{"id":"https://openalex.org/W2903499208","doi":"https://doi.org/10.1093/humrep/dey349","title":"Tracking quality: can embryology key performance indicators be used to identify clinically relevant shifts in pregnancy rate?","display_name":"Tracking quality: can embryology key performance indicators be used to identify clinically relevant shifts in pregnancy rate?","publication_year":2018,"publication_date":"2018-11-23","ids":{"openalex":"https://openalex.org/W2903499208","doi":"https://doi.org/10.1093/humrep/dey349","mag":"2903499208","pmid":"https://pubmed.ncbi.nlm.nih.gov/30517659"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/dey349","doi":"https://doi.org/10.1093/humrep/dey349","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/dey349","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019318257","display_name":"Elizabeth R. Andersen Hammond","orcid":"https://orcid.org/0000-0003-0660-940X","observed_orcids":["https://orcid.org/0000-0003-0660-940X"]},"institutions":[{"id":"https://openalex.org/I4405269831","display_name":"Fertility Associates (New Zealand)","ror":"https://ror.org/05bh55528","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4405269831"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Elizabeth R Hammond","raw_affiliation_strings":["Fertility Associates, 7 Ellerslie Racecourse Drive, Remuera, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fertility Associates, 7 Ellerslie Racecourse Drive, Remuera, Auckland, New Zealand","institution_ids":["https://openalex.org/I4405269831"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007027543","display_name":"Dean E. Morbeck","orcid":"https://orcid.org/0000-0002-8787-9331","observed_orcids":["https://orcid.org/0000-0002-8787-9331"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4405269831","display_name":"Fertility Associates (New Zealand)","ror":"https://ror.org/05bh55528","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4405269831"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Dean E Morbeck","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand","Fertility Associates, 7 Ellerslie Racecourse Drive, Remuera, Auckland, New Zealand"],"raw_orcid":"https://orcid.org/0000-0002-8787-9331","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Fertility Associates, 7 Ellerslie Racecourse Drive, Remuera, Auckland, New Zealand","institution_ids":["https://openalex.org/I4405269831"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007027543"],"corresponding_institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4405269831"],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":2.3435,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.87395412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"34","issue":"1","first_page":"37","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.06469999998807907,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statistical-process-control","display_name":"statistical process control","score":0.8659999966621399},{"id":"https://openalex.org/keywords/shewhart-control-charts","display_name":"Shewhart control charts","score":0.9610000252723694},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.9459999799728394},{"id":"https://openalex.org/keywords/early-warning-indicators","display_name":"early warning indicators","score":0.5189999938011169},{"id":"https://openalex.org/keywords/embryo-culture","display_name":"embryo culture","score":0.32899999618530273},{"id":"https://openalex.org/keywords/cumulative-pregnancy-rate","display_name":"cumulative pregnancy rate","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.6195585131645203},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5885704755783081},{"id":"https://openalex.org/C27971861","wikidata":"https://www.wikidata.org/wiki/Q131683","display_name":"Embryology","level":2,"score":0.5687178373336792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3871283531188965},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.37195321917533875},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.36245429515838623},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34691327810287476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33697742223739624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09427568316459656},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001723","descriptor_name":"Birth Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004626","descriptor_name":"Embryology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007753","descriptor_name":"Laboratories","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D010043","descriptor_name":"Outcome and Process Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018873","descriptor_name":"Pregnancy Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020554","descriptor_name":"Sperm Injections, Intracytoplasmic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050498","descriptor_name":"Live Birth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/humrep/dey349","doi":"https://doi.org/10.1093/humrep/dey349","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/dey349","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmid:30517659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30517659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"},{"id":"pmid:30715339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30715339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W255182328","https://openalex.org/W1254024368","https://openalex.org/W1573834997","https://openalex.org/W1986188860","https://openalex.org/W2084626691","https://openalex.org/W2126057618","https://openalex.org/W2148963547","https://openalex.org/W2151928999","https://openalex.org/W2276356401","https://openalex.org/W2292436881","https://openalex.org/W2506764256","https://openalex.org/W2590422350","https://openalex.org/W2768062237","https://openalex.org/W2794546039","https://openalex.org/W3132626214","https://openalex.org/W4289991095"],"related_works":["https://openalex.org/W2891255495","https://openalex.org/W3201184488","https://openalex.org/W2977192866","https://openalex.org/W3158948893","https://openalex.org/W2891026199","https://openalex.org/W7167731323","https://openalex.org/W2976978959","https://openalex.org/W3163613600","https://openalex.org/W7167024639","https://openalex.org/W2044329828"],"abstract_inverted_index":{"STUDY":[0,123,419],"QUESTION:":[1],"Can":[2],"embryology":[3,30,46,207,341],"key":[4],"performance":[5,12,62],"indicators":[6],"(KPIs)":[7],"detect":[8],"shifts":[9,80,115,365,416],"in":[10,16,39,51,81,118,156,271,291,299,318,366,409,417],"laboratory":[11,66,82,119,202,342],"that":[13,32,60,87,331,393],"precede":[14],"changes":[15,50,117],"clinical":[17,52,172,383],"outcomes?":[18],"SUMMARY":[19],"ANSWER:":[20],"Day":[21],"5":[22],"usable":[23,35],"blastocyst":[24,36,334],"rate":[25,37,174,335,374],"(D5BUR)":[26],"is":[27,84,121],"an":[28,64,75],"important":[29],"KPI":[31,350,364,395],"complements":[33],"total":[34],"(TBUR)":[38],"its":[40],"ability":[41],"to":[42,49,236,265,401],"rapidly":[43],"identify":[44],"adverse":[45,407],"outcomes,":[47],"prior":[48],"outcomes.":[53],"WHAT":[54],"IS":[55],"KNOWN":[56],"ALREADY:":[57],"The":[58,90,198,348,430],"hypothesis":[59,86],"monitoring":[61,98,351,396],"of":[63,79,107,131,200,406,435],"IVF":[65,100,136,166],"using":[67,108,183,214],"statistical":[68,349,394],"process":[69],"controls":[70],"(SPCs)":[71],"can":[72],"act":[73],"as":[74,381],"early":[76,404],"warning":[77,192],"signal":[78],"conditions":[83],"a":[85,215,262,382],"requires":[88],"validation.":[89],"Vienna":[91],"consensus":[92],"report":[93],"recently":[94],"defined":[95],"KPIs":[96,110,132,188,208],"for":[97,111,133,181,325,427],"fresh":[99,135],"and":[101,137,147,171,179,194,209,222,244,306],"ICSI":[102,138,163],"cycles,":[103],"but":[104,281],"the":[105,151,157,201,239,245,253,266,275,289,297,316,332,355,399,428],"effectiveness":[106],"these":[109],"detecting":[112],"clinically":[113],"relevant":[114],"following":[116],"processes":[120],"unknown.":[122],"DESIGN,":[124],"SIZE,":[125],"DURATION:":[126],"A":[127,269],"retrospective,":[128],"multicentre,":[129],"analysis":[130],"1971":[134],"cycles":[139],"during":[140,149],"three":[141,327],"consecutive":[142],"5-month":[143],"periods":[144],"(P1,":[145],"P2":[146],"P3)":[148],"which":[150],"culture":[152,203,240,300,319,328],"medium":[153,204,241,276,301],"was":[154,212,242,247,278,282,312,378],"changed":[155],"middle":[158],"period.":[159],"PARTICIPANTS/MATERIALS,":[160],"SETTING,":[161],"METHODS:":[162],"fertilisation":[164,167],"rate,":[165,168],"D5BUR,":[169,304],"TBUR":[170,310],"pregnancy":[173],"(CPR)":[175],"were":[176,189,425],"tracked":[177],"monthly":[178],"analysed":[180],"SPC":[182],"Shewhart":[184],"control":[185,195,323],"charts.":[186],"Out-of-control":[187],"identified":[190],"by":[191,315,354],"(2-sigma)":[193],"(3-sigma)":[196],"limits.":[197],"effect":[199],"change":[205,254,263,277,298,317],"on":[206],"cumulative":[210,307],"CPR":[211,272,305],"investigated":[213],"one-way":[216],"ANOVA":[217],"or":[218,414],"Pearson":[219],"Chi-squared":[220],"test":[221],"logistic":[223],"regression.":[224],"MAIN":[225],"RESULTS":[226],"AND":[227],"THE":[228,388],"ROLE":[229],"OF":[230,387],"CHANCE:":[231],"D5BUR":[232,258,292],"decreased":[233],"from":[234],"32":[235],"25%":[237],"after":[238,252,261,274,288,412],"changed,":[243],"decrease":[246,270],"detected":[248,284],"within":[249,322],"1":[250],"week":[251],"(P":[255,293],"<":[256],"0.0001).":[257],"subsequently":[259],"increased":[260],"back":[264],"original":[267],"medium.":[268],"(51-36%)":[273],"also":[279],"observed":[280],"not":[283,313,338,379],"until":[285],"3":[286],"months":[287],"shift":[290],"=":[294],"0.0005).":[295],"Overall,":[296],"independently":[302],"influenced":[303],"CPR.":[308],"Importantly,":[309],"(41%)":[311],"affected":[314],"medium,":[320],"remaining":[321],"limits":[324],"all":[326],"periods,":[329],"indicating":[330],"overall":[333],"alone":[336],"may":[337,358],"sufficiently":[339],"monitor":[340],"performance.":[343],"LIMITATIONS":[344],"REASONS":[345],"FOR":[346],"CAUTION:":[347],"system":[352],"demonstrated":[353],"current":[356],"study":[357,391],"be":[359],"less":[360],"effective":[361],"at":[362],"identifying":[363],"smaller":[367],"clinics":[368],"with":[369],"lower":[370],"cycle":[371,376],"volumes.":[372],"Live-birth":[373],"per":[375],"started":[377],"included":[380],"KPI.":[384],"WIDER":[385],"IMPLICATIONS":[386],"FINDINGS:":[389],"This":[390],"demonstrates":[392],"systems":[397],"have":[398,432],"potential":[400],"provide":[402],"systematic,":[403],"detection":[405],"outcomes":[408],"ART":[410],"laboratories":[411],"planned":[413],"unexpected":[415],"conditions.":[418],"FUNDING/COMPETING":[420],"INTEREST(S):":[421],"No":[422],"external":[423],"funds":[424],"used":[426],"study.":[429],"authors":[431],"no":[433],"conflicts":[434],"interest.":[436],"TRIAL":[437],"REGISTRATION":[438],"NUMBER:":[439],"Not":[440],"applicable.":[441]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-12-11T00:00:00"}
