{"id":"https://openalex.org/W2904426752","doi":"https://doi.org/10.25208/0042-4609-2018-94-4-73-82","title":"Impact of topical anti-inflammatory therapy on morpho-functional characteristics of epidermal barrier. Optimization of atopic dermatitis treatment schedules","display_name":"Impact of topical anti-inflammatory therapy on morpho-functional characteristics of epidermal barrier. Optimization of atopic dermatitis treatment schedules","publication_year":2018,"publication_date":"2018-08-07","ids":{"openalex":"https://openalex.org/W2904426752","doi":"https://doi.org/10.25208/0042-4609-2018-94-4-73-82","mag":"2904426752"},"language":"en","primary_location":{"id":"doi:10.25208/0042-4609-2018-94-4-73-82","doi":"https://doi.org/10.25208/0042-4609-2018-94-4-73-82","is_oa":true,"landing_page_url":"https://doi.org/10.25208/0042-4609-2018-94-4-73-82","pdf_url":"https://vestnikdv.ru/jour/article/download/427/408","source":{"id":"https://openalex.org/S2751822536","display_name":"Vestnik dermatologii i venerologii","issn_l":"0042-4609","issn":["0042-4609","2313-6294"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4322632794","host_organization_name":"State Scientific Center of Dermatovenereology and Cosmetology","host_organization_lineage":["https://openalex.org/P4322632794"],"host_organization_lineage_names":["State Scientific Center of Dermatovenereology and Cosmetology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik dermatologii i venerologii","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://vestnikdv.ru/jour/article/download/427/408","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087841320","display_name":"Larisa Sergeevna Kruglova","orcid":"https://orcid.org/0000-0002-5044-5265","observed_orcids":["https://orcid.org/0000-0002-5044-5265"]},"institutions":[{"id":"https://openalex.org/I4210106113","display_name":"Central State Medical Academy","ror":"https://ror.org/00xx5qr89","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800573802","https://openalex.org/I4210106113"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. S. Kruglova","raw_affiliation_strings":["Central State Medical Academy of A ffairs Management Depar tment of President of Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central State Medical Academy of A ffairs Management Depar tment of President of Russian Federation","institution_ids":["https://openalex.org/I4210106113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062303896","display_name":"Dmitry D. Petrunin","orcid":"https://orcid.org/0000-0002-6309-7044","observed_orcids":["https://orcid.org/0000-0002-6309-7044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. D. Petrunin","raw_affiliation_strings":["LEO Pharma\u0441eutical Products, LLC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LEO Pharma\u0441eutical Products, LLC","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5273,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.69112074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"94","issue":"4","first_page":"73","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.953000009059906},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.8529999852180481},{"id":"https://openalex.org/keywords/protopic","display_name":"Protopic","score":0.8199999928474426},{"id":"https://openalex.org/keywords/skin-barrier","display_name":"skin barrier","score":0.9679999947547913},{"id":"https://openalex.org/keywords/stratum-corneum-integrity","display_name":"stratum corneum integrity","score":0.9229999780654907},{"id":"https://openalex.org/keywords/epidermal-thickness","display_name":"epidermal thickness","score":0.7960000038146973},{"id":"https://openalex.org/keywords/skin-hydration","display_name":"skin hydration","score":0.7170000076293945},{"id":"https://openalex.org/keywords/skin-ph","display_name":"skin pH","score":0.6980000138282776},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/skin-barrier-lipids","display_name":"skin barrier lipids","score":0.6380000114440918},{"id":"https://openalex.org/keywords/treatment-schedule-optimization","display_name":"treatment schedule optimization","score":0.6729999780654907},{"id":"https://openalex.org/keywords/corticosteroid-withdrawal","display_name":"corticosteroid withdrawal","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8564437627792358},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.8480690717697144},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6683040261268616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5829223394393921},{"id":"https://openalex.org/C2991981033","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Skin barrier","level":2,"score":0.49350154399871826},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.48883336782455444},{"id":"https://openalex.org/C190684412","wikidata":"https://www.wikidata.org/wiki/Q21201832","display_name":"Filaggrin","level":3,"score":0.46675562858581543},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.4405973553657532},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1704005002975464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1187489926815033},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.25208/0042-4609-2018-94-4-73-82","doi":"https://doi.org/10.25208/0042-4609-2018-94-4-73-82","is_oa":true,"landing_page_url":"https://doi.org/10.25208/0042-4609-2018-94-4-73-82","pdf_url":"https://vestnikdv.ru/jour/article/download/427/408","source":{"id":"https://openalex.org/S2751822536","display_name":"Vestnik dermatologii i venerologii","issn_l":"0042-4609","issn":["0042-4609","2313-6294"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4322632794","host_organization_name":"State Scientific Center of Dermatovenereology and Cosmetology","host_organization_lineage":["https://openalex.org/P4322632794"],"host_organization_lineage_names":["State Scientific Center of Dermatovenereology and Cosmetology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik dermatologii i venerologii","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:875ff912868b41948907b40b8584823c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/875ff912868b41948907b40b8584823c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vestnik Dermatologii i Venerologii, Vol 94, Iss 4, Pp 73-82 (2018)","raw_type":"article"},{"id":"mag:3085653051","doi":null,"is_oa":true,"landing_page_url":"https://vestnikdv.ru/jour/article/download/427/408","pdf_url":null,"source":{"id":"https://openalex.org/S2751822536","display_name":"Vestnik dermatologii i venerologii","issn_l":"0042-4609","issn":["0042-4609","2313-6294"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4322632794","host_organization_name":"State Scientific Center of Dermatovenereology and Cosmetology","host_organization_lineage":["https://openalex.org/P4322632794"],"host_organization_lineage_names":["State Scientific Center of Dermatovenereology and Cosmetology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0412\u0435\u0441\u0442\u043d\u0438\u043a \u0434\u0435\u0440\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0432\u0435\u043d\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438","raw_type":null}],"best_oa_location":{"id":"doi:10.25208/0042-4609-2018-94-4-73-82","doi":"https://doi.org/10.25208/0042-4609-2018-94-4-73-82","is_oa":true,"landing_page_url":"https://doi.org/10.25208/0042-4609-2018-94-4-73-82","pdf_url":"https://vestnikdv.ru/jour/article/download/427/408","source":{"id":"https://openalex.org/S2751822536","display_name":"Vestnik dermatologii i venerologii","issn_l":"0042-4609","issn":["0042-4609","2313-6294"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4322632794","host_organization_name":"State Scientific Center of Dermatovenereology and Cosmetology","host_organization_lineage":["https://openalex.org/P4322632794"],"host_organization_lineage_names":["State Scientific Center of Dermatovenereology and Cosmetology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik dermatologii i venerologii","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2904426752.pdf","grobid_xml":"https://content.openalex.org/works/W2904426752.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W342524884","https://openalex.org/W1781875597","https://openalex.org/W1916016072","https://openalex.org/W1970845333","https://openalex.org/W1979267735","https://openalex.org/W1982992814","https://openalex.org/W1988028898","https://openalex.org/W1991202990","https://openalex.org/W1992560570","https://openalex.org/W1992880428","https://openalex.org/W2018152806","https://openalex.org/W2033677151","https://openalex.org/W2034950600","https://openalex.org/W2035754178","https://openalex.org/W2042984025","https://openalex.org/W2052015840","https://openalex.org/W2065971856","https://openalex.org/W2069127774","https://openalex.org/W2076268655","https://openalex.org/W2084224801","https://openalex.org/W2088008728","https://openalex.org/W2092065094","https://openalex.org/W2116671089","https://openalex.org/W2136448926","https://openalex.org/W2142327072","https://openalex.org/W2146159260","https://openalex.org/W2151754510","https://openalex.org/W2306524933","https://openalex.org/W2336226774","https://openalex.org/W2414979532","https://openalex.org/W3134986606","https://openalex.org/W4210958096","https://openalex.org/W4232685799"],"related_works":["https://openalex.org/W2146159260","https://openalex.org/W2035754178","https://openalex.org/W4240863519","https://openalex.org/W1781875597","https://openalex.org/W2996459227","https://openalex.org/W3137900875","https://openalex.org/W2080412111","https://openalex.org/W2063338590","https://openalex.org/W3181425005","https://openalex.org/W3085653051"],"abstract_inverted_index":{"In":[0],"this":[1],"literature":[2],"review":[3],"data":[4,79],"regarding":[5],"impact":[6,30],"of":[7,20,45,66,76,85,88],"topical":[8,11,86],"therapy":[9,87],"with":[10,91],"corticosteroids":[12],"(TCS)":[13],"and":[14,40,43],"tacrolimus":[15,57],"ointment":[16,58],"on":[17,31,63],"morpho-functional":[18],"characteristics":[19],"epidermal":[21,34,38],"barrier":[22,35],"is":[23],"analyzed.":[24],"Whereas":[25],"TCS":[26,95],"has":[27],"profound":[28],"negative":[29],"nearly":[32],"all":[33],"parameters,":[36,69],"including":[37],"structure":[39,55],"thickness,":[41],"integrity":[42],"cohesion":[44],"stratum":[46],"corneum,":[47],"protease":[48],"activity,":[49],"hydration,":[50],"pH,":[51],"differentiation,":[52],"lipid":[53],"lamellae":[54],"etc.,":[56],"(Protopic\u00ae)":[59],"exerts":[60],"positive":[61],"effect":[62,75],"the":[64,67],"majority":[65],"aforementioned":[68],"thus":[70],"allowing":[71],"to":[72,96],"compensate":[73],"deleterious":[74],"TCS.":[77],"These":[78],"allow":[80],"defining":[81],"recommendations":[82],"upon":[83],"optimization":[84],"atopic":[89],"dermatitis":[90],"stepwise":[92],"switching":[93],"from":[94],"Protopic\u00ae":[97],"ointment.":[98]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-12-22T00:00:00"}
