{"id":"https://openalex.org/W2904945331","doi":"https://doi.org/10.3384/diss.diva-153266","title":"Investigating mechanisms of angiogenesis in health and disease using zebrafish models","display_name":"Investigating mechanisms of angiogenesis in health and disease using zebrafish models","publication_year":2018,"publication_date":"2018-12-09","ids":{"openalex":"https://openalex.org/W2904945331","doi":"https://doi.org/10.3384/diss.diva-153266","mag":"2904945331"},"language":"en","primary_location":{"id":"doi:10.3384/diss.diva-153266","doi":"https://doi.org/10.3384/diss.diva-153266","is_oa":true,"landing_page_url":"https://doi.org/10.3384/diss.diva-153266","pdf_url":"http://liu.diva-portal.org/smash/get/diva2:1268873/FULLTEXT01","source":{"id":"https://openalex.org/S4210202515","display_name":"Link\u00f6ping University medical dissertations","issn_l":"0345-0082","issn":["0345-0082"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317096","host_organization_name":"Link\u00f6ping University Electronic Press","host_organization_lineage":["https://openalex.org/P4310317096"],"host_organization_lineage_names":["Link\u00f6ping University Electronic Press"],"type":"ebook platform"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Link\u00f6ping University Medical Dissertations","raw_type":"monograph"},"volume":null,"type":"book","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://liu.diva-portal.org/smash/get/diva2:1268873/FULLTEXT01","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005341276","display_name":"Zaheer Ali","orcid":"https://orcid.org/0000-0002-6505-3096","observed_orcids":["https://orcid.org/0000-0002-6505-3096"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT","SE"],"is_corresponding":true,"raw_author_name":"Zaheer Ali","raw_affiliation_strings":["Department of Medical and Health Sciences, Division of Cardiovascular Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden","Department of Biology University of Padua, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Health Sciences, Division of Cardiovascular Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]},{"raw_affiliation_string":"Department of Biology University of Padua, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005341276"],"corresponding_institution_ids":["https://openalex.org/I102134673","https://openalex.org/I138689650"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.3813000023365021,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.8989999890327454},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.6909999847412109},{"id":"https://openalex.org/keywords/choriocapillaris","display_name":"choriocapillaris","score":0.8669999837875366},{"id":"https://openalex.org/keywords/intussusception","display_name":"intussusception","score":0.8629999756813049},{"id":"https://openalex.org/keywords/sprouting-angiogenesis","display_name":"sprouting angiogenesis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8270000219345093},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.7379999756813049},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.4390000104904175},{"id":"https://openalex.org/keywords/vegfr-3","display_name":"VEGFR-3","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9472613334655762},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7572483420372009},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5278475284576416},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47739237546920776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43557441234588623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29480886459350586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26308268308639526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15333285927772522},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12386399507522583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05772203207015991}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3384/diss.diva-153266","doi":"https://doi.org/10.3384/diss.diva-153266","is_oa":true,"landing_page_url":"https://doi.org/10.3384/diss.diva-153266","pdf_url":"http://liu.diva-portal.org/smash/get/diva2:1268873/FULLTEXT01","source":{"id":"https://openalex.org/S4210202515","display_name":"Link\u00f6ping University medical dissertations","issn_l":"0345-0082","issn":["0345-0082"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317096","host_organization_name":"Link\u00f6ping University Electronic Press","host_organization_lineage":["https://openalex.org/P4310317096"],"host_organization_lineage_names":["Link\u00f6ping University Electronic Press"],"type":"ebook platform"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Link\u00f6ping University Medical Dissertations","raw_type":"monograph"},{"id":"pmh:oai:DiVA.org:liu-153266","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153266","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.3384/diss.diva-153266","doi":"https://doi.org/10.3384/diss.diva-153266","is_oa":true,"landing_page_url":"https://doi.org/10.3384/diss.diva-153266","pdf_url":"http://liu.diva-portal.org/smash/get/diva2:1268873/FULLTEXT01","source":{"id":"https://openalex.org/S4210202515","display_name":"Link\u00f6ping University medical dissertations","issn_l":"0345-0082","issn":["0345-0082"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317096","host_organization_name":"Link\u00f6ping University Electronic Press","host_organization_lineage":["https://openalex.org/P4310317096"],"host_organization_lineage_names":["Link\u00f6ping University Electronic Press"],"type":"ebook platform"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Link\u00f6ping University Medical Dissertations","raw_type":"monograph"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2904945331.pdf","grobid_xml":"https://content.openalex.org/works/W2904945331.grobid-xml"},"referenced_works_count":224,"referenced_works":["https://openalex.org/W10096759","https://openalex.org/W32135351","https://openalex.org/W137591732","https://openalex.org/W157384827","https://openalex.org/W219468270","https://openalex.org/W321022283","https://openalex.org/W390410672","https://openalex.org/W763617670","https://openalex.org/W1000482241","https://openalex.org/W1209724774","https://openalex.org/W1486063524","https://openalex.org/W1493672163","https://openalex.org/W1539324883","https://openalex.org/W1544942262","https://openalex.org/W1546928690","https://openalex.org/W1547863599","https://openalex.org/W1560901631","https://openalex.org/W1565041471","https://openalex.org/W1595732636","https://openalex.org/W1600542667","https://openalex.org/W1749022239","https://openalex.org/W1759779443","https://openalex.org/W1776117151","https://openalex.org/W1826880678","https://openalex.org/W1875554126","https://openalex.org/W1875582044","https://openalex.org/W1877572006","https://openalex.org/W1963545628","https://openalex.org/W1964677780","https://openalex.org/W1966901116","https://openalex.org/W1967450352","https://openalex.org/W1967909721","https://openalex.org/W1969773444","https://openalex.org/W1970504857","https://openalex.org/W1971240021","https://openalex.org/W1972785397","https://openalex.org/W1974718993","https://openalex.org/W1975107877","https://openalex.org/W1975497809","https://openalex.org/W1976384923","https://openalex.org/W1977013517","https://openalex.org/W1977411489","https://openalex.org/W1978268544","https://openalex.org/W1979923168","https://openalex.org/W1980954887","https://openalex.org/W1982635732","https://openalex.org/W1982993862","https://openalex.org/W1983244945","https://openalex.org/W1984015906","https://openalex.org/W1985043086","https://openalex.org/W1987027200","https://openalex.org/W1987227366","https://openalex.org/W1990477666","https://openalex.org/W1990484548","https://openalex.org/W1992515128","https://openalex.org/W1992663358","https://openalex.org/W1993419164","https://openalex.org/W1994108115","https://openalex.org/W1996427377","https://openalex.org/W1996781360","https://openalex.org/W2000000541","https://openalex.org/W2000227520","https://openalex.org/W2000292756","https://openalex.org/W2000329618","https://openalex.org/W2000671659","https://openalex.org/W2001658518","https://openalex.org/W2002012034","https://openalex.org/W2003161345","https://openalex.org/W2004643661","https://openalex.org/W2005729255","https://openalex.org/W2006644254","https://openalex.org/W2007631412","https://openalex.org/W2007897263","https://openalex.org/W2010087085","https://openalex.org/W2011912935","https://openalex.org/W2013340612","https://openalex.org/W2013692456","https://openalex.org/W2013730676","https://openalex.org/W2015187541","https://openalex.org/W2019675142","https://openalex.org/W2020968632","https://openalex.org/W2022084143","https://openalex.org/W2022123494","https://openalex.org/W2022369905","https://openalex.org/W2023568503","https://openalex.org/W2024373998","https://openalex.org/W2024548441","https://openalex.org/W2027243767","https://openalex.org/W2028382049","https://openalex.org/W2028994295","https://openalex.org/W2030687817","https://openalex.org/W2034772593","https://openalex.org/W2035138652","https://openalex.org/W2036303851","https://openalex.org/W2037623358","https://openalex.org/W2041625092","https://openalex.org/W2041797267","https://openalex.org/W2042130990","https://openalex.org/W2044640065","https://openalex.org/W2046584597","https://openalex.org/W2049012407","https://openalex.org/W2050896990","https://openalex.org/W2051524047","https://openalex.org/W2052677817","https://openalex.org/W2053863330","https://openalex.org/W2053868595","https://openalex.org/W2055972615","https://openalex.org/W2056023823","https://openalex.org/W2056668196","https://openalex.org/W2058266372","https://openalex.org/W2058432785","https://openalex.org/W2059328178","https://openalex.org/W2059385151","https://openalex.org/W2060504609","https://openalex.org/W2062480745","https://openalex.org/W2065383576","https://openalex.org/W2066187005","https://openalex.org/W2066639629","https://openalex.org/W2067817921","https://openalex.org/W2068104262","https://openalex.org/W2071062791","https://openalex.org/W2072890764","https://openalex.org/W2073232859","https://openalex.org/W2075218366","https://openalex.org/W2075845352","https://openalex.org/W2076151830","https://openalex.org/W2077129920","https://openalex.org/W2077433826","https://openalex.org/W2078766485","https://openalex.org/W2080173566","https://openalex.org/W2082835477","https://openalex.org/W2083395032","https://openalex.org/W2083613396","https://openalex.org/W2084613660","https://openalex.org/W2085523081","https://openalex.org/W2085609942","https://openalex.org/W2085852746","https://openalex.org/W2086690729","https://openalex.org/W2090084294","https://openalex.org/W2090507360","https://openalex.org/W2091760375","https://openalex.org/W2091774189","https://openalex.org/W2091917736","https://openalex.org/W2092061050","https://openalex.org/W2093044616","https://openalex.org/W2094033351","https://openalex.org/W2094177787","https://openalex.org/W2094384984","https://openalex.org/W2094863064","https://openalex.org/W2098155102","https://openalex.org/W2102105402","https://openalex.org/W2102927263","https://openalex.org/W2104503053","https://openalex.org/W2105239075","https://openalex.org/W2107092681","https://openalex.org/W2111487756","https://openalex.org/W2112528263","https://openalex.org/W2114234975","https://openalex.org/W2120335426","https://openalex.org/W2122426257","https://openalex.org/W2122974013","https://openalex.org/W2124069646","https://openalex.org/W2124415048","https://openalex.org/W2125349610","https://openalex.org/W2125355416","https://openalex.org/W2126747203","https://openalex.org/W2129572698","https://openalex.org/W2133940750","https://openalex.org/W2141046053","https://openalex.org/W2141744996","https://openalex.org/W2147407942","https://openalex.org/W2147921405","https://openalex.org/W2148122132","https://openalex.org/W2149158668","https://openalex.org/W2150627711","https://openalex.org/W2153532131","https://openalex.org/W2154711032","https://openalex.org/W2155008946","https://openalex.org/W2158058021","https://openalex.org/W2161467354","https://openalex.org/W2163525929","https://openalex.org/W2164279183","https://openalex.org/W2165591693","https://openalex.org/W2166156136","https://openalex.org/W2166984623","https://openalex.org/W2167386631","https://openalex.org/W2170149729","https://openalex.org/W2170450396","https://openalex.org/W2172905429","https://openalex.org/W2188530474","https://openalex.org/W2198083081","https://openalex.org/W2201396629","https://openalex.org/W2217612888","https://openalex.org/W2322318138","https://openalex.org/W2324588265","https://openalex.org/W2339568953","https://openalex.org/W2371948111","https://openalex.org/W2403145859","https://openalex.org/W2409658634","https://openalex.org/W2488433791","https://openalex.org/W2503575521","https://openalex.org/W2519979747","https://openalex.org/W2521944793","https://openalex.org/W2535136867","https://openalex.org/W2586753497","https://openalex.org/W2597176650","https://openalex.org/W2603601489","https://openalex.org/W2739754133","https://openalex.org/W2748775553","https://openalex.org/W2753209992","https://openalex.org/W2788713106","https://openalex.org/W2792308221","https://openalex.org/W2793323124","https://openalex.org/W2793510327","https://openalex.org/W3104090091","https://openalex.org/W4211099584","https://openalex.org/W4233377855","https://openalex.org/W4233657213","https://openalex.org/W4241398143","https://openalex.org/W4241844862","https://openalex.org/W4249856617","https://openalex.org/W4250861623","https://openalex.org/W4256101427","https://openalex.org/W4300173368"],"related_works":["https://openalex.org/W1610274505","https://openalex.org/W7099755416","https://openalex.org/W17760017","https://openalex.org/W2053863330","https://openalex.org/W2035138652","https://openalex.org/W7099824690","https://openalex.org/W2337875371","https://openalex.org/W1605821760","https://openalex.org/W1979923168","https://openalex.org/W7075693884"],"abstract_inverted_index":{"Angiogenesis,":[0],"the":[1,38,53,56,87,108,135,140,168,181,190,214,220,224,240,291,305,310,323,349,355,374,387,391,396,433],"growth":[2],"of":[3,83,89,113,131,139,154,211,259,307,322,337,351,376,393,449],"blood":[4],"vessels":[5,16,50,59,353],"from":[6,14,287],"an":[7],"existing":[8],"vasculature,":[9],"can":[10,145],"occur":[11,332],"by":[12,18,238,333,426],"sprouting":[13,314],"preexisting":[15],"or":[17,177,184],"vessel":[19],"splitting":[20],"(intussusception).Pathological":[21],"angiogenesis":[22,144,176,179,199,400,425],"drives":[23],"choroidal":[24],"neovascularization":[25],"(CNV)":[26],"in":[27,107,116,134,167,174,180,200,213,227,281,301,309,325,354,373,386,395,432],"age":[28],"related":[29,197],"macular":[30],"degeneration":[31],"(AMD)":[32],"which":[33,90],"is":[34,371,401],"commonly":[35],"restricted":[36],"under":[37],"retinal":[39],"pigment":[40],"epithelium":[41],"(RPE),":[42],"called":[43,269],"occult":[44,233,248],"CNV,":[45],"but":[46,96,161,262,358,378],"may":[47],"also":[48,123,163,263,279,346],"involve":[49,316],"penetrating":[51],"through":[52],"RPE":[54],"into":[55],"sub-retinal":[57],"space.Pathological":[58],"are":[60,70,100,111],"poorly":[61,266,402],"developed,":[62],"insufficiently":[63],"perfused":[64],"and":[65,76,122,159,207,230,275,284,295,319,390],"highly":[66,101],"leaky,":[67],"phenotypes":[68],"that":[69,232,247,277,290,304,408],"considered":[71],"to":[72,78,152,192,198,242,331,446],"drive":[73],"disease":[74],"progression":[75,375],"lead":[77,445],"poor":[79],"prognosis.Currently,":[80],"a":[81,204,264,334,413,436],"number":[82],"anti-angiogenic":[84],"drugs":[85,156],"exists,":[86],"majority":[88],"target":[91],"vascular":[92],"endothelial":[93,397,428,434],"factor":[94,365],"(VEGF),":[95],"although":[97],"they":[98,110],"often":[99],"beneficial":[102],"for":[103,129,149,157,203,219,348,439],"treating":[104],"eye":[105,132],"diseases":[106,118,133,212],"short-term,":[109],"generally":[112],"limited":[114],"efficacy":[115,126],"other":[117,164],"such":[119],"as":[120,421,423],"cancer,":[121],"have":[124],"poorer":[125],"when":[127],"used":[128],"treatment":[130,150,210,444],"long-term.A":[136],"better":[137,155],"understanding":[138],"mechanisms":[141,172],"underlying":[142],"pathological":[143,178,420],"generate":[146],"new":[147],"targets":[148],"leading":[151],"development":[153,306,328,350],"cancer":[158],"retinopathies,":[160],"perhaps":[162],"angiogenesis-dependent":[165],"diseases,":[166],"future.In":[169,215],"this":[170,278,360,379],"thesis":[171],"involved":[173,272,372],"developmental":[175,424],"choroid,":[182],"cornea":[183],"melanoma":[185],"was":[186,293,329,345,361],"identified.These":[187],"findings":[188],"highlight":[189],"need":[191],"further":[193],"elaborate":[194],"our":[195],"knowledge":[196],"different":[201],"tissues/conditions":[202],"more":[205],"targeted,":[206],"potentially":[208],"effective":[209],"paper":[216,302,404],"I,":[217],"we":[218,245,299,406],"first":[221],"time":[222],"identified":[223],"choriocapillaries":[225],"(CCs)":[226],"adult":[228],"zebrafish":[229,311,356],"found":[231,246,300,330,407],"CNV":[234,249],"could":[235],"be":[236],"induced":[237],"exposing":[239],"fish":[241],"severe":[243],"hypoxia.Interestingly,":[244],"relied":[250],"on":[251,313,363],"intussusception,":[252],"involving":[253],"not":[254],"only":[255],"de":[256],"novo":[257],"generation":[258],"intussusceptive":[260],"pillars":[261],"previously":[265],"understood":[267],"mechanism":[268,292],"pillar":[270],"splitting.This":[271],"HIF-VEGF-VEGFR2":[273],"signaling":[274,370,380,411,431],"evidence":[276],"occurred":[280],"both":[282],"rats":[283],"humans":[285],"suffering":[286],"AMD":[288],"suggested":[289],"conserved":[294],"clinically":[296],"relevant.In":[297],"contrast,":[298],"II":[303],"CCs":[308],"relies":[312],"angiogenesis,":[315,377],"continuous":[317],"remodeling,":[318],"delayed":[320],"maturation":[321],"vasculature":[324],"2D.The":[326],"initial":[327],"unique":[335],"process":[336],"tissuewide":[338],"synchronized":[339],"vasculogenesis.As":[340],"expected,":[341],"VEGFA":[342],"via":[343],"VEGFR2":[344],"critical":[347],"these":[352],"embryo,":[357],"surprisingly":[359],"independent":[362],"hypoxia-inducible":[364],"(HIF)-1.Inflammatory":[366],"nuclear":[367],"factor-kB":[368],"(NF-kB)":[369],"pathway":[381],"has":[382],"mainly":[383],"been":[384],"studied":[385],"inflammatory":[388,450],"cells":[389,398],"role":[392],"NF-kB":[394,410,430],"during":[399],"understood.In":[403],"III,":[405],"blocking":[409],"using":[412],"specific":[414],"IKK2":[415],"blocker":[416],"IMD0354,":[417],"specifically":[418],"blocks":[419],"well":[422],"targeting":[427],"cell":[429],"cells.Using":[435],"rat":[437],"model":[438],"suture-induced":[440],"corneal":[441],"neovascularization,":[442],"IMD0354":[443],"reduced":[447],"production":[448],"C-C":[451],"motif":[452]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-12-22T00:00:00"}
