{"id":"https://openalex.org/W2905047533","doi":"https://doi.org/10.2478/acph-2019-0003","title":"Sesquiterpenes \u03b1-humulene and \u03b2-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells","display_name":"Sesquiterpenes \u03b1-humulene and \u03b2-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells","publication_year":2018,"publication_date":"2018-12-07","ids":{"openalex":"https://openalex.org/W2905047533","doi":"https://doi.org/10.2478/acph-2019-0003","mag":"2905047533","pmid":"https://pubmed.ncbi.nlm.nih.gov/31259712"},"language":"en","primary_location":{"id":"doi:10.2478/acph-2019-0003","doi":"https://doi.org/10.2478/acph-2019-0003","is_oa":true,"landing_page_url":"https://doi.org/10.2478/acph-2019-0003","pdf_url":"https://content.sciendo.com/downloadpdf/journals/acph/69/1/article-p121.pdf","source":{"id":"https://openalex.org/S6622299","display_name":"Acta Pharmaceutica","issn_l":"1330-0075","issn":["1330-0075","1846-9558"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://content.sciendo.com/downloadpdf/journals/acph/69/1/article-p121.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067256960","display_name":"Martin Ambro\u017e","orcid":"https://orcid.org/0000-0002-4626-1025","observed_orcids":["https://orcid.org/0000-0002-4626-1025"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Martin Ambro\u017e","raw_affiliation_strings":["Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078321792","display_name":"Mark\u00e9ta \u0160matov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Mark\u00e9ta \u0160matov\u00e1","raw_affiliation_strings":["Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089201085","display_name":"Michaela \u0160adibolov\u00e1","orcid":"https://orcid.org/0000-0002-5527-3802","observed_orcids":["https://orcid.org/0000-0002-5527-3802"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michaela \u0160adibolov\u00e1","raw_affiliation_strings":["Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005079691","display_name":"Eva Posp\u00ed\u0161ilov\u00e1","orcid":"https://orcid.org/0009-0008-9597-791X","observed_orcids":["https://orcid.org/0009-0008-9597-791X"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Eva Posp\u00ed\u0161ilov\u00e1","raw_affiliation_strings":["Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051342378","display_name":"Pavl\u00edna Hadravsk\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Pavl\u00edna Hadravsk\u00e1","raw_affiliation_strings":["Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michaela Ka\u0161parov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michaela Ka\u0161parov\u00e1","raw_affiliation_strings":["Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074301558","display_name":"Veronika Skarkov\u00e1","orcid":"https://orcid.org/0000-0002-4244-799X","observed_orcids":["https://orcid.org/0000-0002-4244-799X"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Veronika Hanu\u0161ov\u00e1 Skarkov\u00e1","raw_affiliation_strings":["Department of Medical Biology and Genetics , Charles University in Prague Faculty of Medicine in Hradec Kr\u00e1lov\u00e9 \u0160imkova 870, Hradec Kr\u00e1lov\u00e9 CZ-500 38 , Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Genetics , Charles University in Prague Faculty of Medicine in Hradec Kr\u00e1lov\u00e9 \u0160imkova 870, Hradec Kr\u00e1lov\u00e9 CZ-500 38 , Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057502131","display_name":"V\u011bra Kr\u00e1lov\u00e1","orcid":"https://orcid.org/0000-0001-5971-4110","observed_orcids":["https://orcid.org/0000-0001-5971-4110"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"V\u011bra Kr\u00e1lov\u00e1","raw_affiliation_strings":["Department of Medical Biology and Genetics , Charles University in Prague Faculty of Medicine in Hradec Kr\u00e1lov\u00e9 \u0160imkova 870, Hradec Kr\u00e1lov\u00e9 CZ-500 38 , Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Genetics , Charles University in Prague Faculty of Medicine in Hradec Kr\u00e1lov\u00e9 \u0160imkova 870, Hradec Kr\u00e1lov\u00e9 CZ-500 38 , Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004289752","display_name":"Lenka Sk\u00e1lov\u00e1","orcid":"https://orcid.org/0000-0003-0741-3871","observed_orcids":["https://orcid.org/0000-0003-0741-3871"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Lenka Sk\u00e1lov\u00e1","raw_affiliation_strings":["Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004289752"],"corresponding_institution_ids":["https://openalex.org/I21250087"],"apc_list":{"value":900,"currency":"EUR","value_usd":970},"apc_paid":{"value":900,"currency":"EUR","value_usd":970},"fwci":1.9595,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.86062681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"69","issue":"1","first_page":"121","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sesquiterpenes","display_name":"sesquiterpenes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/alpha-humulene","display_name":"\u03b1-humulene","score":0.9660000205039978},{"id":"https://openalex.org/keywords/caryophyllene-oxide","display_name":"caryophyllene oxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/valencene","display_name":"valencene","score":0.9739999771118164},{"id":"https://openalex.org/keywords/trans-nerolidol","display_name":"trans-nerolidol","score":0.996999979019165},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":1.0},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6039999723434448},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9490000009536743},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/sw620-cells","display_name":"SW620 cells","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.8901859521865845},{"id":"https://openalex.org/C2777291603","wikidata":"https://www.wikidata.org/wiki/Q1995108","display_name":"Humulene","level":3,"score":0.7113999724388123},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6870737671852112},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6346719861030579},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.622600257396698},{"id":"https://openalex.org/C2778706202","wikidata":"https://www.wikidata.org/wiki/Q358375","display_name":"Agarwood","level":3,"score":0.5310388207435608},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5269278287887573},{"id":"https://openalex.org/C2778905741","wikidata":"https://www.wikidata.org/wiki/Q72494054","display_name":"Nerolidol","level":4,"score":0.5240293145179749},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5131497979164124},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4576948285102844},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44813475012779236},{"id":"https://openalex.org/C2776211264","wikidata":"https://www.wikidata.org/wiki/Q80218","display_name":"Sesquiterpene","level":2,"score":0.4371489882469177},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3912576138973236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38449162244796753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32468271255493164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23296254873275757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23175275325775146},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2181376814842224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12144285440444946},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07754117250442505},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0761629045009613},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779729912","wikidata":"https://www.wikidata.org/wiki/Q410932","display_name":"Linalool","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000081222","descriptor_name":"Monocyclic Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000081223","descriptor_name":"Polycyclic Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2478/acph-2019-0003","doi":"https://doi.org/10.2478/acph-2019-0003","is_oa":true,"landing_page_url":"https://doi.org/10.2478/acph-2019-0003","pdf_url":"https://content.sciendo.com/downloadpdf/journals/acph/69/1/article-p121.pdf","source":{"id":"https://openalex.org/S6622299","display_name":"Acta Pharmaceutica","issn_l":"1330-0075","issn":["1330-0075","1846-9558"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica","raw_type":"journal-article"},{"id":"pmid:31259712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31259712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmaceutica (Zagreb, Croatia)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:984dafe5b5f846dc8a00a5f9063c1539","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/984dafe5b5f846dc8a00a5f9063c1539","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharmaceutica, Vol 69, Iss 1, Pp 121-128 (2019)","raw_type":"article"},{"id":"pmh:oai:hrcak.srce.hr:203824","doi":null,"is_oa":true,"landing_page_url":"https://hrcak.srce.hr/203824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharmaceutica","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2478/acph-2019-0003","doi":"https://doi.org/10.2478/acph-2019-0003","is_oa":true,"landing_page_url":"https://doi.org/10.2478/acph-2019-0003","pdf_url":"https://content.sciendo.com/downloadpdf/journals/acph/69/1/article-p121.pdf","source":{"id":"https://openalex.org/S6622299","display_name":"Acta Pharmaceutica","issn_l":"1330-0075","issn":["1330-0075","1846-9558"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1392344949","display_name":null,"funder_award_id":"SVV260416","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"},{"id":"https://openalex.org/G1771545823","display_name":"Centre of drug-dietary supplements interactions and nutrigenetics","funder_award_id":"GBP303/12/G163","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G2290185683","display_name":null,"funder_award_id":"P303/12/G163","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"}],"funders":[{"id":"https://openalex.org/F4320309755","display_name":"Univerzita Karlova v Praze","ror":"https://ror.org/024d6js02"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2905047533.pdf","grobid_xml":"https://content.openalex.org/works/W2905047533.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1786522444","https://openalex.org/W1910284107","https://openalex.org/W1975558044","https://openalex.org/W1986462113","https://openalex.org/W2013072274","https://openalex.org/W2036451832","https://openalex.org/W2086836946","https://openalex.org/W2096439168","https://openalex.org/W2104510791","https://openalex.org/W2126891371","https://openalex.org/W2274106006","https://openalex.org/W2586778891","https://openalex.org/W2720104353"],"related_works":["https://openalex.org/W7135850216","https://openalex.org/W7135750578","https://openalex.org/W7135533985","https://openalex.org/W4321789925","https://openalex.org/W7135506805","https://openalex.org/W2985372050","https://openalex.org/W2753718788","https://openalex.org/W4392459543","https://openalex.org/W2578628508","https://openalex.org/W7135778564"],"abstract_inverted_index":{"The":[0,54,90],"present":[1],"study":[2],"is":[3],"designed":[4],"to":[5,21,65,101,108,125],"find":[6],"out":[7],"if":[8],"sesquiterpenes,":[9],"\u03b1-humulene":[10],"(HUM),":[11],"valencene":[12],"(VAL),":[13],"\u03b2-caryphyllene-oxide":[14],"(CAO)":[15],"and":[16,32,42,61,72,79,86,107,135],"trans-nerolidol":[17],"(NER),":[18],"are":[19,52,88,115],"able":[20],"improve":[22],"the":[23,46,67,82,103,127],"antiproliferative":[24],"effect":[25],"of":[26,49,59,63,70,92,132],"classical":[27],"cytostatic":[28],"drugs,":[29],"5-fluorouracil":[30],"(FU)":[31],"oxaliplatin":[33],"(1,2-diaminocyclohexaneoxalato-platinum,":[34],"OxPt),":[35],"in":[36,74],"colon":[37,133],"cancer":[38,75],"cell":[39,76],"lines":[40,77],"Caco-2":[41,78],"SW-620.":[43,80],"In":[44],"addition,":[45],"possible":[47],"mechanisms":[48,114],"sesquiterpene":[50],"action":[51,91],"studied.":[53],"results":[55],"show":[56],"significant":[57],"ability":[58,100],"HUM":[60],"especially":[62],"CAO":[64,93,123],"enhance":[66],"anti-proliferative":[68],"effects":[69],"FU":[71],"OxPt":[73],"On":[81],"other":[83,113],"hand,":[84],"VAL":[85],"NER":[87],"ineffective.":[89],"could":[94],"be":[95],"partly":[96],"based":[97],"on":[98,120],"its":[99],"disrupt":[102],"mitochondrial":[104],"membrane":[105],"potential":[106,128],"activate":[109],"initiator":[110],"caspases,":[111],"but":[112],"probably":[116],"also":[117],"involved.":[118],"Based":[119],"these":[121],"results,":[122],"seems":[124],"have":[126],"for":[129],"combination":[130],"therapy":[131],"cancers":[134],"deserves":[136],"further":[137],"study.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-22T00:00:00"}