{"id":"https://openalex.org/W290636258","doi":null,"title":"Using NMR approaches to drive the search for new CNS therapeutics.","display_name":"Using NMR approaches to drive the search for new CNS therapeutics.","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W290636258","mag":"290636258","pmid":"https://pubmed.ncbi.nlm.nih.gov/20571972","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3010855"},"language":"en","primary_location":{"id":"pmid:20571972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20571972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3010855/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091764355","display_name":"David Borsook","orcid":"https://orcid.org/0000-0001-9825-0064","observed_orcids":["https://orcid.org/0000-0001-9825-0064"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Borsook","raw_affiliation_strings":["Pain & Analgesia Imaging Neuroscience (PAIN) Group, Massachusetts General Hospital, Athinoula Martinos Center for Biomedical Imaging, Department of Radiology and Psychiatry, Charlestown, MA 02129, USA. dborsook@partners.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain & Analgesia Imaging Neuroscience (PAIN) Group, Massachusetts General Hospital, Athinoula Martinos Center for Biomedical Imaging, Department of Radiology and Psychiatry, Charlestown, MA 02129, USA. dborsook@partners.org","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062546791","display_name":"Lino R. Becerra","orcid":"https://orcid.org/0000-0002-5840-1160","observed_orcids":["https://orcid.org/0000-0002-5840-1160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lino Becerra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3008,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.2421466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"7","first_page":"771","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cns-therapeutics","display_name":"CNS therapeutics","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pharmacological-mri","display_name":"pharmacological MRI","score":0.8920000195503235},{"id":"https://openalex.org/keywords/magnetic-resonance-spectroscopy","display_name":"magnetic resonance spectroscopy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.5839999914169312},{"id":"https://openalex.org/keywords/preclinical-disease-models","display_name":"preclinical disease models","score":0.8759999871253967},{"id":"https://openalex.org/keywords/longitudinal-imaging","display_name":"longitudinal imaging","score":0.49799999594688416},{"id":"https://openalex.org/keywords/neurochemical-changes","display_name":"neurochemical changes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/regulatory-acceptance","display_name":"regulatory acceptance","score":0.5419999957084656},{"id":"https://openalex.org/keywords/good-clinical-practice","display_name":"good clinical practice","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.7358402013778687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6756515502929688},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.67555832862854},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5742798447608948},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5698860883712769},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5095999240875244},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.497938871383667},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.47295328974723816},{"id":"https://openalex.org/C2991673738","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Brain disease","level":3,"score":0.44408395886421204},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.42902472615242004},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.41410937905311584},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29793113470077515},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2747151255607605},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.26777827739715576},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22983336448669434},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16924959421157837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12542575597763062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11282852292060852},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08647304773330688},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.079016774892807}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018803","descriptor_name":"Models, Economic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:20571972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20571972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3010855","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3010855/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Investig Drugs","raw_type":"Text"},{"id":"mag:290636258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20571972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3010855","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3010855/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Investig Drugs","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G195611419","display_name":"Imaging Pain and Analgesia: Mentoring in Basic and Applied Research","funder_award_id":"K24NS064050","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W125747422","https://openalex.org/W1570307718","https://openalex.org/W1796074129","https://openalex.org/W1927461748","https://openalex.org/W1967931162","https://openalex.org/W1968462371","https://openalex.org/W1969475893","https://openalex.org/W1972953622","https://openalex.org/W1974139212","https://openalex.org/W1983482668","https://openalex.org/W1994133687","https://openalex.org/W1995458911","https://openalex.org/W1995942098","https://openalex.org/W2002660165","https://openalex.org/W2003207603","https://openalex.org/W2006209961","https://openalex.org/W2011224808","https://openalex.org/W2014157362","https://openalex.org/W2015287537","https://openalex.org/W2020178289","https://openalex.org/W2021352247","https://openalex.org/W2023485724","https://openalex.org/W2025177502","https://openalex.org/W2025918112","https://openalex.org/W2026784776","https://openalex.org/W2028640606","https://openalex.org/W2029214174","https://openalex.org/W2031430565","https://openalex.org/W2032639611","https://openalex.org/W2033777218","https://openalex.org/W2036125924","https://openalex.org/W2039857736","https://openalex.org/W2041823936","https://openalex.org/W2044052132","https://openalex.org/W2045414097","https://openalex.org/W2046812892","https://openalex.org/W2048207814","https://openalex.org/W2051295243","https://openalex.org/W2055832690","https://openalex.org/W2056565769","https://openalex.org/W2060851420","https://openalex.org/W2066830829","https://openalex.org/W2070780907","https://openalex.org/W2074163347","https://openalex.org/W2075405577","https://openalex.org/W2077406389","https://openalex.org/W2077752708","https://openalex.org/W2084529241","https://openalex.org/W2084699651","https://openalex.org/W2088765491","https://openalex.org/W2092814340","https://openalex.org/W2095901107","https://openalex.org/W2107495849","https://openalex.org/W2110415846","https://openalex.org/W2121531670","https://openalex.org/W2123282007","https://openalex.org/W2131287696","https://openalex.org/W2131346520","https://openalex.org/W2133615927","https://openalex.org/W2143548516","https://openalex.org/W2146461945","https://openalex.org/W2147901502","https://openalex.org/W2149141821","https://openalex.org/W2151270078","https://openalex.org/W2169212716","https://openalex.org/W2171048285","https://openalex.org/W4241128332"],"related_works":["https://openalex.org/W4405854758","https://openalex.org/W2267213542","https://openalex.org/W43179976","https://openalex.org/W2016937147","https://openalex.org/W997751442","https://openalex.org/W2025857336","https://openalex.org/W4415673792","https://openalex.org/W1217325132","https://openalex.org/W2115637253","https://openalex.org/W2169310327"],"abstract_inverted_index":{"The":[0],"use":[1],"of":[2,14,21,57,67,87,103,108,119,158],"MRI-based":[3],"imaging":[4,34,82,138],"in":[5,33,95,144],"drug":[6,47,104,145],"development":[7,20,86],"has":[8,83],"received":[9],"increased":[10],"interest":[11],"recently":[12],"because":[13],"the":[15,19,74,85,100,112,117,149,156],"difficulties":[16],"associated":[17,128],"with":[18,129],"CNS":[22],"pharmacotherapies.":[23],"While":[24],"not":[25],"yet":[26],"routine,":[27],"there":[28],"have":[29],"been":[30],"significant":[31],"advances":[32],"that":[35,167],"allow":[36],"this":[37],"technology":[38],"to":[39,63,72,169],"be":[40,61,170],"used":[41],"for":[42],"evaluating":[43],"disease":[44,50,68,75,90],"state":[45,76],"and":[46,54,77,125,151,162],"effects.":[48],"For":[49],"states,":[51],"both":[52,148],"single":[53],"longitudinal":[55],"studies":[56],"non-invasive":[58],"measures":[59,107],"may":[60,139],"obtained":[62],"provide":[64],"a":[65],"read-out":[66],"processes":[69],"and,":[70],"potentially,":[71],"predict":[73],"its":[78],"evolution.":[79],"In":[80],"addition,":[81],"enabled":[84],"improved":[88],"preclinical":[89,150],"models":[91],"based":[92],"on":[93,111,122],"changes":[94,124,127],"brain":[96,123,131],"circuitry.":[97],"Pharmacological":[98],"MRI,":[99],"imaging-based":[101],"evaluation":[102],"effects,":[105],"includes":[106],"direct":[109],"effects":[110,118,132],"brain,":[113],"as":[114,116],"well":[115],"chronic":[120],"dosing":[121],"neurochemical":[126],"these":[130],"using":[133],"magnetic":[134],"resonance":[135],"spectroscopy.":[136],"Thus,":[137],"become":[140],"an":[141],"integrated":[142],"process":[143],"development,":[146],"during":[147],"clinical":[152,160],"stages.":[153],"However,":[154],"validation,":[155],"implementation":[157],"good":[159],"practices":[161],"regulatory":[163],"acceptance":[164],"are":[165],"hurdles":[166],"remain":[168],"overcome.":[171]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
