{"id":"https://openalex.org/W2906461986","doi":"https://doi.org/10.1002/path.5228","title":"High\u2010throughput sequencing identifies aetiology\u2010dependent differences in ductular reaction in human chronic liver disease","display_name":"High\u2010throughput sequencing identifies aetiology\u2010dependent differences in ductular reaction in human chronic liver disease","publication_year":2018,"publication_date":"2018-12-25","ids":{"openalex":"https://openalex.org/W2906461986","doi":"https://doi.org/10.1002/path.5228","mag":"2906461986","pmid":"https://pubmed.ncbi.nlm.nih.gov/30584802"},"language":"en","primary_location":{"id":"doi:10.1002/path.5228","doi":"https://doi.org/10.1002/path.5228","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.5228","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/retrieve/9519e3e8-e1a3-478f-9167-ffc130920887","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031369445","display_name":"Olivier Govaere","orcid":"https://orcid.org/0000-0002-4426-6930","observed_orcids":["https://orcid.org/0000-0002-4426-6930"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","GB"],"is_corresponding":true,"raw_author_name":"Olivier Govaere","raw_affiliation_strings":["Department of Imaging and Pathology KU Leuven and University Hospitals Leuven Leuven Belgium","Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"],"raw_orcid":"https://orcid.org/0000-0002-4426-6930","affiliations":[{"raw_affiliation_string":"Department of Imaging and Pathology KU Leuven and University Hospitals Leuven Leuven Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049863628","display_name":"Simon Cockell","orcid":"https://orcid.org/0000-0002-6831-9806","observed_orcids":["https://orcid.org/0000-0002-6831-9806"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Cockell","raw_affiliation_strings":["Bioinformatics Support Unit Newcastle University Newcastle upon Tyne UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Support Unit Newcastle University Newcastle upon Tyne UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012329478","display_name":"Matthias Van Haele","orcid":"https://orcid.org/0000-0003-1064-5809","observed_orcids":["https://orcid.org/0000-0003-1064-5809"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Matthias Van Haele","raw_affiliation_strings":["Department of Imaging and Pathology KU Leuven and University Hospitals Leuven Leuven Belgium"],"raw_orcid":"https://orcid.org/0000-0003-1064-5809","affiliations":[{"raw_affiliation_string":"Department of Imaging and Pathology KU Leuven and University Hospitals Leuven Leuven Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052205823","display_name":"Jasper Wouters","orcid":"https://orcid.org/0000-0002-7129-2990","observed_orcids":["https://orcid.org/0000-0002-7129-2990"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jasper Wouters","raw_affiliation_strings":["Department of Human Genetics KU Leuven Leuven Belgium","VIB Center for Brain and Disease Research KU Leuven Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics KU Leuven Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Center for Brain and Disease Research KU Leuven Leuven Belgium","institution_ids":["https://openalex.org/I4210153928","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033424795","display_name":"Wouter Van Delm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Wouter Van Delm","raw_affiliation_strings":["VIB Nucleomics Core KU Leuven Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VIB Nucleomics Core KU Leuven Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110084722","display_name":"Kathleen Van den Eynde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kathleen Van den Eynde","raw_affiliation_strings":["Department of Imaging and Pathology KU Leuven and University Hospitals Leuven Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Imaging and Pathology KU Leuven and University Hospitals Leuven Leuven Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011642135","display_name":"Arianna Bianchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arianna Bianchi","raw_affiliation_strings":["Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054248122","display_name":"Rudy G. E. van Eijsden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rudy van Eijsden","raw_affiliation_strings":["VIB Nucleomics Core KU Leuven Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VIB Nucleomics Core KU Leuven Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103713931","display_name":"Werner Van Steenbergen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Werner Van Steenbergen","raw_affiliation_strings":["Department of Hepatology KU Leuven and University Hospitals Leuven Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology KU Leuven and University Hospitals Leuven Leuven Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080615654","display_name":"Diethard R.L. Monbaliu","orcid":"https://orcid.org/0000-0002-0506-1609","observed_orcids":["https://orcid.org/0000-0002-0506-1609"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Diethard Monbaliu","raw_affiliation_strings":["Department of Abdominal Transplant Surgery KU Leuven and University Hospitals Leuven Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Abdominal Transplant Surgery KU Leuven and University Hospitals Leuven Leuven Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080844718","display_name":"Frederik Nevens","orcid":"https://orcid.org/0000-0003-2905-5112","observed_orcids":["https://orcid.org/0000-0003-2905-5112"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Frederik Nevens","raw_affiliation_strings":["Department of Hepatology KU Leuven and University Hospitals Leuven Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology KU Leuven and University Hospitals Leuven Leuven Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067200658","display_name":"Tania Roskams","orcid":"https://orcid.org/0000-0002-2816-1530","observed_orcids":["https://orcid.org/0000-0002-2816-1530"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tania Roskams","raw_affiliation_strings":["Department of Imaging and Pathology KU Leuven and University Hospitals Leuven Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Imaging and Pathology KU Leuven and University Hospitals Leuven Leuven Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031369445"],"corresponding_institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I84884186","https://openalex.org/I99464096"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":2.5603,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.90316364,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"248","issue":"1","first_page":"66","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductular-reaction","display_name":"ductular reaction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatic-progenitor-cells","display_name":"hepatic progenitor cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.6899999976158142},{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.628000020980835},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6510000228881836},{"id":"https://openalex.org/keywords/macrophage-recruitment","display_name":"macrophage recruitment","score":0.6029999852180481},{"id":"https://openalex.org/keywords/marco","display_name":"MARCO","score":0.7789999842643738},{"id":"https://openalex.org/keywords/ccl28","display_name":"CCL28","score":0.8389999866485596},{"id":"https://openalex.org/keywords/lymphocytic-infiltration","display_name":"lymphocyte infiltration","score":0.7279999852180481},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.953000009059906},{"id":"https://openalex.org/keywords/fibrogenesis","display_name":"fibrogenesis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45212841033935547},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.435939759016037},{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.43043747544288635},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4285220503807068},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4095991849899292},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40756064653396606},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32899051904678345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31960439682006836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2332562804222107},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.2042485773563385},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.12782281637191772},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12599623203277588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/path.5228","doi":"https://doi.org/10.1002/path.5228","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.5228","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},{"id":"pmid:30584802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30584802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/631875","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/631875","pdf_url":"https://lirias.kuleuven.be/retrieve/9519e3e8-e1a3-478f-9167-ffc130920887","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Of Pathology, vol. 248 (1), (66-76)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.25405/ncl.34375230","doi":"https://doi.org/10.25405/ncl.34375230","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34375230","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34375230.v1","doi":"https://doi.org/10.25405/ncl.34375230.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34375230.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/631875","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/631875","pdf_url":"https://lirias.kuleuven.be/retrieve/9519e3e8-e1a3-478f-9167-ffc130920887","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Of Pathology, vol. 248 (1), (66-76)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321454","display_name":"Belgian Federal Science Policy Office","ror":"https://ror.org/01fapfv42"},{"id":"https://openalex.org/F4320327317","display_name":"Kom op tegen Kanker","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906461986.pdf","grobid_xml":"https://content.openalex.org/works/W2906461986.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1786911182","https://openalex.org/W1939313462","https://openalex.org/W1969833092","https://openalex.org/W1972128179","https://openalex.org/W1976109983","https://openalex.org/W1985404678","https://openalex.org/W1986132627","https://openalex.org/W2003338481","https://openalex.org/W2006041438","https://openalex.org/W2006099253","https://openalex.org/W2025966264","https://openalex.org/W2026201390","https://openalex.org/W2028593002","https://openalex.org/W2038346033","https://openalex.org/W2038747312","https://openalex.org/W2039742298","https://openalex.org/W2063463246","https://openalex.org/W2069819211","https://openalex.org/W2074647644","https://openalex.org/W2074921121","https://openalex.org/W2083517200","https://openalex.org/W2094735775","https://openalex.org/W2096049380","https://openalex.org/W2096086497","https://openalex.org/W2097065948","https://openalex.org/W2097948046","https://openalex.org/W2102869463","https://openalex.org/W2103752974","https://openalex.org/W2106803099","https://openalex.org/W2108234281","https://openalex.org/W2111589020","https://openalex.org/W2112067172","https://openalex.org/W2119171121","https://openalex.org/W2122046893","https://openalex.org/W2123106337","https://openalex.org/W2130410032","https://openalex.org/W2132908880","https://openalex.org/W2133516530","https://openalex.org/W2134526812","https://openalex.org/W2136227880","https://openalex.org/W2146948091","https://openalex.org/W2156298113","https://openalex.org/W2178003817","https://openalex.org/W2330393805","https://openalex.org/W2507952693","https://openalex.org/W2537623931","https://openalex.org/W2547910053","https://openalex.org/W2734880494","https://openalex.org/W2744555195","https://openalex.org/W2758475711","https://openalex.org/W2803013275"],"related_works":["https://openalex.org/W2924780102","https://openalex.org/W4254608446","https://openalex.org/W7222814029","https://openalex.org/W7135015960","https://openalex.org/W7028084219","https://openalex.org/W4365794130","https://openalex.org/W2068261572","https://openalex.org/W1780260732","https://openalex.org/W1966481391","https://openalex.org/W2039742298"],"abstract_inverted_index":{"Ductular":[0],"reaction":[1],"(DR)":[2],"represents":[3],"the":[4,36,44,94,118,135,191,199,213,249,268],"activation":[5],"of":[6,17,38,100,127,185,201,212,225,237,251,270,287],"hepatic":[7],"progenitor":[8],"cells":[9,29,129,247],"(HPCs)":[10],"and":[11,34,105,122,125,151,165,175,258,276,290],"has":[12],"been":[13],"associated":[14],"with":[15,75],"features":[16],"advanced":[18,107,202],"chronic":[19,57,279],"liver":[20,58,280],"disease;":[21],"yet":[22],"it":[23],"is":[24],"not":[25],"clear":[26],"whether":[27],"these":[28],"contribute":[30],"to":[31,49,145,232],"disease":[32,197],"progression":[33],"how":[35],"composition":[37],"their":[39],"micro-environment":[40],"differs":[41],"depending":[42,133],"on":[43,134,267],"aetiology.":[45,136],"This":[46],"study":[47],"aimed":[48],"identify":[50],"HPC-associated":[51],"signalling":[52],"pathways":[53],"relevant":[54],"in":[55,120,138,159,190,195,198,205,220,248,272,278],"different":[56,132],"diseases":[59],"using":[60,68],"a":[61,98,143,182,209],"high-throughput":[62],"sequencing":[63],"approach.":[64],"DR/HPCs":[65,219,252,271],"were":[66,91,113,130,140,161],"isolated":[67],"laser":[69],"microdissection":[70],"from":[71],"patient":[72],"samples":[73],"diagnosed":[74],"HCV":[76,121,160],"or":[77,86],"primary":[78],"sclerosing":[79],"cholangitis":[80],"(PSC),":[81],"as":[82],"models":[83],"for":[84,97],"hepatocellular":[85],"biliary":[87],"regeneration.":[88],"Key":[89],"signals":[90],"validated":[92],"at":[93],"protein":[95],"level":[96],"cohort":[99],"56":[101],"patients":[102],"(20":[103],"early":[104,196],"36":[106],"stage).":[108],"In":[109,180,261],"total,":[110],"330":[111],"genes":[112,239],"significantly":[114],"differentially":[115],"expressed":[116],"between":[117,173],"HPCs":[119,137,158,174,207],"PSC.":[123],"Recruitment":[124],"homing":[126],"inflammatory":[128],"distinctly":[131],"PSC":[139,221],"characterised":[141],"by":[142,163,293],"response":[144],"oxidative":[146],"stress":[147],"(e.g.":[148,227,240,256],"JUN,":[149],"VNN1)":[150],"neutrophil-attractant":[152],"chemokines":[153],"(CXCL5,":[154],"CXCL6,":[155],"IL-8),":[156],"whereas":[157],"identified":[162],"T-":[164],"B-lymphocyte":[166],"infiltration.":[167],"Moreover,":[168],"we":[169],"found":[170],"that":[171],"communication":[172],"macrophages":[176,187],"was":[177,188,243],"aetiology":[178],"driven.":[179],"PSC,":[181],"high":[183],"frequency":[184],"CCL28-positive":[186],"observed":[189],"portal":[192],"infiltrate,":[193],"already":[194],"absence":[200],"fibrosis,":[203],"while":[204],"HCV,":[206,233],"showed":[208,222,253],"strong":[210],"expression":[211],"macrophage":[214],"scavenger":[215],"receptor":[216],"MARCO.":[217],"Interestingly,":[218],"more":[223],"deposition":[224],"ECM":[226],"FN1,":[228],"LAMC2,":[229],"collagens)":[230],"compared":[231],"where":[234],"an":[235],"increase":[236],"pro-invasive":[238],"PDGFRA,":[241],"IGF2)":[242],"observed.":[244],"Additionally,":[245],"endothelial":[246],"vicinity":[250],"differential":[254],"immunopositivity":[255],"IGF2":[257],"INHBA":[259],"expression).":[260],"conclusion,":[262],"our":[263],"data":[264],"shine":[265],"light":[266],"role":[269],"immune":[273],"signalling,":[274],"fibrogenesis":[275],"angiogenesis":[277],"disease.":[281],"Copyright":[282],"\u00a9":[283],"2018":[284],"Pathological":[285],"Society":[286],"Great":[288],"Britain":[289],"Ireland.":[291],"Published":[292],"John":[294],"Wiley":[295],"&":[296],"Sons,":[297],"Ltd.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-01-01T00:00:00"}