{"id":"https://openalex.org/W2903393655","doi":"https://doi.org/10.1039/c8ra08925f","title":"Racemic vs. enantiopure inert Ti( iv ) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines","display_name":"Racemic vs. enantiopure inert Ti( iv ) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2903393655","doi":"https://doi.org/10.1039/c8ra08925f","mag":"2903393655","pmid":"https://pubmed.ncbi.nlm.nih.gov/30713687"},"language":"en","primary_location":{"id":"doi:10.1039/c8ra08925f","doi":"https://doi.org/10.1039/c8ra08925f","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c8ra08925f","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2018/ra/c8ra08925f","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2018/ra/c8ra08925f","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113934216","display_name":"Maya Miller","orcid":"https://orcid.org/0000-0002-7764-4512","observed_orcids":["https://orcid.org/0000-0002-7764-4512"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Maya Miller","raw_affiliation_strings":["Institute of Chemistry","Israel","Jerusalem 9190401","The Hebrew University of Jerusalem","Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Israel","institution_ids":[]},{"raw_affiliation_string":"Jerusalem 9190401","institution_ids":[]},{"raw_affiliation_string":"The Hebrew University of Jerusalem","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066437006","display_name":"Edit Y. Tshuva","orcid":"https://orcid.org/0000-0001-7452-3611","observed_orcids":["https://orcid.org/0000-0001-7452-3611"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Edit Y. Tshuva","raw_affiliation_strings":["Institute of Chemistry","Israel","Jerusalem 9190401","The Hebrew University of Jerusalem","Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel"],"raw_orcid":"https://orcid.org/0000-0001-7452-3611","affiliations":[{"raw_affiliation_string":"Institute of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Israel","institution_ids":[]},{"raw_affiliation_string":"Jerusalem 9190401","institution_ids":[]},{"raw_affiliation_string":"The Hebrew University of Jerusalem","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066437006"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.3383,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63379956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"69","first_page":"39731","last_page":"39734"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/titanium-iv-complexes","display_name":"titanium(IV) complexes","score":0.902999997138977},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/drug-resistant-cancer-cells","display_name":"drug-resistant cancer cells","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.718999981880188},{"id":"https://openalex.org/keywords/hydrolytic-stability","display_name":"hydrolytic stability","score":0.8550000190734863},{"id":"https://openalex.org/keywords/enantiomeric-resolution","display_name":"enantiomer resolution","score":0.7409999966621399},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.5070000290870667},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/a2780-cells","display_name":"A2780 cells","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C93237805","wikidata":"https://www.wikidata.org/wiki/Q5375227","display_name":"Enantiopure drug","level":4,"score":0.9180495142936707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7345376014709473},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.7250130772590637},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6609821319580078},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.6206209063529968},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6085820198059082},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49050015211105347},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4499186873435974},{"id":"https://openalex.org/C154256306","wikidata":"https://www.wikidata.org/wiki/Q41795528","display_name":"Inert","level":2,"score":0.42931535840034485},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36790722608566284},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20547163486480713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19935262203216553},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11650106310844421},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.11516618728637695},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1039/c8ra08925f","doi":"https://doi.org/10.1039/c8ra08925f","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c8ra08925f","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2018/ra/c8ra08925f","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmid:30713687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30713687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5338251","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6333245","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6333245","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6333245","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmh:oai:zenodo.org:3750720","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/3750720","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1039/c8ra08925f","doi":"https://doi.org/10.1039/c8ra08925f","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c8ra08925f","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2018/ra/c8ra08925f","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5754680543","display_name":"Highly Competent and Safe Titanium(IV) Therapeutic Frameworks that are Cancer Targeted based on Complex 1, 2, and 3D Chemical Architectures","funder_award_id":"681243","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2903393655.pdf","grobid_xml":"https://content.openalex.org/works/W2903393655.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W103660396","https://openalex.org/W1527376333","https://openalex.org/W1556983269","https://openalex.org/W1768340483","https://openalex.org/W1968092609","https://openalex.org/W1980251832","https://openalex.org/W1982158713","https://openalex.org/W1995129984","https://openalex.org/W1996850060","https://openalex.org/W2001533230","https://openalex.org/W2002788196","https://openalex.org/W2007101829","https://openalex.org/W2015694743","https://openalex.org/W2016642274","https://openalex.org/W2036066786","https://openalex.org/W2036508655","https://openalex.org/W2050545246","https://openalex.org/W2057245127","https://openalex.org/W2058928933","https://openalex.org/W2063472119","https://openalex.org/W2080756265","https://openalex.org/W2084825376","https://openalex.org/W2089193667","https://openalex.org/W2091680603","https://openalex.org/W2106227686","https://openalex.org/W2110037743","https://openalex.org/W2113453000","https://openalex.org/W2116871687","https://openalex.org/W2118718238","https://openalex.org/W2130215449","https://openalex.org/W2138497443","https://openalex.org/W2138707441","https://openalex.org/W2148316789","https://openalex.org/W2164278620","https://openalex.org/W2196283803","https://openalex.org/W2241061912","https://openalex.org/W2291770760","https://openalex.org/W2314264539","https://openalex.org/W2315909663","https://openalex.org/W2322813316","https://openalex.org/W2326738961","https://openalex.org/W2329538513","https://openalex.org/W2330509577","https://openalex.org/W2335350605","https://openalex.org/W2415291408","https://openalex.org/W2460604176","https://openalex.org/W2556722893","https://openalex.org/W2581297334","https://openalex.org/W2757913947","https://openalex.org/W2809237130","https://openalex.org/W2951965892","https://openalex.org/W3004576110","https://openalex.org/W4376597761"],"related_works":["https://openalex.org/W2098533732","https://openalex.org/W2908488772","https://openalex.org/W1989251164","https://openalex.org/W2003186025","https://openalex.org/W2952814565","https://openalex.org/W2083653101","https://openalex.org/W2112355874","https://openalex.org/W2118882114","https://openalex.org/W2002046721","https://openalex.org/W2150196878"],"abstract_inverted_index":{"A":[0],"tetrakis(phenolato)":[1],"Ti(iv)":[2],"complex":[3],"was":[4],"synthesized":[5],"in":[6],"racemic":[7],"and":[8,16,25,37],"optically":[9],"pure":[10],"form,":[11],"exhibiting":[12],"high":[13],"hydrolytic":[14],"stability,":[15],"similar":[17],"cytotoxicity":[18],"for":[19],"all":[20],"stereochemical":[21],"forms":[22],"on":[23,34],"HT-29":[24],"A2780":[26],"cancer":[27],"cells.":[28],"Higher":[29],"activity":[30,43],"of":[31,44],"the":[32],"racemate":[33],"drug-resistant":[35],"A2780cp":[36],"A2780adr":[38],"lines":[39],"implies":[40],"a":[41],"beneficial":[42],"both":[45],"enantiomers":[46],"rendering":[47],"enantiomeric":[48],"resolution":[49],"unnecessary.":[50]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-12-11T00:00:00"}