{"id":"https://openalex.org/W2904583809","doi":"https://doi.org/10.1371/journal.pone.0208957","title":"Epstein-Barr virus infection and variants of Epstein-Barr nuclear antigen-1 in synovial tissues of rheumatoid arthritis","display_name":"Epstein-Barr virus infection and variants of Epstein-Barr nuclear antigen-1 in synovial tissues of rheumatoid arthritis","publication_year":2018,"publication_date":"2018-12-11","ids":{"openalex":"https://openalex.org/W2904583809","doi":"https://doi.org/10.1371/journal.pone.0208957","mag":"2904583809","pmid":"https://pubmed.ncbi.nlm.nih.gov/30533036","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6289453"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0208957","doi":"https://doi.org/10.1371/journal.pone.0208957","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0208957","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0208957&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0208957&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016054559","display_name":"Shotaro Masuoka","orcid":"https://orcid.org/0000-0003-3522-8673","observed_orcids":["https://orcid.org/0000-0003-3522-8673"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shotaro Masuoka","raw_affiliation_strings":["Department of Internal Medicine, Toho University Graduate School of Medicine, Tokyo, Japan","Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Toho University Graduate School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056283302","display_name":"Natsuko Kusunoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsuko Kusunoki","raw_affiliation_strings":["Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan","Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088194447","display_name":"Ryo Takamatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Takamatsu","raw_affiliation_strings":["Department of Orthopedic Surgery, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101831601","display_name":"Hiroshi Takahashi","orcid":"https://orcid.org/0000-0002-8153-8202","observed_orcids":["https://orcid.org/0000-0002-8153-8202"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Takahashi","raw_affiliation_strings":["Department of Orthopedic Surgery, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112637835","display_name":"Kazuaki Tsuchiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuaki Tsuchiya","raw_affiliation_strings":["Department of Orthopedic Surgery, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072175179","display_name":"Shinichi Kawai","orcid":"https://orcid.org/0000-0002-3996-0039","observed_orcids":["https://orcid.org/0000-0002-3996-0039"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Kawai","raw_affiliation_strings":["Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081181665","display_name":"Toshihiro Nanki","orcid":"https://orcid.org/0000-0002-3482-074X","observed_orcids":["https://orcid.org/0000-0002-3482-074X"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshihiro Nanki","raw_affiliation_strings":["Department of Internal Medicine, Toho University Graduate School of Medicine, Tokyo, Japan","Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3482-074X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Toho University Graduate School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081181665"],"corresponding_institution_ids":["https://openalex.org/I129634264"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.1177,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.74250799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"12","first_page":"e0208957","last_page":"e0208957"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus-infection","display_name":"Epstein-Barr virus infection","score":0.9049999713897705},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.9610000252723694},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hla-drb1-shared-epitope","display_name":"HLA-DRB1 shared epitope","score":0.9620000123977661},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.9620000123977661},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6101622581481934},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.5807888507843018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5383995175361633},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5340121388435364},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.5336101055145264},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5110052824020386},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5049737095832825},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.4676840901374817},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4656178951263428},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.46391716599464417},{"id":"https://openalex.org/C2780494569","wikidata":"https://www.wikidata.org/wiki/Q5384031","display_name":"Epstein\u2013Barr virus infection","level":4,"score":0.4367806315422058},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35362786054611206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28706488013267517},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1956326961517334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06961601972579956},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0208957","doi":"https://doi.org/10.1371/journal.pone.0208957","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0208957","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0208957&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5279351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6289453","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30533036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30533036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6289453","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6289453/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:10cb590e40fa4fa09b9a66b80d3f0f19","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/10cb590e40fa4fa09b9a66b80d3f0f19","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 13, Iss 12, p e0208957 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0208957","doi":"https://doi.org/10.1371/journal.pone.0208957","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0208957","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0208957&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2904583809.pdf","grobid_xml":"https://content.openalex.org/works/W2904583809.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W352453586","https://openalex.org/W978402759","https://openalex.org/W1963945655","https://openalex.org/W1972167997","https://openalex.org/W1980464074","https://openalex.org/W2015221134","https://openalex.org/W2016738466","https://openalex.org/W2032118018","https://openalex.org/W2053446639","https://openalex.org/W2063082418","https://openalex.org/W2065419533","https://openalex.org/W2088961262","https://openalex.org/W2097312606","https://openalex.org/W2112017954","https://openalex.org/W2118819906","https://openalex.org/W2122347870","https://openalex.org/W2138643450","https://openalex.org/W2139615194","https://openalex.org/W2141780372","https://openalex.org/W2144712056","https://openalex.org/W2152348310","https://openalex.org/W2166881790","https://openalex.org/W2404093619","https://openalex.org/W2405057486","https://openalex.org/W2411870195","https://openalex.org/W2418260013","https://openalex.org/W4313344718"],"related_works":["https://openalex.org/W2088961262","https://openalex.org/W4409458019","https://openalex.org/W2405057486","https://openalex.org/W1972167997","https://openalex.org/W2566467055","https://openalex.org/W4281291166","https://openalex.org/W352453586","https://openalex.org/W2129827067","https://openalex.org/W130288425","https://openalex.org/W2337383400"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,46,62,96,113,153,173,192],"objective":[2],"of":[3,21,57,65,87,98,139,184,194,231,237,273,278],"the":[4,19,55,66,84,116,137,156,182,229,235,271],"present":[5,174],"study":[6],"was":[7,41,49,69,73,79,121,142,198],"to":[8,181,283,285],"investigate":[9],"Epstein-Barr":[10],"virus":[11],"(EBV)":[12],"infection":[13,179,263],"as":[14],"an":[15,266],"environmental":[16,267],"factor":[17,217,227,269],"for":[18,54,218,228,270],"development":[20,230,272],"rheumatoid":[22],"arthritis":[23],"(RA).":[24],"METHODS:":[25],"Synovial":[26],"tissues":[27,86],"were":[28],"collected":[29],"during":[30],"surgery":[31],"from":[32,43],"128":[33],"RA":[34,88,106,125,135,185,205,248],"and":[35,107,146,165,186,200,206,246,256],"98":[36],"osteoarthritis":[37],"(OA)":[38],"patients.":[39,249],"DNA":[40,78,141],"extracted":[42],"synovial":[44,85,190],"tissues.":[45,191],"EBV":[47,58,77,140,178,238,262],"gene":[48,196,211,241],"assessed":[50],"by":[51],"nested":[52],"PCR":[53,67],"amplification":[56],"nuclear":[59],"antigen-1":[60],"(EBNA-1).":[61],"nucleotide":[63,276],"sequence":[64],"product":[68],"elucidated.":[70],"HLA-DRB1":[71,117,220],"genotyping":[72],"also":[74],"performed.":[75],"RESULTS:":[76],"more":[80],"frequently":[81],"detected":[82],"in":[83,124,129,189],"patients":[89,93,126,131,148,167],"(32.8%)":[90],"than":[91,128],"OA":[92,108,130],"(15.3%)":[94],"(p<0.01).":[95],"frequency":[97,193],"EBNA-1":[99,157,195,210,240,279],"variants":[100,197,212,242,277],"did":[101,159],"not":[102,160,201,214,281],"significantly":[103,122,161,202],"differ":[104,162],"between":[105,163,204,244],"(RA:":[109],"17%,":[110],"OA:":[111],"13%).":[112],"population":[114,154],"with":[115,155,221],"shared":[118],"epitope":[119],"(SE)":[120],"higher":[123],"(70.3%)":[127],"(44.9%)":[132],"(p<0.001).":[133],"In":[134],"patients,":[136],"presence":[138,236],"similar":[143],"among":[144],"SE-positive":[145,164,245],"-negative":[147,166,247],"(SE-positive:":[149,168],"34.4%,":[150],"-negative:":[151,170],"28.9%).":[152],"variant":[158],"12.9%,":[169],"27.3%).":[171],"DISCUSSION:":[172],"results":[175],"indicate":[176],"that":[177,209],"contributes":[180],"onset":[183],"chronic":[187],"inflammation":[188],"low":[199],"different":[203],"OA,":[207],"suggesting":[208],"are":[213],"a":[215,224],"risk":[216,226,253,268],"RA.":[219,232],"SE":[222,255],"is":[223],"genetic":[225],"However,":[233],"neither":[234],"nor":[239],"differed":[243],"Therefore,":[250],"these":[251],"two":[252],"factors,":[254],"EBV,":[257],"may":[258,264],"be":[259,265],"independent.":[260],"CONCLUSION:":[261],"RA,":[274],"while":[275],"do":[280],"appear":[282],"contribute":[284],"its":[286],"development.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-22T00:00:00"}