{"id":"https://openalex.org/W2905682255","doi":"https://doi.org/10.1093/jjco/hyy187","title":"Clinical outcomes following conventional external beam radiotherapy boost in Japanese patients with cervical cancer who are ineligible for intracavitary brachytherapy","display_name":"Clinical outcomes following conventional external beam radiotherapy boost in Japanese patients with cervical cancer who are ineligible for intracavitary brachytherapy","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2905682255","doi":"https://doi.org/10.1093/jjco/hyy187","mag":"2905682255","pmid":"https://pubmed.ncbi.nlm.nih.gov/30576504"},"language":"en","primary_location":{"id":"doi:10.1093/jjco/hyy187","doi":"https://doi.org/10.1093/jjco/hyy187","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jjco/hyy187","pdf_url":null,"source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081787271","display_name":"Kei Ito","orcid":"https://orcid.org/0000-0001-5792-3795","observed_orcids":["https://orcid.org/0000-0001-5792-3795","https://orcid.org/0000-0003-4695-5227"]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kei Ito","raw_affiliation_strings":["Department of Radiology, Division of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Division of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049066873","display_name":"Takuya Shimizuguchi","orcid":"https://orcid.org/0000-0001-9763-0743","observed_orcids":["https://orcid.org/0000-0001-9763-0743"]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Shimizuguchi","raw_affiliation_strings":["Department of Radiology, Division of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Division of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103126127","display_name":"Katsuyuki Karasawa","orcid":"https://orcid.org/0000-0003-3505-2655","observed_orcids":["https://orcid.org/0000-0003-3505-2655"]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyuki Karasawa","raw_affiliation_strings":["Department of Radiology, Division of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Division of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I3020605285"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081787271"],"corresponding_institution_ids":["https://openalex.org/I3020605285"],"apc_list":{"value":3604,"currency":"USD","value_usd":3604},"apc_paid":null,"fwci":1.8996,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84688884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"49","issue":"3","first_page":"270","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/external-beam-radiotherapy-boost","display_name":"external beam radiotherapy boost","score":0.9610000252723694},{"id":"https://openalex.org/keywords/locally-advanced-cervical-cancer","display_name":"locally advanced cervical cancer","score":0.9399999976158142},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9079999923706055},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9150000214576721},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/radiation-adverse-events","display_name":"radiation adverse events","score":0.6010000109672546},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9457526206970215},{"id":"https://openalex.org/C2775908122","wikidata":"https://www.wikidata.org/wiki/Q3070621","display_name":"External beam radiotherapy","level":4,"score":0.8452459573745728},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.8033533096313477},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.7688233852386475},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7256879210472107},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5513119101524353},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.45905622839927673},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.4195000231266022},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4078335762023926},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3867560029029846},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3262248933315277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3135228157043457},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.28021401166915894},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.18519628047943115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001918","descriptor_name":"Brachytherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010388","descriptor_name":"Pelvis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010388","descriptor_name":"Pelvis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jjco/hyy187","doi":"https://doi.org/10.1093/jjco/hyy187","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jjco/hyy187","pdf_url":null,"source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:30576504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30576504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of clinical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322299","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1971646270","https://openalex.org/W1980908298","https://openalex.org/W1985214870","https://openalex.org/W2019607817","https://openalex.org/W2022889321","https://openalex.org/W2045842425","https://openalex.org/W2046727315","https://openalex.org/W2065574271","https://openalex.org/W2076075334","https://openalex.org/W2101957247","https://openalex.org/W2105240431","https://openalex.org/W2120661828","https://openalex.org/W2121960517","https://openalex.org/W2142450264","https://openalex.org/W2151262158","https://openalex.org/W2155798732","https://openalex.org/W2157372207","https://openalex.org/W2496556253","https://openalex.org/W2608166935","https://openalex.org/W2779019585","https://openalex.org/W2783573457","https://openalex.org/W2801957051"],"related_works":["https://openalex.org/W1974664200","https://openalex.org/W2151262158","https://openalex.org/W7161141588","https://openalex.org/W2769228745","https://openalex.org/W4392634327","https://openalex.org/W3089492568","https://openalex.org/W3088417992","https://openalex.org/W2897213055","https://openalex.org/W3129685147","https://openalex.org/W4412746198"],"abstract_inverted_index":{"OBJECTIVE:":[0],"While":[1],"external":[2,42,56,71,236],"beam":[3,43,57,72,237],"radiotherapy":[4,44,58,73,155,238],"boost":[5,239],"has":[6],"been":[7],"one":[8],"of":[9,101,123,139,145,190,198,229,241,255,268],"the":[10,175,253],"standard":[11],"management":[12],"options":[13],"for":[14,59,63,263],"locally":[15],"advanced":[16],"cervical":[17,38,60,232],"cancer":[18,39,61,233],"that":[19],"is":[20],"not":[21],"treatable":[22],"with":[23,37,54,214,231,235,265],"intracavitary":[24,64,242],"brachytherapy,":[25,65],"its":[26],"efficacy":[27],"remains":[28],"unclear.":[29],"We":[30],"assessed":[31],"clinical":[32,120],"outcomes":[33,217],"in":[34],"Japanese":[35],"patients":[36,146,230,264],"who":[40],"underwent":[41],"alone":[45],"and":[46,70,85,92,116,125,132,167,172,182,187,200,204,221,270,274],"identified":[47],"related":[48],"prognostic":[49],"factors.":[50],"METHODS:":[51],"Patients":[52],"treated":[53,234],"definitive":[55],"unsuitable":[62],"including":[66],"whole":[67],"pelvic":[68],"irradiation":[69],"boost,":[74],"were":[75,80,95,170,180,212],"retrospectively":[76],"examined.":[77],"The":[78,105,150,161],"endpoints":[79],"progression-free":[81,102,162,191],"survival,":[82],"overall":[83,177],"survival":[84,163,178,192],"adverse":[86],"events.":[87],"Additionally,":[88],"various":[89],"patient-,":[90],"tumor-":[91],"treatment-specific":[93],"factors":[94],"evaluated":[96],"to":[97],"identify":[98],"significant":[99],"predictors":[100],"survival.":[103],"RESULTS:":[104],"study":[106],"included":[107],"37":[108],"patients;":[109],"3":[110],"(8%),":[111],"5":[112],"(14%),":[113],"17":[114,157],"(46%)":[115],"12":[117],"(32%)":[118],"had":[119],"International":[121,196,266],"Federation":[122,197,267],"Gynecology":[124,199,269],"Obstetrics":[126,201,271],"(FIGO)":[127],"stages":[128],"I,":[129],"II,":[130],"III":[131],"IVA,":[133],"respectively.":[134,184],"A":[135],"total":[136],"radiation":[137],"dose":[138],"56-70.2":[140],"Gy":[141],"was":[142,156],"administered":[143],"(84%":[144],"received":[147],"59.4-60.4":[148],"Gy).":[149],"median":[151],"follow-up":[152],"period":[153],"after":[154],"(range,":[158],"2-84)":[159],"months.":[160],"rates":[164,179],"at":[165,193],"1":[166],"2":[168,194,248],"years":[169],"45":[171],"29%,":[173],"respectively;":[174],"corresponding":[176],"74":[181],"43%,":[183],"On":[185],"univariate":[186],"multivariate":[188],"analyses":[189],"years,":[195],"stage":[202,272],"IVA":[203,273],"a":[205],"maximum":[206],"primary":[207,276],"tumor":[208],"diameter":[209],">5":[210],"cm":[211],"associated":[213],"significantly":[215],"worse":[216],"(P":[218],"=":[219,223],"0.026":[220],"P":[222],"0.027,":[224],"respectively).":[225],"CONCLUSION:":[226],"Approximately":[227],"70%":[228],"instead":[240],"brachytherapy":[243,259],"experienced":[244],"disease":[245],"progression":[246],"within":[247],"years.":[249],"These":[250],"results":[251],"stress":[252],"necessity":[254],"devising":[256],"alternative":[257],"non-intracavitary":[258],"treatment":[260],"approaches,":[261],"particularly":[262],"bulky":[275],"tumors.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-01T00:00:00"}
