891955852508545},{"id":"https://openalex.org/C106434640","wikidata":"https://www.wikidata.org/wiki/Q2844797","display_name":"Amelogenin","level":3,"score":0.8855067491531372},{"id":"https://openalex.org/C199106506","wikidata":"https://www.wikidata.org/wiki/Q2844786","display_name":"Amelogenesis","level":4,"score":0.8398543000221252},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6807069778442383},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.676548957824707},{"id":"https://openalex.org/C156887251","wikidata":"https://www.wikidata.org/wiki/Q2386424","display_name":"Enamel paint","level":2,"score":0.6579379439353943},{"id":"https://openalex.org/C176860957","wikidata":"https://www.wikidata.org/wiki/Q3355925","display_name":"Enamel organ","level":4,"score":0.526509702205658},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5211986899375916},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4829213321208954},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4300791025161743},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.41963356733322144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4002220630645752},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.16166168451309204},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1193864643573761},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:34348","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/34348/1/Xu%20Yang.pdf","pdf_url":"https://d-scholarship.pitt.edu/34348/1/Xu%20Yang.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2906469882","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/34348/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1624946627","https://openalex.org/W1727897997","https://openalex.org/W1770152899","https://openalex.org/W1963573377","https://openalex.org/W1965993201","https://openalex.org/W1968239184","https://openalex.org/W1968261842","https://openalex.org/W1968774879","https://openalex.org/W1969831606","https://openalex.org/W1973268693","https://openalex.org/W1978084442","https://openalex.org/W1981401588","https://openalex.org/W1986191206","https://openalex.org/W1997062000","https://openalex.org/W2001773800","https://openalex.org/W2003785333","https://openalex.org/W2004247840","https://openalex.org/W2008709931","https://openalex.org/W2009713857","https://openalex.org/W2016266703","https://openalex.org/W2016330709","https://openalex.org/W2019237002","https://openalex.org/W2020212296","https://openalex.org/W2030214706","https://openalex.org/W2039677504","https://openalex.org/W2043185443","https://openalex.org/W2044709834","https://openalex.org/W2052061148","https://openalex.org/W2055985848","https://openalex.org/W2057805673","https://openalex.org/W2059307851","https://openalex.org/W2064231882","https://openalex.org/W2065635384","https://openalex.org/W2068691610","https://openalex.org/W2069039144","https://openalex.org/W2076815127","https://openalex.org/W2078959581","https://openalex.org/W2080596065","https://openalex.org/W2081621872","https://openalex.org/W2082372749","https://openalex.org/W2084933310","https://openalex.org/W2085197129","https://openalex.org/W2088954369","https://openalex.org/W2090533989","https://openalex.org/W2092004042","https://openalex.org/W2095765587","https://openalex.org/W2096603548","https://openalex.org/W2101971953","https://openalex.org/W2106728955","https://openalex.org/W2106753260","https://openalex.org/W2107248656","https://openalex.org/W2109070574","https://openalex.org/W2114577521","https://openalex.org/W2114693484","https://openalex.org/W2115718131","https://openalex.org/W2118399496","https://openalex.org/W2118577784","https://openalex.org/W2120193545","https://openalex.org/W2120550370","https://openalex.org/W2124657728","https://openalex.org/W2139602730","https://openalex.org/W2145650946","https://openalex.org/W2147593554","https://openalex.org/W2149652604","https://openalex.org/W2160513335","https://openalex.org/W2163952331","https://openalex.org/W2167249865","https://openalex.org/W2169542233","https://openalex.org/W2197617593","https://openalex.org/W2566427422","https://openalex.org/W2608201564"],"related_works":["https://openalex.org/W2981247381","https://openalex.org/W2954178103","https://openalex.org/W2765153212","https://openalex.org/W4312172520","https://openalex.org/W7015177244","https://openalex.org/W1968339504","https://openalex.org/W2197617593","https://openalex.org/W7146361070","https://openalex.org/W2054276703","https://openalex.org/W2072174062"],"abstract_inverted_index":{"Keratin-75,":[0],"originally":[1],"identified":[2],"as":[3,100,177],"a":[4,17,178,195,321,337,341],"hair":[5],"follicle":[6],"specific":[7],"keratin,":[8],"was":[9,86,107,256,267,270,347],"recently":[10],"discovered":[11],"in":[12,45,57,65,73,82,93,109,116,134,141,162,272,297],"enamel":[13,24,46,70,156],"tissue.":[14],"Individuals":[15],"carrying":[16],"K75":[18,44,64,80,106,133,152,191,199,231,245,281,296,319],"A161T":[19],"mutation":[20],"presented":[21],"with":[22,124,155,187,232,249,259,308],"altered":[23],"structure":[25],"and":[26,48,69,77,113,120,136,145,160,168,235,251,261,275,330],"increased":[27],"susceptibility":[28],"to":[29,39,49,88,215,284],"dental":[30],"caries.":[31],"The":[32,208],"first":[33,335],"objective":[34,210],"of":[35,43,151,165,180,203,211,222,230,295],"this":[36,212,226],"dissertation":[37,213],"is":[38,182,200,206,214,299,305,333],"verify":[40],"the":[41,54,61,63,89,149,204,219,287,334],"existence":[42,62],"tissue":[47],"study":[50],"its":[51],"distribution,":[52],"especially":[53],"subcellular":[55],"localization":[56,294],"ameloblasts.":[58,313],"We":[59],"confirmed":[60],"ameloblasts,":[66],"stratum":[67],"intermediate":[68],"matrix":[71,157],"through":[72],"situ":[74],"hybridization,":[75],"immunofluorescence(IF),":[76],"mass":[78],"spectrometry.":[79],"expression":[81],"forming":[83],"rodent":[84],"teeth":[85],"confined":[87],"secretory":[90,311,338],"stage":[91,312],"ameloblasts":[92,185,298],"IF":[94,125,167],"studies.":[95],"Unlike":[96],"other":[97,188],"cytokeratins,":[98],"such":[99],"K14,":[101],"which":[102,327],"forms":[103],"fibrillar":[104],"networks,":[105],"found":[108],"large":[110,135],"granular":[111],"bodies":[112],"diffuse":[114],"signal":[115,153,196],"ameloblast":[117,142],"cell":[118,143,205],"body":[119,144],"Tomes\u2019":[121,146],"processes.":[122,147],"Consistent":[123],"observations,":[126],"immuno-gold":[127],"transmission":[128],"electron":[129],"microscopy(IG-TEM)":[130],"studies":[131,229],"detected":[132],"small":[137],"membrane-delineated":[138],"vesicles":[139],"located":[140],"Moreover,":[148,314],"majority":[150],"overlapped":[154],"proteins(EMPs)":[158],"ameloblastin":[159,269],"amelogenin":[161],"both":[163],"types":[164],"vesicles.":[166],"IG-TEM":[169],"data":[170],"strongly":[171],"indicate":[172],"that":[173,293,318],"K75,":[174],"traditionally":[175],"regarded":[176],"component":[179],"cytoskeleton,":[181],"secreted":[183,306],"by":[184,310],"together":[186],"EMPs.":[189],"Since":[190],"does":[192],"not":[193],"have":[194],"peptide,":[197,346],"how":[198],"transported":[201],"out":[202],"intriguing.":[207],"second":[209],"obtain":[216],"insights":[217],"into":[218,286],"trafficking":[220,237,266],"pathway":[221,326,339],"K75.":[223],"To":[224],"address":[225],"objective,":[227],"co-localization":[228],"organelle":[233],"markers":[234],"conventional":[236],"inhibition":[238],"experiments":[239],"were":[240],"done.":[241],"Under":[242],"physiological":[243],"conditions,":[244],"showed":[246],"limited":[247],"overlap":[248],"ER":[250],"lysosome":[252],"markers,":[253],"however":[254],"it":[255],"highly":[257],"co-localized":[258],"ER-Golgi-Intermediate-Compartment(ERGIC)":[260],"Golgi":[262,278],"markers.":[263],"When":[264],"ER-Golgi":[265],"inhibited,":[268],"detained":[271],"rER":[273],"lumen":[274],"isolated":[276],"from":[277,301],"apparatus":[279],"whereas":[280],"still":[282],"managed":[283],"translocate":[285],"Golgi.":[288,331],"In":[289],"summary,":[290],"we":[291],"demonstrate":[292],"different":[300],"typical":[302],"cytokeratins.":[303],"It":[304],"extracellularly":[307],"EMPs":[309],"our":[315],"results":[316],"suggest":[317],"utilizes":[320],"novel":[322],"unconventional":[323],"protein":[324],"secretion":[325],"involves":[328],"ERGIC":[329],"This":[332],"time":[336],"for":[340],"cytosolic":[342],"cytokeratin,":[343],"lacking":[344],"signaling":[345],"revealed.":[348]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-01-01T00:00:00"}
