{"id":"https://openalex.org/W2906284455","doi":null,"title":"The role of CHMP2B mutations in astrocytic dysfunction: implications for neurodegeneration","display_name":"The role of CHMP2B mutations in astrocytic dysfunction: implications for neurodegeneration","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2906284455","mag":"2906284455"},"language":"en","primary_location":{"id":"pmh:oai:clok.uclan.ac.uk:24030","doi":null,"is_oa":false,"landing_page_url":"https://clok.uclan.ac.uk/24030/2/24030%20Bosworth%20Emma%20e-Thesis%20Submission%20Form.doc","pdf_url":null,"source":{"id":"https://openalex.org/S4306402361","display_name":"CLOK (University of Central Lancashire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185852735","host_organization_name":"University of Lancashire","host_organization_lineage":["https://openalex.org/I185852735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024659514","display_name":"Emma Bosworth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emma Bosworth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024659514"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.42309999465942383,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.42309999465942383,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.05950000137090683,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chmp2b","display_name":"CHMP2B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":0.8949999809265137},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/astrocyte-dysfunction","display_name":"astrocyte dysfunction","score":0.7310000061988831},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.8539999723434448},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":1.0},{"id":"https://openalex.org/keywords/glutamate-regulation","display_name":"glutamate regulation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8309999704360962},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7689999938011169},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7381975054740906},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.6056498289108276},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5839894413948059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5669429302215576},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5397942662239075},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5160179138183594},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4774366319179535},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.4564589858055115},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.435440331697464},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4006870687007904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2727002501487732},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22661766409873962},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20506137609481812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19228610396385193},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.17449530959129333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15286049246788025},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09518730640411377},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.0798872709274292},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0680198073387146},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:clok.uclan.ac.uk:24030","doi":null,"is_oa":false,"landing_page_url":"https://clok.uclan.ac.uk/24030/2/24030%20Bosworth%20Emma%20e-Thesis%20Submission%20Form.doc","pdf_url":null,"source":{"id":"https://openalex.org/S4306402361","display_name":"CLOK (University of Central Lancashire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185852735","host_organization_name":"University of Lancashire","host_organization_lineage":["https://openalex.org/I185852735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2906284455","doi":null,"is_oa":false,"landing_page_url":"http://clok.uclan.ac.uk/24030/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1984824912","https://openalex.org/W1993064034","https://openalex.org/W2029582543","https://openalex.org/W2058205271","https://openalex.org/W2122582684","https://openalex.org/W2146546145","https://openalex.org/W2171502370"],"related_works":["https://openalex.org/W2294193285","https://openalex.org/W3184483357","https://openalex.org/W2015736055","https://openalex.org/W1973917546","https://openalex.org/W2478312039","https://openalex.org/W4377047284","https://openalex.org/W160086153","https://openalex.org/W3217009084","https://openalex.org/W2170025525","https://openalex.org/W2053675131"],"abstract_inverted_index":{"The":[0],"ESCRT":[1,25],"machinery":[2],"is":[3,13,19,76,148],"a":[4,20,36,65],"group":[5],"of":[6,23,40,67,74,132,140,154,158,167,175,183],"cytosolic":[7],"protein":[8,21],"complexes":[9],"whose":[10],"main":[11],"function":[12],"to":[14,34,83,109,137,162,171,218,224],"form":[15,39],"intraluminal":[16],"vesicles.":[17],"CHMP2B":[18,79,111,141,147],"subunit":[22],"the":[24,71,118,173,184],"III":[26],"complex":[27],"which,":[28],"when":[29,197,222],"mutated,":[30],"has":[31,80,90],"been":[32,55,81],"seen":[33],"cause":[35],"rare":[37],"familial":[38],"frontotemporal":[41,104],"dementia.":[42,105],"These":[43],"mutations":[44,225],"produce":[45],"aberrant":[46],"endocytic":[47],"and":[48,61,115,129,144,181,188,200],"autophagic":[49],"activity":[50],"within":[51],"cells.":[52],"Astrocytes":[53],"have":[54],"implicated":[56],"in":[57,70,94,100,113,142,150,169,195,206,226],"virtually":[58],"all":[59],"neuropathologies":[60,102],"are":[62],"responsible":[63],"for":[64],"variety":[66],"key":[68],"functions":[69],"brain,":[72],"one":[73],"which":[75],"glutamate":[77,185,207],"regulation.":[78],"reported":[82],"be":[84],"ubiquitously":[85],"expressed":[86,149],"however":[87],"no":[88,193],"research":[89],"specifically":[91],"investigated":[92],"it":[93],"astrocytes":[95,114,143],"despite":[96],"their":[97],"emerging":[98],"role":[99],"these":[101],"including":[103],"This":[106,211],"project":[107,212],"aimed":[108],"determine":[110],"expression":[112,139,155,165],"elucidate":[116],"whether":[117],"FTD":[119],"associated":[120],"mutation":[121,177],"CHMP2BIntron5":[122,168,201],"affected":[123],"basic":[124,219],"astrocyte":[125,220],"biology.":[126],"Western":[127],"blotting":[128],"immunofluorescence":[130],"staining":[131],"cell":[133,179],"lines":[134],"was":[135,160,203],"conducted":[136],"confirm":[138],"revealed":[145],"that":[146],"astrocytes.":[151],"Following":[152],"confirmation":[153],"transient":[156],"transfection":[157],"cells":[159,196],"used":[161],"create":[163],"an":[164],"model":[166],"order":[170],"analyse":[172],"effects":[174],"this":[176],"on":[178],"morphology":[180],"localisation":[182,209],"transporters":[186],"EAAT1":[187],"EAAT2.":[189],"Morphological":[190],"analysis":[191],"showed":[192],"difference":[194,205],"comparing":[198],"CHMP2BWT":[199],"nor":[202],"any":[204,216],"transporter":[208],"observed.":[210],"did":[213],"not":[214],"find":[215],"alterations":[217],"biology":[221],"exposed":[223],"CHMP2B.":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-01T00:00:00"}