{"id":"https://openalex.org/W2902883267","doi":"https://doi.org/10.1038/s12276-018-0185-z","title":"A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming","display_name":"A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2902883267","doi":"https://doi.org/10.1038/s12276-018-0185-z","mag":"2902883267","pmid":"https://pubmed.ncbi.nlm.nih.gov/30523246","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6283868"},"language":"en","primary_location":{"id":"doi:10.1038/s12276-018-0185-z","doi":"https://doi.org/10.1038/s12276-018-0185-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-018-0185-z","pdf_url":"https://www.nature.com/articles/s12276-018-0185-z.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental &amp; Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s12276-018-0185-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010108216","display_name":"Myung Jin Son","orcid":"https://orcid.org/0000-0003-3487-4809","observed_orcids":["https://orcid.org/0000-0003-3487-4809"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Myung Jin Son","raw_affiliation_strings":["Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea. mjson@kribb.re.kr","Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. mjson@kribb.re.kr","Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea. mjson@kribb.re.kr","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. mjson@kribb.re.kr","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113710057","display_name":"Jae Kap Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086078","display_name":"Hanall Biopharma (South Korea)","ror":"https://ror.org/00gd17e24","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210086078"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Kap Jeong","raw_affiliation_strings":["HanAll Biopharma, Bongeunsaro114-gil 12, 9th Floor, Kangnam-gu, Seoul, Republic of Korea","SCAS-BTT Bioanalysis Co., Ltd, Ochang Scientific Complex 53, Yengudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, 28115, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HanAll Biopharma, Bongeunsaro114-gil 12, 9th Floor, Kangnam-gu, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210086078"]},{"raw_affiliation_string":"SCAS-BTT Bioanalysis Co., Ltd, Ochang Scientific Complex 53, Yengudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, 28115, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008602785","display_name":"Youjeong Kwon","orcid":"https://orcid.org/0000-0002-3915-8740","observed_orcids":["https://orcid.org/0000-0002-3915-8740"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Youjeong Kwon","raw_affiliation_strings":["Center for Biomolecular Sciences, University of Illinois at Chicago, 900 South Ashland Ave. 3018, Chicago, IL, 60607, USA","Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea","Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomolecular Sciences, University of Illinois at Chicago, 900 South Ashland Ave. 3018, Chicago, IL, 60607, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006385051","display_name":"Jae\u2010Sung Ryu","orcid":"https://orcid.org/0009-0001-7409-4535","observed_orcids":["https://orcid.org/0009-0001-7409-4535"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Sung Ryu","raw_affiliation_strings":["Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017367524","display_name":"Seon Ju Mun","orcid":"https://orcid.org/0000-0001-8045-9038","observed_orcids":["https://orcid.org/0000-0001-8045-9038"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seon Ju Mun","raw_affiliation_strings":["Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea","Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423752","display_name":"Hye Jin Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]},{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Jin Kim","raw_affiliation_strings":["Eco-Friendly and New Materials Research Center, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea","Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eco-Friendly and New Materials Research Center, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea","institution_ids":["https://openalex.org/I4210151417"]},{"raw_affiliation_string":"Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010183684","display_name":"Sungwuk Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]},{"id":"https://openalex.org/I4210086078","display_name":"Hanall Biopharma (South Korea)","ror":"https://ror.org/00gd17e24","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210086078"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Sung-wuk Kim","raw_affiliation_strings":["HanAll Biopharma, Bongeunsaro114-gil 12, 9th Floor, Kangnam-gu, Seoul, Republic of Korea","ImmunoMet Therapeutics Inc., JLABS at Texas Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HanAll Biopharma, Bongeunsaro114-gil 12, 9th Floor, Kangnam-gu, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210086078"]},{"raw_affiliation_string":"ImmunoMet Therapeutics Inc., JLABS at Texas Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA","institution_ids":["https://openalex.org/I1337852284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004497802","display_name":"Sanghee Yoo","orcid":"https://orcid.org/0000-0003-2216-8405","observed_orcids":["https://orcid.org/0000-0003-2216-8405"]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanghee Yoo","raw_affiliation_strings":["ImmunoMet Therapeutics Inc., JLABS at Texas Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImmunoMet Therapeutics Inc., JLABS at Texas Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA","institution_ids":["https://openalex.org/I1337852284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039341946","display_name":"Jiae Kook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiae Kook","raw_affiliation_strings":["ImmunoMet Therapeutics Inc., JLABS at Texas Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImmunoMet Therapeutics Inc., JLABS at Texas Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA","institution_ids":["https://openalex.org/I1337852284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049275788","display_name":"Hongbum Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbum Lee","raw_affiliation_strings":["ImmunoMet Therapeutics Inc., JLABS at Texas Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImmunoMet Therapeutics Inc., JLABS at Texas Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA","institution_ids":["https://openalex.org/I1337852284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101406769","display_name":"Janghwan Kim","orcid":"https://orcid.org/0000-0003-3227-958X","observed_orcids":["https://orcid.org/0000-0003-3227-958X"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Janghwan Kim","raw_affiliation_strings":["Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea","Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3227-958X","affiliations":[{"raw_affiliation_string":"Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028958052","display_name":"Kyung\u2010Sook Chung","orcid":"https://orcid.org/0000-0002-0862-0779","observed_orcids":["https://orcid.org/0000-0002-0862-0779"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyung-Sook Chung","raw_affiliation_strings":["Biomedical Translational Research Center, KRIBB, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. kschung@kribb.re.kr","Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea. kschung@kribb.re.kr","Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Translational Research Center, KRIBB, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. kschung@kribb.re.kr","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea. kschung@kribb.re.kr","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea","institution_ids":["https://openalex.org/I88761825"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010108216","https://openalex.org/A5028958052"],"corresponding_institution_ids":["https://openalex.org/I73616290","https://openalex.org/I88761825"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":{"value":4490,"currency":"USD","value_usd":4490},"fwci":2.9001,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.91012453,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"50","issue":"12","first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-follicle-regeneration","display_name":"hair follicle regeneration","score":0.984000027179718},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.7699999809265137},{"id":"https://openalex.org/keywords/small-molecules","display_name":"small molecules","score":0.652999997138977},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.8650000095367432},{"id":"https://openalex.org/keywords/stem-cell-metabolism","display_name":"stem cell metabolism","score":0.9129999876022339},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mitochondrial-oxidative-phosphorylation","display_name":"mitochondrial oxidative phosphorylation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.7509999871253967},{"id":"https://openalex.org/keywords/anagen-phase","display_name":"anagen phase","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hair-cycle","display_name":"hair cycle","score":0.796999990940094},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.5329999923706055},{"id":"https://openalex.org/keywords/minoxidil","display_name":"minoxidil","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hair-regrowth","display_name":"hair regrowth","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.8055076003074646},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7280727028846741},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7266803979873657},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7229480147361755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6389492154121399},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.587083101272583},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5532879829406738},{"id":"https://openalex.org/C2991961867","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair cycle","level":3,"score":0.4793068468570709},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25018519163131714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16487067937850952},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.07280096411705017},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001645","descriptor_name":"Biguanides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001645","descriptor_name":"Biguanides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048091","descriptor_name":"Guided Tissue Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s12276-018-0185-z","doi":"https://doi.org/10.1038/s12276-018-0185-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-018-0185-z","pdf_url":"https://www.nature.com/articles/s12276-018-0185-z.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental &amp; Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5260571","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6283868","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30523246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30523246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6283868","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6283868/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Mol Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:af78d44cff2940358f43e469203c4b43","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/af78d44cff2940358f43e469203c4b43","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-15 (2018)","raw_type":"article"},{"id":"pmh:oai:http://repository.kribb.re.kr:201005/18263","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1038/s12276-018-0185-z","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/16297.pdf","raw_type":"Article"},{"id":"pmh:oai:https://repository.kribb.re.kr:201005/18263","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1038/s12276-018-0185-z","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/16297.pdf","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/s12276-018-0185-z","doi":"https://doi.org/10.1038/s12276-018-0185-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-018-0185-z","pdf_url":"https://www.nature.com/articles/s12276-018-0185-z.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental &amp; Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1384268224","display_name":null,"funder_award_id":"D36402","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"},{"id":"https://openalex.org/G8775210787","display_name":null,"funder_award_id":"2015M3A9C7030128","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322109","display_name":"Korea Research Council of Fundamental Science and Technology","ror":"https://ror.org/058rymf81"},{"id":"https://openalex.org/F4320322110","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07"},{"id":"https://openalex.org/F4320322111","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2902883267.pdf","grobid_xml":"https://content.openalex.org/works/W2902883267.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1544045643","https://openalex.org/W1605270587","https://openalex.org/W1964872204","https://openalex.org/W1966092430","https://openalex.org/W1969503475","https://openalex.org/W1970924670","https://openalex.org/W1976008730","https://openalex.org/W1977109906","https://openalex.org/W1980100502","https://openalex.org/W1980246541","https://openalex.org/W1993852989","https://openalex.org/W1996842151","https://openalex.org/W1998566517","https://openalex.org/W2001250643","https://openalex.org/W2003151530","https://openalex.org/W2009397177","https://openalex.org/W2019019085","https://openalex.org/W2023011577","https://openalex.org/W2029600421","https://openalex.org/W2031402508","https://openalex.org/W2039212784","https://openalex.org/W2041819610","https://openalex.org/W2044922756","https://openalex.org/W2045565875","https://openalex.org/W2048252195","https://openalex.org/W2050249780","https://openalex.org/W2051418621","https://openalex.org/W2057343637","https://openalex.org/W2059542071","https://openalex.org/W2061632247","https://openalex.org/W2062184366","https://openalex.org/W2066852179","https://openalex.org/W2067575395","https://openalex.org/W2083248307","https://openalex.org/W2100325414","https://openalex.org/W2100466458","https://openalex.org/W2101967659","https://openalex.org/W2104054545","https://openalex.org/W2125631342","https://openalex.org/W2125987139","https://openalex.org/W2127311839","https://openalex.org/W2128367294","https://openalex.org/W2142046859","https://openalex.org/W2142920152","https://openalex.org/W2143681046","https://openalex.org/W2147863793","https://openalex.org/W2149114035","https://openalex.org/W2152951302","https://openalex.org/W2153027227","https://openalex.org/W2153354074","https://openalex.org/W2164361361","https://openalex.org/W2179359265","https://openalex.org/W2247011864","https://openalex.org/W2263704974","https://openalex.org/W2271930197","https://openalex.org/W2280169910","https://openalex.org/W2293868015","https://openalex.org/W2485884487","https://openalex.org/W2520333406","https://openalex.org/W2565424224","https://openalex.org/W2594543006","https://openalex.org/W2598540218","https://openalex.org/W2618322398","https://openalex.org/W2618797847","https://openalex.org/W2624155732","https://openalex.org/W4237271357"],"related_works":["https://openalex.org/W3024423886","https://openalex.org/W4241307189","https://openalex.org/W2280169910","https://openalex.org/W2663203974","https://openalex.org/W4400235047","https://openalex.org/W3124882239","https://openalex.org/W6921423076","https://openalex.org/W4416536313","https://openalex.org/W7154976029","https://openalex.org/W3131256500"],"abstract_inverted_index":{"Targeting":[0],"hair":[1,11,39,49,109,118,128,157,172,190,219,299,308],"follicle":[2,110,119,129,173],"regeneration":[3,40,111,158],"has":[4],"been":[5,23],"investigated":[6],"for":[7,207,217],"the":[8,32,38,48,96,103,114,117,122,127,134,146,156,164,168,180,194,258,278,293,314],"treatment":[9,81,166],"of":[10,27,35,52,99,106,116,171,197,246,257,262],"loss,":[12],"and":[13,19,31,70,87,125,151,240,264,267,318],"fundamental":[14],"studies":[15],"investigating":[16],"stem":[17,28,63,76,135,198,209,228,289,329],"cells":[18,210,229,296],"their":[20],"niche":[21,152],"have":[22,270],"described.":[24],"However,":[25],"knowledge":[26],"cell":[29,64,77,136,150,290,330],"metabolism":[30],"specific":[33],"regulation":[34],"bioenergetics":[36],"during":[37,72,95,167],"process":[41,159],"is":[42],"currently":[43],"insufficient.":[44],"Here,":[45],"we":[46],"report":[47],"regrowth-promoting":[50],"effect":[51],"a":[53,139,214,231,272,328],"newly":[54],"synthesized":[55],"novel":[56,181],"small":[57,182],"molecule,":[58],"IM176OUT05":[59],"(IM),":[60],"which":[61,91],"activates":[62],"metabolism.":[65],"IM":[66,80,107,165,184],"facilitated":[67],"stemness":[68,93,286],"induction":[69,94],"maintenance":[71],"an":[73],"induced":[74],"pluripotent":[75,232],"generation":[78],"process.":[79],"mildly":[82],"inhibited":[83],"mitochondrial":[84,224],"oxidative":[85],"phosphorylation":[86],"concurrently":[88],"increased":[89,126],"glycolysis,":[90],"accelerated":[92,108],"early":[97,169],"phase":[98,124,170],"reprogramming.":[100],"More":[101],"importantly,":[102],"topical":[104],"application":[105,302],"by":[112,163,192,253],"stimulating":[113],"progression":[115],"cycle":[120],"to":[121,237],"anagen":[123],"number":[130],"in":[131,145,155,189,287,310,322],"mice.":[132,148],"Furthermore,":[133],"population":[137],"with":[138],"glycolytic":[140],"metabotype":[141],"appeared":[142],"slightly":[143],"earlier":[144],"IM-treated":[147],"Stem":[149],"signaling":[153],"involved":[154],"was":[160],"also":[161,212],"activated":[162],"regeneration.":[174],"Overall,":[175],"these":[176,247],"results":[177],"show":[178],"that":[179,202,222,234,275,297],"molecule":[183],"promotes":[185],"tissue":[186],"regeneration,":[187],"specifically":[188],"regrowth,":[191],"restructuring":[193],"metabolic":[195,204],"configuration":[196],"cells.":[199],"A":[200],"compound":[201,274],"establishes":[203],"conditions":[205],"favorable":[206],"sustaining":[208],"may":[211],"offer":[213],"safe":[215],"drug":[216,283,316],"promoting":[218,307],"regrowth.":[220],"Drugs":[221],"inhibit":[223],"activity":[225],"help":[226],"lock":[227],"into":[230],"state":[233],"allows":[235],"them":[236],"actively":[238],"divide":[239],"repair":[241],"various":[242],"tissues,":[243],"but":[244],"many":[245],"drugs":[248],"are":[249],"toxic.":[250],"Researchers":[251],"led":[252],"Myung":[254],"Jin":[255],"Son":[256],"Korea":[259],"Research":[260],"Institute":[261],"Bioscience":[263],"Biotechnology,":[265],"Daejeon":[266],"ImmunoMet,":[268],"USA":[269],"identified":[271],"new":[273],"safely":[276],"achieves":[277],"same":[279],"effect.":[280],"This":[281],"potential":[282],"helped":[284],"promote":[285],"diverse":[288],"types,":[291],"including":[292],"highly":[294],"proliferative":[295],"comprise":[298],"follicles.":[300],"Topical":[301],"proved":[303],"more":[304],"effective":[305],"at":[306],"regrowth":[309],"female":[311],"mice":[312],"than":[313],"baldness":[315],"minoxidil,":[317],"matched":[319],"its":[320,325],"performance":[321],"males,":[323],"demonstrating":[324],"potency":[326],"as":[327],"modulator.":[331]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-11T00:00:00"}
