{"id":"https://openalex.org/W2906005107","doi":null,"title":"The role of impaired serum bactericidal activity in chronic Pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis","display_name":"The role of impaired serum bactericidal activity in chronic Pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2906005107","mag":"2906005107"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:8548","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/8548/1/Whitters18MD.pdf","pdf_url":"http://etheses.bham.ac.uk/8548/1/Whitters18MD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/8548/1/Whitters18MD.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063202074","display_name":"Deborah Whitters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Deborah Whitters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063202074"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-cystic-fibrosis-bronchiectasis","display_name":"non-cystic fibrosis bronchiectasis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9800000190734863},{"id":"https://openalex.org/keywords/serum-bactericidal-activity","display_name":"serum bactericidal activity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/inhibitory-antibodies","display_name":"inhibitory antibodies","score":0.8360000252723694},{"id":"https://openalex.org/keywords/igg2","display_name":"IgG2","score":0.8169999718666077},{"id":"https://openalex.org/keywords/o-antigen","display_name":"O-antigen","score":0.6449999809265137},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9800000190734863},{"id":"https://openalex.org/keywords/complement-mediated-killing","display_name":"complement-mediated killing","score":0.9139999747276306},{"id":"https://openalex.org/keywords/bacterial-colonization","display_name":"bacterial colonization","score":0.7749999761581421},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.6700000166893005},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2779379686","wikidata":"https://www.wikidata.org/wiki/Q32778","display_name":"Bronchiectasis","level":3,"score":0.8931070566177368},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.8658031821250916},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7690778374671936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.623725414276123},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6166092157363892},{"id":"https://openalex.org/C2778974779","wikidata":"https://www.wikidata.org/wiki/Q1758380","display_name":"Tobramycin","level":4,"score":0.548335075378418},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5000643730163574},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4870891571044922},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4543416500091553},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4536844491958618},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4447501003742218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39885178208351135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3937760591506958},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.32479774951934814},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1941785216331482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1056557297706604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:8548","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/8548/1/Whitters18MD.pdf","pdf_url":"http://etheses.bham.ac.uk/8548/1/Whitters18MD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2906005107","doi":null,"is_oa":false,"landing_page_url":"https://etheses.bham.ac.uk/id/eprint/8548/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.bham.ac.uk:8548","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/8548/1/Whitters18MD.pdf","pdf_url":"http://etheses.bham.ac.uk/8548/1/Whitters18MD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906005107.pdf","grobid_xml":"https://content.openalex.org/works/W2906005107.grobid-xml"},"referenced_works_count":200,"referenced_works":["https://openalex.org/W45096837","https://openalex.org/W57877038","https://openalex.org/W201977584","https://openalex.org/W203060707","https://openalex.org/W1486365785","https://openalex.org/W1504943018","https://openalex.org/W1525067598","https://openalex.org/W1557367249","https://openalex.org/W1573540165","https://openalex.org/W1581777415","https://openalex.org/W1660712537","https://openalex.org/W1709830154","https://openalex.org/W1738289412","https://openalex.org/W1787158122","https://openalex.org/W1871258347","https://openalex.org/W1873207088","https://openalex.org/W1892457185","https://openalex.org/W1897193595","https://openalex.org/W1916739835","https://openalex.org/W1917578416","https://openalex.org/W1923624029","https://openalex.org/W1963778872","https://openalex.org/W1964165536","https://openalex.org/W1970294462","https://openalex.org/W1970344276","https://openalex.org/W1971063314","https://openalex.org/W1971097439","https://openalex.org/W1971264244","https://openalex.org/W1971647859","https://openalex.org/W1975601738","https://openalex.org/W1975724151","https://openalex.org/W1975815184","https://openalex.org/W1976858537","https://openalex.org/W1976899223","https://openalex.org/W1978651681","https://openalex.org/W1980548993","https://openalex.org/W1983262214","https://openalex.org/W1984226967","https://openalex.org/W1984314703","https://openalex.org/W1985192581","https://openalex.org/W1985687704","https://openalex.org/W1988291530","https://openalex.org/W1990591441","https://openalex.org/W1992873661","https://openalex.org/W1998218749","https://openalex.org/W1998500870","https://openalex.org/W1998729399","https://openalex.org/W1999169778","https://openalex.org/W2000461931","https://openalex.org/W2002773042","https://openalex.org/W2003204942","https://openalex.org/W2006135740","https://openalex.org/W2006845738","https://openalex.org/W2007150427","https://openalex.org/W2008243630","https://openalex.org/W2008418299","https://openalex.org/W2008746601","https://openalex.org/W2010445536","https://openalex.org/W2011712988","https://openalex.org/W2012307839","https://openalex.org/W2014745588","https://openalex.org/W2015905438","https://openalex.org/W2016282816","https://openalex.org/W2017383182","https://openalex.org/W2021897314","https://openalex.org/W2025059479","https://openalex.org/W2028001141","https://openalex.org/W2028321468","https://openalex.org/W2028502510","https://openalex.org/W2032044151","https://openalex.org/W2033188019","https://openalex.org/W2037705234","https://openalex.org/W2039343298","https://openalex.org/W2039747727","https://openalex.org/W2040954468","https://openalex.org/W2041189581","https://openalex.org/W2044205606","https://openalex.org/W2045598269","https://openalex.org/W2052678646","https://openalex.org/W2053760924","https://openalex.org/W2054340639","https://openalex.org/W2055368585","https://openalex.org/W2056396010","https://openalex.org/W2058754447","https://openalex.org/W2058907807","https://openalex.org/W2060627925","https://openalex.org/W2061090791","https://openalex.org/W2064659273","https://openalex.org/W2070300719","https://openalex.org/W2070576387","https://openalex.org/W2071605567","https://openalex.org/W2073471936","https://openalex.org/W2073676623","https://openalex.org/W2077035887","https://openalex.org/W2078854698","https://openalex.org/W2079413893","https://openalex.org/W2079698171","https://openalex.org/W2079989275","https://openalex.org/W2081866466","https://openalex.org/W2082263581","https://openalex.org/W2084343696","https://openalex.org/W2084814184","https://openalex.org/W2087444519","https://openalex.org/W2087865186","https://openalex.org/W2087993538","https://openalex.org/W2088012555","https://openalex.org/W2088808467","https://openalex.org/W2088849723","https://openalex.org/W2089628353","https://openalex.org/W2093019529","https://openalex.org/W2093062650","https://openalex.org/W2100571512","https://openalex.org/W2101606279","https://openalex.org/W2102561895","https://openalex.org/W2105494428","https://openalex.org/W2105845379","https://openalex.org/W2105876918","https://openalex.org/W2106838332","https://openalex.org/W2107767157","https://openalex.org/W2107829061","https://openalex.org/W2108213807","https://openalex.org/W2108615239","https://openalex.org/W2110104778","https://openalex.org/W2111407500","https://openalex.org/W2111504875","https://openalex.org/W2111893100","https://openalex.org/W2112765415","https://openalex.org/W2117107524","https://openalex.org/W2117307634","https://openalex.org/W2118858765","https://openalex.org/W2119832209","https://openalex.org/W2120707153","https://openalex.org/W2121543526","https://openalex.org/W2121738142","https://openalex.org/W2121890764","https://openalex.org/W2123611988","https://openalex.org/W2124689223","https://openalex.org/W2126475210","https://openalex.org/W2128301658","https://openalex.org/W2128457081","https://openalex.org/W2129101518","https://openalex.org/W2131067912","https://openalex.org/W2131116287","https://openalex.org/W2131727615","https://openalex.org/W2133197545","https://openalex.org/W2133481056","https://openalex.org/W2133985721","https://openalex.org/W2134164511","https://openalex.org/W2134256289","https://openalex.org/W2135316483","https://openalex.org/W2135909713","https://openalex.org/W2136379226","https://openalex.org/W2138361755","https://openalex.org/W2139043493","https://openalex.org/W2140274822","https://openalex.org/W2141835187","https://openalex.org/W2141963202","https://openalex.org/W2143426164","https://openalex.org/W2143808244","https://openalex.org/W2144086845","https://openalex.org/W2144384981","https://openalex.org/W2144705024","https://openalex.org/W2145672858","https://openalex.org/W2149588950","https://openalex.org/W2149848838","https://openalex.org/W2151163381","https://openalex.org/W2151355567","https://openalex.org/W2153734927","https://openalex.org/W2155069031","https://openalex.org/W2156756792","https://openalex.org/W2157473711","https://openalex.org/W2157996877","https://openalex.org/W2158922072","https://openalex.org/W2159325262","https://openalex.org/W2160553490","https://openalex.org/W2163139680","https://openalex.org/W2165409221","https://openalex.org/W2165572249","https://openalex.org/W2165617076","https://openalex.org/W2167061432","https://openalex.org/W2168400885","https://openalex.org/W2168960819","https://openalex.org/W2169392385","https://openalex.org/W2169484633","https://openalex.org/W2169545551","https://openalex.org/W2169656611","https://openalex.org/W2170309616","https://openalex.org/W2171000821","https://openalex.org/W2171120557","https://openalex.org/W2195693652","https://openalex.org/W2219152942","https://openalex.org/W2232425676","https://openalex.org/W2326707926","https://openalex.org/W2345335473","https://openalex.org/W2410278191","https://openalex.org/W2431430972","https://openalex.org/W2461828862","https://openalex.org/W2531934031","https://openalex.org/W2562687264","https://openalex.org/W2598504265"],"related_works":["https://openalex.org/W7071042249","https://openalex.org/W2163226458","https://openalex.org/W2004264734","https://openalex.org/W2149848838","https://openalex.org/W2981631338","https://openalex.org/W2323301781","https://openalex.org/W3197359560","https://openalex.org/W2598504265","https://openalex.org/W2898745236","https://openalex.org/W2530093987"],"abstract_inverted_index":{"Non":[0],"Cystic":[1],"Fibrosis":[2],"bronchiectasis":[3,18],"is":[4,28],"characterised":[5],"by":[6],"perpetual":[7],"neutrophilic":[8],"inflammation":[9,34],"in":[10,74],"the":[11,38,45,60,69,75,90,118],"lungs.":[12],"The":[13],"ongoing":[14],"vicious":[15],"cycle":[16],"of":[17,31,37,44,62,71,81,121],"leads":[19],"to":[20,23,41],"further":[21],"damage":[22],"already":[24],"damaged":[25],"airways":[26],"and":[27,35,51,95],"a":[29,48,79,86,104],"culmination":[30],"repeated":[32],"infection,":[33],"failure":[36],"host":[39,91],"response":[40],"maintain":[42],"sterility":[43],"airway,":[46],"despite":[47],"sophisticated":[49],"innate":[50],"adaptive":[52,92],"immune":[53,93],"system.":[54],"\\n":[55,99],"\\nPseudomonas":[56],"aeruginosa":[57,83,112],"commonly":[58],"colonises":[59],"lungs":[61],"patients":[63,108],"with":[64,110],"bronchiectasis.":[65],"I":[66,101],"hypothesised":[67],"that":[68],"concept":[70],"inhibitory":[72],"antibodies":[73,115],"serum":[76],"may":[77],"be":[78],"feature":[80],"Pseudomonas":[82,111],"colonisation":[84],"through":[85],"specific":[87,97],"interaction":[88],"between":[89],"system":[94],"strain":[96],"features.":[98],"\\nHere":[100],"have":[102],"identified":[103],"mechanism":[105],"where":[106],"some":[107],"colonised":[109],"produce":[113],"IgG2":[114],"specifically":[116],"against":[117],"O":[119],"antigen":[120],"bacterial":[122],"LPS,":[123],"which":[124],"rather":[125],"than":[126],"promote":[127],"complement-mediated":[128],"killing":[129],"actually":[130],"inhibits":[131],"it.":[132]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-01-01T00:00:00"}
