{"id":"https://openalex.org/W2905720384","doi":"https://doi.org/10.24171/j.phrp.2018.9.6.06","title":"Association between Beta-lactam Antibiotic Resistance and Virulence Factors in AmpC Producing Clinical Strains of P. aeruginosa","display_name":"Association between Beta-lactam Antibiotic Resistance and Virulence Factors in AmpC Producing Clinical Strains of P. aeruginosa","publication_year":2018,"publication_date":"2018-12-20","ids":{"openalex":"https://openalex.org/W2905720384","doi":"https://doi.org/10.24171/j.phrp.2018.9.6.06","mag":"2905720384","pmid":"https://pubmed.ncbi.nlm.nih.gov/30584496","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6296806"},"language":"en","primary_location":{"id":"doi:10.24171/j.phrp.2018.9.6.06","doi":"https://doi.org/10.24171/j.phrp.2018.9.6.06","is_oa":true,"landing_page_url":"https://doi.org/10.24171/j.phrp.2018.9.6.06","pdf_url":"https://ophrp.org/upload/pdf/ophrp-09-325.pdf","source":{"id":"https://openalex.org/S2765061833","display_name":"Osong Public Health and Research Perspectives","issn_l":"2210-9099","issn":["2210-9099","2233-6052"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong Public Health and Research Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ophrp.org/upload/pdf/ophrp-09-325.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017190427","display_name":"Sanaz Dehbashi","orcid":"https://orcid.org/0000-0002-6932-1633","observed_orcids":["https://orcid.org/0000-0002-6932-1633"]},"institutions":[{"id":"https://openalex.org/I112312016","display_name":"Hamedan University of Medical Sciences","ror":"https://ror.org/02ekfbp48","country_code":"IR","type":"education","lineage":["https://openalex.org/I112312016"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sanaz Dehbashi","raw_affiliation_strings":["Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran","institution_ids":["https://openalex.org/I112312016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036814651","display_name":"Hamed Tahmasebi","orcid":"https://orcid.org/0000-0002-9257-4479","observed_orcids":["https://orcid.org/0000-0002-9257-4479"]},"institutions":[{"id":"https://openalex.org/I4210133472","display_name":"Zahedan University of Medical Sciences","ror":"https://ror.org/03r42d171","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210133472"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hamed Tahmasebi","raw_affiliation_strings":["Department of Microbiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran","institution_ids":["https://openalex.org/I4210133472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072555725","display_name":"Mohammad Reza Arabestani","orcid":"https://orcid.org/0000-0001-9991-8193","observed_orcids":["https://orcid.org/0000-0001-9991-8193"]},"institutions":[{"id":"https://openalex.org/I112312016","display_name":"Hamedan University of Medical Sciences","ror":"https://ror.org/02ekfbp48","country_code":"IR","type":"education","lineage":["https://openalex.org/I112312016"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Reza Arabestani","raw_affiliation_strings":["Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran","institution_ids":["https://openalex.org/I112312016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072555725"],"corresponding_institution_ids":["https://openalex.org/I112312016"],"apc_list":null,"apc_paid":null,"fwci":1.4264,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.7723239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"9","issue":"6","first_page":"325","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":1.0},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.890999972820282},{"id":"https://openalex.org/keywords/ampc-beta-lactamase","display_name":"AmpC beta-lactamase","score":0.972000002861023},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8190000057220459},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cefotaxime-resistance","display_name":"cefotaxime resistance","score":0.8029999732971191},{"id":"https://openalex.org/keywords/aztreonam-resistance","display_name":"aztreonam resistance","score":0.9169999957084656},{"id":"https://openalex.org/keywords/igf2bp3","display_name":"IGF2BP3","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2780416669","wikidata":"https://www.wikidata.org/wiki/Q418546","display_name":"Aztreonam","level":5,"score":0.9459836483001709},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7981244325637817},{"id":"https://openalex.org/C2778719061","wikidata":"https://www.wikidata.org/wiki/Q417968","display_name":"Cefotaxime","level":3,"score":0.7335401773452759},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7210297584533691},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7003337144851685},{"id":"https://openalex.org/C2776968632","wikidata":"https://www.wikidata.org/wiki/Q808845","display_name":"Ceftazidime","level":4,"score":0.6974908113479614},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5933322310447693},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5858306884765625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49921441078186035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47138696908950806},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24696263670921326},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16839930415153503},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.1507692039012909}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.24171/j.phrp.2018.9.6.06","doi":"https://doi.org/10.24171/j.phrp.2018.9.6.06","is_oa":true,"landing_page_url":"https://doi.org/10.24171/j.phrp.2018.9.6.06","pdf_url":"https://ophrp.org/upload/pdf/ophrp-09-325.pdf","source":{"id":"https://openalex.org/S2765061833","display_name":"Osong Public Health and Research Perspectives","issn_l":"2210-9099","issn":["2210-9099","2233-6052"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong Public Health and Research Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5273912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6296806","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30584496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30584496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong public health and research perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6296806","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6296806/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong Public Health Res Perspect","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d4cabcf192fe498f9726031571c2a4a5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d4cabcf192fe498f9726031571c2a4a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osong Public Health and Research Perspectives, Vol 9, Iss 6, Pp 325-333 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.24171/j.phrp.2018.9.6.06","doi":"https://doi.org/10.24171/j.phrp.2018.9.6.06","is_oa":true,"landing_page_url":"https://doi.org/10.24171/j.phrp.2018.9.6.06","pdf_url":"https://ophrp.org/upload/pdf/ophrp-09-325.pdf","source":{"id":"https://openalex.org/S2765061833","display_name":"Osong Public Health and Research Perspectives","issn_l":"2210-9099","issn":["2210-9099","2233-6052"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osong Public Health and Research Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322813","display_name":"Hamadan University of Medical Sciences","ror":"https://ror.org/02ekfbp48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2905720384.pdf","grobid_xml":"https://content.openalex.org/works/W2905720384.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1942549872","https://openalex.org/W1963885628","https://openalex.org/W1969601061","https://openalex.org/W1985280035","https://openalex.org/W1991016928","https://openalex.org/W2031578200","https://openalex.org/W2043690768","https://openalex.org/W2093568929","https://openalex.org/W2104996287","https://openalex.org/W2117147188","https://openalex.org/W2125731426","https://openalex.org/W2130079858","https://openalex.org/W2138624787","https://openalex.org/W2144943888","https://openalex.org/W2150758995","https://openalex.org/W2159309010","https://openalex.org/W2168409658","https://openalex.org/W2171062223","https://openalex.org/W2187421208","https://openalex.org/W2221640021","https://openalex.org/W2254805360","https://openalex.org/W2289367194","https://openalex.org/W2345269428","https://openalex.org/W2411689746","https://openalex.org/W2419642397","https://openalex.org/W2511101540","https://openalex.org/W2579748466","https://openalex.org/W2592133557","https://openalex.org/W2724943347","https://openalex.org/W2732477940","https://openalex.org/W2752999018","https://openalex.org/W2806103585","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2265773661","https://openalex.org/W2790007486","https://openalex.org/W2350396803","https://openalex.org/W4402843973","https://openalex.org/W2367580130","https://openalex.org/W2390940637","https://openalex.org/W3102088030","https://openalex.org/W3032056029","https://openalex.org/W2054746080","https://openalex.org/W4386407504"],"abstract_inverted_index":{"Objectives:":[0],"The":[1],"purpose":[2],"of":[3,11,19,26,36,82,115],"this":[4,31,190],"study":[5,191],"was":[6,61,71,89,98,139,148,164],"to":[7,63,73,90,99],"determine":[8,74],"the":[9,27,46,75,85,95,113,116,146,172],"presence":[10],"IMP":[12,175],"and":[13,66,92,94,101,134,145,161,171,174,185],"OXA":[14],"genes":[15,118,154,176],"in":[16,141,150,189,197],"clinical":[17,34],"strains":[18,50],"Pseudomonas":[20],"aeruginosa":[21,38,202],"(P.aeruginosa)":[22],"that":[23,107],"are":[24],"carriers":[25],"ampC":[28],"gene.Methods:":[29],"In":[30],"study,":[32],"105":[33,80],"isolates":[35,81,105,143,152],"P.":[37,83,201],"were":[39,43,54,103],"collected.Antibiotic":[40],"resistance":[41,65,88,97,117,184],"patterns":[42],"determined":[44],"using":[45],"disk":[47,59],"diffusion":[48],"method.The":[49],"carrying":[51],"AmpC":[52,110],"enzymes":[53],"characterized":[55],"by":[56],"a":[57,165],"combination":[58],"method.Multiplex-PCR":[60],"used":[62,72],"identify":[64],"virulence":[67,169,186],"genes,":[68],"chi-square":[69],"test":[70],"relationship":[76,167,181],"between":[77,168,182],"variables.Results:":[78],"Among":[79],"aeruginosa,":[84],"highest":[86],"antibiotic":[87,183],"cefotaxime":[91],"aztreonam,":[93],"least":[96],"colictin":[100],"ceftazidime.There":[102],"49":[104],"(46.66%)":[106],"showed":[108],"an":[109,194],"phenotype.In":[111],"addition,":[112],"frequencies":[114],"were;":[119],"OXA48":[120],"gene":[121,138],"85.2%,":[122],"OXA199,":[123],"139":[124],"3.8%,":[125,127,131],"OXA23":[126],"OXA2":[128],"66.6%,":[129],"OXA10":[130],"OXA51":[132],"85.2%":[133],"OXA58":[135],"3.8%.The":[136],"IMP27":[137],"detected":[140,149,155],"9":[142],"(8.57%)":[144],"IMP3.34":[147],"11":[151],"(10.47%).Other":[153],"included;":[156],"lasR":[157],"(17.1%),":[158],"lasB":[159],"(18%)":[160],"lasA":[162],"(26.6%).There":[163],"significant":[166],"factors":[170,187],"OX":[173],"(p":[177],"\u2264":[178],"0.05).":[179],"Conclusion:The":[180],"observed":[188],"could":[192],"play":[193],"important":[195],"role":[196],"outbreaks":[198],"associated":[199],"with":[200],"infections.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-01-01T00:00:00"}