{"id":"https://openalex.org/W2902621929","doi":"https://doi.org/10.1080/14787210.2019.1555031","title":"Current research toward optimizing dosing of first-line antituberculosis treatment","display_name":"Current research toward optimizing dosing of first-line antituberculosis treatment","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2902621929","doi":"https://doi.org/10.1080/14787210.2019.1555031","mag":"2902621929","pmid":"https://pubmed.ncbi.nlm.nih.gov/30501530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6364307"},"language":"en","primary_location":{"id":"doi:10.1080/14787210.2019.1555031","doi":"https://doi.org/10.1080/14787210.2019.1555031","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14787210.2019.1555031","pdf_url":null,"source":{"id":"https://openalex.org/S185628608","display_name":"Expert Review of Anti-infective Therapy","issn_l":"1478-7210","issn":["1478-7210","1744-8336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anti-infective Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1080/14787210.2019.1555031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025069184","display_name":"Helen McIlleron","orcid":"https://orcid.org/0000-0002-0982-6226","observed_orcids":["https://orcid.org/0000-0002-0982-6226"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Helen McIlleron","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072683436","display_name":"Maxwell Chirehwa","orcid":"https://orcid.org/0000-0002-1685-4882","observed_orcids":["https://orcid.org/0000-0002-1685-4882"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Maxwell T Chirehwa","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025069184"],"corresponding_institution_ids":["https://openalex.org/I157614274"],"apc_list":null,"apc_paid":null,"fwci":0.6967,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.6009822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"27","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pharmacokinetic-variability","display_name":"pharmacokinetic variability","score":0.7919999957084656},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.9010000228881836},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.7699999809265137},{"id":"https://openalex.org/keywords/population-pharmacokinetic-model","display_name":"population pharmacokinetic model","score":0.871999979019165},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.871999979019165},{"id":"https://openalex.org/keywords/acetylator-phenotype","display_name":"acetylator phenotype","score":0.7680000066757202},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8149999976158142},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.6880000233650208},{"id":"https://openalex.org/keywords/african-patients","display_name":"African patients","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8887320756912231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7839437127113342},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6533414125442505},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6283011436462402},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.5604450702667236},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5430753231048584},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5187954306602478},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45297330617904663},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4469265341758728},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.1550983190536499},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08299520611763}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/14787210.2019.1555031","doi":"https://doi.org/10.1080/14787210.2019.1555031","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14787210.2019.1555031","pdf_url":null,"source":{"id":"https://openalex.org/S185628608","display_name":"Expert Review of Anti-infective Therapy","issn_l":"1478-7210","issn":["1478-7210","1744-8336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anti-infective Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5365639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6364307","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6364307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6364307","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Rev Anti Infect Ther","raw_type":"Text"},{"id":"pmid:30501530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30501530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of anti-infective therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/14787210.2019.1555031","doi":"https://doi.org/10.1080/14787210.2019.1555031","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14787210.2019.1555031","pdf_url":null,"source":{"id":"https://openalex.org/S185628608","display_name":"Expert Review of Anti-infective Therapy","issn_l":"1478-7210","issn":["1478-7210","1744-8336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anti-infective Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2636380970","display_name":"Optimal dosing of 1st line antituberculosis and antiretroviral drugs in children","funder_award_id":"R01HD069175","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G519773201","display_name":"Pharmacometrics to advance novel regimens for drug-resistant tuberculosis (PandrTB)","funder_award_id":"206379/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7519271958","display_name":"Pharmacometric optimization of second line drugs for MDR tuberculosis treatment","funder_award_id":"R01AI116155","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W99576858","https://openalex.org/W1211808353","https://openalex.org/W1488707870","https://openalex.org/W1564336530","https://openalex.org/W1584321696","https://openalex.org/W1777541362","https://openalex.org/W1834506558","https://openalex.org/W1928732711","https://openalex.org/W1965435438","https://openalex.org/W1968940867","https://openalex.org/W2002519994","https://openalex.org/W2011863437","https://openalex.org/W2012174175","https://openalex.org/W2025169590","https://openalex.org/W2027951201","https://openalex.org/W2030371954","https://openalex.org/W2039809703","https://openalex.org/W2046797497","https://openalex.org/W2052296327","https://openalex.org/W2060396702","https://openalex.org/W2061653261","https://openalex.org/W2077507092","https://openalex.org/W2080320250","https://openalex.org/W2089176235","https://openalex.org/W2091277908","https://openalex.org/W2095750649","https://openalex.org/W2096624362","https://openalex.org/W2098049342","https://openalex.org/W2104477113","https://openalex.org/W2107834145","https://openalex.org/W2109242366","https://openalex.org/W2112124041","https://openalex.org/W2112348327","https://openalex.org/W2119493899","https://openalex.org/W2120873364","https://openalex.org/W2122527560","https://openalex.org/W2132145963","https://openalex.org/W2132389528","https://openalex.org/W2134655561","https://openalex.org/W2138753225","https://openalex.org/W2139044436","https://openalex.org/W2139687934","https://openalex.org/W2139724863","https://openalex.org/W2144692033","https://openalex.org/W2145156925","https://openalex.org/W2145195813","https://openalex.org/W2147213334","https://openalex.org/W2147786693","https://openalex.org/W2148205948","https://openalex.org/W2149849113","https://openalex.org/W2154816797","https://openalex.org/W2155862922","https://openalex.org/W2159717558","https://openalex.org/W2164438043","https://openalex.org/W2169788739","https://openalex.org/W2170012142","https://openalex.org/W2172137232","https://openalex.org/W2176098060","https://openalex.org/W2181876900","https://openalex.org/W2196011820","https://openalex.org/W2206624792","https://openalex.org/W2324439816","https://openalex.org/W2327719413","https://openalex.org/W2341048433","https://openalex.org/W2398732098","https://openalex.org/W2405813868","https://openalex.org/W2409045489","https://openalex.org/W2412764979","https://openalex.org/W2418925998","https://openalex.org/W2461259691","https://openalex.org/W2493897159","https://openalex.org/W2509765170","https://openalex.org/W2522462032","https://openalex.org/W2539238579","https://openalex.org/W2543303947","https://openalex.org/W2549324448","https://openalex.org/W2582762749","https://openalex.org/W2586728247","https://openalex.org/W2588740789","https://openalex.org/W2605856369","https://openalex.org/W2608626794","https://openalex.org/W2610178523","https://openalex.org/W2610453835","https://openalex.org/W2610736830","https://openalex.org/W2620504851","https://openalex.org/W2624688081","https://openalex.org/W2637028878","https://openalex.org/W2743570739","https://openalex.org/W2770076510","https://openalex.org/W2773907647","https://openalex.org/W2778803543","https://openalex.org/W2780747016","https://openalex.org/W2793084722","https://openalex.org/W2794743410","https://openalex.org/W2795574439","https://openalex.org/W2799300912","https://openalex.org/W2799936020","https://openalex.org/W2802200589","https://openalex.org/W2802249081","https://openalex.org/W2802877139","https://openalex.org/W2806252171","https://openalex.org/W2808516542","https://openalex.org/W2809562126","https://openalex.org/W2811190177","https://openalex.org/W2811297459","https://openalex.org/W2890636891","https://openalex.org/W2916572998","https://openalex.org/W2922622268","https://openalex.org/W2976597144","https://openalex.org/W4247927788"],"related_works":["https://openalex.org/W2922622268","https://openalex.org/W980735245","https://openalex.org/W3206437796","https://openalex.org/W2965285215","https://openalex.org/W2923456140","https://openalex.org/W2965751143","https://openalex.org/W7023842082","https://openalex.org/W4408576712","https://openalex.org/W2334036212","https://openalex.org/W3049724417"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Drug":[1],"concentrations":[2],"in":[3,43,105,121],"tuberculosis":[4,50,125],"patients":[5,122,175,200],"on":[6,32],"standard":[7],"regimens":[8],"vary":[9],"widely":[10],"with":[11,25,65,123,201],"clinically":[12],"important":[13,81],"consequences.":[14],"Areas":[15],"covered:":[16],"We":[17],"review":[18],"the":[19,37,58,193],"available":[20,59],"literature":[21],"identifying":[22],"factors":[23],"correlated":[24],"pharmacokinetic":[26,34,82],"variability":[27,83],"of":[28,48,57,80,93,109,116,119,155,163,186,195],"antituberculosis":[29,187],"drugs.":[30],"Based":[31],"population":[33],"models":[35],"and":[36,40,91,95,129,166,176],"weight,":[38],"height,":[39],"sex":[41],"distributions":[42],"a":[44,133],"large":[45],"data":[46],"base":[47],"African":[49],"patients,":[51],"we":[52],"propose":[53],"simplified":[54],"weight-based":[55,74],"doses":[56,118],"fixed":[60],"dose":[61],"combination(FDC)":[62],"for":[63,76,151,159,174],"adults":[64],"drug":[66,110,188],"susceptible":[67],"tuberculosis.":[68,202],"Emerging":[69],"studies":[70],"will":[71,103],"support":[72],"optimized":[73],"dosing":[75,102,141],"children.":[77,160],"Other":[78],"sources":[79],"include":[84],"genetic":[85],"variants,":[86],"drug-drug":[87],"interactions,":[88],"formulation":[89],"quality,":[90],"methods":[92],"preparation":[94],"administration.":[96],"Expert":[97],"commentary:":[98],"Optimized":[99],"weight":[100],"band-based":[101],"result":[104],"more":[106,130,152],"equitable":[107],"distribution":[108],"exposures":[111],"by":[112],"weight.":[113],"The":[114,161],"use":[115,194],"high":[117],"isoniazid":[120],"drug-resistant":[124],"would":[126],"be":[127],"safer":[128],"effective":[131],"if":[132],"feasible":[134],"test":[135],"was":[136],"developed":[137],"to":[138,143,182,198],"allow":[139,171],"stratified":[140],"according":[142],"acetylator":[144],"type.":[145],"There":[146],"is":[147],"an":[148],"urgent":[149],"need":[150],"suitable":[153],"formulations":[154],"many":[156],"second-line":[157],"drugs":[158],"adoption":[162],"new":[164],"technologies":[165],"efficient":[167],"FDC":[168],"design":[169],"may":[170],"further":[172],"advances":[173],"treatment":[177],"programs.":[178],"Lastly,":[179],"current":[180],"efforts":[181],"ensure":[183],"adequate":[184],"quality":[185],"products":[189,197],"are":[190],"not":[191],"preventing":[192],"substandard":[196],"treat":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-12-11T00:00:00"}
