{"id":"https://openalex.org/W2904965415","doi":"https://doi.org/10.22456/1679-9216.88542","title":"Effects of Flunixin Meglumine on Oxidant and Antioxidant System after Disbudding with Caustic Paste in Calves","display_name":"Effects of Flunixin Meglumine on Oxidant and Antioxidant System after Disbudding with Caustic Paste in Calves","publication_year":2018,"publication_date":"2018-10-27","ids":{"openalex":"https://openalex.org/W2904965415","doi":"https://doi.org/10.22456/1679-9216.88542","mag":"2904965415"},"language":"en","primary_location":{"id":"doi:10.22456/1679-9216.88542","doi":"https://doi.org/10.22456/1679-9216.88542","is_oa":true,"landing_page_url":"https://doi.org/10.22456/1679-9216.88542","pdf_url":"https://seer.ufrgs.br/ActaScientiaeVeterinariae/article/download/88542/50904","source":{"id":"https://openalex.org/S167064729","display_name":"ACTA SCIENTIAE VETERINARIAE","issn_l":"1678-0345","issn":["1678-0345","1679-9216"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310312571","host_organization_name":"Federal University of Rio Grande do Sul","host_organization_lineage":["https://openalex.org/P4310312571"],"host_organization_lineage_names":["Federal University of Rio Grande do Sul"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Scientiae Veterinariae","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://seer.ufrgs.br/ActaScientiaeVeterinariae/article/download/88542/50904","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023758423","display_name":"Selvinaz Yakan","orcid":"https://orcid.org/0000-0002-6274-9012","observed_orcids":["https://orcid.org/0000-0002-6274-9012"]},"institutions":[{"id":"https://openalex.org/I307617284","display_name":"A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University","ror":"https://ror.org/054y2mb78","country_code":"TR","type":"education","lineage":["https://openalex.org/I307617284"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Selvinaz Yakan","raw_affiliation_strings":["Department of Animal Health, Ele\u015fkirt Celal Oru\u00e7 Animal Production School, A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University, A\u011fr\u0131, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Health, Ele\u015fkirt Celal Oru\u00e7 Animal Production School, A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University, A\u011fr\u0131, Turkey","institution_ids":["https://openalex.org/I307617284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016097070","display_name":"Vesile D\u00fczg\u00fcner","orcid":"https://orcid.org/0000-0002-4101-8480","observed_orcids":["https://orcid.org/0000-0002-4101-8480"]},"institutions":[{"id":"https://openalex.org/I133229071","display_name":"Ardahan University","ror":"https://ror.org/042ejbk14","country_code":"TR","type":"education","lineage":["https://openalex.org/I133229071"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Vesile Duzguner","raw_affiliation_strings":["School of Health Sciences, Ardahan University, Ardahan, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Sciences, Ardahan University, Ardahan, Turkey","institution_ids":["https://openalex.org/I133229071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083261430","display_name":"\u00d6zg\u00fcr Aksoy","orcid":"https://orcid.org/0000-0002-4800-6079","observed_orcids":["https://orcid.org/0000-0002-4800-6079"]},"institutions":[{"id":"https://openalex.org/I135987583","display_name":"Kafkas University","ror":"https://ror.org/04v302n28","country_code":"TR","type":"education","lineage":["https://openalex.org/I135987583"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozgur Aksoy","raw_affiliation_strings":["Faculty of Veterinary Medicine, Department of Surgery, Kafkas University, Kars, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Department of Surgery, Kafkas University, Kars, Turkey","institution_ids":["https://openalex.org/I135987583"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6366,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.82110036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"46","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10838","display_name":"Animal Behavior and Welfare Studies","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flunixin-meglumine","display_name":"flunixin meglumine","score":0.9390000104904175},{"id":"https://openalex.org/keywords/disbudding","display_name":"disbudding","score":0.9440000057220459},{"id":"https://openalex.org/keywords/calves","display_name":"calves","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7950000166893005},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.6660000085830688},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.777999997138977},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.925000011920929},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.7559999823570251},{"id":"https://openalex.org/keywords/simmental-cattle","display_name":"Simmental cattle","score":0.7139999866485596},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.7590000033378601},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6790338158607483},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6505485773086548},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.49108457565307617},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.4790421724319458},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16762199997901917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.22456/1679-9216.88542","doi":"https://doi.org/10.22456/1679-9216.88542","is_oa":true,"landing_page_url":"https://doi.org/10.22456/1679-9216.88542","pdf_url":"https://seer.ufrgs.br/ActaScientiaeVeterinariae/article/download/88542/50904","source":{"id":"https://openalex.org/S167064729","display_name":"ACTA SCIENTIAE VETERINARIAE","issn_l":"1678-0345","issn":["1678-0345","1679-9216"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310312571","host_organization_name":"Federal University of Rio Grande do Sul","host_organization_lineage":["https://openalex.org/P4310312571"],"host_organization_lineage_names":["Federal University of Rio Grande do Sul"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Scientiae Veterinariae","raw_type":"journal-article"},{"id":"pmh:oai:seer.ufrgs.br:article/88542","doi":null,"is_oa":false,"landing_page_url":"https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/88542","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:acikerisim.agri.edu.tr:20.500.12501/759","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12501/759","pdf_url":null,"source":{"id":"https://openalex.org/S7407055365","display_name":"A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Web of Science","raw_type":"article"}],"best_oa_location":{"id":"doi:10.22456/1679-9216.88542","doi":"https://doi.org/10.22456/1679-9216.88542","is_oa":true,"landing_page_url":"https://doi.org/10.22456/1679-9216.88542","pdf_url":"https://seer.ufrgs.br/ActaScientiaeVeterinariae/article/download/88542/50904","source":{"id":"https://openalex.org/S167064729","display_name":"ACTA SCIENTIAE VETERINARIAE","issn_l":"1678-0345","issn":["1678-0345","1679-9216"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310312571","host_organization_name":"Federal University of Rio Grande do Sul","host_organization_lineage":["https://openalex.org/P4310312571"],"host_organization_lineage_names":["Federal University of Rio Grande do Sul"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Scientiae Veterinariae","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2904965415.pdf","grobid_xml":"https://content.openalex.org/works/W2904965415.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1964658576","https://openalex.org/W1967533226","https://openalex.org/W1973603716","https://openalex.org/W1979202322","https://openalex.org/W1981579921","https://openalex.org/W1989024382","https://openalex.org/W1989133556","https://openalex.org/W1997496740","https://openalex.org/W1999799239","https://openalex.org/W2000297605","https://openalex.org/W2008126113","https://openalex.org/W2016887547","https://openalex.org/W2017286444","https://openalex.org/W2024334992","https://openalex.org/W2024694120","https://openalex.org/W2028213542","https://openalex.org/W2032520737","https://openalex.org/W2035538627","https://openalex.org/W2053484176","https://openalex.org/W2054618762","https://openalex.org/W2055434498","https://openalex.org/W2055503099","https://openalex.org/W2060287422","https://openalex.org/W2081827995","https://openalex.org/W2085731862","https://openalex.org/W2112450427","https://openalex.org/W2144794987","https://openalex.org/W2146053956","https://openalex.org/W2161747039","https://openalex.org/W2162748743","https://openalex.org/W2163926749","https://openalex.org/W2313023472","https://openalex.org/W2323827078","https://openalex.org/W2741465125","https://openalex.org/W2766947138","https://openalex.org/W2772737750","https://openalex.org/W2788918792","https://openalex.org/W2949586320","https://openalex.org/W2950922603","https://openalex.org/W2952110064","https://openalex.org/W3005130933","https://openalex.org/W3011036181","https://openalex.org/W3157713657","https://openalex.org/W4239932705"],"related_works":["https://openalex.org/W4214743316","https://openalex.org/W6887575283","https://openalex.org/W4220849675","https://openalex.org/W4210512500","https://openalex.org/W3157156817","https://openalex.org/W4281252786","https://openalex.org/W7138874660","https://openalex.org/W3033942865","https://openalex.org/W2049227391","https://openalex.org/W2055434498"],"abstract_inverted_index":{"Background:":[0],"Disbudding":[1],"is":[2,67,315,491],"often":[3],"practiced":[4],"in":[5,57,90,118,147,293,308,351,358,390,396,404,438,474,480,483],"modern":[6],"farm":[7],"because":[8],"of":[9,15,23,34,47,61,93,110,144,196,224,237,262,328,344,349,527],"the":[10,13,16,21,32,82,85,91,97,111,151,183,189,203,235,238,243,304,309,316,342,369,379,391,405,439,475,487,495,499,512,516,521,525],"reasons":[11],"for":[12,326,341],"safekeeping":[14],"animal,":[17],"other":[18],"animals":[19],"lessen":[20],"risk":[22],"injury":[24],"and":[25,42,52,87,101,128,164,202,219,227,257,265,276,297,319,355,393,418,429,446,464,529],"less":[26],"aggressive":[27],"behavior.":[28],"Without":[29],"regard":[30],"to":[31,37,59,80,302,485,493,507],"method":[33],"disbudding":[35,94,170,241,476,517],"leads":[36],"disruption":[38],"behavioral":[39,64],"changes,":[40],"cardiac":[41],"endocrine":[43,488],"responses":[44],"related":[45],"pain":[46,70,350],"animals.":[48],"Sedation,":[49],"local":[50,465],"anesthesia":[51,466,496],"analgesia":[53,248],"are":[54],"performed":[55,207,292],"studies":[56],"order":[58,484],"eliminate":[60],"cardiac,":[62],"endocrine,":[63],"response":[65],"which":[66,314],"caused":[68],"by":[69,95,208,336,364],"associated":[71],"with":[72,100,172,242,362,477,498],"disbudding.":[73],"In":[74,150,182,232,368],"this":[75],"study,":[76],"it":[77,490],"was":[78,113,199,206,375,387,519],"aimed":[79],"determine":[81,303],"effect":[83],"on":[84,121],"oxidant":[86,273],"antioxidant":[88,278,345,522],"system":[89],"calves":[92,117,146,239],"using":[96,338,365,408],"caustic":[98,156,173,209,478],"paste":[99,210,479],"without":[102,371,441],"painkiller.Materials,":[103],"Methods":[104],"&":[105],"Results:":[106],"The":[107,136],"animal":[108],"material":[109],"study":[112],"created":[114],"24":[115],"Simmentals":[116],"different":[119],"sexes":[120],"average":[122],"2":[123,126,142,180],"weeks":[124],"(\u00b1":[125,131],"days)":[127],"50":[129],"kg":[130],"15":[132],"kg)":[133],"live":[134],"weight.":[135],"cases":[137],"were":[138,177,214,230,240,252,268,291,300,334,360,402,435,452],"randomly":[139],"divided":[140,178],"into":[141,179],"groups":[143],"12":[145],"each":[148],"group.":[149,399],"group":[152,165,233,370,406,440],"I":[153,184],"(analgesia":[154],"group);":[155,168],"paste+painkiller":[157],"(2.2":[158],"mg-1":[159,198],"flunixin":[160,191,372,503],"meglumine":[161,192],"intravenous,":[162],"IV)":[163],"II":[166],"(non-analgesia":[167],"as":[169,462,468,502],"applied":[171],"pasta":[174],"application":[175],"only":[176],"groups.":[181,295],"group,":[185],"15th":[186,380,414],"min":[187,221,259,381,395,421],"before":[188,515],"application,":[190],"at":[193,216,254,413],"a":[194],"dose":[195],"2.2":[197],"administered":[200,398],"IV":[201],"horn":[204,225,263],"blunting":[205,226,264],"method.":[211],"Blood":[212,250],"samples":[213,251],"taken":[215,253],"15,":[217,255],"30":[218,256,392],"60th":[220,258,394,420],"after":[222,260],"completion":[223,261],"physiological":[228,266],"findings":[229,267],"recorded.":[231],"II,":[234],"horns":[236],"same":[244],"technique":[245],"(but":[246],"no":[247,388],"aplication).":[249],"record.":[269],"Cortisol,":[270],"glucose,":[271],"total":[272,277],"capacity":[274,279],"(TOC)":[275],"(TAC),":[280],"8-hydroxy-2\u2019-deoxyguanosine":[281],"(8-OHdG),":[282],"glutathione":[283],"(GSH),":[284],"superoxide":[285],"dismutase":[286],"(SOD)":[287],"enzymes":[288,333],"measurements":[289],"(ELISA)":[290,354],"both":[294],"TOC":[296,425],"TAC":[298],"tests":[299],"used":[301,412],"oxidative":[305,322,329,530],"stress":[306,473],"index":[307],"obtained":[310],"serum,":[311],"8-OHdG":[312,430],"measurement":[313],"most":[317,320],"sensitive":[318],"frequent":[321],"DNA":[323],"damage":[324],"indicator":[325],"determination":[327],"damage;":[330],"GSH,":[331],"SOD":[332,447],"analyzed":[335],"ELISA":[337,363],"commercial":[339,366],"kit":[340],"evaluation":[343,348],"potential.":[346],"For":[347],"animals,":[352],"cortisol":[353,374,528],"glucose":[356],"level":[357,526],"serum":[359],"measured":[361],"kit.":[367],"meglumine,":[373],"increased":[376],"significantly":[377,436,453],"from":[378],"(P":[382,415,422,426,431,449],"<":[383,416,423,427,432,450],"0.05),":[384],"but":[385],"there":[386],"increase":[389],"painkiller":[397,442,513],"Glucose":[400],"levels":[401,448],"higher":[403,437],"not":[407],"painkillers":[409],"than":[410],"those":[411],"0.001)":[417,428],"30,":[419],"0.05).":[424],"0.05)":[433,451],"values":[434],"while":[443],"TAC,":[444],"GSH":[445],"decreased.Discussion:":[454],"It":[455],"has":[456],"been":[457],"observed":[458],"that":[459,511],"sedation":[460],"(such":[461,467,501],"xylazine)":[463],"lidocaine)":[469],"use":[470],"removed":[471],"pain-induced":[472],"calves.":[481],"However,":[482],"remove":[486],"response,":[489],"necessary":[492],"combine":[494],"protocol":[497],"analgesic":[500],"meglumine)":[504],"combination.":[505],"According":[506],"our":[508],"results":[509],"concluded":[510],"given":[514],"process":[518],"supporting":[520],"system,":[523],"reducing":[524],"stress.":[531]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-12-22T00:00:00"}