{"id":"https://openalex.org/W2903386536","doi":"https://doi.org/10.3389/fimmu.2018.02762","title":"DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop","display_name":"DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop","publication_year":2018,"publication_date":"2018-11-27","ids":{"openalex":"https://openalex.org/W2903386536","doi":"https://doi.org/10.3389/fimmu.2018.02762","mag":"2903386536","pmid":"https://pubmed.ncbi.nlm.nih.gov/30538709","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6277526"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2018.02762","doi":"https://doi.org/10.3389/fimmu.2018.02762","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.02762","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.02762/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.02762/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068386037","display_name":"Menglin Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menglin Fan","raw_affiliation_strings":["State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602130","display_name":"Yanan Li","orcid":"https://orcid.org/0000-0003-4396-0557","observed_orcids":["https://orcid.org/0000-0003-4396-0557"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Li","raw_affiliation_strings":["State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067402151","display_name":"Chun-hua Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhua Yao","raw_affiliation_strings":["State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100735904","display_name":"Xiufeng Liu","orcid":"https://orcid.org/0000-0002-3315-8571","observed_orcids":["https://orcid.org/0000-0002-3315-8571"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiufeng Liu","raw_affiliation_strings":["State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629650","display_name":"Jihua Liu","orcid":"https://orcid.org/0000-0002-5769-9989","observed_orcids":["https://orcid.org/0000-0002-5769-9989"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jihua Liu","raw_affiliation_strings":["State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020248771","display_name":"Boyang Yu","orcid":"https://orcid.org/0000-0002-1401-9250","observed_orcids":["https://orcid.org/0000-0002-1401-9250"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boyang Yu","raw_affiliation_strings":["State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100629650","https://openalex.org/A5100735904"],"corresponding_institution_ids":["https://openalex.org/I161716053"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":10.2711,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.98888818,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"2762","last_page":"2762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.4629000127315521,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.4629000127315521,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.41110000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.09000000357627869,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.9599999785423279},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nrf2-ho-1-signaling-pathway","display_name":"Nrf2/HO-1 pathway","score":0.7599999904632568},{"id":"https://openalex.org/keywords/selective-autophagy","display_name":"selective autophagy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.5210000276565552},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.6000000238418579},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.984000027179718},{"id":"https://openalex.org/keywords/3-methyladenine","display_name":"3-methyladenine","score":0.8619999885559082},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.6439999938011169},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2776529522","wikidata":"https://www.wikidata.org/wiki/Q18034700","display_name":"KEAP1","level":4,"score":0.7966228723526001},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7040512561798096},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6926174163818359},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6221403479576111},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6002871990203857},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5637818574905396},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5009400844573975},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4954758882522583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4935876131057739},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4729287922382355},{"id":"https://openalex.org/C2781160685","wikidata":"https://www.wikidata.org/wiki/Q5276420","display_name":"Dihydroartemisinin","level":5,"score":0.46978867053985596},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45776182413101196},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4420596659183502},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4245438575744629},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3706117272377014},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33218643069267273},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3298340439796448},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3018379211425781},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2645012140274048},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20042821764945984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17832869291305542},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.11201763153076172},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.07327315211296082},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2018.02762","doi":"https://doi.org/10.3389/fimmu.2018.02762","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.02762","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.02762/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5254262","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6277526","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30538709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30538709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6277526","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6277526/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f1d3a56a561d4f7cabc23b1048fd1102","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f1d3a56a561d4f7cabc23b1048fd1102","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2018.02762","doi":"https://doi.org/10.3389/fimmu.2018.02762","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.02762","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.02762/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1257722382","display_name":null,"funder_award_id":"BK20160756","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336049","display_name":"National Science and Technology Program during the Twelfth Five-year Plan Period","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2903386536.pdf","grobid_xml":"https://content.openalex.org/works/W2903386536.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W154133038","https://openalex.org/W775311174","https://openalex.org/W1904693734","https://openalex.org/W1973884972","https://openalex.org/W1974142420","https://openalex.org/W1974983170","https://openalex.org/W1978339195","https://openalex.org/W1980327861","https://openalex.org/W1985343980","https://openalex.org/W1985745093","https://openalex.org/W2008098615","https://openalex.org/W2010611237","https://openalex.org/W2019440591","https://openalex.org/W2023598683","https://openalex.org/W2024369550","https://openalex.org/W2026271536","https://openalex.org/W2028078823","https://openalex.org/W2044327528","https://openalex.org/W2046266642","https://openalex.org/W2046364172","https://openalex.org/W2049528479","https://openalex.org/W2070871300","https://openalex.org/W2071015953","https://openalex.org/W2085355045","https://openalex.org/W2102354517","https://openalex.org/W2102776209","https://openalex.org/W2113024198","https://openalex.org/W2126934086","https://openalex.org/W2144342799","https://openalex.org/W2146607274","https://openalex.org/W2178915804","https://openalex.org/W2180685702","https://openalex.org/W2181051316","https://openalex.org/W2184577754","https://openalex.org/W2311442028","https://openalex.org/W2340338776","https://openalex.org/W2370934500","https://openalex.org/W2528816232","https://openalex.org/W2529101401","https://openalex.org/W2545887135","https://openalex.org/W2561420332","https://openalex.org/W2604497619","https://openalex.org/W2636131768","https://openalex.org/W2728293569","https://openalex.org/W2765400885","https://openalex.org/W2770432229","https://openalex.org/W2775161791","https://openalex.org/W2805053653","https://openalex.org/W2881092739","https://openalex.org/W2897602500","https://openalex.org/W4308769923"],"related_works":["https://openalex.org/W2952044106","https://openalex.org/W2897602500","https://openalex.org/W4224942357","https://openalex.org/W2775421057","https://openalex.org/W4385188620","https://openalex.org/W2798114001","https://openalex.org/W1485669853","https://openalex.org/W4393003845","https://openalex.org/W4317566565","https://openalex.org/W1964342138"],"abstract_inverted_index":{"Artemisinins":[0],"have":[1,5],"been":[2],"reported":[3],"to":[4,46,187],"diverse":[6],"functions,":[7],"such":[8],"as":[9],"antimalaria,":[10],"anticancer,":[11],"anti-inflammation,":[12],"and":[13,38,54,77,102,115,118,146,148,182,219,224,238],"immunoregulation":[14],"activities.":[15],"DC32":[16,51,63,96,109,125,139,171,204],"[(9\u03b1,12\u03b1-dihydroartemisinyl)":[17],"bis(2'-chlorocinnmate)],":[18],"a":[19,188,239],"dihydroartemisinin":[20],"derivative":[21],"possessing":[22],"potent":[23],"immunosuppressive":[24],"properties,":[25],"was":[26],"synthesized":[27],"in":[28,35,41,83,235],"our":[29,199],"previous":[30],"study.":[31],"Collagen-induced":[32],"arthritis":[33,208],"(CIA)":[34],"DBA/1":[36,84],"mice":[37,85],"inflammatory":[39],"model":[40],"NIH-3T3":[42,92,151],"cells":[43,93,152],"were":[44],"established":[45],"evaluate":[47],"the":[48,56,73,79,99,122,142,154,160,173,211,217],"effect":[49,123],"of":[50,81,105,112,124,138,144,150,162,175,195,222],"on":[52,126],"RA":[53,236],"discover":[55],"underlying":[57],"mechanisms.":[58],"The":[59],"results":[60,168],"showed":[61],"that":[62,95,170,183,203],"could":[64,97,129,140],"markedly":[65],"alleviate":[66],"footpad":[67],"inflammation,":[68],"reduce":[69],"cartilage":[70],"degradation,":[71],"activate":[72],"Nrf2/HO-1":[74],"signaling":[75],"pathway,":[76],"increase":[78,98],"transcription":[80],"p62":[82,119,133,184,226],"with":[86,91,153],"CIA.":[87],"Further":[88],"mechanistic":[89],"exploration":[90],"indicated":[94],"transcription,":[100],"expression,":[101],"nuclear":[103],"translocation":[104],"Nrf2.":[106,196],"In":[107,197],"addition,":[108],"promoted":[110],"degradation":[111,128,161,174],"Keap1":[113,127,163],"protein":[114,220],"upregulated":[116],"HO-1":[117],"expression.":[120,227],"Furthermore,":[121],"be":[130],"prevented":[131],"by":[132,165,177,215],"knockdown":[134],"using":[135],"siRNA.":[136],"Administration":[137],"inhibit":[141],"activation":[143,194],"Akt/mTOR":[145],"ERK,":[147],"pretreatment":[149],"autophagy":[155,181],"inhibitor":[156],"3-methyladenine":[157],"(3-MA)":[158],"attenuated":[159],"induced":[164],"DC32.":[166],"These":[167,228],"suggest":[169],"inhibits":[172],"Nrf2":[176,223],"promoting":[178],"p62-mediated":[179],"selective":[180],"upregulation":[185],"contributed":[186],"positive":[189],"feedback":[190,213],"loop":[191,214],"for":[192,233,242],"persistent":[193],"summary,":[198],"present":[200],"study":[201],"demonstrated":[202],"significantly":[205],"suppressed":[206],"rheumatoid":[207],"(RA)":[209],"via":[210],"Nrf2-p62-Keap1":[212],"increasing":[216],"mRNA":[218],"levels":[221],"inducing":[225],"findings":[229],"provide":[230],"new":[231],"mechanisms":[232],"artemisinins":[234],"treatment":[237],"potential":[240],"strategy":[241],"discovering":[243],"antirheumatic":[244],"drugs.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-11T00:00:00"}