{"id":"https://openalex.org/W2904934367","doi":"https://doi.org/10.1186/s12885-018-5100-4","title":"Ponatinib induces a sustained deep molecular response in a chronic myeloid leukaemia patient with an early relapse with a T315I mutation following allogeneic hematopoietic stem cell transplantation: a case report","display_name":"Ponatinib induces a sustained deep molecular response in a chronic myeloid leukaemia patient with an early relapse with a T315I mutation following allogeneic hematopoietic stem cell transplantation: a case report","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2904934367","doi":"https://doi.org/10.1186/s12885-018-5100-4","mag":"2904934367","pmid":"https://pubmed.ncbi.nlm.nih.gov/30526517","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6286606"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-018-5100-4","doi":"https://doi.org/10.1186/s12885-018-5100-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-018-5100-4","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-5100-4","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-5100-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055292099","display_name":"Nuno Cerveira","orcid":"https://orcid.org/0000-0001-5098-3840","observed_orcids":["https://orcid.org/0000-0001-5098-3840"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Nuno Cerveira","raw_affiliation_strings":["Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. nuno.cerveira@ipoporto.min-saude.pt","Department of Genetics, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-5098-3840","affiliations":[{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. nuno.cerveira@ipoporto.min-saude.pt","institution_ids":["https://openalex.org/I4210103180","https://openalex.org/I4210111164"]},{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006757004","display_name":"Rosa Branca Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rosa Branca Ferreira","raw_affiliation_strings":["Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017716183","display_name":"Susana Bizarro","orcid":"https://orcid.org/0000-0002-3495-2080","observed_orcids":["https://orcid.org/0000-0002-3495-2080"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Bizarro","raw_affiliation_strings":["Department of Genetics, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051027059","display_name":"Cec\u00edlia Correia","orcid":"https://orcid.org/0000-0002-4838-7756","observed_orcids":["https://orcid.org/0000-0002-4838-7756"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cec\u00edlia Correia","raw_affiliation_strings":["Department of Genetics, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109747819","display_name":"Lurdes Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lurdes Torres","raw_affiliation_strings":["Department of Genetics, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087314729","display_name":"Susana Lisboa","orcid":"https://orcid.org/0000-0002-9773-331X","observed_orcids":["https://orcid.org/0000-0002-9773-331X"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Lisboa","raw_affiliation_strings":["Department of Genetics, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005314301","display_name":"Joana Vieira","orcid":"https://orcid.org/0000-0002-0608-2137","observed_orcids":["https://orcid.org/0000-0002-0608-2137"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Vieira","raw_affiliation_strings":["Department of Genetics, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102052071","display_name":"Rui Marques dos Santos","orcid":"https://orcid.org/0000-0002-0957-1665","observed_orcids":["https://orcid.org/0000-0002-0957-1665"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Santos","raw_affiliation_strings":["Department of Genetics, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050587192","display_name":"Fernando Campilho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fernando Campilho","raw_affiliation_strings":["Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083732248","display_name":"Carlos Pinho Vaz","orcid":"https://orcid.org/0000-0002-5574-4459","observed_orcids":["https://orcid.org/0000-0002-5574-4459"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carlos Pinho Vaz","raw_affiliation_strings":["Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lu\u00eds Leite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Leite","raw_affiliation_strings":["Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047343715","display_name":"Manuel Rodrigues Teixeira","orcid":"https://orcid.org/0000-0002-4896-5982","observed_orcids":["https://orcid.org/0000-0002-4896-5982","https://orcid.org/0000-0002-3633-1659"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Manuel R. Teixeira","raw_affiliation_strings":["Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]},{"raw_affiliation_string":"Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022184235","display_name":"Ant\u00f3nio Campos","orcid":"https://orcid.org/0000-0002-7110-0792","observed_orcids":["https://orcid.org/0000-0002-7110-0792"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ant\u00f3nio Campos","raw_affiliation_strings":["Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bone Marrow Transplantation, Portuguese Oncology Institute, Porto, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055292099"],"corresponding_institution_ids":["https://openalex.org/I4210103180","https://openalex.org/I4210111164"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":1.6409,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.83138449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"1","first_page":"1229","last_page":"1229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ponatinib","display_name":"ponatinib","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/t315i-mutation","display_name":"T315I mutation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/early-recurrence","display_name":"early recurrence","score":0.7269999980926514},{"id":"https://openalex.org/keywords/deep-molecular-response","display_name":"deep molecular response","score":0.781000018119812},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.7300000190734863},{"id":"https://openalex.org/keywords/bcr-abl-mutations","display_name":"BCR-ABL mutations","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2780381907","wikidata":"https://www.wikidata.org/wiki/Q198728","display_name":"Ponatinib","level":5,"score":0.8076937794685364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7390495538711548},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.5883988738059998},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5371260046958923},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5255259871482849},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5154641270637512},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4692440330982208},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46099212765693665},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4378044903278351},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4001753330230713},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37608054280281067},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.2890070676803589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14740589261054993},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13284489512443542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12885-018-5100-4","doi":"https://doi.org/10.1186/s12885-018-5100-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-018-5100-4","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-5100-4","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5262555","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6286606","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30526517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30526517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:6286606","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6286606/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:db074203b03449e28d051182f4025ac3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/db074203b03449e28d051182f4025ac3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 18, Iss 1, Pp 1-5 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-018-5100-4","doi":"https://doi.org/10.1186/s12885-018-5100-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-018-5100-4","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-5100-4","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317544","display_name":"Incyte","ror":"https://ror.org/00cvzzg84"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2904934367.pdf","grobid_xml":"https://content.openalex.org/works/W2904934367.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1525555980","https://openalex.org/W1966239454","https://openalex.org/W1968747503","https://openalex.org/W1992579939","https://openalex.org/W2031824081","https://openalex.org/W2036862498","https://openalex.org/W2047412642","https://openalex.org/W2062288565","https://openalex.org/W2075786831","https://openalex.org/W2078327579","https://openalex.org/W2082580993","https://openalex.org/W2101390452","https://openalex.org/W2119629171","https://openalex.org/W2145335197","https://openalex.org/W2157875918","https://openalex.org/W2163108727","https://openalex.org/W2471881801","https://openalex.org/W2478829584","https://openalex.org/W2792470925","https://openalex.org/W2848111060"],"related_works":["https://openalex.org/W2951545363","https://openalex.org/W2047412642","https://openalex.org/W2145335197","https://openalex.org/W3031614389","https://openalex.org/W6902362608","https://openalex.org/W3203242311","https://openalex.org/W2922290622","https://openalex.org/W2747587923","https://openalex.org/W2978221847","https://openalex.org/W2974488794"],"abstract_inverted_index":{"BACKGROUND:":[0],"Atypical":[1],"BCR-ABL1":[2,40],"transcripts":[3],"are":[4],"detected":[5],"in":[6,28],"less":[7],"than":[8],"5%":[9],"of":[10,18,74,87,108],"patients":[11,118],"diagnosed":[12],"with":[13,26,46,52,63],"chronic":[14],"myeloid":[15],"leukaemia":[16],"(CML),":[17],"which":[19],"e19a2":[20,116],"is":[21,44],"the":[22,29,38,72,75,80,85,105],"most":[23],"frequently":[24],"observed,":[25],"breakpoints":[27],"micro":[30],"breakpoint":[31],"cluster":[32],"region":[33],"(\u03bc-BCR)":[34],"and":[35,50],"coding":[36],"for":[37,115],"p230":[39,42],"protein.":[41],"CML":[43,117],"associated":[45],"various":[47],"clinical":[48],"presentations":[49],"courses":[51],"variable":[53],"responses":[54],"to":[55,78,84],"first-line":[56],"imatinib.":[57],"CASE":[58],"PRESENTATION:":[59],")":[60],"after":[61,94,126],"treatment":[62,113],"single-agent":[64],"ponatinib.":[65],"Using":[66],"CastPCR,":[67],"we":[68],"could":[69],"trace":[70],"back":[71],"presence":[73],"T315I":[76,122],"mutation":[77,89,123],"all":[79],"RNA":[81],"samples":[82],"up":[83],"detection":[86],"T315":[88],"by":[90],"Sanger":[91],"sequencing":[92],"shortly":[93],"allogeneic":[95],"hematopoietic":[96],"stem":[97],"cell":[98],"transplantation":[99],"(HSCT).":[100],"CONCLUSION:":[101],"This":[102],"case":[103],"illustrates":[104],"major":[106],"interest":[107],"ponatinib":[109],"as":[110],"a":[111,121],"valid":[112],"option":[114],"who":[119],"present":[120],"following":[124],"relapse":[125],"HSCT.":[127]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-22T00:00:00"}
