{"id":"https://openalex.org/W2903097347","doi":"https://doi.org/10.1093/ofid/ofy210.364","title":"353. HSV-Induced Anti-NMDAR Encephalitis","display_name":"353. HSV-Induced Anti-NMDAR Encephalitis","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2903097347","doi":"https://doi.org/10.1093/ofid/ofy210.364","mag":"2903097347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6255570"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofy210.364","doi":"https://doi.org/10.1093/ofid/ofy210.364","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.364","pdf_url":"https://academic.oup.com/ofid/article-pdf/5/suppl_1/S139/27558437/ofy210.364.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/article-pdf/5/suppl_1/S139/27558437/ofy210.364.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013658205","display_name":"Najmus Sahar","orcid":"https://orcid.org/0000-0001-5554-7650","observed_orcids":["https://orcid.org/0000-0001-5554-7650"]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Najmus Sahar","raw_affiliation_strings":["Infectious Diseases, Wright State University Boonshoft School of Medicine, Dayton, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Wright State University Boonshoft School of Medicine, Dayton, Ohio","institution_ids":["https://openalex.org/I19648265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013658205"],"corresponding_institution_ids":["https://openalex.org/I19648265"],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"suppl_1","first_page":"S139","last_page":"S139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-nmda-receptor-encephalitis","display_name":"anti-NMDA receptor encephalitis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/herpes-simplex-encephalitis","display_name":"herpes simplex encephalitis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/autoimmune-encephalitis","display_name":"autoimmune encephalitis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/plasmapheresis","display_name":"plasmapheresis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/paraneoplastic-encephalitis","display_name":"paraneoplastic encephalitis","score":0.703000009059906},{"id":"https://openalex.org/keywords/ovarian-teratoma","display_name":"ovarian teratoma","score":0.7760000228881836},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cognitive-and-behavioral-change","display_name":"cognitive and behavioral change","score":0.4320000112056732},{"id":"https://openalex.org/keywords/older-male-patients","display_name":"elderly male patient","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8589263558387756},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.7776678800582886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4579005539417267},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.4331987500190735},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.43033531308174133},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4267522096633911},{"id":"https://openalex.org/C2781460105","wikidata":"https://www.wikidata.org/wiki/Q16918461","display_name":"Autoimmune encephalitis","level":4,"score":0.41414570808410645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2858518362045288},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.15735888481140137}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/ofid/ofy210.364","doi":"https://doi.org/10.1093/ofid/ofy210.364","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.364","pdf_url":"https://academic.oup.com/ofid/article-pdf/5/suppl_1/S139/27558437/ofy210.364.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5239587","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6255570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6255570","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6255570/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofy210.364","doi":"https://doi.org/10.1093/ofid/ofy210.364","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.364","pdf_url":"https://academic.oup.com/ofid/article-pdf/5/suppl_1/S139/27558437/ofy210.364.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2903097347.pdf","grobid_xml":"https://content.openalex.org/works/W2903097347.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391685852","https://openalex.org/W2989261378","https://openalex.org/W827726204","https://openalex.org/W3108755818","https://openalex.org/W3120308352","https://openalex.org/W2970739132","https://openalex.org/W6931308687","https://openalex.org/W1987159859","https://openalex.org/W2037247123","https://openalex.org/W3113549938"],"abstract_inverted_index":{"N-Methyl-d-aspartate":[0],"receptor":[1,6],"(NMDAR)":[2],"is":[3,19,40,173,207,287],"a":[4,20,41,117,174,219],"glutamate":[5],"on":[7],"nerve":[8],"cells":[9],"that":[10,134,276],"controls":[11],"synaptic":[12],"plasticity":[13],"and":[14,53,70,80,95,126,180,198,210,252,293],"memory":[15],"function.":[16],"Anti-NMDAR":[17],"encephalitis":[18,38,138,172,305],"rare":[21,175],"autoimmune":[22,171,221,299],"disease":[23],"causes":[24],"by":[25],"antibodies":[26],"(Ab)":[27],"against":[28],"GluN1":[29],"subunit":[30],"of":[31,85,152,284,290],"the":[32,279,288,291,307],"NMDAR.":[33],"Preceding":[34],"Herpes":[35],"simplex":[36],"virus-1":[37],"(HSVE)":[39],"well-recognized":[42],"infectious":[43],"trigger.":[44],"First":[45],"reported":[46,251,317],"in":[47,60,163,196,201,239,262,273,306],"female":[48],"patients":[49,311],"with":[50,56,66,78,82,98,130,160,224,232,243],"ovarian":[51],"teratoma,":[52],"more":[54],"recently":[55],"germ":[57],"cell":[58],"tumors":[59,247],"males.":[61],"A":[62,141],"61-year-old":[63],"male":[64],"presented":[65],"agitation,":[67],"behavioral":[68],"changes,":[69],"confusion.":[71],"Eight":[72],"months":[73,103,158],"prior,":[74],"he":[75,90],"was":[76,113,139],"diagnosed":[77],"HSVE":[79,169,266,295],"treated":[81],"21":[83],"days":[84],"intravenous":[86],"acyclovir.":[87],"Following":[88],"therapy,":[89],"suffered":[91],"from":[92],"residual":[93],"cognitive":[94],"personality":[96],"changes":[97,128],"slow":[99],"recovery":[100],"until":[101],"3":[102],"prior":[104],"to":[105,254],"admission":[106],"encephalopathy":[107],"again":[108],"worsened.":[109],"An":[110],"extensive":[111],"investigation":[112],"unrevealing":[114],"except":[115],"for":[116,236,270,309],"CSF":[118,204],"lymphocytic":[119],"pleocytosis,":[120],"positive":[121],"anti-NMDAR":[122,137,304],"Ab":[123,184,205],"titer":[124,206],"1:64":[125],"imaging":[127],"consistent":[129],"post-viral":[131],"encephalitis.":[132],"At":[133],"point,":[135],"HSV-induced":[136],"diagnosed.":[140],"PET":[142],"scan":[143],"did":[144],"not":[145,249],"show":[146],"any":[147],"occult":[148],"malignancies.":[149],"Two":[150],"cycles":[151],"plasmapheresis":[153],"were":[154],"attempted":[155],"over":[156],"4":[157],"period":[159],"limited":[161],"success":[162],"improving":[164],"his":[165],"worsening":[166],"neurologic":[167,263],"deficits.":[168],"induced":[170],"complication,":[176],"primarily":[177],"affecting":[178],"children":[179,197],"young":[181,202],"adults.":[182,203],"Auto":[183],"develop":[185],"1\u20134":[186],"weeks":[187],"after":[188],"HSVE,":[189],"manifesting":[190],"as":[191],"choreoathetosis":[192],"and/or":[193],"orofacial":[194],"dyskinesia":[195],"psychiatric":[199],"symptoms":[200],"highly":[208],"sensitive":[209],"specific.":[211],"Proposed":[212],"mechanisms":[213],"include":[214],"either":[215],"viral":[216],"reactivation":[217],"or":[218],"post-infectious":[220],"process.":[222,300],"Immunotherapy":[223],"tumor":[225],"resection":[226],"(if":[227],"present)":[228],"has":[229,257],"been":[230,250,258],"promising":[231],"less":[233],"frequent":[234],"need":[235],"second-line":[237],"therapy":[238,256],"primary":[240],"condition,":[241],"compare":[242],"HSVE-induced":[244],"condition":[245],"where":[246],"have":[248],"resistance":[253],"first-line":[255],"observed.":[259],"Progressive":[260],"decline":[261],"function":[264],"post":[265,312],"prompted":[267],"an":[268],"evaluation":[269],"paraneoplastic":[271],"conditions":[272],"our":[274],"patient":[275,292],"ultimately":[277],"revealed":[278],"diagnosis.":[280],"The":[281],"unique":[282],"feature":[283],"this":[285,298],"case":[286],"age":[289],"preceding":[294],"which":[296],"triggered":[297],"Physicians":[301],"should":[302],"consider":[303],"differentials":[308],"relapsing":[310],"HSVE.":[313],"All":[314],"authors:":[315],"No":[316],"disclosures.":[318]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-12-11T00:00:00"}