{"id":"https://openalex.org/W2906366641","doi":"https://doi.org/10.1183/13993003.congress-2018.pa4381","title":"Extrafine beclometasone dipropionate, formoterol fumarate, glycopyrronium (BDP/FF/G) and exacerbation recurrence: post-hoc analysis of the TRIBUTE study.","display_name":"Extrafine beclometasone dipropionate, formoterol fumarate, glycopyrronium (BDP/FF/G) and exacerbation recurrence: post-hoc analysis of the TRIBUTE study.","publication_year":2018,"publication_date":"2018-09-15","ids":{"openalex":"https://openalex.org/W2906366641","doi":"https://doi.org/10.1183/13993003.congress-2018.pa4381","mag":"2906366641"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2018.pa4381","doi":"https://doi.org/10.1183/13993003.congress-2018.pa4381","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2018.pa4381","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010278392","display_name":"Leonardo Michele Fabbri","orcid":"https://orcid.org/0000-0001-8894-1689","observed_orcids":["https://orcid.org/0000-0001-8894-1689"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leonardo Fabbri","raw_affiliation_strings":["Department of medecine (University), Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of medecine (University), Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068917661","display_name":"Dave Singh","orcid":"https://orcid.org/0000-0001-8918-7075","observed_orcids":["https://orcid.org/0000-0001-8918-7075"]},"institutions":[{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dave Singh","raw_affiliation_strings":["Medecines Evaluation Unit, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medecines Evaluation Unit, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210151016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083312029","display_name":"J\u00f8rgen Vestbo","orcid":"https://orcid.org/0000-0001-6355-6362","observed_orcids":["https://orcid.org/0000-0001-6355-6362"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jorgen Vestbo","raw_affiliation_strings":["Division of infection, immunity and Respiratory medecine (university), Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of infection, immunity and Respiratory medecine (university), Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046019803","display_name":"Massimo Corradi","orcid":"https://orcid.org/0000-0002-2808-4184","observed_orcids":["https://orcid.org/0000-0002-2808-4184"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Corradi","raw_affiliation_strings":["Department of medecine and surgery (university), Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of medecine and surgery (university), Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087246234","display_name":"Alessandro Guasconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162628","display_name":"Chiesi (Italy)","ror":"https://ror.org/0511bn634","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210162628"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Guasconi","raw_affiliation_strings":["Chiesi Farmaceutici SpA, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiesi Farmaceutici SpA, Parma, Italy","institution_ids":["https://openalex.org/I4210162628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073459963","display_name":"Mario Scuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162628","display_name":"Chiesi (Italy)","ror":"https://ror.org/0511bn634","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210162628"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Scuri","raw_affiliation_strings":["Chiesi Farmaceutici SpA, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiesi Farmaceutici SpA, Parma, Italy","institution_ids":["https://openalex.org/I4210162628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025047595","display_name":"George C. Georges","orcid":"https://orcid.org/0000-0002-0303-2273","observed_orcids":["https://orcid.org/0000-0002-0303-2273"]},"institutions":[{"id":"https://openalex.org/I4210162628","display_name":"Chiesi (Italy)","ror":"https://ror.org/0511bn634","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210162628"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"George Georges","raw_affiliation_strings":["Chiesi Farmaceutici SpA, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiesi Farmaceutici SpA, Parma, Italy","institution_ids":["https://openalex.org/I4210162628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015381171","display_name":"Isabella Montagna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162628","display_name":"Chiesi (Italy)","ror":"https://ror.org/0511bn634","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210162628"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Isabella Montagna","raw_affiliation_strings":["Chiesi Farmaceutici SpA, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiesi Farmaceutici SpA, Parma, Italy","institution_ids":["https://openalex.org/I4210162628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018090172","display_name":"Helene Prunier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162628","display_name":"Chiesi (Italy)","ror":"https://ror.org/0511bn634","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210162628"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Prunier","raw_affiliation_strings":["Chiesi Farmaceutici SpA, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiesi Farmaceutici SpA, Parma, Italy","institution_ids":["https://openalex.org/I4210162628"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stefano Vezzoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162628","display_name":"Chiesi (Italy)","ror":"https://ror.org/0511bn634","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210162628"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Vezzoli","raw_affiliation_strings":["Chiesi Farmaceutici SpA, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiesi Farmaceutici SpA, Parma, Italy","institution_ids":["https://openalex.org/I4210162628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045751851","display_name":"Stefano Petruzzelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162628","display_name":"Chiesi (Italy)","ror":"https://ror.org/0511bn634","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210162628"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Petruzzelli","raw_affiliation_strings":["Chiesi Farmaceutici SpA, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiesi Farmaceutici SpA, Parma, Italy","institution_ids":["https://openalex.org/I4210162628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030660777","display_name":"Alberto A. Papi","orcid":"https://orcid.org/0000-0002-6924-4500","observed_orcids":["https://orcid.org/0000-0002-6924-4500"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Papi","raw_affiliation_strings":["Research centre on asthma and COPD, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research centre on asthma and COPD, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA4381","last_page":"PA4381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.7459999918937683},{"id":"https://openalex.org/keywords/exacerbation-recurrence","display_name":"exacerbation recurrence","score":0.9200000166893005},{"id":"https://openalex.org/keywords/indacaterol-glycopyrronium","display_name":"indacaterol/glycopyrronium","score":0.968999981880188},{"id":"https://openalex.org/keywords/long-acting-beta-agonists","display_name":"long-acting beta2-agonists","score":0.7279999852180481},{"id":"https://openalex.org/keywords/triple-therapy","display_name":"triple therapy","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C2778884479","wikidata":"https://www.wikidata.org/wiki/Q425654","display_name":"Indacaterol","level":4,"score":0.8807262182235718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8581898212432861},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.8096112012863159},{"id":"https://openalex.org/C2777992530","wikidata":"https://www.wikidata.org/wiki/Q421475","display_name":"Beclometasone dipropionate","level":4,"score":0.7826178669929504},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.7476564645767212},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6443623304367065},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5322551131248474},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4116343855857849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4012201130390167},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.10863879323005676},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0859031081199646},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.0},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2018.pa4381","doi":"https://doi.org/10.1183/13993003.congress-2018.pa4381","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2018.pa4381","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2906405323","https://openalex.org/W2907038628","https://openalex.org/W2922183847","https://openalex.org/W2920900625","https://openalex.org/W2785999277","https://openalex.org/W2922300150","https://openalex.org/W3095068028","https://openalex.org/W4416134473","https://openalex.org/W2906664926","https://openalex.org/W2922447076"],"abstract_inverted_index":{"Introduction:":[0],"Exacerbations":[1],"are":[2,12],"an":[3,21],"important":[4],"outcome":[5],"measure":[6],"in":[7,50,147],"COPD":[8,51],"and":[9,28,79,89,121,134],"recurrent":[10,18,39],"events":[11,19,40,81,113],"of":[13,17,24,34,41,141,160],"particular":[14],"importance.":[15],"Analysis":[16],"provides":[20],"optimal":[22],"evaluation":[23],"treatment":[25],"effect.":[26],"Aims":[27],"objectives:":[29],"We":[30,54,84],"report":[31],"the":[32,42,76,99,106,137,149,156,170],"results":[33,132],"a":[35],"post-hoc":[36],"analysis":[37],"on":[38],"TRIBUTE":[43],"study":[44],"comparing":[45],"BDP/FF/G":[46,96,143],"vs":[47],"Indacaterol/Glycopyrronium":[48],"(IND/GLY)":[49],"patients.":[52],"Methods:":[53],"applied":[55],"Wei,":[56],"Lin,":[57],"Weissfeld":[58],"(WLW)":[59],"method":[60],"for":[61,72,111,169],"multiple":[62,112],"failure":[63],"time":[64,100,115,122,150,157,171],"data;":[65],"Cox":[66],"proportional":[67],"hazard":[68],"model":[69],"was":[70],"estimated":[71],"three":[73],"strata":[74],"(i.e.":[75],"1st,":[77],"2nd,":[78],"3rd":[80],"were":[82],"considered).":[83],"present":[85],"both":[86],"combined":[87],"estimates":[88],"stratum-specific":[90],"estimates.":[91],"Results:":[92],"Compared":[93],"to":[94,101,116,123,145,151,158,172],"IND/GLY,":[95],"significantly":[97],"prolonged":[98],"exacerbation":[102,118,125,152],"(HR":[103],"0.84),":[104],"with":[105],"effect":[107],"size":[108],"becoming":[109],"greater":[110],"i.e.":[114],"second":[117],"(HR:":[119,126],"0.80)":[120],"third":[124],"0.58)":[127],"(Table":[128],"1).":[129],"Conclusions:":[130],"These":[131],"complement":[133],"further":[135],"support":[136],"superior":[138],"clinical":[139],"benefit":[140],"extrafine":[142],"compared":[144],"IND/GLY":[146],"delaying":[148],"and,":[153],"more":[154],"importantly,":[155],"recurrence":[159],"exacerbations.":[161],"Table":[162],"1.":[163],"Hazard":[164],"Ratios":[165],"(95%":[166],"confidence":[167],"interval)":[168],"event":[173]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-01T00:00:00"}
