{"id":"https://openalex.org/W2905428211","doi":"https://doi.org/10.1021/acsabm.8b00562","title":"How Cross-Linking Mechanisms of Methacrylated Gellan Gum Hydrogels Alter Macrophage Phenotype","display_name":"How Cross-Linking Mechanisms of Methacrylated Gellan Gum Hydrogels Alter Macrophage Phenotype","publication_year":2018,"publication_date":"2018-12-07","ids":{"openalex":"https://openalex.org/W2905428211","doi":"https://doi.org/10.1021/acsabm.8b00562","mag":"2905428211","pmid":"https://pubmed.ncbi.nlm.nih.gov/35016344"},"language":"en","primary_location":{"id":"doi:10.1021/acsabm.8b00562","doi":"https://doi.org/10.1021/acsabm.8b00562","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.8b00562","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086311823","display_name":"Zhuqing Li","orcid":"https://orcid.org/0009-0003-6568-7202","observed_orcids":["https://orcid.org/0009-0003-6568-7202"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuqing Li","raw_affiliation_strings":["Department of Materials Science & Engineering, Iowa State University, Ames, Iowa 50011, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science & Engineering, Iowa State University, Ames, Iowa 50011, United States","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062005382","display_name":"Kaitlin M. Bratlie","orcid":"https://orcid.org/0000-0002-5197-0176","observed_orcids":["https://orcid.org/0000-0002-5197-0176"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I2802789608","display_name":"Ames National Laboratory","ror":"https://ror.org/041m9xr71","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I173911158","https://openalex.org/I2802789608","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kaitlin M. Bratlie","raw_affiliation_strings":["Department of Chemical & Biological Engineering, Iowa State University, Ames, Iowa 50011, United States","Department of Materials Science & Engineering, Iowa State University, Ames, Iowa 50011, United States","Division of Materials Sciences & Engineering, Ames National Laboratory, Ames, Iowa 50011, United States"],"raw_orcid":"https://orcid.org/0000-0002-5197-0176","affiliations":[{"raw_affiliation_string":"Department of Chemical & Biological Engineering, Iowa State University, Ames, Iowa 50011, United States","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Department of Materials Science & Engineering, Iowa State University, Ames, Iowa 50011, United States","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Division of Materials Sciences & Engineering, Ames National Laboratory, Ames, Iowa 50011, United States","institution_ids":["https://openalex.org/I2802789608"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062005382"],"corresponding_institution_ids":["https://openalex.org/I173911158","https://openalex.org/I2802789608"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7581,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.64361269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2","issue":"1","first_page":"217","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-phenotype","display_name":"macrophage phenotype","score":0.9200000166893005},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.859000027179718},{"id":"https://openalex.org/keywords/thiol-ene-crosslinking","display_name":"thiol-ene crosslinking","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ionic-crosslinking","display_name":"ionic crosslinking","score":0.9110000133514404},{"id":"https://openalex.org/keywords/calcium-crosslinking","display_name":"calcium crosslinking","score":0.7160000205039978},{"id":"https://openalex.org/keywords/substrate-stiffness","display_name":"substrate stiffness","score":0.7400000095367432},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nitrite-production","display_name":"nitrite production","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.7630000114440918},{"id":"https://openalex.org/keywords/biomedical-implants","display_name":"biomedical implants","score":0.6320000290870667},{"id":"https://openalex.org/keywords/host-response","display_name":"host response","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2781220964","wikidata":"https://www.wikidata.org/wiki/Q416694","display_name":"Gellan gum","level":2,"score":0.9432039856910706},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.8639057278633118},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5711766481399536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5475224256515503},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4333966076374054},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2189033031463623},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.16182926297187805},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1504921317100525},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13089513778686523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/acsabm.8b00562","doi":"https://doi.org/10.1021/acsabm.8b00562","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.8b00562","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},{"id":"pmid:35016344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35016344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied bio materials","raw_type":"Journal Article"},{"id":"pmh:oai:lib.dr.iastate.edu:mse_pubs-1321","doi":null,"is_oa":false,"landing_page_url":"https://lib.dr.iastate.edu/mse_pubs/318","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Materials Science and Engineering Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G160853578","display_name":null,"funder_award_id":"13\u20134265","funder_id":"https://openalex.org/F4320306274","funder_display_name":"Roy J. Carver Charitable Trust"}],"funders":[{"id":"https://openalex.org/F4320306274","display_name":"Roy J. Carver Charitable Trust","ror":"https://ror.org/01ah2ch91"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1149703769","https://openalex.org/W1489759013","https://openalex.org/W1800487788","https://openalex.org/W1893790899","https://openalex.org/W1959993328","https://openalex.org/W1966296130","https://openalex.org/W1969049128","https://openalex.org/W1990249097","https://openalex.org/W1995528629","https://openalex.org/W1999382841","https://openalex.org/W2004105242","https://openalex.org/W2017254150","https://openalex.org/W2019811317","https://openalex.org/W2020352995","https://openalex.org/W2027280434","https://openalex.org/W2048166553","https://openalex.org/W2052634646","https://openalex.org/W2067617591","https://openalex.org/W2070173212","https://openalex.org/W2077713404","https://openalex.org/W2083080528","https://openalex.org/W2085701716","https://openalex.org/W2089023014","https://openalex.org/W2096147603","https://openalex.org/W2114118213","https://openalex.org/W2114124979","https://openalex.org/W2130764540","https://openalex.org/W2135479557","https://openalex.org/W2140380746","https://openalex.org/W2143695056","https://openalex.org/W2147712642","https://openalex.org/W2149466673","https://openalex.org/W2171253547","https://openalex.org/W2234275440","https://openalex.org/W2290591367","https://openalex.org/W2324067007","https://openalex.org/W2443767567","https://openalex.org/W2471594003","https://openalex.org/W2482650304","https://openalex.org/W2508586975","https://openalex.org/W2533102687","https://openalex.org/W2560134761","https://openalex.org/W2581595789","https://openalex.org/W2591517555","https://openalex.org/W2607750507","https://openalex.org/W2617095879","https://openalex.org/W2811370059"],"related_works":["https://openalex.org/W3013067729","https://openalex.org/W4417347207","https://openalex.org/W3177845529","https://openalex.org/W2326884802","https://openalex.org/W4393303984","https://openalex.org/W3149420077","https://openalex.org/W4415132208","https://openalex.org/W3195975756","https://openalex.org/W4226042047","https://openalex.org/W4393304103"],"abstract_inverted_index":{"In":[0,55],"tissue":[1],"engineering":[2],"scaffolds,":[3],"macrophages":[4,93,135],"play":[5],"a":[6,26],"critical":[7],"role":[8],"in":[9],"determining":[10],"the":[11,22,51,60,74,138,163,170,178,189,196],"host":[12,23],"response":[13,52],"to":[14,37,45,137,184],"implanted":[15],"biomaterials.":[16],"Macrophage":[17],"phenotype":[18,70,180],"is":[19,30,43,186],"dynamic":[20],"throughout":[21],"response,":[24],"and":[25,71,88,108,120,132,143,195],"balance":[27],"of":[28,53,62,77,81,127,169,198],"phenotypes":[29],"essential":[31],"for":[32,146,167],"timely":[33],"progression":[34],"from":[35,129,182],"injury":[36],"proper":[38],"wound":[39],"healing.":[40],"Therefore,":[41],"it":[42],"important":[44],"predict":[46],"how":[47],"materials":[48],"will":[49],"modulate":[50],"macrophages.":[54],"this":[56],"study,":[57],"we":[58],"investigated":[59],"effect":[61],"methacrylated":[63,97,199],"gellan":[64,98,200],"gum":[65,99,201],"(GG)":[66],"hydrogels":[67,100,116],"on":[68,96],"macrophage":[69,172,179],"proliferation":[72,164],"with":[73,86,104],"ultimate":[75],"goal":[76],"improving":[78],"rational":[79],"design":[80],"biomedical":[82],"implants.":[83],"Na\u00efve,":[84],"along":[85],"classically":[87,133],"alternatively":[89,147],"activated":[90,134,148],"RAW":[91],"264.7":[92],"were":[94,102],"seeded":[95],"that":[101,114,177],"fabricated":[103],"different":[105,190],"thiol-ene":[106],"ratios":[107],"cross-linking":[109,191],"mechanisms.":[110],"Live/dead":[111],"assays":[112],"showed":[113],"all":[115],"supported":[117],"cell":[118],"attachment":[119],"proliferation.":[121],"Stiffer":[122],"substrates":[123],"enhanced":[124],"anti-inflammatory":[125],"production":[126],"nitrites":[128],"both":[130],"na\u00efve":[131],"compared":[136],"softer":[139],"substrates.":[140],"Moreover,":[141],"arginine":[142],"CD206":[144],"expression-markers":[145],"macrophages-were":[149],"inhibited":[150],"by":[151,188],"higher":[152],"thiol":[153],"content.":[154],"Introducing":[155],"ionic":[156],"cross-links":[157],"using":[158],"calcium":[159],"did":[160],"not":[161],"influence":[162],"or":[165],"polarization":[166],"any":[168],"three":[171],"phenotypes.":[173],"Our":[174],"results":[175],"suggest":[176],"shift":[181],"M1":[183],"M2":[185],"controlled":[187],"mechanisms,":[192],"physical":[193],"properties,":[194],"chemistry":[197],"hydrogels.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2018-12-22T00:00:00"}
