{"id":"https://openalex.org/W29051884","doi":null,"title":"Brain metastases in renal cell carcinoma: management with gamma knife radiosurgery.","display_name":"Brain metastases in renal cell carcinoma: management with gamma knife radiosurgery.","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W29051884","mag":"29051884","pmid":"https://pubmed.ncbi.nlm.nih.gov/11131486"},"language":"en","primary_location":{"id":"pmid:11131486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11131486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer journal (Sudbury, Mass.)","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103003533","display_name":"Beatriz E. Amendola","orcid":"https://orcid.org/0000-0002-8335-0035","observed_orcids":["https://orcid.org/0000-0002-8335-0035"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B E Amendola","raw_affiliation_strings":["Miami Neuroscience Center, Coral Gables, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami Neuroscience Center, Coral Gables, Florida, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112835361","display_name":"Aizik L. Wolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Wolf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005851714","display_name":"Sammie Coy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S R Coy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Amendola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Amendola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"L Bloch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Bloch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9062,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.85104302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"6","first_page":"372","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8939999938011169},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/gamma-knife-radiosurgery","display_name":"gamma knife radiosurgery","score":0.9879999756813049},{"id":"https://openalex.org/keywords/whole-brain-radiotherapy","display_name":"whole brain radiotherapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/local-control","display_name":"local control","score":0.8500000238418579},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.9810000061988831},{"id":"https://openalex.org/keywords/radiation-necrosis","display_name":"radiation necrosis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/multiple-brain-metastases","display_name":"multiple brain metastases","score":0.7559999823570251},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8756231069564819},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.8671836853027344},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.826012134552002},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.5463106036186218},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5183204412460327},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.49034810066223145},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4541241526603699},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4462837874889374},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3863566219806671},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3669886589050293},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.34259647130966187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17905959486961365},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17000922560691833}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016634","descriptor_name":"Radiosurgery","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11131486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11131486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer journal (Sudbury, Mass.)","raw_type":"Clinical Trial"},{"id":"mag:29051884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11131486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2238882375"],"related_works":["https://openalex.org/W4245728384","https://openalex.org/W2029304967","https://openalex.org/W1970777620","https://openalex.org/W2078359283","https://openalex.org/W4242130115","https://openalex.org/W2025135672","https://openalex.org/W2133534290","https://openalex.org/W7063462604","https://openalex.org/W2346970997","https://openalex.org/W3009234232"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,49,72,81,96,148,202],"purpose":[2],"of":[3,13,83,122,150,167,177,184,188,219,235,246],"this":[4],"study":[5],"was":[6,101,108,115,136,194],"to":[7,89,156],"evaluate":[8],"survival":[9,176,204],"and":[10,77,104,140,243,248],"local":[11,192,240],"control":[12,193,241],"brain":[14,221],"metastases":[15],"in":[16,117,206,216],"patients":[17,44,85,124,130,171,186,207],"with":[18,45,126,173,208],"renal":[19,46,209,227],"cell":[20,47,210,228],"carcinoma.":[21,48],"METHODS":[22],"AND":[23],"MATERIALS:":[24],"From":[25],"November":[26],"1993":[27],"through":[28],"March":[29],"1999,":[30],"38":[31,88],"radiosurgical":[32,64],"treatments":[33,65],"using":[34],"the":[35,84,105,217],"Leksell":[36],"gamma":[37],"knife":[38,224],"unit":[39],"were":[40,53,66,131],"performed":[41],"on":[42,68],"22":[43,123],"indications":[50],"for":[51,145,226],"treatment":[52],"failure":[54],"after":[55],"whole-brain":[56,112],"radiation":[57,113,199],"therapy":[58,114],"or":[59],"de":[60],"novo":[61],"treatment.":[62,236],"All":[63],"given":[67],"an":[69,231],"outpatient":[70],"basis.":[71],"workup":[73],"included":[74],"computed":[75],"tomography":[76],"magnetic":[78],"resonance":[79],"imaging.":[80],"age":[82],"ranged":[86,153],"from":[87,154],"80":[90],"years":[91],"(median":[92],"age,":[93],"60":[94],"years).":[95],"mean":[97,106],"minimum":[98],"tumor":[99],"dose":[100],"18":[102],"Gy,":[103],"volume":[107],"3.9":[109],"cc.":[110],"Previous":[111],"used":[116],"11/22":[118],"(50%)":[119],"patients.":[120],"Four":[121],"presented":[125],"single":[127],"metastasis.":[128],"Thirteen":[129],"treated":[132,137,152],"once,":[133],"one":[134,141,155],"patient":[135,142,160,197],"four":[138],"times":[139,144],"seven":[143],"new":[146],"lesions.":[147],"number":[149],"lesions":[151],"21.":[157],"RESULTS:":[158],"One":[159,196],"is":[161,230],"al":[162],"ive":[163],"at":[164],"63":[165],"months":[166,179],"fol":[168],"low-up.":[169],"Twenty-one":[170],"died,":[172],"a":[174],"median":[175],"8":[178],"(range,":[180],"1-38":[181],"months).":[182],"Eighteen":[183],"21":[185],"died":[187],"nonneurologic":[189],"causes.":[190],"Overall":[191],"98.5%.":[195],"developed":[198],"necrosis.":[200],"CONCLUSIONS":[201],"long-term":[203],"achieved":[205],"carcinoma":[211,229],"requires":[212],"aggressive":[213],"management,":[214],"even":[215],"presence":[218],"multiple":[220],"metastases.":[222],"Gamma":[223],"radiosurgery":[225],"effective":[232],"noninvasive":[233],"modality":[234],"It":[237],"offers":[238],"high":[239],"rate":[242],"improved":[244],"quality":[245],"life":[247],"survival.":[249]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}