{"id":"https://openalex.org/W2906256142","doi":"https://doi.org/10.1136/annrheumdis-2018-eular.4407","title":"THU0053 Anti-fractalkine monoclonal antibody ameliorates joint destruction in collagen-induced arthritis model by inhibition of osteoclast precursor cell survival and migration","display_name":"THU0053 Anti-fractalkine monoclonal antibody ameliorates joint destruction in collagen-induced arthritis model by inhibition of osteoclast precursor cell survival and migration","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2906256142","doi":"https://doi.org/10.1136/annrheumdis-2018-eular.4407","mag":"2906256142"},"language":"en","primary_location":{"id":"doi:10.1136/annrheumdis-2018-eular.4407","doi":"https://doi.org/10.1136/annrheumdis-2018-eular.4407","is_oa":true,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2018-eular.4407","pdf_url":"https://ard.bmj.com/content/annrheumdis/77/Suppl_2/251.2.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ard.bmj.com/content/annrheumdis/77/Suppl_2/251.2.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044519948","display_name":"Yoshikazu Kuboi","orcid":"https://orcid.org/0000-0002-0782-565X","observed_orcids":["https://orcid.org/0000-0002-0782-565X"]},"institutions":[{"id":"https://openalex.org/I4210115373","display_name":"KAN Research Institute","ror":"https://ror.org/02b3jn477","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Kuboi","raw_affiliation_strings":["KAN Research Institute, Inc., Kobe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KAN Research Institute, Inc., Kobe","institution_ids":["https://openalex.org/I4210115373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014507927","display_name":"Kana Hoshino\u2010Negishi","orcid":"https://orcid.org/0009-0006-5154-7999","observed_orcids":["https://orcid.org/0009-0006-5154-7999"]},"institutions":[{"id":"https://openalex.org/I4210115373","display_name":"KAN Research Institute","ror":"https://ror.org/02b3jn477","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Hoshino-Negishi","raw_affiliation_strings":["KAN Research Institute, Inc., Kobe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KAN Research Institute, Inc., Kobe","institution_ids":["https://openalex.org/I4210115373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010824251","display_name":"Masayoshi Ohkuro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146021","display_name":"EA Pharma (Japan)","ror":"https://ror.org/04cjrna85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146021","https://openalex.org/I4210146667","https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ohkuro","raw_affiliation_strings":["EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan","institution_ids":["https://openalex.org/I4210146021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028087275","display_name":"Wataru Ikeda","orcid":"https://orcid.org/0000-0002-6907-9058","observed_orcids":["https://orcid.org/0000-0002-6907-9058"]},"institutions":[{"id":"https://openalex.org/I4210115373","display_name":"KAN Research Institute","ror":"https://ror.org/02b3jn477","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"W. Ikeda","raw_affiliation_strings":["KAN Research Institute, Inc., Kobe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KAN Research Institute, Inc., Kobe","institution_ids":["https://openalex.org/I4210115373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037287387","display_name":"Tomoya Nakatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115373","display_name":"KAN Research Institute","ror":"https://ror.org/02b3jn477","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Nakatani","raw_affiliation_strings":["KAN Research Institute, Inc., Kobe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KAN Research Institute, Inc., Kobe","institution_ids":["https://openalex.org/I4210115373"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115373","display_name":"KAN Research Institute","ror":"https://ror.org/02b3jn477","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Ishii","raw_affiliation_strings":["KAN Research Institute, Inc., Kobe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KAN Research Institute, Inc., Kobe","institution_ids":["https://openalex.org/I4210115373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061087608","display_name":"Nobuyuki Yasuda","orcid":"https://orcid.org/0000-0003-0117-0784","observed_orcids":["https://orcid.org/0000-0003-0117-0784"]},"institutions":[{"id":"https://openalex.org/I4210115373","display_name":"KAN Research Institute","ror":"https://ror.org/02b3jn477","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Yasuda","raw_affiliation_strings":["KAN Research Institute, Inc., Kobe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KAN Research Institute, Inc., Kobe","institution_ids":["https://openalex.org/I4210115373"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027763231","display_name":"Toshio Imai","orcid":"https://orcid.org/0000-0002-4022-1962","observed_orcids":["https://orcid.org/0000-0002-4022-1962"]},"institutions":[{"id":"https://openalex.org/I4210115373","display_name":"KAN Research Institute","ror":"https://ror.org/02b3jn477","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Imai","raw_affiliation_strings":["KAN Research Institute, Inc., Kobe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KAN Research Institute, Inc., Kobe","institution_ids":["https://openalex.org/I4210115373"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":null,"first_page":"251","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cx3cr1","display_name":"CX3CR1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/osteoclast-precursor-cells","display_name":"osteoclast precursor cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/joint-damage","display_name":"joint destruction","score":0.8289999961853027},{"id":"https://openalex.org/keywords/osteoclast-migration","display_name":"osteoclast migration","score":0.7699999809265137},{"id":"https://openalex.org/keywords/osteoclast-survival","display_name":"osteoclast survival","score":0.8159999847412109},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.734000027179718},{"id":"https://openalex.org/keywords/cartilage-destruction","display_name":"cartilage destruction","score":0.7369999885559082},{"id":"https://openalex.org/keywords/bone-injuries","display_name":"bone injuries","score":0.574999988079071},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.46799999475479126},{"id":"https://openalex.org/keywords/cartilage-oligomeric-matrix-protein","display_name":"cartilage oligomeric matrix protein","score":0.7390000224113464},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-3","display_name":"matrix metalloproteinase-3","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7274079322814941},{"id":"https://openalex.org/C31179232","wikidata":"https://www.wikidata.org/wiki/Q14911549","display_name":"CX3CR1","level":5,"score":0.6529244184494019},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5461696982383728},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5175901651382446},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5138478875160217},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5105279684066772},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.48918941617012024},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4015377163887024},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38893598318099976},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.37934449315071106},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.29068976640701294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20933866500854492},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17975810170173645},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.16833209991455078}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/annrheumdis-2018-eular.4407","doi":"https://doi.org/10.1136/annrheumdis-2018-eular.4407","is_oa":true,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2018-eular.4407","pdf_url":"https://ard.bmj.com/content/annrheumdis/77/Suppl_2/251.2.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1136/annrheumdis-2018-eular.4407","doi":"https://doi.org/10.1136/annrheumdis-2018-eular.4407","is_oa":true,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2018-eular.4407","pdf_url":"https://ard.bmj.com/content/annrheumdis/77/Suppl_2/251.2.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906256142.pdf","grobid_xml":"https://content.openalex.org/works/W2906256142.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2951243011","https://openalex.org/W2755447903","https://openalex.org/W2887885773","https://openalex.org/W2166328404","https://openalex.org/W2554124068","https://openalex.org/W2756348063","https://openalex.org/W6998721784","https://openalex.org/W2431719516","https://openalex.org/W2730857027","https://openalex.org/W2493812037"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-01-01T00:00:00"}