{"id":"https://openalex.org/W2906123772","doi":"https://doi.org/10.1117/12.2506660","title":"Voxelwise meta-analysis of brain structural associations with genome-wide polygenic risk for Alzheimer\u2019s disease","display_name":"Voxelwise meta-analysis of brain structural associations with genome-wide polygenic risk for Alzheimer\u2019s disease","publication_year":2018,"publication_date":"2018-12-21","ids":{"openalex":"https://openalex.org/W2906123772","doi":"https://doi.org/10.1117/12.2506660","mag":"2906123772"},"language":"en","primary_location":{"id":"doi:10.1117/12.2506660","doi":"https://doi.org/10.1117/12.2506660","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2506660","pdf_url":null,"source":{"id":"https://openalex.org/S7407088386","display_name":"International Symposium on Medical Information Processing and Analysis (SIPAIM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"14th International Symposium on Medical Information Processing and Analysis","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074408395","display_name":"Linda Ding","orcid":"https://orcid.org/0000-0002-6209-6998","observed_orcids":["https://orcid.org/0000-0002-6209-6998"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Ding","raw_affiliation_strings":["The Univ. of Southern California (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059222630","display_name":"Asta Kristine Haberg","orcid":"https://orcid.org/0000-0002-9007-1202","observed_orcids":["https://orcid.org/0000-0002-9007-1202"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Asta H\u00e5berg","raw_affiliation_strings":["Norwegian Univ. of Science and Technology  (Norway)","St. Olav's Hospital, Trondheim Univ. Hospital (Norway)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwegian Univ. of Science and Technology  (Norway)","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"St. Olav's Hospital, Trondheim Univ. Hospital (Norway)","institution_ids":["https://openalex.org/I4210104358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867","observed_orcids":["https://orcid.org/0000-0002-4720-8867","https://orcid.org/0000-0003-2476-2803","https://orcid.org/0000-0002-2305-8438"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Thompson","raw_affiliation_strings":["The Univ. of Southern California (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781190","display_name":"Neda Jahanshad","orcid":"https://orcid.org/0000-0003-4401-8950","observed_orcids":["https://orcid.org/0000-0003-4401-8950"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Jahanshad","raw_affiliation_strings":["The Univ. of Southern California (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005941814","display_name":"Joshua Faskowitz","orcid":"https://orcid.org/0000-0003-1814-7206","observed_orcids":["https://orcid.org/0000-0003-1814-7206"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Faskowitz","raw_affiliation_strings":["The Univ. of Southern California (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066345371","display_name":"Alyssa H. Zhu","orcid":"https://orcid.org/0000-0003-0083-5107","observed_orcids":["https://orcid.org/0000-0003-0083-5107"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa Zhu","raw_affiliation_strings":["The Univ. of Southern California (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026555194","display_name":"Arvin Saremi","orcid":"https://orcid.org/0000-0003-2395-8249","observed_orcids":["https://orcid.org/0000-0003-2395-8249"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arvin Saremi","raw_affiliation_strings":["The Univ. of Southern California (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5531,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.86537077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"46","issue":null,"first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.07109999656677246,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.8690000176429749},{"id":"https://openalex.org/keywords/brain-structure","display_name":"brain structure","score":0.7480000257492065},{"id":"https://openalex.org/keywords/brain-morphometry","display_name":"brain morphometry","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ventricular-volume","display_name":"ventricular volume","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.996999979019165},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8830000162124634},{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.7059999704360962},{"id":"https://openalex.org/keywords/genetic-risk","display_name":"genetic risk","score":0.593999981880188},{"id":"https://openalex.org/keywords/tensor-based-morphometry","display_name":"tensor-based morphometry","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5674776434898376},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.5583321452140808},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.5456732511520386},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5115833878517151},{"id":"https://openalex.org/C2779632907","wikidata":"https://www.wikidata.org/wiki/Q13444883","display_name":"Brain Structure and Function","level":3,"score":0.5099657773971558},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5021111965179443},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4830939769744873},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.46995973587036133},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.43790966272354126},{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.4349724054336548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38354840874671936},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3567908704280853},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34678149223327637},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2878471910953522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2823219895362854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18702462315559387},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1833256185054779},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.179154634475708},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.11521956324577332},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09755700826644897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2506660","doi":"https://doi.org/10.1117/12.2506660","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2506660","pdf_url":null,"source":{"id":"https://openalex.org/S7407088386","display_name":"International Symposium on Medical Information Processing and Analysis (SIPAIM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"14th International Symposium on Medical Information Processing and Analysis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1681270005","https://openalex.org/W1988649618","https://openalex.org/W2020139159","https://openalex.org/W2020745232","https://openalex.org/W2052644075","https://openalex.org/W2073098702","https://openalex.org/W2098597355","https://openalex.org/W2110065044","https://openalex.org/W2110811354","https://openalex.org/W2114940313","https://openalex.org/W2115779804","https://openalex.org/W2123971761","https://openalex.org/W2135255861","https://openalex.org/W2136145485","https://openalex.org/W2140054173","https://openalex.org/W2155513557","https://openalex.org/W2161633633","https://openalex.org/W2293595655","https://openalex.org/W2318738152","https://openalex.org/W2519328654","https://openalex.org/W2591133298","https://openalex.org/W4241074797","https://openalex.org/W4251404648","https://openalex.org/W4255951163"],"related_works":["https://openalex.org/W7117131558","https://openalex.org/W2300754229","https://openalex.org/W6920868413","https://openalex.org/W4406200818","https://openalex.org/W4414524008","https://openalex.org/W7221322962","https://openalex.org/W4390198467","https://openalex.org/W4396626466","https://openalex.org/W4210325896","https://openalex.org/W3112190541"],"abstract_inverted_index":{"Polygenic":[0],"risk":[1,13,30,135],"scores":[2,42],"(PRSs)":[3],"may":[4,155],"be":[5],"used":[6],"to":[7,24,163],"investigate":[8],"the":[9,27,48,65,132,139,164],"effects":[10],"of":[11,51,70,75,144,167],"genetic":[12,29,146,157],"for":[14,31,117],"disease":[15,33,168],"on":[16,81,148],"complex":[17],"human":[18],"traits.":[19],"Here":[20],"we":[21],"set":[22],"out":[23],"determine":[25],"how":[26],"overall":[28],"Alzheimer\u2019s":[32],"(AD)":[34],"shapes":[35],"brain":[36,76,82],"structure":[37,83],"in":[38,64,90,104,111,152],"non-AD":[39],"populations.":[40],"PRS":[41,71,116],"were":[43,57],"computed":[44,58],"using":[45],"results":[46],"from":[47,138],"International":[49],"Genomics":[50],"Alzheimer's":[52],"Project":[53],"(IGAP)":[54],"study.":[55],"PRSs":[56],"at":[59],"14":[60],"different":[61],"significance":[62],"thresholds":[63],"IGAP":[66],"results.":[67],"The":[68],"effect":[69],"as":[72,84],"a":[73,112],"predictor":[74],"morphometry":[77,88],"was":[78,119],"mapped":[79],"voxelwise":[80],"determined":[85],"by":[86],"tensor-based":[87],"(TBM)":[89],"three":[91],"cohorts:":[92],"ADNI1,":[93],"ADNI2,":[94],"and":[95,124,158],"HUNT.":[96],"Our":[97],"multi-cohort":[98],"TBM":[99],"framework":[100],"first":[101],"tests":[102],"associations":[103],"each":[105],"cohort":[106],"individually,":[107],"then":[108],"meta-analyzes":[109],"findings":[110],"common":[113,145],"space.":[114],"Higher":[115],"AD":[118,134],"associated":[120],"with":[121],"greater":[122],"ventricular":[123],"lower":[125],"hippocampal":[126],"volumes.":[127],"Associations":[128],"remained":[129],"after":[130],"removing":[131],"major":[133],"gene,":[136],"APOE,":[137],"PRS.":[140],"This":[141],"cumulative":[142],"influence":[143],"variants":[147],"brain-wide":[149],"structural":[150],"variation":[151],"nondemented":[153],"individuals":[154],"pinpoint":[156],"neurological":[159],"pathways":[160],"that":[161],"contribute":[162],"preclinical":[165],"assessment":[166],"risk.":[169]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-01-01T00:00:00"}
