{"id":"https://openalex.org/W2903385913","doi":"https://doi.org/10.1021/acs.oprd.8b00362","title":"Conversion of 2,4,6-Trimethylaniline to 3-(Mesitylthio)-1H-1,2,4-triazole Using a Continuous-Flow Reactor","display_name":"Conversion of 2,4,6-Trimethylaniline to 3-(Mesitylthio)-1H-1,2,4-triazole Using a Continuous-Flow Reactor","publication_year":2018,"publication_date":"2018-11-26","ids":{"openalex":"https://openalex.org/W2903385913","doi":"https://doi.org/10.1021/acs.oprd.8b00362","mag":"2903385913"},"language":"en","primary_location":{"id":"doi:10.1021/acs.oprd.8b00362","doi":"https://doi.org/10.1021/acs.oprd.8b00362","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.oprd.8b00362","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research & Development","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2903385913"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101807465","display_name":"Zhiqun Yu","orcid":"https://orcid.org/0000-0001-5072-1509","observed_orcids":["https://orcid.org/0000-0001-5072-1509"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqun Yu","raw_affiliation_strings":["National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069216708","display_name":"Jianyang Chen","orcid":"https://orcid.org/0000-0001-7402-2390","observed_orcids":["https://orcid.org/0000-0001-7402-2390"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianyang Chen","raw_affiliation_strings":["National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101825160","display_name":"Jiming Liu","orcid":"https://orcid.org/0000-0003-2926-8038","observed_orcids":["https://orcid.org/0000-0003-2926-8038"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiming Liu","raw_affiliation_strings":["Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041454822","display_name":"Zhengkang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengkang Wu","raw_affiliation_strings":["Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101653702","display_name":"Weike Su","orcid":"https://orcid.org/0000-0003-2544-1948","observed_orcids":["https://orcid.org/0000-0003-2544-1948"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weike Su","raw_affiliation_strings":["National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals \u00a0and\u00a0 Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals \u00a0and\u00a0 Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China","institution_ids":["https://openalex.org/I55712492"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101653702"],"corresponding_institution_ids":["https://openalex.org/I55712492"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.4968,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.54586073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"12","first_page":"1828","last_page":"1834"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.15479999780654907,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/continuous-flow-reactor","display_name":"continuous flow reactor","score":0.871999979019165},{"id":"https://openalex.org/keywords/diazotization","display_name":"diazotization","score":0.8650000095367432},{"id":"https://openalex.org/keywords/diazonium-chloride","display_name":"diazonium chloride","score":0.8659999966621399},{"id":"https://openalex.org/keywords/azo-coupling","display_name":"azo coupling","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dediazoniation","display_name":"dediazoniation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/triazole-synthesis","display_name":"triazole synthesis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/side-reaction-suppression","display_name":"side reaction suppression","score":0.625},{"id":"https://openalex.org/keywords/dimerization","display_name":"dimerization","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.7438031435012817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.74109947681427},{"id":"https://openalex.org/C2985264121","wikidata":"https://www.wikidata.org/wiki/Q216320","display_name":"Continuous flow","level":2,"score":0.6369460821151733},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.5893566012382507},{"id":"https://openalex.org/C2777907353","wikidata":"https://www.wikidata.org/wiki/Q903341","display_name":"Triazole","level":2,"score":0.581056535243988},{"id":"https://openalex.org/C2780020378","wikidata":"https://www.wikidata.org/wiki/Q161300","display_name":"1,2,4-Triazole","level":2,"score":0.5564054846763611},{"id":"https://openalex.org/C132482357","wikidata":"https://www.wikidata.org/wiki/Q5462089","display_name":"Flow chemistry","level":3,"score":0.5165459513664246},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4845277667045593},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.45680707693099976},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4335242509841919},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3200921416282654},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.19965249300003052},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14680594205856323},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.oprd.8b00362","doi":"https://doi.org/10.1021/acs.oprd.8b00362","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.oprd.8b00362","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research & Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4904887177","display_name":null,"funder_award_id":"21776254","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W939075134","https://openalex.org/W1541612385","https://openalex.org/W1937018166","https://openalex.org/W1972617936","https://openalex.org/W1979782102","https://openalex.org/W1982259586","https://openalex.org/W1995579083","https://openalex.org/W2026823120","https://openalex.org/W2063634449","https://openalex.org/W2065518405","https://openalex.org/W2118719691","https://openalex.org/W2142495898","https://openalex.org/W2154566821","https://openalex.org/W2231668957","https://openalex.org/W2291845424","https://openalex.org/W2316240799","https://openalex.org/W2318342972","https://openalex.org/W2341727092","https://openalex.org/W2465080249","https://openalex.org/W2480605224","https://openalex.org/W2550104641","https://openalex.org/W2552793446","https://openalex.org/W2553456000","https://openalex.org/W2574290081","https://openalex.org/W2751217140","https://openalex.org/W2952131313"],"related_works":["https://openalex.org/W2302837323","https://openalex.org/W2529732657","https://openalex.org/W2763570236","https://openalex.org/W3012228277","https://openalex.org/W2953004222","https://openalex.org/W4391310561","https://openalex.org/W2995924613","https://openalex.org/W2520256069","https://openalex.org/W2581876790","https://openalex.org/W2888204569"],"abstract_inverted_index":{"An":[0],"expeditious":[1],"and":[2,33,56],"highly":[3],"efficient":[4],"continuous-flow":[5,64],"process":[6],"was":[7,20],"developed":[8],"for":[9],"the":[10,63],"synthesis":[11],"of":[12,46],"3-(mesitylthio)-1":[13,37],"H":[14,31,38],"-1,2,4-triazole.":[15],"The":[16,49],"starting":[17],"material":[18],"2,4,6-trimethylaniline":[19],"diazotized":[21],"to":[22,35],"give":[23],"diazonium":[24],"chloride,":[25],"followed":[26],"by":[27,62],"azo-coupling":[28],"with":[29,43],"1":[30],"-1,2,4-triazole-3-thiol":[32],"dediazoniation":[34],"provide":[36],"-1,2,4-triazole":[39],"in":[40],"85%":[41],"yield":[42],"a":[44],"productivity":[45],"344":[47],"g/h.":[48],"side":[50],"reactions":[51],"such":[52],"as":[53],"hydrolysis,":[54],"dimerization,":[55],"intramolecular":[57],"coupling":[58],"were":[59],"significantly":[60],"inhibited":[61],"technology.":[65]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2018-12-11T00:00:00"}