{"id":"https://openalex.org/W2903630948","doi":"https://doi.org/10.1097/mph.0000000000001375","title":"Response to Pazopanib in Patients With Relapsed Osteosarcoma","display_name":"Response to Pazopanib in Patients With Relapsed Osteosarcoma","publication_year":2018,"publication_date":"2018-12-07","ids":{"openalex":"https://openalex.org/W2903630948","doi":"https://doi.org/10.1097/mph.0000000000001375","mag":"2903630948","pmid":"https://pubmed.ncbi.nlm.nih.gov/30531600"},"language":"en","primary_location":{"id":"doi:10.1097/mph.0000000000001375","doi":"https://doi.org/10.1097/mph.0000000000001375","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000001375","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013696290","display_name":"Kunal Elete","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kunal R. Elete","raw_affiliation_strings":["University of North Texas Health Science Center, Texas College of Osteopathic Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Texas Health Science Center, Texas College of Osteopathic Medicine","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003791140","display_name":"Karen H. Albritton","orcid":"https://orcid.org/0000-0002-4427-5634","observed_orcids":["https://orcid.org/0000-0002-4427-5634"]},"institutions":[{"id":"https://openalex.org/I4210090149","display_name":"Cook Children's Medical Center","ror":"https://ror.org/009z5t729","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210090149","https://openalex.org/I4210102753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen H. Albritton","raw_affiliation_strings":["Cook Children\u2019s Medical Center, Fort Worth, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cook Children\u2019s Medical Center, Fort Worth, TX","institution_ids":["https://openalex.org/I4210090149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064840856","display_name":"Lauren J. Akers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090149","display_name":"Cook Children's Medical Center","ror":"https://ror.org/009z5t729","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210090149","https://openalex.org/I4210102753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren J. Akers","raw_affiliation_strings":["Cook Children\u2019s Medical Center, Fort Worth, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cook Children\u2019s Medical Center, Fort Worth, TX","institution_ids":["https://openalex.org/I4210090149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007695569","display_name":"Riyaz M. Basha","orcid":"https://orcid.org/0000-0002-4071-0993","observed_orcids":["https://orcid.org/0000-0002-4071-0993","https://orcid.org/0000-0002-6955-5448"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Riyaz Basha","raw_affiliation_strings":["University of North Texas Health Science Center, Texas College of Osteopathic Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Texas Health Science Center, Texas College of Osteopathic Medicine","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072440595","display_name":"Anish Ray","orcid":"https://orcid.org/0000-0002-6349-1869","observed_orcids":["https://orcid.org/0000-0002-6349-1869"]},"institutions":[{"id":"https://openalex.org/I4210090149","display_name":"Cook Children's Medical Center","ror":"https://ror.org/009z5t729","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210090149","https://openalex.org/I4210102753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anish Ray","raw_affiliation_strings":["Cook Children\u2019s Medical Center, Fort Worth, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cook Children\u2019s Medical Center, Fort Worth, TX","institution_ids":["https://openalex.org/I4210090149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007695569","https://openalex.org/A5013696290"],"corresponding_institution_ids":["https://openalex.org/I165139151"],"apc_list":null,"apc_paid":null,"fwci":0.9418,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77044709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"4","first_page":"e254","last_page":"e257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pazopanib","display_name":"pazopanib","score":0.9620000123977661},{"id":"https://openalex.org/keywords/relapsed-osteosarcoma","display_name":"relapsed osteosarcoma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.7749999761581421},{"id":"https://openalex.org/keywords/metastatic-osteosarcoma","display_name":"metastatic osteosarcoma","score":0.7860000133514404},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.48399999737739563},{"id":"https://openalex.org/keywords/pediatric-sarcoma","display_name":"pediatric sarcoma","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2778439243","wikidata":"https://www.wikidata.org/wiki/Q7157043","display_name":"Pazopanib","level":4,"score":0.9915533661842346},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8598214387893677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8289270401000977},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6206103563308716},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5809564590454102},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5553796291351318},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5392988324165344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5103055834770203},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.509425699710846},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4679590165615082},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4495738744735718},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3617553114891052},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30557531118392944},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2970954179763794},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24745497107505798},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.15379399061203003}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/mph.0000000000001375","doi":"https://doi.org/10.1097/mph.0000000000001375","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000001375","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:30531600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30531600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W10207493","https://openalex.org/W202471535","https://openalex.org/W1715359867","https://openalex.org/W1971063058","https://openalex.org/W1978141358","https://openalex.org/W1998120322","https://openalex.org/W2054551521","https://openalex.org/W2077186772","https://openalex.org/W2097608507","https://openalex.org/W2101776780","https://openalex.org/W2104688502","https://openalex.org/W2116452300","https://openalex.org/W2125474267","https://openalex.org/W2142340671","https://openalex.org/W2154962291","https://openalex.org/W2160605524","https://openalex.org/W2166050970","https://openalex.org/W2400314950","https://openalex.org/W2415553333","https://openalex.org/W2536236658","https://openalex.org/W2732316920","https://openalex.org/W2768853417","https://openalex.org/W6683520536","https://openalex.org/W6746306685"],"related_works":["https://openalex.org/W2942765104","https://openalex.org/W2889964457","https://openalex.org/W2142834543","https://openalex.org/W2890746729","https://openalex.org/W4205899024","https://openalex.org/W7120176681","https://openalex.org/W4214949429","https://openalex.org/W2998558444","https://openalex.org/W4379280776","https://openalex.org/W4411661569"],"abstract_inverted_index":{"Axial":[0],"skeleton":[1],"primary":[2],"tumor,":[3],"metastatic":[4],"disease":[5],"at":[6],"presentation,":[7],"incomplete":[8],"surgical":[9],"resection,":[10],"and":[11,48,70,79],"<90%":[12],"tumor":[13],"necrosis":[14],"have":[15],"all":[16],"been":[17],"known":[18],"to":[19,65],"influence":[20],"prognosis":[21],"adversely":[22],"in":[23],"osteosarcoma.":[24],"Relapse":[25],"of":[26,35,41,90],"osteosarcoma,":[27],"typically":[28],"occurring":[29],"within":[30],"the":[31],"first":[32],"18":[33],"months":[34],"therapy,":[36],"with":[37,45,57],"an":[38],"incidence":[39],"rate":[40],"50%":[42],"is":[43],"treated":[44,56],"surgery,":[46],"chemotherapy,":[47],"targeted":[49],"therapy.":[50],"Here,":[51],"we":[52],"discuss":[53],"2":[54,84],"patients":[55],"pazopanib,":[58],"a":[59],"multi-tyrosine":[60],"kinase":[61],"inhibitor":[62],"presently":[63],"approved":[64],"treat":[66],"renal":[67],"cell":[68],"carcinoma":[69],"soft":[71],"tissue":[72],"sarcomas.":[73],"Case":[74,83],"1":[75],"achieved":[76],"positive":[77],"response":[78],"remains":[80],"on":[81],"pazopanib.":[82],"sustained":[85],"gastrointestinal":[86],"toxicity":[87],"requiring":[88],"suspension":[89],"drug,":[91],"despite":[92],"achieving":[93],"stable":[94],"disease.":[95]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-12-22T00:00:00"}
