{"id":"https://openalex.org/W2902587537","doi":null,"title":"Eicosapentaenoic Acid and Vitamin E Against Doxorubicin Induced Cardiac and Renal Damages: Role of Cytochrome c and iNOS.","display_name":"Eicosapentaenoic Acid and Vitamin E Against Doxorubicin Induced Cardiac and Renal Damages: Role of Cytochrome c and iNOS.","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2902587537","mag":"2902587537","pmid":"https://pubmed.ncbi.nlm.nih.gov/30551690"},"language":"en","primary_location":{"id":"pmid:30551690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30551690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Iranian medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070218946","display_name":"Ahmed M. Fayez","orcid":"https://orcid.org/0000-0001-6622-0653","observed_orcids":["https://orcid.org/0000-0001-6622-0653"]},"institutions":[{"id":"https://openalex.org/I895027328","display_name":"October University of Modern Sciences and Arts","ror":"https://ror.org/01nvnhx40","country_code":"EG","type":"education","lineage":["https://openalex.org/I895027328"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed M Fayez","raw_affiliation_strings":["Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, Egypt","institution_ids":["https://openalex.org/I895027328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023990211","display_name":"Mai A. Zaafan","orcid":"https://orcid.org/0000-0002-5295-0003","observed_orcids":["https://orcid.org/0000-0002-5295-0003"]},"institutions":[{"id":"https://openalex.org/I895027328","display_name":"October University of Modern Sciences and Arts","ror":"https://ror.org/01nvnhx40","country_code":"EG","type":"education","lineage":["https://openalex.org/I895027328"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mai A Zaafan","raw_affiliation_strings":["Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, Egypt","institution_ids":["https://openalex.org/I895027328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I895027328"],"apc_list":null,"apc_paid":null,"fwci":0.9435,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75398988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"21","issue":"11","first_page":"502","last_page":"508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.05090000107884407,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.9570000171661377},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9929999709129333},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":1.0},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9769999980926514},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.43700000643730164},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.6179999709129333},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.847000002861023},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.7290340065956116},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.5889546871185303},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5497463941574097},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5491538047790527},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.5330663323402405},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5172575116157532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5064159631729126},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.44879332184791565},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.4485081434249878},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4410228431224823},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4154627025127411},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.4107832908630371},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.40847906470298767},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4024542570114136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39734816551208496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37883850932121277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3190414309501648},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29705995321273804},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.21039611101150513},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.20522341132164001},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1969643235206604},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14389124512672424}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015118","descriptor_name":"Eicosapentaenoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:30551690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30551690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Iranian medicine","raw_type":"Journal Article"},{"id":"mag:2902587537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30551690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2955982701","https://openalex.org/W2028744694","https://openalex.org/W2006216932","https://openalex.org/W2068399996","https://openalex.org/W2574023248","https://openalex.org/W2054374174","https://openalex.org/W14153883","https://openalex.org/W2460040015","https://openalex.org/W2168220191","https://openalex.org/W3104725379"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,120,172],"current":[2],"study":[3,174],"aimed":[4],"to":[5,31,149],"evaluate":[6],"the":[7,85,92,150,176],"mechanisms":[8,122],"involved":[9],"in":[10,159],"protection":[11,113,124],"against":[12,212],"doxorubicin-induced":[13,115],"cardiac":[14,116,189],"and":[15,23,43,56,71,108,117,129,139,161,183,190,198,204],"renal":[16,118,191],"toxicities":[17,192],"upon":[18],"treatment":[19],"with":[20,48,143],"eicosapentaenoic":[21,39,181,202],"acid":[22,40,107,182,203],"vitamin":[24,49,109,184,205],"E.":[25,50],"METHODS:":[26],"Rats":[27],"were":[28,75,79,94],"randomly":[29],"assigned":[30],"4":[32],"groups:":[33],"normal":[34],"control,":[35,38],"doxorubicin":[36,151,187],"inducted":[37],"treated":[41],"group":[42,46],"a":[44],"final":[45],"pretreated":[47],"Lipid":[51],"peroxidation,":[52],"reduced":[53],"glutathione":[54,65],"(GSH)":[55],"tumor":[57],"necrosis":[58],"factor-alpha":[59],"(TNF-\u03b1)":[60],"contents":[61,141],"as":[62,64,132,134,147],"well":[63,133],"peroxidase":[66],"(GPx),":[67],"superoxide":[68],"dismutase":[69],"(SOD)":[70],"myeloperoxidase":[72],"(MPO)":[73],"activities":[74,163],"assessed.":[76],"Moreover,":[77,154],"hearts":[78],"used":[80,95],"for":[81,96,123],"immunohistochemical":[82],"detection":[83,97],"of":[84,98,168,180],"pro-apoptotic":[86],"protein":[87],"cytochrome":[88,127],"c":[89,128],"expression,":[90],"while":[91],"kidneys":[93],"inducible":[99],"nitric":[100],"oxide":[101],"synthase":[102],"(iNOS)":[103],"expression.":[104],"RESULTS:":[105],"Eicosapentaenoic":[106],"E":[110,185,206],"produced":[111],"significant":[112,166],"from":[114,186],"toxicities.":[119],"suggested":[121],"included":[125],"decreased":[126,136],"iNOS":[130],"expression":[131],"markedly":[135],"lipid":[137],"peroxides":[138],"TNF-\u03b1":[140],"accompanied":[142,164],"increased":[144],"GSH":[145],"content":[146],"compared":[148],"control":[152],"group.":[153],"there":[155],"was":[156],"marked":[157],"increase":[158],"GPx":[160],"SOD":[162],"by":[165],"suppression":[167],"MPO":[169],"activity.":[170],"CONCLUSION:":[171],"present":[173],"demonstrated":[175],"potent":[177,195],"protective":[178,210],"effects":[179],"induced":[188],"through":[193],"their":[194],"anti-oxidant,":[196],"anti-inflammatory":[197],"anti-apoptotic":[199],"properties.":[200],"Hence,":[201],"could":[207],"be":[208],"promising":[209],"agents":[211],"doxorubicintoxicity.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-11T00:00:00"}
