{"id":"https://openalex.org/W2905809641","doi":"https://doi.org/10.1111/dgd.12588","title":"Strontium ions promote in vitro human bone marrow stromal cell proliferation and differentiation in calcium\u2010lacking media","display_name":"Strontium ions promote in vitro human bone marrow stromal cell proliferation and differentiation in calcium\u2010lacking media","publication_year":2018,"publication_date":"2018-12-25","ids":{"openalex":"https://openalex.org/W2905809641","doi":"https://doi.org/10.1111/dgd.12588","mag":"2905809641","pmid":"https://pubmed.ncbi.nlm.nih.gov/30585307"},"language":"en","primary_location":{"id":"doi:10.1111/dgd.12588","doi":"https://doi.org/10.1111/dgd.12588","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dgd.12588","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12588","source":{"id":"https://openalex.org/S103234284","display_name":"Development Growth & Differentiation","issn_l":"0012-1592","issn":["0012-1592","1440-169X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development, Growth & Differentiation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12588","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020221291","display_name":"Benjamin Kruppke","orcid":"https://orcid.org/0000-0002-0659-0238","observed_orcids":["https://orcid.org/0000-0002-0659-0238"]},"institutions":[{"id":"https://openalex.org/I4210107560","display_name":"Max Bergmann Center of Biomaterials","ror":"https://ror.org/01t4pzq33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210107560","https://openalex.org/I4210111834","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Benjamin Kruppke","raw_affiliation_strings":["Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany"],"raw_orcid":"https://orcid.org/0000-0002-0659-0238","affiliations":[{"raw_affiliation_string":"Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany","institution_ids":["https://openalex.org/I4210107560","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086126403","display_name":"Christiane Heinemann","orcid":"https://orcid.org/0000-0002-1343-4938","observed_orcids":["https://orcid.org/0000-0002-1343-4938"]},"institutions":[{"id":"https://openalex.org/I4210107560","display_name":"Max Bergmann Center of Biomaterials","ror":"https://ror.org/01t4pzq33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210107560","https://openalex.org/I4210111834","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Heinemann","raw_affiliation_strings":["Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany","institution_ids":["https://openalex.org/I4210107560","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060771523","display_name":"Alena\u2010Svenja Wagner","orcid":"https://orcid.org/0000-0002-4413-9405","observed_orcids":["https://orcid.org/0000-0002-4413-9405"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alena\u2010Svenja Wagner","raw_affiliation_strings":["Clinic of Small Animals c/o Institute of Veterinary\u2010Anatomy, \u2010Histology and \u2010Embryology Justus\u2010Liebig\u2010University Gie\u00dfen  Gie\u00dfen Germany","Institute of Veterinary Physiology and Biochemistry Justus\u2010Liebig\u2010University Gie\u00dfen  Gie\u00dfen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Small Animals c/o Institute of Veterinary\u2010Anatomy, \u2010Histology and \u2010Embryology Justus\u2010Liebig\u2010University Gie\u00dfen  Gie\u00dfen Germany","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"Institute of Veterinary Physiology and Biochemistry Justus\u2010Liebig\u2010University Gie\u00dfen  Gie\u00dfen Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103593820","display_name":"Jana Farack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107560","display_name":"Max Bergmann Center of Biomaterials","ror":"https://ror.org/01t4pzq33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210107560","https://openalex.org/I4210111834","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jana Farack","raw_affiliation_strings":["Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany","institution_ids":["https://openalex.org/I4210107560","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039776940","display_name":"Sabine Wenisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Wenisch","raw_affiliation_strings":["Clinic of Small Animals c/o Institute of Veterinary\u2010Anatomy, \u2010Histology and \u2010Embryology Justus\u2010Liebig\u2010University Gie\u00dfen  Gie\u00dfen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Small Animals c/o Institute of Veterinary\u2010Anatomy, \u2010Histology and \u2010Embryology Justus\u2010Liebig\u2010University Gie\u00dfen  Gie\u00dfen Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111970423","display_name":"Hans\u2010Peter Wiesmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107560","display_name":"Max Bergmann Center of Biomaterials","ror":"https://ror.org/01t4pzq33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210107560","https://openalex.org/I4210111834","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans\u2010Peter Wiesmann","raw_affiliation_strings":["Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany","institution_ids":["https://openalex.org/I4210107560","https://openalex.org/I78650965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075933409","display_name":"Thomas Hanke","orcid":"https://orcid.org/0000-0001-7202-9468","observed_orcids":["https://orcid.org/0000-0001-7202-9468"]},"institutions":[{"id":"https://openalex.org/I4210107560","display_name":"Max Bergmann Center of Biomaterials","ror":"https://ror.org/01t4pzq33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210107560","https://openalex.org/I4210111834","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Hanke","raw_affiliation_strings":["Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany","institution_ids":["https://openalex.org/I4210107560","https://openalex.org/I78650965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020221291"],"corresponding_institution_ids":["https://openalex.org/I4210107560","https://openalex.org/I78650965"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.801,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.65602341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"61","issue":"2","first_page":"166","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/strontium-ions","display_name":"strontium ions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.968999981880188},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/calcium-deficiency","display_name":"calcium deficiency","score":0.8309999704360962},{"id":"https://openalex.org/keywords/calcium-free-medium","display_name":"calcium-free medium","score":0.7820000052452087},{"id":"https://openalex.org/keywords/apatite-precipitation","display_name":"apatite precipitation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/bone-substitutes","display_name":"bone substitutes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/strontium-release","display_name":"strontium release","score":0.8220000267028809},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cell-culture-medium","display_name":"cell culture media","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.9068011045455933},{"id":"https://openalex.org/C518915863","wikidata":"https://www.wikidata.org/wiki/Q938","display_name":"Strontium","level":2,"score":0.8559755086898804},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4816512167453766},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.43307510018348694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4293373227119446},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.42628753185272217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2823810875415802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24060553312301636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16245192289352417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11635822057723999},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013324","descriptor_name":"Strontium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/dgd.12588","doi":"https://doi.org/10.1111/dgd.12588","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dgd.12588","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12588","source":{"id":"https://openalex.org/S103234284","display_name":"Development Growth & Differentiation","issn_l":"0012-1592","issn":["0012-1592","1440-169X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development, Growth & Differentiation","raw_type":"journal-article"},{"id":"pmid:30585307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30585307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development, growth & differentiation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/dgd.12588","doi":"https://doi.org/10.1111/dgd.12588","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dgd.12588","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12588","source":{"id":"https://openalex.org/S103234284","display_name":"Development Growth & Differentiation","issn_l":"0012-1592","issn":["0012-1592","1440-169X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development, Growth & Differentiation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4155205038","display_name":null,"funder_award_id":"TRR 79","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G476245946","display_name":"TRR 79: Werkstoffe f\u00fcr die Geweberegeneration im systemisch erkrankten Knochen","funder_award_id":"107540325","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7003747836","display_name":null,"funder_award_id":"M3 and B5","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2905809641.pdf","grobid_xml":"https://content.openalex.org/works/W2905809641.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1904326581","https://openalex.org/W1954370170","https://openalex.org/W1966481184","https://openalex.org/W1975739194","https://openalex.org/W1976394493","https://openalex.org/W1977950302","https://openalex.org/W1980688132","https://openalex.org/W1982414211","https://openalex.org/W1983452389","https://openalex.org/W1984229392","https://openalex.org/W1988721981","https://openalex.org/W2019621158","https://openalex.org/W2031894367","https://openalex.org/W2034741915","https://openalex.org/W2035582618","https://openalex.org/W2035912390","https://openalex.org/W2067063738","https://openalex.org/W2069742231","https://openalex.org/W2069969067","https://openalex.org/W2077023833","https://openalex.org/W2080443939","https://openalex.org/W2080944811","https://openalex.org/W2085944676","https://openalex.org/W2098056363","https://openalex.org/W2100180594","https://openalex.org/W2114072494","https://openalex.org/W2116557384","https://openalex.org/W2120555029","https://openalex.org/W2147169897","https://openalex.org/W2152205487","https://openalex.org/W2153745500","https://openalex.org/W2157592498","https://openalex.org/W2161988995","https://openalex.org/W2162150486","https://openalex.org/W2205475353","https://openalex.org/W2328340213","https://openalex.org/W2531772591","https://openalex.org/W2572222138","https://openalex.org/W2588523756","https://openalex.org/W2589203314","https://openalex.org/W2606436432","https://openalex.org/W2624608863"],"related_works":["https://openalex.org/W2792122529","https://openalex.org/W2309175979","https://openalex.org/W2531614911","https://openalex.org/W2969536497","https://openalex.org/W2366977813","https://openalex.org/W2069742231","https://openalex.org/W1985911969","https://openalex.org/W7146317709","https://openalex.org/W7095367508","https://openalex.org/W1574380700"],"abstract_inverted_index":{"In":[0,152],"order":[1],"to":[2,21,56,70,96,165,199,205,212],"investigate":[3],"the":[4,41,47,63,75,81,89,98,112,234],"influence":[5],"of":[6,49,91,100,105,154,168,203,229],"calcium":[7,65,101,110,134,204,213],"and":[8,18,139,149],"strontium":[9,86,107,143,175,196,217],"ion":[10,66,135,144,214,218],"concentration":[11,51,67,87,145],"on":[12,80],"human":[13],"bone":[14,38,221,230],"marrow":[15],"stromal":[16],"cells":[17],"their":[19],"differentiation":[20,162],"osteoblasts,":[22],"different":[23],"cell":[24],"culture":[25],"media":[26,113,131,235],"have":[27],"been":[28],"used.":[29],"Even":[30],"though":[31],"this":[32,44],"study":[33,45],"does":[34],"not":[35],"contain":[36],"a":[37,61,201,206,216],"substitute":[39,222],"material,":[40],"reason":[42],"for":[43,185,227],"was":[46,78,126,163,171,183],"decrease":[48],"cation":[50],"by":[52,173],"many":[53],"biomaterials,":[54],"due":[55],"induced":[57],"apatite":[58],"precipitation.":[59],"As":[60],"consequence,":[62],"reduced":[64],"is":[68,197],"known":[69],"affect":[71],"osteoblastic":[72],"development.":[73],"Therefore,":[74],"main":[76],"focus":[77],"put":[79],"question,":[82],"whether":[83],"an":[84],"increased":[85,159,172],"(in":[88],"range":[90],"mM)":[92],"might":[93,224],"be":[94,193,225],"suitable":[95],"compensate":[97,200],"lack":[99,202],"ions.":[102],"The":[103],"effect":[104],"solely":[106,174],"ions-with":[108],"only":[109,177],"in":[111,128,210],"resulting":[114],"from":[115,220],"fetal":[116],"calf":[117],"serum-was":[118],"investigated.":[119],"Commercially":[120],"available":[121],"calcium-free":[122],"medium":[123],"(modified":[124],"\u03b1-MEM)":[125],"tested":[127],"comparison":[129],"with":[130,132],"varied":[133],"concentrations":[136,157],"(0.9,":[137],"1.8,":[138,148],"3.6":[140,150],"mM),":[141],"or":[142],"(0.4,":[146],"0.9,":[147],"mM).":[151],"case":[153],"calcium,":[155],"higher":[156],"cause":[158],"proliferation,":[160],"while":[161,181],"shifted":[164],"earlier":[166],"points":[167],"time.":[169],"Differentiation":[170],"ions":[176],"at":[178],"0.4-0.9":[179],"mM,":[180],"proliferation":[182],"highest":[184],"0.9-1.8":[186],"mM.":[187],"From":[188],"these":[189],"results,":[190],"it":[191],"can":[192],"concluded":[194],"that":[195],"able":[198],"certain":[207],"degree.":[208],"Thus,":[209],"contrast":[211],"release,":[215],"release":[219],"materials":[223],"applicable":[226],"stimulation":[228],"regeneration":[231],"without":[232],"influencing":[233],"saturation.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-01-01T00:00:00"}