{"id":"https://openalex.org/W2905695453","doi":"https://doi.org/10.1182/blood-2018-99-117537","title":"Combining p38MAPK Inhibitors with a Second Targeted Agent Enhances Blockade of Inflammatory Signaling-Mediated Survival in Acute Myeloid Leukemia Cells","display_name":"Combining p38MAPK Inhibitors with a Second Targeted Agent Enhances Blockade of Inflammatory Signaling-Mediated Survival in Acute Myeloid Leukemia Cells","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2905695453","doi":"https://doi.org/10.1182/blood-2018-99-117537","mag":"2905695453"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-117537","doi":"https://doi.org/10.1182/blood-2018-99-117537","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-117537","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075070858","display_name":"Stephen E. Kurtz","orcid":"https://orcid.org/0000-0003-4762-389X","observed_orcids":["https://orcid.org/0000-0003-4762-389X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen E Kurtz","raw_affiliation_strings":["Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030828526","display_name":"Christopher A. Eide","orcid":"https://orcid.org/0000-0001-8835-8928","observed_orcids":["https://orcid.org/0000-0001-8835-8928"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher A. Eide","raw_affiliation_strings":["Howard Hughes Medical Institute, Portland, OR","Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Portland, OR","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048410290","display_name":"Narain P. Dubey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Narain P. Dubey","raw_affiliation_strings":["Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049723692","display_name":"Andy J. Kaempf","orcid":"https://orcid.org/0000-0001-9425-6936","observed_orcids":["https://orcid.org/0000-0001-9425-6936"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andy Kaempf","raw_affiliation_strings":["Knight Cancer Institute, Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cancer Institute, Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066373576","display_name":"Shannon K. McWeeney","orcid":"https://orcid.org/0000-0001-8333-6607","observed_orcids":["https://orcid.org/0000-0001-8333-6607"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shannon K. McWeeney","raw_affiliation_strings":["Division of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014545118","display_name":"Cristina E. Tognon","orcid":"https://orcid.org/0000-0002-4872-3078","observed_orcids":["https://orcid.org/0000-0002-4872-3078"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cristina E. Tognon","raw_affiliation_strings":["Howard Hughes Medical Institute, Portland, OR","Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Portland, OR","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088481479","display_name":"Motomi Mori","orcid":"https://orcid.org/0000-0003-1390-4917","observed_orcids":["https://orcid.org/0000-0003-1390-4917"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Motomi Mori","raw_affiliation_strings":["Knight Cancer Institute, Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR","School of Public Health, Portland State University/Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cancer Institute, Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]},{"raw_affiliation_string":"School of Public Health, Portland State University/Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I126345244","https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125591963","display_name":"Brian J. Druker","orcid":"https://orcid.org/0000-0001-8331-8206","observed_orcids":["https://orcid.org/0000-0001-8331-8206"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Druker","raw_affiliation_strings":["Howard Hughes Medical Institute, Portland, OR","Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Portland, OR","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134831711","display_name":"Jeffrey W Tyner","orcid":"https://orcid.org/0000-0002-2133-0960","observed_orcids":["https://orcid.org/0000-0002-2133-0960"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Tyner","raw_affiliation_strings":["Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR","Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076074507","display_name":"Anupriya Agarwal","orcid":"https://orcid.org/0000-0002-8319-6162","observed_orcids":["https://orcid.org/0000-0002-8319-6162"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupriya Agarwal","raw_affiliation_strings":["Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014545118","https://openalex.org/A5030828526","https://openalex.org/A5048410290","https://openalex.org/A5049723692","https://openalex.org/A5066373576","https://openalex.org/A5075070858","https://openalex.org/A5088481479"],"corresponding_institution_ids":["https://openalex.org/I126345244","https://openalex.org/I1344073410","https://openalex.org/I165690674","https://openalex.org/I4390039369"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"2726","last_page":"2726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p38-mapk-inhibitor","display_name":"p38 MAPK inhibitor","score":0.8820000290870667},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9340000152587891},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7540000081062317},{"id":"https://openalex.org/keywords/inflammatory-signaling-pathways","display_name":"inflammatory signaling","score":0.7039999961853027},{"id":"https://openalex.org/keywords/leukemia-cell-survival","display_name":"leukemia cell survival","score":0.8299999833106995},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.4480000138282776},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.7350000143051147},{"id":"https://openalex.org/keywords/npm1-mutation","display_name":"NPM1 mutation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9860000014305115},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ex-vivo-drug-screening","display_name":"ex vivo drug testing","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7026290893554688},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6731629371643066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5484049916267395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5234469771385193},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.48206382989883423},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.4508679211139679},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4485366642475128},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.43459394574165344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3932102620601654},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.0938626229763031},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-117537","doi":"https://doi.org/10.1182/blood-2018-99-117537","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-117537","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2574318671","https://openalex.org/W4200618440","https://openalex.org/W4210749282","https://openalex.org/W2122051507","https://openalex.org/W1980554214","https://openalex.org/W2125025774","https://openalex.org/W2013765904","https://openalex.org/W2556666341","https://openalex.org/W2903583358","https://openalex.org/W2531031953"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],":":[2,65,265,544],"Various":[3],"pro-inflammatory":[4],"and":[5,20,32,51,79,136,171,180,196,236,241,256,320,329,342,369,374,413,450,469,517,529,532,556],"stress-related":[6],"stimuli":[7],"activate":[8],"p38":[9],"mitogen-activated":[10],"protein":[11],"kinase":[12,56],"(p38MAPK),":[13],"triggering":[14],"cascades":[15],"of":[16,46,88,103,110,222,283,308,337,340,344,359,445,467,509,554,565,573,600,614,628,641,657,669,681,696,709,739,756,788,831],"cell":[17],"proliferation,":[18],"differentiation,":[19],"apoptosis":[21],"signaling.":[22],"We":[23,66],"have":[24],"previously":[25],"found":[26],"that":[27,117],"inflammatory":[28,47,533],"cytokines":[29],"promote":[30],"growth":[31],"survival":[33],"in":[34,61,100,229,355,401,456,541],"primary":[35],"cells":[36,92],"from":[37,94,140,185,200,215],"acute":[38,151,156],"myeloid":[39,152,167],"leukemia":[40,95,153,158,163,168],"(AML)":[41],"patients.":[42],"The":[43],"downstream":[44],"mediator":[45],"pathways":[48,575],"is":[49,540,559],"p38MAPK,":[50,555],"blocking":[52],"this":[53,333,557],"regulator":[54],"with":[55,112,257,281,306,347,357,379,396,458,477,493,507,526,563,582],"inhibitors":[57,78,135,358,564],"abrogates":[58],"inflammation":[59],"signaling":[60],"AML":[62,223,270,432,537,545],"cells.":[63],"Methods":[64],"used":[67],"a":[68,113,121,208,220,425],"functional":[69],"ex":[70,549],"vivo":[71,550],"screening":[72],"assay":[73],"to":[74,231,335,389,406,443,454,465,522,552],"identify":[75],"small-molecule":[76],"targeted":[77,115],"inhibitor":[80,106],"combinations":[81,109,378,466],"demonstrating":[82],"selective":[83],"efficacy":[84,387,404,558],"across":[85,251],"broad":[86],"categories":[87],"leukemia.":[89,585],"Primary":[90],"mononuclear":[91],"isolated":[93],"patients":[96,143,581],"(n=408)":[97],"were":[98,144,183,198,244,298,326,420,436,452],"plated":[99],"the":[101,104,273,430,483],"presence":[102],"p38MAPK":[105],"doramapimod":[107,111,278,395,455,468,484,501],"or":[108,119,176,203,381,398,461,471,480,568,602,616,630,643,659,671,683,698,711,741,758,790,833],"second":[114],"agent":[116,134,409],"inhibits":[118],"effects":[120],"non-overlapping":[122],"biological":[123],"pathway.":[124],"A":[125],"7-point":[126],"concentration":[127],"series":[128],"was":[129,213,227,352,473,491,505],"evaluated":[130],"for":[131,188,194,277,496,536],"both":[132,444],"single":[133,391,408],"combinations.":[137],"Leukemia":[138,619],"specimens":[139,271,297,547],"408":[141],"unique":[142],"classified":[145],"into":[146],"5":[147],"diagnosis":[148],"subgroups":[149,268],"including":[150],"(AML;":[154],"n=206),":[155],"lymphoblastic":[157],"(ALL;":[159],"n=42),":[160],"chronic":[161,166],"lymphocytic":[162],"(CLL;":[164],"n=115),":[165],"(CML;":[169],"n=16)":[170],"myeloproliferative":[172],"neoplasms/myelodysplastic":[173],"syndrome":[174],"(MPN":[175],"MDS/MPN;":[177],"n=29).":[178],"IC50":[179,240,276,289,324],"AUC":[181,242,423],"values":[182,243,290,325,439],"derived":[184],"probit-based":[186],"regression":[187],"each":[189,407],"response":[190],"curve.":[191],"Mutational":[192],"status":[193,212],"FLT3-ITD":[195],"NPM1":[197],"compiled":[199],"clinical":[201,216,528,578],"labs":[202],"by":[204,248,253,260],"capillary":[205],"electrophoresis":[206],"using":[207,422],"QiaXcel":[209],"instrument.":[210],"Disease":[211],"obtained":[214,228,421],"chart":[217],"review.":[218],"For":[219,317,482,500],"subset":[221],"samples,":[224],"RNAseq":[225],"analysis":[226,521],"parallel":[230],"drug":[232,238,426,488,524],"sensitivity":[233,489,504,551],"testing.":[234],"Single":[235],"combination":[237,356,457],"treatment":[239],"compared":[245,388,405],"within":[246],"groups":[247,252],"Friedman":[249],"test,":[250,255],"Kruskal-Wallis":[254],"continuous":[258],"variables":[259],"Spearman":[261],"rank":[262],"correlation.":[263],"Results":[264],"Among":[266],"diagnostic":[267],"tested,":[269,434],"showed":[272],"lowest":[274],"median":[275,323],"(1.71":[279],"uM),":[280,305],"75":[282],"206":[284,431],"samples":[285,310,346,433,539],"tested":[286,311,354],"(36%)":[287],"exhibiting":[288],"<":[291,440],"0.5":[292,315,349,441],"uM.":[293,316,350],"In":[294],"contrast,":[295],"CLL":[296],"significantly":[299,402,475],"less":[300],"sensitive":[301,437,453],"(median":[302,410],"IC50:":[303,411],"4.73":[304],"27":[307],"115":[309],"(23%)":[312],"showing":[313],"IC50<":[314,348],"ALL,":[318,338],"CML,":[319,341],"MDS/MPN":[321,345],"subgroups,":[322],"10,":[327],"3.19,":[328],"6.78":[330],"uM,":[331,415],"respectively;":[332,416],"translated":[334],"17%":[336],"19%":[339],"38%":[343],"Doramapimod":[351,377],"also":[353],"histone":[360],"deacetylase":[361],"(panobinostat),":[362],"cyclin-dependent":[363],"kinases":[364],"4/6":[365],"(CDK4/6;":[366],"palbociclib),":[367],"bromodomain":[368],"extra-terminal":[370],"(BET)":[371],"domain":[372],"(JQ1),":[373],"BCL2":[375],"(venetoclax).":[376],"panobinostat":[380],"JQ1":[382],"did":[383],"not":[384,474],"show":[385],"enhanced":[386,403,560],"either":[390,478,566],"agent.":[392],"However,":[393],"combining":[394],"palbociclib":[397,460,470,486],"venetoclax":[399,472],"resulted":[400],"0.014":[412],"0.075":[414],"p<0.0001).":[417],"Similar":[418],"results":[419],"as":[424],"effect":[427],"measure.":[428],"Of":[429],"75%":[435],"(IC50":[438],"uM)":[442],"these":[446,574],"combinations,":[447],"whereas":[448],"8%":[449],"14%":[451],"only":[459],"venetoclax,":[462,503],"respectively.":[463],"Sensitivity":[464],"associated":[476],"age":[479],"gender.":[481],"+":[485,502],"combination,":[487],"(AUC)":[490],"correlated":[492,506],"gene":[494,534],"expression":[495,508,535],"p38MAPK\u03b4(Spearman":[497],"r:":[498,514],"-0.25).":[499],"BCL2,":[510,569],"MCL1,":[511],"p38MAPK\u03b3":[512],"(Spearman":[513],"-0.53,":[515],"0.23,":[516],"-0.33,":[518],"respectively).":[519],"Further":[520],"align":[523],"sensitivities":[525],"additional":[527],"genetic":[530],"features":[531],"patient":[538,546],"progress.":[542],"Conclusions":[543],"demonstrate":[548],"inhibition":[553,572],"when":[561],"combined":[562],"CDK4/6":[567],"suggesting":[570],"dual":[571],"may":[576],"extend":[577],"utility":[579],"among":[580],"genetically":[583],"heterogeneous":[584],"Disclosures":[586],"Druker:":[587],"Celgene:":[588],"Consultancy;":[589,716,777],"Blueprint":[590],"Medicines:":[591],"Consultancy,":[592,606,651,675,688,703,733],"Equity":[593,607,689],"Ownership,":[594,608,690],"Membership":[595,609,623,636,652,664,676,691,704,734,751,783,826],"on":[596,610,624,637,653,665,677,692,705,735,752,784,827],"an":[597,611,625,638,654,666,678,693,706,736,753,785,828],"entity's":[598,612,626,639,655,667,679,694,707,737,754,786,829],"Board":[599,613,627,640,656,668,680,695,708,738,755,787,830],"Directors":[601,615,629,642,658,670,682,697,710,740,757,789,832],"advisory":[603,617,631,644,660,672,684,699,712,742,759,791,834],"committees;":[604,618,645,661,673,685,700,713,743,760,792],"MolecularMD:":[605],"&":[620,719,724,730,763,767],"Lymphoma":[621],"Society:":[622],"committees,":[632],"Research":[633,648,746,772,774,779,798,801,804,807,810,813,816,819,822],"Funding;":[634,649,747,775,780,799,802,805,808,811,814,817,820,823],"Amgen:":[635],"Bristol-Meyers":[646],"Squibb:":[647],"Cepheid:":[650],"Beta":[662],"Cat:":[663],"ALLCRON:":[674],"Aptose":[686],"Therapeutics:":[687,715,750],"Gilead":[701],"Sciences:":[702],"Aileron":[714],"Millipore:":[717],"Patents":[718,723,729,766],"Royalties;":[720,725,731,768],"McGraw":[721],"Hill:":[722],"Henry":[726],"Stewart":[727],"Talks:":[728],"GRAIL:":[732],"Novartis":[744],"Pharmaceuticals:":[745],"Third":[748],"Coast":[749],"Oregon":[761],"Health":[762],"Science":[764],"University:":[765],"Fred":[769],"Hutchinson":[770],"Cancer":[771],"Center:":[773],"Monojul:":[776],"ARIAD:":[778],"Vivid":[781,824],"Biosciences:":[782,825],"Patient":[793],"True":[794],"Talk:":[795],"Consultancy.":[796],"Tyner:Genentech:":[797],"Aptose:":[800],"Janssen:":[803],"Array:":[806],"Incyte:":[809],"Takeda:":[812],"AstraZeneca:":[815],"Constellation:":[818],"Gilead:":[821],"committees.":[835]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-01-01T00:00:00"}
