{"id":"https://openalex.org/W2903608254","doi":"https://doi.org/10.1002/jcb.27602","title":"Methylene blue regulates inflammatory response in osteoarthritis by noncoding long chain RNA CILinc02","display_name":"Methylene blue regulates inflammatory response in osteoarthritis by noncoding long chain RNA CILinc02","publication_year":2018,"publication_date":"2018-12-12","ids":{"openalex":"https://openalex.org/W2903608254","doi":"https://doi.org/10.1002/jcb.27602","mag":"2903608254","pmid":"https://pubmed.ncbi.nlm.nih.gov/30548658"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.27602","doi":"https://doi.org/10.1002/jcb.27602","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.27602","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2903608254"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102229541","display_name":"Jiapeng Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiapeng Zheng","raw_affiliation_strings":["Department of Orthopedic, Southeast Hospital Affiliated to Xiamen University, ZhangZhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic, Southeast Hospital Affiliated to Xiamen University, ZhangZhou, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100429934","display_name":"Qiang Li","orcid":"https://orcid.org/0000-0002-0909-4440","observed_orcids":["https://orcid.org/0000-0002-0909-4440"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qiang Li","raw_affiliation_strings":["The Second Department of Orthopedics, Zhang Zhou Zhengxing Hospital, Zhangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-0909-4440","affiliations":[{"raw_affiliation_string":"The Second Department of Orthopedics, Zhang Zhou Zhengxing Hospital, Zhangzhou, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100429934"],"corresponding_institution_ids":[],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":1.8628,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.82724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"120","issue":"3","first_page":"3331","last_page":"3338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.8389999866485596},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9860000014305115},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cartilage-inflammation","display_name":"cartilage inflammation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-13","display_name":"matrix metalloproteinase-13","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.859000027179718},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9629999995231628},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chondrocyte-apoptosis","display_name":"chondrocyte apoptosis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cartilage-matrix","display_name":"cartilage matrix","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.6713564991950989},{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.6306935548782349},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.6166571974754333},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.4602545499801636},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.4552809000015259},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4145655035972595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3913234770298004},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3649570345878601},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35015183687210083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3314073085784912},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3031192421913147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24649548530578613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18186280131340027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16605758666992188},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13781288266181946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11891064047813416},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.27602","doi":"https://doi.org/10.1002/jcb.27602","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.27602","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:30548658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30548658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W251085771","https://openalex.org/W609404933","https://openalex.org/W1565801945","https://openalex.org/W1567262636","https://openalex.org/W1982483937","https://openalex.org/W1999319535","https://openalex.org/W1999784056","https://openalex.org/W2003678590","https://openalex.org/W2012489076","https://openalex.org/W2019189895","https://openalex.org/W2028149799","https://openalex.org/W2048630477","https://openalex.org/W2067963434","https://openalex.org/W2080546670","https://openalex.org/W2083372885","https://openalex.org/W2093006109","https://openalex.org/W2109875857","https://openalex.org/W2119887587","https://openalex.org/W2121768822","https://openalex.org/W2134823467","https://openalex.org/W2180591043","https://openalex.org/W2343137005","https://openalex.org/W2398042202","https://openalex.org/W2417725630","https://openalex.org/W2465561362","https://openalex.org/W2505200398","https://openalex.org/W2509799551","https://openalex.org/W2560791165","https://openalex.org/W4250908540"],"related_works":["https://openalex.org/W2328816421","https://openalex.org/W2180591043","https://openalex.org/W3159217287","https://openalex.org/W3197785636","https://openalex.org/W3110368910","https://openalex.org/W4311130583","https://openalex.org/W4408115577","https://openalex.org/W3143131033","https://openalex.org/W3126005722","https://openalex.org/W3104767632"],"abstract_inverted_index":{"Long":[0],"noncoding":[1],"RNAs":[2],"serve":[3],"as":[4,77,201],"novel":[5],"regulatory":[6],"molecules":[7],"involved":[8,92],"in":[9,16,35,50,57,93,98,129,134,157,191],"various":[10],"biological":[11],"processes,":[12],"but":[13,138],"their":[14],"role":[15],"osteoarthritis":[17],"(OA)":[18],"remains":[19],"unknown.":[20],"Therefore,":[21],"we":[22],"aimed":[23],"to":[24,40,170,208],"reveal":[25],"the":[26,42,94,143,153,162,177,187,210],"inflammatory":[27,203,211],"mechanisms":[28],"regulated":[29],"by":[30,113,205],"CILinc02":[31,46,56,99,126,151,207],"and":[32,39,47,61,88,118,133,155,182],"methylene":[33,48,108,139,165,173,197],"blue":[34,49,109,140,166,174,198],"human":[36],"osteoarthritic":[37,130],"cartilage":[38,59,131],"explore":[41],"potential":[43],"functions":[44],"of":[45,55,85,96,145,150,164,179,189],"OA.":[51,192],"The":[52,74,122],"expression":[53,144,178],"level":[54],"OA":[58,101,135,159],"tissues":[60,132],"primary":[62,102,136,158],"cells":[63],"was":[64,127,167],"obtained":[65],"using":[66],"quantitative":[67],"reverse":[68],"transcriptase":[69],"polymerase":[70],"chain":[71],"reaction":[72],"(qRT-PCR).":[73],"cytokines,":[75],"such":[76],"interleukin":[78],"1":[79],"(IL-1),":[80],"IL-6,":[81],"IL-17,":[82],"tissue":[83],"inhibitor":[84,204],"metalloproteinase-1":[86],"(TIMP-1)":[87],"matrix":[89],"metalloproteinase":[90],"(MMPs),":[91],"degradation":[95,188],"chondrocyte":[97,190],"knockdown":[100],"cells,":[103,137,160],"which":[104],"were":[105,111],"treated":[106],"with":[107],"that":[110,125,196],"determined":[112],"enzyme-linked":[114],"immunosorbent":[115],"assay,":[116],"qRT-PCR":[117],"Western":[119],"blot":[120],"analysis.":[121],"results":[123],"showed":[124],"overexpressed":[128],"can":[141,175,199],"inhibit":[142],"CILinc02.":[146,171],"In":[147],"addition,":[148],"overexpression":[149],"induced":[152],"inflammation":[154],"apoptosis":[156],"however,":[161],"effect":[163],"reversed":[168],"compared":[169],"Meanwhile,":[172],"regulate":[176,209],"TIMP-1,":[180],"MMP-1,":[181],"MMP-13":[183],"proteins,":[184],"thereby":[185],"suppressing":[186],"This":[193],"evidence":[194],"indicates":[195],"act":[200],"an":[202],"targeting":[206],"response.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-12-22T00:00:00"}