{"id":"https://openalex.org/W2904058752","doi":"https://doi.org/10.1186/s13287-018-1078-8","title":"Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review","display_name":"Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2904058752","doi":"https://doi.org/10.1186/s13287-018-1078-8","mag":"2904058752","pmid":"https://pubmed.ncbi.nlm.nih.gov/30526687","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6286545"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-018-1078-8","doi":"https://doi.org/10.1186/s13287-018-1078-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-018-1078-8","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-1078-8","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-1078-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020905298","display_name":"Ioannis Christodoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210127711"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Christodoulou","raw_affiliation_strings":["Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece","institution_ids":["https://openalex.org/I4210127711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065204856","display_name":"Maria Goulielmaki","orcid":"https://orcid.org/0000-0001-9596-5048","observed_orcids":["https://orcid.org/0000-0001-9596-5048"]},"institutions":[{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210127711"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Goulielmaki","raw_affiliation_strings":["Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece","institution_ids":["https://openalex.org/I4210127711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009787957","display_name":"Marina Devetzi","orcid":"https://orcid.org/0000-0002-7123-7991","observed_orcids":["https://orcid.org/0000-0002-7123-7991"]},"institutions":[{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210127711"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Marina Devetzi","raw_affiliation_strings":["Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece","institution_ids":["https://openalex.org/I4210127711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107928683","display_name":"Mihalis I. Panayiotidis","orcid":"https://orcid.org/0000-0002-1450-3552","observed_orcids":["https://orcid.org/0000-0002-1450-3552"]},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mihalis Panagiotidis","raw_affiliation_strings":["Northumbria University Newcastle upon Tyne, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northumbria University Newcastle upon Tyne, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049054068","display_name":"George Koliakos","orcid":"https://orcid.org/0000-0003-4350-9061","observed_orcids":["https://orcid.org/0000-0003-4350-9061"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Koliakos","raw_affiliation_strings":["Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020964577","display_name":"Vassilis C. Zoumpourlis","orcid":"https://orcid.org/0000-0002-1026-577X","observed_orcids":["https://orcid.org/0000-0002-1026-577X"]},"institutions":[{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210127711"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Vassilis Zoumpourlis","raw_affiliation_strings":["Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece. vzub@eie.gr","Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece. vzub@eie.gr","institution_ids":["https://openalex.org/I4210127711"]},{"raw_affiliation_string":"Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece","institution_ids":["https://openalex.org/I4210127711"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020964577"],"corresponding_institution_ids":["https://openalex.org/I4210127711"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":1.0656,"has_fulltext":true,"cited_by_count":125,"citation_normalized_percentile":{"value":0.72937294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"336","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":1.0},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.8389999866485596},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/umbilical-cord-mesenchymal-stem-cells","display_name":"human umbilical cord mesenchymal stem cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.42100000381469727},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/preclinical-cancer-models","display_name":"preclinical cancer models","score":0.6700000166893005},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6646686792373657},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6066113114356995},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5859061479568481},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5698699355125427},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5410744547843933},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5301728248596191},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.521118700504303},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5209987759590149},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5204418301582336},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5086968541145325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43403393030166626},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42751413583755493},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4151317775249481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3201596140861511},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31693553924560547},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24499082565307617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1569713056087494},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08739027380943298},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0820830762386322},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.07258394360542297},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13287-018-1078-8","doi":"https://doi.org/10.1186/s13287-018-1078-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-018-1078-8","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-1078-8","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5262494","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6286545","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30526687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30526687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6286545","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6286545/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmh:oai:nrl.northumbria.ac.uk:37176","doi":null,"is_oa":true,"landing_page_url":"http://nrl.northumbria.ac.uk/id/eprint/37176/1/Stem%20Cell%20Research%20%20Therapy.pdf","pdf_url":"http://nrl.northumbria.ac.uk/id/eprint/37176/1/Stem%20Cell%20Research%20%20Therapy.pdf","source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:f213e285c3204d869d7b0a37aab035f9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f213e285c3204d869d7b0a37aab035f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-38 (2018)","raw_type":"article"},{"id":"pmh:oai:https://helios.eie.gr:10442/17342","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10442/17342","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research and Therapy, 9(1), (2018)","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/s13287-018-1078-8","doi":"https://doi.org/10.1186/s13287-018-1078-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-018-1078-8","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-1078-8","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315361","display_name":"\u0395\u03b8\u03bd\u03b9\u03ba\u03cc '\u038a\u03b4\u03c1\u03c5\u03bc\u03b1 \u0395\u03c1\u03b5\u03c5\u03bd\u03ce\u03bd","ror":"https://ror.org/033m02g29"},{"id":"https://openalex.org/F4320321916","display_name":"State Scholarships Foundation","ror":"https://ror.org/023z3dm33"},{"id":"https://openalex.org/F4320321917","display_name":"General Secretariat for Research and Technology","ror":"https://ror.org/04yeh8h63"},{"id":"https://openalex.org/F4320327859","display_name":"Hellenic Foundation for Research and Innovation","ror":"https://ror.org/05v75r592"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2904058752.pdf","grobid_xml":"https://content.openalex.org/works/W2904058752.grobid-xml"},"referenced_works_count":297,"referenced_works":["https://openalex.org/W99481372","https://openalex.org/W153957434","https://openalex.org/W598931438","https://openalex.org/W602478149","https://openalex.org/W1481133043","https://openalex.org/W1481565655","https://openalex.org/W1482981939","https://openalex.org/W1491946515","https://openalex.org/W1505550085","https://openalex.org/W1508072483","https://openalex.org/W1562250847","https://openalex.org/W1563624833","https://openalex.org/W1571768035","https://openalex.org/W1577502880","https://openalex.org/W1599588446","https://openalex.org/W1601030740","https://openalex.org/W1632685005","https://openalex.org/W1851099761","https://openalex.org/W1873195168","https://openalex.org/W1922364744","https://openalex.org/W1926140429","https://openalex.org/W1927732700","https://openalex.org/W1963711254","https://openalex.org/W1964380754","https://openalex.org/W1965691956","https://openalex.org/W1967770107","https://openalex.org/W1967992429","https://openalex.org/W1969103696","https://openalex.org/W1969644104","https://openalex.org/W1970856815","https://openalex.org/W1972002957","https://openalex.org/W1972825083","https://openalex.org/W1973138511","https://openalex.org/W1973863581","https://openalex.org/W1974815597","https://openalex.org/W1975442541","https://openalex.org/W1975807748","https://openalex.org/W1975880740","https://openalex.org/W1976442043","https://openalex.org/W1979704965","https://openalex.org/W1979976356","https://openalex.org/W1980380405","https://openalex.org/W1980424217","https://openalex.org/W1982324918","https://openalex.org/W1982408656","https://openalex.org/W1983493560","https://openalex.org/W1984054570","https://openalex.org/W1987696021","https://openalex.org/W1991889240","https://openalex.org/W1992595068","https://openalex.org/W1993252085","https://openalex.org/W1994426347","https://openalex.org/W1994737096","https://openalex.org/W1995045198","https://openalex.org/W1995591875","https://openalex.org/W1995725520","https://openalex.org/W1996688134","https://openalex.org/W1996773781","https://openalex.org/W1998040484","https://openalex.org/W1998676843","https://openalex.org/W2000534793","https://openalex.org/W2001060367","https://openalex.org/W2001157494","https://openalex.org/W2001213911","https://openalex.org/W2007098561","https://openalex.org/W2007293466","https://openalex.org/W2008021821","https://openalex.org/W2008430665","https://openalex.org/W2009364834","https://openalex.org/W2010573560","https://openalex.org/W2011199880","https://openalex.org/W2014673628","https://openalex.org/W2015050458","https://openalex.org/W2016009669","https://openalex.org/W2016139324","https://openalex.org/W2017593380","https://openalex.org/W2018050150","https://openalex.org/W2018872714","https://openalex.org/W2018984348","https://openalex.org/W2018999161","https://openalex.org/W2019090872","https://openalex.org/W2019586013","https://openalex.org/W2020794309","https://openalex.org/W2021400207","https://openalex.org/W2022035441","https://openalex.org/W2023627055","https://openalex.org/W2024427813","https://openalex.org/W2025309264","https://openalex.org/W2025371271","https://openalex.org/W2029185806","https://openalex.org/W2029488286","https://openalex.org/W2030480905","https://openalex.org/W2031365339","https://openalex.org/W2031790029","https://openalex.org/W2033466069","https://openalex.org/W2035032239","https://openalex.org/W2035065708","https://openalex.org/W2035176325","https://openalex.org/W2035226186","https://openalex.org/W2036061473","https://openalex.org/W2036348189","https://openalex.org/W2037038224","https://openalex.org/W2037041091","https://openalex.org/W2037155465","https://openalex.org/W2038118195","https://openalex.org/W2038540187","https://openalex.org/W2039100374","https://openalex.org/W2039112669","https://openalex.org/W2040002581","https://openalex.org/W2041858615","https://openalex.org/W2041999171","https://openalex.org/W2042554061","https://openalex.org/W2042765500","https://openalex.org/W2043785981","https://openalex.org/W2043898918","https://openalex.org/W2044155847","https://openalex.org/W2044233644","https://openalex.org/W2044702943","https://openalex.org/W2045287986","https://openalex.org/W2045456080","https://openalex.org/W2046143832","https://openalex.org/W2049491375","https://openalex.org/W2049582337","https://openalex.org/W2050775229","https://openalex.org/W2051386941","https://openalex.org/W2052150618","https://openalex.org/W2053713046","https://openalex.org/W2054274983","https://openalex.org/W2054987878","https://openalex.org/W2055569470","https://openalex.org/W2057113858","https://openalex.org/W2058256440","https://openalex.org/W2058855830","https://openalex.org/W2059248234","https://openalex.org/W2061172918","https://openalex.org/W2061954405","https://openalex.org/W2062465944","https://openalex.org/W2062875878","https://openalex.org/W2063927565","https://openalex.org/W2064905355","https://openalex.org/W2065460430","https://openalex.org/W2065801888","https://openalex.org/W2065902307","https://openalex.org/W2067167816","https://openalex.org/W2067509496","https://openalex.org/W2067619412","https://openalex.org/W2068030484","https://openalex.org/W2073024911","https://openalex.org/W2073290778","https://openalex.org/W2076491580","https://openalex.org/W2076704745","https://openalex.org/W2077430928","https://openalex.org/W2077746861","https://openalex.org/W2079293100","https://openalex.org/W2080040601","https://openalex.org/W2080135499","https://openalex.org/W2080860848","https://openalex.org/W2082993707","https://openalex.org/W2083722278","https://openalex.org/W2083991374","https://openalex.org/W2084456385","https://openalex.org/W2084894670","https://openalex.org/W2084936473","https://openalex.org/W2085582924","https://openalex.org/W2086843919","https://openalex.org/W2087092231","https://openalex.org/W2087353148","https://openalex.org/W2090672759","https://openalex.org/W2091012140","https://openalex.org/W2092054789","https://openalex.org/W2092946257","https://openalex.org/W2093759755","https://openalex.org/W2094815181","https://openalex.org/W2095048053","https://openalex.org/W2096676113","https://openalex.org/W2097255042","https://openalex.org/W2097406905","https://openalex.org/W2097942616","https://openalex.org/W2100221605","https://openalex.org/W2101037339","https://openalex.org/W2104225093","https://openalex.org/W2104239016","https://openalex.org/W2104544826","https://openalex.org/W2106360889","https://openalex.org/W2108471042","https://openalex.org/W2110921202","https://openalex.org/W2112699535","https://openalex.org/W2112870074","https://openalex.org/W2113435552","https://openalex.org/W2114222046","https://openalex.org/W2115517178","https://openalex.org/W2121737169","https://openalex.org/W2121774318","https://openalex.org/W2123067662","https://openalex.org/W2125793635","https://openalex.org/W2126467730","https://openalex.org/W2126958075","https://openalex.org/W2127734192","https://openalex.org/W2128382826","https://openalex.org/W2128591213","https://openalex.org/W2129404018","https://openalex.org/W2130362099","https://openalex.org/W2131739064","https://openalex.org/W2132067615","https://openalex.org/W2132128477","https://openalex.org/W2132738790","https://openalex.org/W2133908459","https://openalex.org/W2133957012","https://openalex.org/W2135837345","https://openalex.org/W2136152873","https://openalex.org/W2136497698","https://openalex.org/W2136737404","https://openalex.org/W2137693314","https://openalex.org/W2138811791","https://openalex.org/W2138886664","https://openalex.org/W2141249480","https://openalex.org/W2141815918","https://openalex.org/W2142639029","https://openalex.org/W2143022774","https://openalex.org/W2144906348","https://openalex.org/W2145163108","https://openalex.org/W2147061961","https://openalex.org/W2148842379","https://openalex.org/W2149414199","https://openalex.org/W2149685956","https://openalex.org/W2151105157","https://openalex.org/W2151578787","https://openalex.org/W2153949260","https://openalex.org/W2154200023","https://openalex.org/W2156063893","https://openalex.org/W2158024710","https://openalex.org/W2158049131","https://openalex.org/W2158369920","https://openalex.org/W2158685508","https://openalex.org/W2159358845","https://openalex.org/W2159999899","https://openalex.org/W2160721100","https://openalex.org/W2160846413","https://openalex.org/W2160940108","https://openalex.org/W2161214210","https://openalex.org/W2161768378","https://openalex.org/W2162755712","https://openalex.org/W2163234891","https://openalex.org/W2164829386","https://openalex.org/W2166672922","https://openalex.org/W2168396791","https://openalex.org/W2168631000","https://openalex.org/W2170380796","https://openalex.org/W2172294715","https://openalex.org/W2173497140","https://openalex.org/W2173547382","https://openalex.org/W2193288696","https://openalex.org/W2202177797","https://openalex.org/W2207758069","https://openalex.org/W2220278592","https://openalex.org/W2225050380","https://openalex.org/W2259802687","https://openalex.org/W2271366803","https://openalex.org/W2276751188","https://openalex.org/W2283559094","https://openalex.org/W2293666953","https://openalex.org/W2299926618","https://openalex.org/W2300993721","https://openalex.org/W2314203153","https://openalex.org/W2321953223","https://openalex.org/W2323613689","https://openalex.org/W2333894964","https://openalex.org/W2335030638","https://openalex.org/W2342678451","https://openalex.org/W2343077288","https://openalex.org/W2346698358","https://openalex.org/W2404877004","https://openalex.org/W2405572490","https://openalex.org/W2408490728","https://openalex.org/W2413790386","https://openalex.org/W2414142847","https://openalex.org/W2415378226","https://openalex.org/W2419293200","https://openalex.org/W2461012502","https://openalex.org/W2467363863","https://openalex.org/W2485446467","https://openalex.org/W2495210422","https://openalex.org/W2518770527","https://openalex.org/W2529235752","https://openalex.org/W2530349582","https://openalex.org/W2555969202","https://openalex.org/W2589489476","https://openalex.org/W2593055584","https://openalex.org/W2605036014","https://openalex.org/W2605187236","https://openalex.org/W2608352088","https://openalex.org/W2736212299","https://openalex.org/W2760935141","https://openalex.org/W2762666288","https://openalex.org/W2766971919","https://openalex.org/W4249994679","https://openalex.org/W4322701582"],"related_works":["https://openalex.org/W7218230540","https://openalex.org/W2045179744","https://openalex.org/W3211554128","https://openalex.org/W4403867346","https://openalex.org/W2772555861","https://openalex.org/W2161768378","https://openalex.org/W2345006110","https://openalex.org/W2740532964","https://openalex.org/W4399053110","https://openalex.org/W2088335906"],"abstract_inverted_index":{"Mesenchymal":[0],"stem":[1],"cells":[2,11],"(MSC)":[3],"comprise":[4],"a":[5,49,211,305],"heterogeneous":[6],"population":[7],"of":[8,46,52,60,89,113,143,146,160,175,182,198,214,230,233,250,257,260,267,289],"rapidly":[9,79],"proliferating":[10],"that":[12,181,189],"can":[13,302],"be":[14],"isolated":[15],"from":[16],"adult":[17],"(e.g.,":[18,27],"bone":[19,32],"marrow,":[20],"adipose":[21,35],"tissue)":[22],"as":[23,25,104,162,164,226,228,283,285,304],"well":[24,163,227,284],"fetal":[26],"umbilical":[28,39],"cord)":[29],"tissues":[30],"(termed":[31],"marrow":[33],"(BM)-,":[34],"tissue":[36],"(AT)-,":[37],"and":[38,43,70,98,111,123,152,209,220,281,297],"cord":[40],"(UC)-MSC,":[41],"respectively)":[42],"are":[44,192],"capable":[45],"differentiation":[47],"into":[48,81,318],"wide":[50],"range":[51],"non-hematopoietic":[53],"cell":[54],"types.":[55],"An":[56],"additional,":[57],"unique":[58],"attribute":[59],"MSC":[61,101,145,161,219,266],"is":[62,135,177,186,224],"their":[63],"ability":[64],"to":[65,67,71,156,205,247],"home":[66],"tumor":[68,150,222],"sites":[69],"interact":[72],"with":[73,129],"the":[74,87,90,108,141,168,172,215,221,231,239,248,253,258,279,287,293,315],"local":[75],"supportive":[76],"microenvironment":[77,223],"which":[78],"conceptualized":[80],"MSC-based":[82],"experimental":[83,165,235,261,310],"cancer":[84,126,199],"cytotherapy":[85,241],"at":[86],"turn":[88],"century.":[91],"Towards":[92],"this":[93,300],"purpose,":[94],"both":[95],"na\u00efve":[96,144,183],"(unmodified)":[97],"genetically":[99],"modified":[100],"(GM-MSC;":[102],"used":[103],"delivery":[105],"vehicles":[106],"for":[107,308],"controlled":[109],"expression":[110],"release":[112],"antitumorigenic":[114],"molecules)":[115],"have":[116],"been":[117],"employed":[118],"using":[119],"well-established":[120],"in":[121,124,203,237],"vitro":[122],"vivo":[125],"models,":[127],"albeit":[128],"variable":[130],"success.":[131],"The":[132],"first":[133,254],"approach":[134],"hampered":[136],"by":[137],"contradictory":[138],"findings":[139],"regarding":[140],"effects":[142],"different":[147],"origins":[148],"on":[149,265,273],"growth":[151],"metastasis,":[153],"largely":[154],"attributed":[155],"inherent":[157],"biological":[158],"heterogeneity":[159],"discrepancies.":[166],"In":[167],"second":[169],"case,":[170],"although":[171],"anti-cancer":[173,262],"effect":[174],"GM-MSC":[176],"markedly":[178],"improved":[179],"over":[180,292],"cells,":[184],"it":[185],"yet":[187],"apparent":[188],"some":[190,196],"protocols":[191],"more":[193],"efficient":[194],"against":[195],"types":[197],"than":[200],"others.":[201],"Regardless,":[202],"order":[204],"maximize":[206],"therapeutic":[207],"consistency":[208],"efficacy,":[210],"deeper":[212],"understanding":[213],"complex":[216],"interaction":[217],"between":[218],"required,":[225],"examination":[229],"role":[232],"key":[234],"parameters":[236],"shaping":[238],"final":[240],"outcome.":[242],"This":[243],"systematic":[244],"review":[245],"represents,":[246],"best":[249],"our":[251],"knowledge,":[252],"thorough":[255],"evaluation":[256],"impact":[259],"therapies":[263],"based":[264],"human":[268,274],"origin":[269],"(with":[270],"special":[271],"focus":[272],"BM-/AT-/UC-MSC).":[275],"Importantly,":[276],"we":[277],"dissect":[278],"commonalities":[280],"differences":[282],"address":[286],"shortcomings":[288],"work":[290],"accumulated":[291],"last":[294],"two":[295],"decades":[296],"discuss":[298],"how":[299],"information":[301],"serve":[303],"guide":[306],"map":[307],"optimal":[309],"design":[311],"implementation":[312],"ultimately":[313],"aiding":[314],"effective":[316],"transition":[317],"clinical":[319],"trials.":[320]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-22T00:00:00"}