{"id":"https://openalex.org/W2904576884","doi":"https://doi.org/10.1002/9781119000822.hfcm105","title":"Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer","display_name":"Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer","publication_year":2017,"publication_date":"2017-02-26","ids":{"openalex":"https://openalex.org/W2904576884","doi":"https://doi.org/10.1002/9781119000822.hfcm105","mag":"2904576884"},"language":"en","primary_location":{"id":"doi:10.1002/9781119000822.hfcm105","doi":"https://doi.org/10.1002/9781119000822.hfcm105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781119000822.hfcm105","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Holland\u2010Frei Cancer Medicine","raw_type":"other"},"volume":{"id":"https://openalex.org/W1540358141","display_name":"Holland-Frei Cancer Medicine"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031844208","display_name":"Jonathan S. Berek","orcid":"https://orcid.org/0000-0002-8734-1961","observed_orcids":["https://orcid.org/0000-0002-8734-1961"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Berek","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021894535","display_name":"Michael Leonard Friedlander","orcid":"https://orcid.org/0000-0003-3090-795X","observed_orcids":["https://orcid.org/0000-0003-3090-795X"]},"institutions":[{"id":"https://openalex.org/I2799851941","display_name":"Royal Hospital for Women","ror":"https://ror.org/021cxfs56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799851941","https://openalex.org/I4210147382"]},{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael L. Friedlander","raw_affiliation_strings":["The Prince of Wales Hospital, Consultant Medical Oncologist, Royal Hospital for Women, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Prince of Wales Hospital, Consultant Medical Oncologist, Royal Hospital for Women, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I2799851941","https://openalex.org/I4210108821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067595997","display_name":"Robert C. Bast","orcid":"https://orcid.org/0000-0003-4621-8462","observed_orcids":["https://orcid.org/0000-0003-4621-8462"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Bast","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fallopian-tube-cancer","display_name":"fallopian tube cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/peritoneal-cancer","display_name":"peritoneal cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/brca1-brca2-mutations","display_name":"BRCA1 and BRCA2 mutations","score":0.8149999976158142},{"id":"https://openalex.org/keywords/high-grade-serous-carcinoma","display_name":"high-grade serous carcinoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dna-copy-number-changes","display_name":"DNA copy number changes","score":0.6060000061988831},{"id":"https://openalex.org/keywords/oral-contraceptives","display_name":"oral contraceptives","score":0.652999997138977},{"id":"https://openalex.org/keywords/ovarian-cancer-risk-factors","display_name":"ovarian cancer risk factors","score":0.5699999928474426},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cytoreductive-surgery","display_name":"cytoreductive surgery","score":0.7900000214576721},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.847000002861023},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intraperitoneal-chemotherapy","display_name":"intraperitoneal chemotherapy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":0.8939999938011169},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.6980000138282776},{"id":"https://openalex.org/keywords/liposomal-doxorubicin","display_name":"liposomal doxorubicin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/topotecan","display_name":"topotecan","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7755144834518433},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.6898204684257507},{"id":"https://openalex.org/C2775883341","wikidata":"https://www.wikidata.org/wiki/Q1233836","display_name":"Fallopian tube","level":2,"score":0.6612344980239868},{"id":"https://openalex.org/C2777632260","wikidata":"https://www.wikidata.org/wiki/Q19000698","display_name":"Serous carcinoma","level":4,"score":0.5281962156295776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5277227163314819},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5053980350494385},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.4839496910572052},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4732173979282379},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.46790844202041626},{"id":"https://openalex.org/C2781199814","wikidata":"https://www.wikidata.org/wiki/Q18556242","display_name":"Clear cell carcinoma","level":3,"score":0.43212050199508667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42768123745918274},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41258862614631653},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3530246913433075},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34285104274749756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3387172818183899},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9781119000822.hfcm105","doi":"https://doi.org/10.1002/9781119000822.hfcm105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781119000822.hfcm105","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Holland\u2010Frei Cancer Medicine","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":274,"referenced_works":["https://openalex.org/W10053096","https://openalex.org/W95560627","https://openalex.org/W120771606","https://openalex.org/W121553317","https://openalex.org/W1506934999","https://openalex.org/W1522554466","https://openalex.org/W1543697093","https://openalex.org/W1548467005","https://openalex.org/W1553976553","https://openalex.org/W1599617931","https://openalex.org/W1672387631","https://openalex.org/W1695897458","https://openalex.org/W1758230404","https://openalex.org/W1767413501","https://openalex.org/W1780928079","https://openalex.org/W1835347798","https://openalex.org/W1845622004","https://openalex.org/W1851054576","https://openalex.org/W1854574445","https://openalex.org/W1863225814","https://openalex.org/W1878670617","https://openalex.org/W1884062425","https://openalex.org/W1902157971","https://openalex.org/W1905580151","https://openalex.org/W1913802169","https://openalex.org/W1917258958","https://openalex.org/W1922469696","https://openalex.org/W1927868261","https://openalex.org/W1930308991","https://openalex.org/W1934378440","https://openalex.org/W1939163116","https://openalex.org/W1951029407","https://openalex.org/W1964248161","https://openalex.org/W1966864407","https://openalex.org/W1966928100","https://openalex.org/W1967487645","https://openalex.org/W1968509736","https://openalex.org/W1969320478","https://openalex.org/W1969447467","https://openalex.org/W1969870046","https://openalex.org/W1971399520","https://openalex.org/W1972309293","https://openalex.org/W1973268287","https://openalex.org/W1974498382","https://openalex.org/W1974756790","https://openalex.org/W1974901746","https://openalex.org/W1975017868","https://openalex.org/W1975307022","https://openalex.org/W1977767429","https://openalex.org/W1977958507","https://openalex.org/W1979355909","https://openalex.org/W1979740289","https://openalex.org/W1980181125","https://openalex.org/W1980685727","https://openalex.org/W1981494434","https://openalex.org/W1981672133","https://openalex.org/W1983247267","https://openalex.org/W1987165377","https://openalex.org/W1987974186","https://openalex.org/W1989331806","https://openalex.org/W1991573671","https://openalex.org/W1991826563","https://openalex.org/W1994618801","https://openalex.org/W1995055473","https://openalex.org/W1995250775","https://openalex.org/W1996594767","https://openalex.org/W1998815238","https://openalex.org/W1999659306","https://openalex.org/W1999873690","https://openalex.org/W2000420730","https://openalex.org/W2001446631","https://openalex.org/W2002206423","https://openalex.org/W2002804156","https://openalex.org/W2008293816","https://openalex.org/W2012303003","https://openalex.org/W2013298015","https://openalex.org/W2015231552","https://openalex.org/W2015662449","https://openalex.org/W2018762713","https://openalex.org/W2018887802","https://openalex.org/W2019063894","https://openalex.org/W2019691937","https://openalex.org/W2019809452","https://openalex.org/W2020713814","https://openalex.org/W2021035767","https://openalex.org/W2022751095","https://openalex.org/W2022996385","https://openalex.org/W2023526529","https://openalex.org/W2024533570","https://openalex.org/W2026401917","https://openalex.org/W2026897505","https://openalex.org/W2028682388","https://openalex.org/W2030833474","https://openalex.org/W2032614468","https://openalex.org/W2034373652","https://openalex.org/W2034669369","https://openalex.org/W2034852369","https://openalex.org/W2035624229","https://openalex.org/W2036348866","https://openalex.org/W2037412915","https://openalex.org/W2038209588","https://openalex.org/W2038793520","https://openalex.org/W2040247092","https://openalex.org/W2041035879","https://openalex.org/W2041142804","https://openalex.org/W2041384134","https://openalex.org/W2042051912","https://openalex.org/W2043280980","https://openalex.org/W2043553152","https://openalex.org/W2044013361","https://openalex.org/W2044421413","https://openalex.org/W2045438393","https://openalex.org/W2045603696","https://openalex.org/W2045652619","https://openalex.org/W2046347751","https://openalex.org/W2047075593","https://openalex.org/W2049208988","https://openalex.org/W2052565071","https://openalex.org/W2052814236","https://openalex.org/W2054785621","https://openalex.org/W2056111107","https://openalex.org/W2056739417","https://openalex.org/W2056756533","https://openalex.org/W2056788734","https://openalex.org/W2058192214","https://openalex.org/W2058981542","https://openalex.org/W2059143304","https://openalex.org/W2059647270","https://openalex.org/W2063953472","https://openalex.org/W2066801022","https://openalex.org/W2068273715","https://openalex.org/W2069885515","https://openalex.org/W2070058128","https://openalex.org/W2070636593","https://openalex.org/W2071020286","https://openalex.org/W2073883983","https://openalex.org/W2077330022","https://openalex.org/W2077422971","https://openalex.org/W2078329320","https://openalex.org/W2078839049","https://openalex.org/W2079537409","https://openalex.org/W2081262677","https://openalex.org/W2082203614","https://openalex.org/W2085289651","https://openalex.org/W2086055140","https://openalex.org/W2087025655","https://openalex.org/W2087480162","https://openalex.org/W2090968329","https://openalex.org/W2093252833","https://openalex.org/W2094353179","https://openalex.org/W2094847769","https://openalex.org/W2096889436","https://openalex.org/W2097105130","https://openalex.org/W2097265582","https://openalex.org/W2098050793","https://openalex.org/W2098213562","https://openalex.org/W2099521317","https://openalex.org/W2100030862","https://openalex.org/W2101653483","https://openalex.org/W2101699473","https://openalex.org/W2102719470","https://openalex.org/W2103194390","https://openalex.org/W2104993280","https://openalex.org/W2104998982","https://openalex.org/W2106247280","https://openalex.org/W2106767659","https://openalex.org/W2106951948","https://openalex.org/W2107457010","https://openalex.org/W2107618849","https://openalex.org/W2108203519","https://openalex.org/W2108787610","https://openalex.org/W2109165966","https://openalex.org/W2111513937","https://openalex.org/W2111922520","https://openalex.org/W2112644262","https://openalex.org/W2113098178","https://openalex.org/W2113122060","https://openalex.org/W2114178889","https://openalex.org/W2115027029","https://openalex.org/W2115247765","https://openalex.org/W2116556830","https://openalex.org/W2116996913","https://openalex.org/W2117576401","https://openalex.org/W2117729836","https://openalex.org/W2117995467","https://openalex.org/W2119660221","https://openalex.org/W2124322375","https://openalex.org/W2125064537","https://openalex.org/W2125558775","https://openalex.org/W2126233390","https://openalex.org/W2126500509","https://openalex.org/W2127379638","https://openalex.org/W2130078242","https://openalex.org/W2130941707","https://openalex.org/W2134919151","https://openalex.org/W2134947875","https://openalex.org/W2135525536","https://openalex.org/W2135947389","https://openalex.org/W2137226085","https://openalex.org/W2138035969","https://openalex.org/W2139060364","https://openalex.org/W2141474293","https://openalex.org/W2142397500","https://openalex.org/W2142597742","https://openalex.org/W2143219457","https://openalex.org/W2143698296","https://openalex.org/W2145827555","https://openalex.org/W2145901547","https://openalex.org/W2146239695","https://openalex.org/W2146898191","https://openalex.org/W2147564868","https://openalex.org/W2149882132","https://openalex.org/W2150111967","https://openalex.org/W2151050516","https://openalex.org/W2151509048","https://openalex.org/W2152574852","https://openalex.org/W2154175915","https://openalex.org/W2154885792","https://openalex.org/W2155586874","https://openalex.org/W2157585376","https://openalex.org/W2157769714","https://openalex.org/W2158083229","https://openalex.org/W2158740417","https://openalex.org/W2160466424","https://openalex.org/W2160684474","https://openalex.org/W2162063105","https://openalex.org/W2162104840","https://openalex.org/W2166358808","https://openalex.org/W2168357259","https://openalex.org/W2169178790","https://openalex.org/W2169862738","https://openalex.org/W2170552969","https://openalex.org/W2170845869","https://openalex.org/W2171972386","https://openalex.org/W2180880689","https://openalex.org/W2216554257","https://openalex.org/W2222529560","https://openalex.org/W2223743646","https://openalex.org/W2229819180","https://openalex.org/W2261061437","https://openalex.org/W2267306625","https://openalex.org/W2282932528","https://openalex.org/W2289640058","https://openalex.org/W2315888143","https://openalex.org/W2316501478","https://openalex.org/W2316952834","https://openalex.org/W2322765824","https://openalex.org/W2328105863","https://openalex.org/W2328421677","https://openalex.org/W2329590002","https://openalex.org/W2334610047","https://openalex.org/W2338185498","https://openalex.org/W2407749561","https://openalex.org/W2413848617","https://openalex.org/W2414929332","https://openalex.org/W2437580906","https://openalex.org/W2528228811","https://openalex.org/W2562051866","https://openalex.org/W2588532339","https://openalex.org/W2750256775","https://openalex.org/W2753398179","https://openalex.org/W3089125203","https://openalex.org/W3151500528","https://openalex.org/W4210704032","https://openalex.org/W4232721722","https://openalex.org/W4235038716","https://openalex.org/W4235294707","https://openalex.org/W4236095073","https://openalex.org/W4239451229","https://openalex.org/W4242409456","https://openalex.org/W4245372145","https://openalex.org/W4247623075","https://openalex.org/W4250491166","https://openalex.org/W4253683075"],"related_works":["https://openalex.org/W3005089448","https://openalex.org/W2790840476","https://openalex.org/W4412528048","https://openalex.org/W2326276750","https://openalex.org/W1896442311","https://openalex.org/W2166473248","https://openalex.org/W2424148473","https://openalex.org/W3139173141","https://openalex.org/W2294920394","https://openalex.org/W1554355970"],"abstract_inverted_index":{"Overview":[0],"Ovarian":[1,43],"cancer":[2,44,104,301],"is":[3,45],"one":[4],"of":[5,31,38,57,72,87,95,102,122,128,150,175,207,217,275,286,298,308,318,324,344,374,391],"the":[6,12,34,40,65,69,100,113,126,142,148,154,173,180],"most":[7],"treatable":[8],"solid":[9],"tumors,":[10],"as":[11,162,164],"majority":[13,216],"will":[14,394],"respond":[15,231,267],"temporarily":[16],"to":[17,109,139,170,234,268,272],"surgery":[18,304],"and":[19,27,61,82,89,98,230,236,265,305,310,351,362,378],"cytotoxic":[20,345],"agents.":[21],"The":[22],"disease,":[23,52,119],"however,":[24],"frequently":[25,233,266],"persists":[26],"recurs":[28],"in":[29,59,64,68,74,115,147,172,214,226,261,291,383],"70%":[30,285],"cases,":[32,218],"having":[33],"highest":[35],"fatality\u2010to\u2010case":[36],"ratio":[37],"all":[39],"gynecologic":[41],"cancers.":[42,389],"neither":[46],"a":[47,50,54,62,215,273],"common":[48],"nor":[49],"rare":[51],"with":[53,93,117,249,315,333,342,349,385],"lifetime":[55],"risk":[56,101,114,127],"1":[58,73],"70":[60],"prevalence":[63],"postmenopausal":[66],"population":[67],"United":[70],"States":[71],"2500,":[75],"which":[76],"impact":[77],"strategies":[78],"for":[79,366],"early":[80,227],"detection":[81],"prevention.":[83],"Germ":[84],"line":[85],"mutations":[86,213],"BRCA1":[88],"BRCA2":[90],"are":[91,167,224,252,259,289,381],"associated":[92],"10\u201315%":[94],"ovarian":[96,103,134,143,155,185,199,242,287,300,388],"cancers":[97,135,166,186,200,243,288,368],"increase":[99,112],"dramatically.":[105],"Factors":[106],"that":[107],"contribute":[108],"persistent":[110],"ovulation":[111],"women":[116,314],"sporadic":[118],"whereas":[120,372],"use":[121],"oral":[123],"contraceptives":[124],"decreases":[125],"disease":[129,319,329],"post":[130],"menopause.":[131],"While":[132],"epithelial":[133,299,387],"have":[136],"been":[137],"thought":[138],"arise":[140,171,246],"from":[141,205,247],"surface":[144],"epithelium":[145],"or":[146,182,192,278],"lining":[149],"inclusion":[151],"cysts":[152],"beneath":[153],"surface,":[156],"many":[157],"high\u2010grade":[158,386],"serous":[159],"\u201covarian\u201d":[160],"carcinomas":[161],"well":[163],"peritoneal":[165],"now":[168],"believed":[169],"fimbriae":[174],"fallopian":[176],"tube,":[177],"rather":[178],"than":[179,284],"ovary":[181],"peritoneum.":[183],"Epithelial":[184],"can":[187,203,339],"exhibit":[188],"serous,":[189],"endometrioid,":[190],"mucinous,":[191],"clear":[193],"cell":[194],"histotypes.":[195],"Low\u2010grade":[196],"type":[197,221,240],"I":[198],"grow":[201,244],"slowly,":[202],"evolve":[204],"tumors":[206],"low":[208],"malignant":[209],"potential,":[210],"bear":[211],"Ras":[212],"express":[219],"wild":[220],"TP53,":[222],"often":[223],"detected":[225],"stage":[228,263,294],"(I\u2013II),":[229],"less":[232],"platinum\u2010":[235],"taxane\u2010based":[237],"therapy.":[238],"High\u2010grade":[239],"II":[241],"rapidly,":[245],"precursors":[248],"TP53":[250],"mutations,":[251],"driven":[253],"by":[254],"DNA":[255],"copy":[256],"number":[257],"changes,":[258],"diagnosed":[260,290],"late":[262],"(III\u2013IV),":[264],"combination":[269],"chemotherapy.":[270],"Owing":[271],"lack":[274],"specific":[276],"symptoms":[277],"an":[279,292],"effective":[280],"screening":[281],"strategy,":[282],"more":[283],"advanced":[293],"(III\u2013IV).":[295],"Primary":[296],"treatment":[297],"involves":[302,369],"cytoreductive":[303],"6\u20138":[306],"cycles":[307],"carboplatin":[309],"paclitaxel.":[311],"For":[312],"those":[313],"small":[316],"volumes":[317],"after":[320],"surgery,":[321],"intraperitoneal":[322],"administration":[323],"chemotherapy":[325],"improves":[326],"survival.":[327],"Recurrent":[328],"cannot":[330],"be":[331,340,395],"cured":[332],"currently":[334],"available":[335],"agents,":[336],"but":[337],"survival":[338],"prolonged":[341],"combinations":[343],"agents":[346,354,393],"including":[347],"retreatment":[348],"paclitaxel":[350],"carboplatin.":[352],"Palliative":[353],"include":[355],"liposomal":[356],"doxorubicin,":[357],"gemcitabine,":[358],"topotecan,":[359],"bevacizumab,":[360],"pemetrexed,":[361],"etoposide.":[363],"Experimental":[364],"therapy":[365],"low\u2010grade":[367],"MEK":[370],"inhibitors,":[371],"trials":[373],"PI3K":[375],"pathway":[376],"inhibitors":[377,380],"PARP":[379],"underway":[382],"patients":[384],"Combinations":[390],"targeted":[392],"required.":[396]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-12-22T00:00:00"}